Cplx3 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cplx3
Entrez Gene ID	235415
Full Name	complexin 3
Synonyms	BC016632,CpxIII,ERGIC-53L,ERGL,Lamn1l,Lman1l
General protein information	Preferred Names complexin 3 Names complexin-3 CPX III complexin III lectin, mannose-binding, 1 like
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 B

mRNA and Protein(s)

mRNA	Protein	Name
NM_146223.3	NP_666335.1	complexin-3 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Cplx3	NP_001102765.1
Canis lupus familiaris (dog)	CPLX3	XP_854351.1
Danio rerio (zebrafish)	cplx3a	NP_001165054.1
Xenopus tropicalis (tropical clawed frog)	lman1l	NP_001016497.1
Bos taurus (cattle)	CPLX3	NP_001071357.1
Gallus gallus (chicken)	CPLX3	NP_001107977.1
Danio rerio (zebrafish)	cplx3b	NP_001165061.1
Danio rerio (zebrafish)	LOC100149700	XP_005163127.1
Homo sapiens (human)	CPLX3	NP_001025176.1
Pan troglodytes (chimpanzee)	CPLX3	XP_003314834.1
	CPLX3	XP_002804911.1
Mus musculus (house mouse)	Cplx3	NP_666335.1

Gene Ontology
Bibliography

Related articles in PubMed

Molecularly Defined Subplate Neurons Project Both to Thalamocortical Recipient Layers and Thalamus.
Viswanathan S, Sheikh A, Looger LL, Kanold PO
Cerebral cortex (New York, N.Y. : 1991)27(10)4759-4768(2017 Oct)

TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons.
Caubit X, Gubellini P, Andrieux J, Roubertoux PL, Metwaly M, Jacq B, Fatmi A, Had-Aissouni L, Kwan KY, Salin P, Carlier M, Lied?n A, Rudd E, Shinawi M, Vincent-Delorme C, Cuisset JM, Lemaitre MP, Abderrehamane F, Duban B, Lemaitre JF, Woolf AS, Bockenhauer D, Severac D, Dubois E, Zhu Y, Sestan N, Garratt AN, Goff LK, Fasano L
Nature genetics48(11)1359-1369(2016 Nov)

Functional Roles of Complexin 3 and Complexin 4 at Mouse Photoreceptor Ribbon Synapses.
Babai N, Sendelbeck A, Regus-Leidig H, Fuchs M, Mertins J, Reim K, Brose N, Feigenspan A, Brandst?tter JH
The Journal of neuroscience : the official journal of the Society for Neuroscience36(25)6651-67(2016 06)

Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses.
Mortensen LS, Park SJH, Ke JB, Cooper BH, Zhang L, Imig C, L?wel S, Reim K, Brose N, Demb JB, Rhee JS, Singer JH
Cell reports15(10)2239-2250(2016 06)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The findings of this study reveal a suppressing action of Cplx3/4 on tonic neurotransmitter release, a facilitating action on evoked release, and a regulatory role of Cplx3/4 in the adaptation-dependent availability of synaptic vesicles at mouse photoreceptor ribbon synapses.
Title: Functional Roles of Complexin 3 and Complexin 4 at Mouse Photoreceptor Ribbon Synapses.

This study links Cplx3 expression with synapse and circuit function in a specific retinal pathway and reveals a role for asynchronous release in circuit gain control.
Title: Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses.

This study demonistrated that Cplx3-positive cells are generated during the 2-day peak of subplate neurogenesis (E11.5-E12.5). survive preferentially after the first postnatal week compared with other subplate neurons.
Title: Molecular diversity of early-born subplate neurons.

The lack of Cplx 3 and Cplx 4 differentially impacts the ON and OFF pathways in the retina is corroborated by localization studies of Cplx 3 and Cplx 4 in the retina.
Title: The absence of Complexin 3 and Complexin 4 differentially impacts the ON and OFF pathways in mouse retina.

Results show that complexin 3 and complexin 4 are essential regulators of transmitter release at retinal ribbon synapses.
Title: Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4.

The following Cplx3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cplx3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu12330	NM_146223.3 Latest version!	Mus musculus complexin 3 (Cplx3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	Quote Price

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cplx3 ( NM_146223.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_666335.1 Mus musculus complexin 3 (Cplx3), mRNA.

Price & Availability↑

CloneID	OMu12330
Clone ID Related Accession (Same CDS sequence)	NM_146223.3
Accession Version	NM_146223.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 477bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-26
Organism	Mus musculus(house mouse)
Product	complexin-3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC122528.3 and BC033343.1. On Aug 26, 2009 this sequence version replaced NM_146223.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC033343.1, AK044211.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGTTCA TGGTGAAGTC CATGGTGGGT GGCCAACTGA AGAACCTCAC AGGGAGCCTG 
GGGGGCGGCG AGGACAAGGG GGACGGAGAC AAGTCTGCAG CCGAAGCACA GGGCATGAGC 
CGAGAAGAGT ACGAGGAGTA TCAGAAGCAA CTGGTGGAGG AGAAGATGGA GCGAGATGCA 
CAGTTCACAC AGAGGAAGGC AGAGCGGGCC ACACTGCGAA GTCACTTCAG AGACAAATAC 
CGTCTGCCCA AGAACGAAAC AGATGAAAGC CAGATCCAGC TGGCAGGCGG AGATGTGGAG 
CTGCCTCGGG AGCTAGCCAA GATGATCGAG GAGGATACGG AGGAAGAGGA GGATAAGGCC 
TCTGTGCTCG GGCAGCTGGC CAGCCTCCCT GGCCTAGACC TCAGCTCACT CAAGGACAAA 
GCCCAGACTA CACTAGGGGA CCTCAAGCAA TCAGCTGAGA AGTGCCATAT CATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_666335.1
CDS	138..614
Translation	MAFMVKSMVGGQLKNLTGSLGGGEDKGDGDKSAAEAQGMSREEYEEYQKQLVEEKMERDAQFTQRKAERATLRSHFRDKYRLPKNETDESQIQLAGGDVELPRELAKMIEEDTEEEEDKASVLGQLASLPGLDLSSLKDKAQTTLGDLKQSAEKCHIM

Target ORF information:

RefSeq Version	NM_146223.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus complexin 3 (Cplx3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_146223.3

ORF Insert Sequence:

ATGGCGTTCA TGGTGAAGTC CATGGTGGGT GGCCAACTGA AGAACCTCAC AGGGAGCCTG 
GGGGGCGGCG AGGACAAGGG GGACGGAGAC AAGTCTGCAG CCGAAGCACA GGGCATGAGC 
CGAGAAGAGT ACGAGGAGTA TCAGAAGCAA CTGGTGGAGG AGAAGATGGA GCGAGATGCA 
CAGTTCACAC AGAGGAAGGC AGAGCGGGCC ACACTGCGAA GTCACTTCAG AGACAAATAC 
CGTCTGCCCA AGAACGAAAC AGATGAAAGC CAGATCCAGC TGGCAGGCGG AGATGTGGAG 
CTGCCTCGGG AGCTAGCCAA GATGATCGAG GAGGATACGG AGGAAGAGGA GGATAAGGCC 
TCTGTGCTCG GGCAGCTGGC CAGCCTCCCT GGCCTAGACC TCAGCTCACT CAAGGACAAA 
GCCCAGACTA CACTAGGGGA CCTCAAGCAA TCAGCTGAGA AGTGCCATAT CATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molecularly Defined Subplate Neurons Project Both to Thalamocortical Recipient Layers and Thalamus.
Cerebral cortex (New York, N.Y. : 1991)27(10)4759-4768(2017 Oct)
Viswanathan S,Sheikh A,Looger LL,Kanold PO

TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons.
Nature genetics48(11)1359-1369(2016 Nov)
Caubit X,Gubellini P,Andrieux J,Roubertoux PL,Metwaly M,Jacq B,Fatmi A,Had-Aissouni L,Kwan KY,Salin P,Carlier M,Lied?n A,Rudd E,Shinawi M,Vincent-Delorme C,Cuisset JM,Lemaitre MP,Abderrehamane F,Duban B,Lemaitre JF,Woolf AS,Bockenhauer D,Severac D,Dubois E,Zhu Y,Sestan N,Garratt AN,Goff LK,Fasano L

Functional Roles of Complexin 3 and Complexin 4 at Mouse Photoreceptor Ribbon Synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience36(25)6651-67(2016 06)
Babai N,Sendelbeck A,Regus-Leidig H,Fuchs M,Mertins J,Reim K,Brose N,Feigenspan A,Brandst?tter JH

Complexin 3 Increases the Fidelity of Signaling in a Retinal Circuit by Regulating Exocytosis at Ribbon Synapses.
Cell reports15(10)2239-2250(2016 06)
Mortensen LS,Park SJH,Ke JB,Cooper BH,Zhang L,Imig C,L?wel S,Reim K,Brose N,Demb JB,Rhee JS,Singer JH

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Cplx3 cDNA ORF clone, Mus musculus(house mouse)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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