Gene Symbol | Nell1 |
Entrez Gene ID | 338352 |
Full Name | NEL-like 1 |
Synonyms | B230343H07Rik,l7R6 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Nell1 cDNA ORF clone
gRNAs
Gene Symbol | Nell1 |
Entrez Gene ID | 338352 |
Full Name | NEL-like 1 |
Synonyms | B230343H07Rik,l7R6 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001037906.2 | NP_001032995.1 | protein kinase C-binding protein NELL1 precursor |
Canis lupus familiaris (dog) | NELL1 | XP_534090.3 |
Mus musculus (house mouse) | Nell1 | NP_001032995.1 |
Xenopus tropicalis (tropical clawed frog) | nell1 | XP_004914252.1 |
Rattus norvegicus (Norway rat) | Nell1 | NP_112331.1 |
Gallus gallus (chicken) | NELL1 | XP_001234167.2 |
Homo sapiens (human) | NELL1 | NP_001275642.1 |
Pan troglodytes (chimpanzee) | NELL1 | XP_001173867.3 |
NELL1 | XP_001092428.1 | |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010335 | XP_311609.4 |
Neural EGFL-Like 1 Is a Downstream Regulator of Runt-Related Transcription Factor 2 in Chondrogenic Differentiation and Maturation.
Li C, Jiang J, Zheng Z, Lee KS, Zhou Y, Chen E, Culiat CT, Qiao Y, Chen X, Ting K, Zhang X, Soo C
The American journal of pathology187(5)963-972(2017 May)
Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2.
Jaworski A, Tom I, Tong RK, Gildea HK, Koch AW, Gonzalez LC, Tessier-Lavigne M
Science (New York, N.Y.)350(6263)961-5(2015 Nov)
NELL-1 in the treatment of osteoporotic bone loss.
James AW, Shen J, Zhang X, Asatrian G, Goyal R, Kwak JH, Jiang L, Bengs B, Culiat CT, Turner AS, Seim Iii HB, Wu BM, Lyons K, Adams JS, Ting K, Soo C
Nature communications67362(2015 Jun)
Proliferation and osteogenic differentiation of mesenchymal stem cells induced by a short isoform of NELL-1.
Pang S, Shen J, Liu Y, Chen F, Zheng Z, James AW, Hsu CY, Zhang H, Lee KS, Wang C, Li C, Chen X, Jia H, Zhang X, Soo C, Ting K
Stem cells (Dayton, Ohio)33(3)904-15(2015 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Nell-1-haploinsufficient mice have normal skeletal development but undergo age-related osteoporosis, characterized by a reduction in osteoblast:osteoclast ratio and increased bone fragility.
Title: NELL-1 in the treatment of osteoporotic bone loss.
NELL-1570 has the potential to be used for cell-based or hormone-based therapy of bone regeneration.
Title: Proliferation and osteogenic differentiation of mesenchymal stem cells induced by a short isoform of NELL-1.
These results suggest that an oligomerization-induced conformational change in the C-terminal region of NELL1 is important for the efficient mediation of cell adhesion and spreading by NELL1.
Title: Oligomerization-induced conformational change in the C-terminal region of Nel-like molecule 1 (NELL1) protein is necessary for the efficient mediation of murine MC3T3-E1 cell adhesion and spreading.
Nell-1 might play a role in ameloblast and odontoblast differentiation, secretion and mineralization of the extracellular enamel matrix, molar crown morphogenesis, as well as root formation during the entire development period.
Title: Expression and localization of Nell-1 during murine molar development.
NELL-1 protein promotes cell adhesion in ST2 cells.
Title: NELL-1 promotes cell adhesion and differentiation via Integrin?1.
The following Nell1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nell1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu00125 | |
Clone ID Related Accession (Same CDS sequence) | NM_001037906.2 | |
Accession Version | NM_001037906.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2433bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | protein kinase C-binding protein NELL1 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC116694.9, AC163402.5, AC115080.13, AC161929.4, AC110036.8, AC116734.14, AC128699.4 and AC171557.7. On Nov 17, 2006 this sequence version replaced NM_001037906.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY622226.1, SRR1660811.251556.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCCGATGG ATGTGATTTT AGTTTTGTGG TTCTGTGTGT GCACCGCCAG GACAGTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001032995.1 |
CDS | 40..2472 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGCCGATGG ATGTGATTTT AGTTTTGTGG TTCTGTGTGT GCACCGCCAG GACAGTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Neural EGFL-Like 1 Is a Downstream Regulator of Runt-Related Transcription Factor 2 in Chondrogenic Differentiation and Maturation. |
Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2. |
NELL-1 in the treatment of osteoporotic bone loss. |
Proliferation and osteogenic differentiation of mesenchymal stem cells induced by a short isoform of NELL-1. |