Gene Symbol | CREG1 |
Entrez Gene ID | 433375 |
Full Name | cellular repressor of E1A-stimulated genes 1 |
Synonyms | AA755314,Creg |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(House mouse) |
Genome |
ORF » Species Summary » Mus musculus » CREG1 cDNA ORF clone
Gene Symbol | CREG1 |
Entrez Gene ID | 433375 |
Full Name | cellular repressor of E1A-stimulated genes 1 |
Synonyms | AA755314,Creg |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(House mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_011804.3 | NP_035934.1 | protein CREG1 precursor |
XM_006496930.1 | XP_006496993.1 | protein CREG1 isoform X1 |
NM_011804.2 | NP_035934.1 | protein CREG1 precursor |
Homo sapiens (human) | CREG1 | NP_003842.1 |
Rattus norvegicus (Norway rat) | Creg1 | NP_001099436.1 |
Bos taurus (cattle) | CREG1 | NP_001069410.1 |
Drosophila melanogaster (fruit fly) | CREG | NP_524385.2 |
Pan troglodytes (chimpanzee) | CREG1 | XP_001157266.2 |
Mus musculus (house mouse) | Creg1 | NP_035934.1 |
Danio rerio (zebrafish) | creg1 | NP_001074159.1 |
CREG1 | XP_001089325.1 | |
Canis lupus familiaris (dog) | CREG1 | XP_003435040.2 |
Gallus gallus (chicken) | CREG1 | XP_003640512.1 |
Xenopus tropicalis (tropical clawed frog) | creg1 | XP_002936277.2 |
The novel intracellular protein CREG inhibits hepatic steatosis, obesity, and insulin resistance.
Zhang QY, Zhao LP, Tian XX, Yan CH, Li Y, Liu YX, Wang PX, Zhang XJ, Han YL
Hepatology (Baltimore, Md.)66(3)834-854(2017 09)
Cellular Repressor of E1A-Stimulated Genes Is a Critical Determinant of Vascular Remodeling in Response to Angiotensin II.
Li Y, Liu Y, Tian X, Zhang Y, Song H, Liu M, Zhang X, Liu H, Zhang J, Zhang Q, Liu D, Peng C, Yan C, Han Y
Arteriosclerosis, thrombosis, and vascular biology37(3)485-494(2017 Mar)
CREG1 heterozygous mice are susceptible to high fat diet-induced obesity and insulin resistance.
Tian X, Yan C, Liu M, Zhang Q, Liu D, Liu Y, Li S, Han Y
PloS one12(5)e0176873(2017)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
CREG is a novel mediator of vascular remodeling in response to Ang II.
Title: Cellular Repressor of E1A-Stimulated Genes Is a Critical Determinant of Vascular Remodeling in Response to Angiotensin II.
Study demonstrated that haplodeficiency of Creg1 exacerbated high fat diet-induced obesity, insulin resistance and dyslipidemia. In addition, Creg1+/- mice showed increased systemic and adipose tissue inflammation, possibly through activation of the NF-kappaB pathway.
Title: CREG1 heterozygous mice are susceptible to high fat diet-induced obesity and insulin resistance.
CREG inhibits inflammation and promotes autophagy mediated by lysosome formation; it might be a potential therapeutic target in atherosclerosis.
Title: Cellular repressor of E1A-stimulated genes inhibits inflammation to decrease atherosclerosis in ApoE(-/-) mice.
CREG1 deficiency influenced the maturation of lysosomes and reduced the espression of Rab7, which might be involved in CREG1-induced cardiomyocyte autophagy.
Title: CREG1 ameliorates myocardial fibrosis associated with autophagy activation and Rab7 expression.
Data indicate cellular repressor of E1A-stimulated gene (CREG) as a factor in regulating endothelial differentiation and vasculogenesis via VEGF/PI3K/Akt pathway.
Title: CREG promotes vasculogenesis by activation of VEGF/PI3K/Akt pathway.
The following CREG1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CREG1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu28808 | |
Clone ID Related Accession (Same CDS sequence) | XM_006496930.1 | |
Accession Version | XM_006496930.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | protein CREG1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGCCC GTGCTCCTGA GCTCGCGCGT TCCCTGCTTG CTGCCCTTCT GGCGCCCGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006496993.1 |
CDS | 54..716 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006496930.1 |
1 | ATGGCTGCCC GTGCTCCTGA GCTCGCGCGT TCCCTGCTTG CTGCCCTTCT GGCGCCCGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu08882 | |
Clone ID Related Accession (Same CDS sequence) | NM_011804.3 , NM_011804.2 | |
Accession Version | NM_011804.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-05 | |
Organism | Mus musculus(house mouse) | |
Product | protein CREG1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC124587.5 and AW495378.1. On Sep 20, 2017 this sequence version replaced NM_011804.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK144101.1, BC027426.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCTGCCC GTGCTCCTGA GCTCGCGCGT TCCCTGCTTG CTGCCCTTCT GGCGCCCGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_035934.1 |
CDS | 28..690 |
Translation |
Target ORF information:
Target ORF information:
|
NM_011804.3 |
1 | ATGGCTGCCC GTGCTCCTGA GCTCGCGCGT TCCCTGCTTG CTGCCCTTCT GGCGCCCGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu08882 | |
Clone ID Related Accession (Same CDS sequence) | NM_011804.3 , NM_011804.2 | |
Accession Version | NM_011804.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-02-14 | |
Organism | Mus musculus(House mouse) | |
Product | protein CREG1 precursor | |
Comment | PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC027426.1. On or before Sep 16, 2004 this sequence version replaced XM_358337.2, NM_011804.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC027426.1, AK144101.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCTGCCC GTGCTCCTGA GCTCGCGCGT TCCCTGCTTG CTGCCCTTCT GGCGCCCGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_035934.1 |
CDS | 6..668 |
Translation |
Target ORF information:
Target ORF information:
|
NM_011804.2 |
1 | ATGGCTGCCC GTGCTCCTGA GCTCGCGCGT TCCCTGCTTG CTGCCCTTCT GGCGCCCGCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The novel intracellular protein CREG inhibits hepatic steatosis, obesity, and insulin resistance. |
Cellular Repressor of E1A-Stimulated Genes Is a Critical Determinant of Vascular Remodeling in Response to Angiotensin II. |
CREG1 heterozygous mice are susceptible to high fat diet-induced obesity and insulin resistance. |