| Gene Symbol | Sco1 |
| Entrez Gene ID | 52892 |
| Full Name | SCO1 cytochrome c oxidase assembly protein |
| Synonyms | 2610001C07Rik,D11Bwg1310e |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
gRNAs
The following Sco1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sco1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu18702 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001040026.1 | |
| Accession Version | NM_001040026.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 855bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-06-07 | |
| Organism | Mus musculus(house mouse) | |
| Product | protein SCO1 homolog, mitochondrial | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK011251.1, AK139512.1, AK083729.1 and AK018523.1. On Apr 5, 2006 this sequence version replaced XM_618888.2. ##Evidence-Data-START## Transcript exon combination :: BC139008.1, AK139512.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## | |
1 | ATGGCAGCAC TTGTACGCGC CGCAGTGGTG AGGTCGCAGT GTCGCCAGCT CTGGCGTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001035115.1 |
| CDS | 26..880 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001040026.1 |
1 | ATGGCAGCAC TTGTACGCGC CGCAGTGGTG AGGTCGCAGT GTCGCCAGCT CTGGCGTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu46599 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006533721.1 , XM_006533721.2 | |
| Accession Version | XM_006533721.1 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-06-21 | |
| Organism | Mus musculus(house mouse) | |
| Product | protein SCO1 homolog, mitochondrial isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGAAGTACT TCAAGAAAGA AAAGATAGAA AAGCTGGAGA AACAACGGCA TCGCAGCATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006533784.1 |
| CDS | 154..726 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006533721.1 |
1 | ATGAAGTACT TCAAGAAAGA AAAGATAGAA AAGCTGGAGA AACAACGGCA TCGCAGCATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu46599 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006533721.1 , XM_006533721.2 | |
| Accession Version | XM_006533721.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 573bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-07 | |
| Organism | Mus musculus(house mouse) | |
| Product | protein SCO1 homolog, mitochondrial isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006533721.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGAAGTACT TCAAGAAAGA AAAGATAGAA AAGCTGGAGA AACAACGGCA TCGCAGCATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006533784.1 |
| CDS | 381..953 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006533721.2 |
1 | ATGAAGTACT TCAAGAAAGA AAAGATAGAA AAGCTGGAGA AACAACGGCA TCGCAGCATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart. |
Synthesis of cytochrome c oxidase 1 (SCO1) inhibits insulin sensitivity by decreasing copper levels in adipocytes. |
The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis. |
Unexpected vascular enrichment of SCO1 over SCO2 in mammalian tissues: implications for human mitochondrial disease. |
Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2. |
