Gene Symbol | Kcnj1 |
Entrez Gene ID | 56379 |
Full Name | potassium inwardly-rectifying channel, subfamily J, member 1 |
Synonyms | Kir1.1,ROMK,Romk2 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Kcnj1 cDNA ORF clone
gRNAs
Gene Symbol | Kcnj1 |
Entrez Gene ID | 56379 |
Full Name | potassium inwardly-rectifying channel, subfamily J, member 1 |
Synonyms | Kir1.1,ROMK,Romk2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001168354.1 | NP_001161826.1 | ATP-sensitive inward rectifier potassium channel 1 isoform 1 |
NM_019659.3 | NP_062633.1 | ATP-sensitive inward rectifier potassium channel 1 isoform 2 |
Bos taurus (cattle) | KCNJ1 | NP_001179136.1 |
Rattus norvegicus (Norway rat) | Kcnj1 | NP_058719.1 |
KCNJ1 | XP_001113379.1 | |
Danio rerio (zebrafish) | kcnj1b | NP_001092204.1 |
Xenopus tropicalis (tropical clawed frog) | kcnj1 | XP_004916228.1 |
Pan troglodytes (chimpanzee) | KCNJ1 | XP_522246.2 |
Mus musculus (house mouse) | Kcnj1 | NP_001161826.1 |
Homo sapiens (human) | KCNJ1 | NP_000211.1 |
Canis lupus familiaris (dog) | KCNJ1 | XP_005619620.1 |
Gallus gallus (chicken) | KCNJ1 | XP_004948024.1 |
Urinary Bladder Hypertrophy is Susceptible in Male but Protected in Female ROMK Bartter's Mouse.
Kim JM, Xu S, Guo X, Hu H, Dong K, Wang T
American journal of physiology. Regulatory, integrative and comparative physiologyajpregu003152017(2017 Nov)
Na
Suzuki T, Nakamura K, Mayanagi T, Sobue K, Kubokawa M
Biochemical and biophysical research communications489(2)116-122(2017 07)
ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4
Zhang C, Wang L, Su XT, Zhang J, Lin DH, Wang WH
American journal of physiology. Renal physiology312(4)F682-F688(2017 Apr)
Involvement of WNK1-mediated potassium channels in the sexual dimorphism of blood pressure.
Yu G, Cheng M, Wang W, Zhao R, Liu Z
Biochemical and biophysical research communications485(2)255-260(2017 04)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
ENaC and ROMK channel activity in kidney tubules are inhibited in TgWnk4(pseudoaldosteronism type II) mice. Wnk4(PHAII)-induced inhibition of ENaC and ROMK may contribute to the suppression of K(+) secretion in the tubules.
Title: ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4
The differential regulation of ROMK, large-conductance Ca(2+)-activated K(+) (BK) channel, BK-alpha and NKCC2 between female and male mice, at least, were partly mediated via WNK1 pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control.
Title: Involvement of WNK1-mediated potassium channels in the sexual dimorphism of blood pressure.
Suggest that the hyperkalemia in knock-in mouse with the CUL3(Delta403-459) mutation is not caused by reduced ROMK expression in the distal nephron.
Title: ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3?403-459 mutation.
animal knockouts of ROMK1 do not produce Bartter phenotype. ROMK1 is critical in response to high K intake-stimulated K+ secretion in the collecting tubule.
Title: Romk1 Knockout Mice Do Not Produce Bartter Phenotype but Exhibit Impaired K Excretion.
The following Kcnj1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnj1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu13626 | |
Clone ID Related Accession (Same CDS sequence) | NM_019659.3 | |
Accession Version | NM_019659.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-23 | |
Organism | Mus musculus(house mouse) | |
Product | ATP-sensitive inward rectifier potassium channel 1 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC132114.4 and CF168846.1. On Dec 4, 2009 this sequence version replaced NM_019659.2. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK085262.1, BF786795.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTTCAAAC ATCTTCGAAG ATGGTTTGTC ACTCACATAT TTGGGCGTTC TCGGCAACGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_062633.1 |
CDS | 218..1336 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGTTCAAAC ATCTTCGAAG ATGGTTTGTC ACTCACATAT TTGGGCGTTC TCGGCAACGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu13778 | |
Clone ID Related Accession (Same CDS sequence) | NM_001168354.1 | |
Accession Version | NM_001168354.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1179bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-23 | |
Organism | Mus musculus(house mouse) | |
Product | ATP-sensitive inward rectifier potassium channel 1 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC132114.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC020525.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGATGCTT CAGATCGGAG GTGTATGTGC AGAGTGCTGA TCAGGGCACT GACAGAAAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001161826.1 |
CDS | 160..1338 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGATGCTT CAGATCGGAG GTGTATGTGC AGAGTGCTGA TCAGGGCACT GACAGAAAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Urinary Bladder Hypertrophy is Susceptible in Male but Protected in Female ROMK Bartter's Mouse. |
Na |
ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4 |
Involvement of WNK1-mediated potassium channels in the sexual dimorphism of blood pressure. |