Cib2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cib2
Entrez Gene ID	56506
Full Name	calcium and integrin binding family member 2
Synonyms	2810434I23Rik,AI449053
General protein information	Preferred Names calcium and integrin binding family member 2 Names calcium and integrin-binding family member 2 KIP 2 calcium binding protein Kip 2 calcium binding protein Kip2 kinase-interacting protein 2
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 9 Map Location: 9\|9 A5.3

mRNA and Protein(s)

mRNA	Protein	Name
NM_019686.5	NP_062660.1	calcium and integrin-binding family member 2
NM_019686.6	NP_062660.1	calcium and integrin-binding family member 2

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	CG9236	NP_611523.3
Bos taurus (cattle)	CIB2	XP_002696710.2
Danio rerio (zebrafish)	cib2	NP_957000.1
Pan troglodytes (chimpanzee)	CIB2	XP_510523.1
Mus musculus (house mouse)	Cib2	NP_062660.1
Homo sapiens (human)	CIB2	NP_006374.1
Canis lupus familiaris (dog)	CIB2	XP_548660.1
Gallus gallus (chicken)	CIB2	XP_413749.1
	CIB2	XP_001106401.1
Rattus norvegicus (Norway rat)	Cib2	NP_001015010.1
Caenorhabditis elegans (roundworm)	calm-1	NP_492514.2
Xenopus tropicalis (tropical clawed frog)	cib2	NP_001072810.1

Gene Ontology
Bibliography

Related articles in PubMed

CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival.
Michel V, Booth KT, Patni P, Cortese M, Azaiez H, Bahloul A, Kahrizi K, Labb? M, Emptoz A, Lelli A, D?gardin J, Dupont T, Aghaie A, Oficjalska-Pham D, Picaud S, Najmabadi H, Smith RJ, Bowl MR, Brown SD, Avan P, Petit C, El-Amraoui A
EMBO molecular medicine9(12)1711-1731(2017 Dec)

Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.
Rutledge EA, Benazet JD, McMahon AP
Development (Cambridge, England)144(17)3177-3188(2017 09)

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.
Giese APJ, Tang YQ, Sinha GP, Bowl MR, Goldring AC, Parker A, Freeman MJ, Brown SDM, Riazuddin S, Fettiplace R, Schafer WR, Frolenkov GI, Ahmed ZM
Nature communications8(1)43(2017 06)

The roles of USH1 proteins and PDZ domain-containing USH proteins in USH2 complex integrity in cochlear hair cells.
Zou J, Chen Q, Almishaal A, Mathur PD, Zheng T, Tian C, Zheng QY, Yang J
Human molecular genetics26(3)624-636(2017 02)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study showed that calcium and integrin-binding protein 2 binds to the components of the hair cell mechanotransduction complex, TMC1 and TMC2, and these interactions are disrupted by deafness-causing Cib2 mutations.
Title: CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.

Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2 chain-deficient muscular dystrophy
Title: Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2 chain-deficient muscular dystrophy.

The following Cib2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cib2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu11615	NM_019686.6 Latest version!	Mus musculus calcium and integrin binding family member 2 (Cib2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OMu11615	NM_019686.5	Mus musculus calcium and integrin binding family member 2 (Cib2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cib2 ( NM_019686.5 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062660.1 Mus musculus calcium and integrin binding family member 2 (Cib2), mRNA.

Price & Availability↑

CloneID	OMu11615
Clone ID Related Accession (Same CDS sequence)	NM_019686.5 , NM_019686.6
Accession Version	NM_019686.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-19
Organism	Mus musculus(house mouse)
Product	calcium and integrin-binding family member 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB016080.1. On Jun 10, 2007 this sequence version replaced NM_019686.4. ##Evidence-Data-START## Transcript exon combination :: AB016080.1, BC005739.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164131 [ECO:0000348] ##Evidence-Data-END##

ATGGGGAACA AGCAGACCAT CTTCACTGAA GAGCAGCTGG ACAACTACCA GGACTGCACT 
TTCTTCAATA AGAAGGACAT CCTCAAGCTT CATGCACGGT TCTATGAGCT GGCTCCCAAC 
CTCGTCCCGA TGGACTACAG GAAGAGTCCC ATCGTCCATG TACCCATGAG CCTCATCATT 
CAGATGCCGG AGCTCCGGGA GAATCCCTTC AAAGAGAGGA TTGTGGAGGC TTTCTCCGAG 
GATGGCGAGG GGAACCTCAC CTTCAATGAC TTTGTGGACA TGTTCTCTGT GCTCTGCGAA 
TCAGCGCCTC GGGAGCTCAA GGCAAACTAT GCCTTCAAGA TCTATGACTT CAACACTGAC 
AATTTCATCT GTAAAGAAGA CTTAGAGATG ACGCTGGCCC GACTCACCAA GTCTGAGTTG 
GAAGAGGATG AGGTAGTGCT TGTGTGTGAC AAAGTCATTG AAGAGGCTGA CCTGGATGGT 
GACGGCAAGC TGGGCTTTGC TGACTTTGAG GACATGATCG CCAAGGCCCC TGATTTTCTC 
AGCACCTTCC ACATTCGAAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062660.1
CDS	62..625
Translation	MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHARFYELAPNLVPMDYRKSPIVHVPMSLIIQMPELRENPFKERIVEAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLEMTLARLTKSELEEDEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFLSTFHIRI

Target ORF information:

RefSeq Version	NM_019686.5
Organism	Mus musculus(house mouse)
Definition	Mus musculus calcium and integrin binding family member 2 (Cib2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019686.5

ORF Insert Sequence:

ATGGGGAACA AGCAGACCAT CTTCACTGAA GAGCAGCTGG ACAACTACCA GGACTGCACT 
TTCTTCAATA AGAAGGACAT CCTCAAGCTT CATGCACGGT TCTATGAGCT GGCTCCCAAC 
CTCGTCCCGA TGGACTACAG GAAGAGTCCC ATCGTCCATG TACCCATGAG CCTCATCATT 
CAGATGCCGG AGCTCCGGGA GAATCCCTTC AAAGAGAGGA TTGTGGAGGC TTTCTCCGAG 
GATGGCGAGG GGAACCTCAC CTTCAATGAC TTTGTGGACA TGTTCTCTGT GCTCTGCGAA 
TCAGCGCCTC GGGAGCTCAA GGCAAACTAT GCCTTCAAGA TCTATGACTT CAACACTGAC 
AATTTCATCT GTAAAGAAGA CTTAGAGATG ACGCTGGCCC GACTCACCAA GTCTGAGTTG 
GAAGAGGATG AGGTAGTGCT TGTGTGTGAC AAAGTCATTG AAGAGGCTGA CCTGGATGGT 
GACGGCAAGC TGGGCTTTGC TGACTTTGAG GACATGATCG CCAAGGCCCC TGATTTTCTC 
AGCACCTTCC ACATTCGAAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cib2 ( NM_019686.6 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_062660.1 Mus musculus calcium and integrin binding family member 2 (Cib2), mRNA.

Price & Availability↑

CloneID	OMu11615
Clone ID Related Accession (Same CDS sequence)	NM_019686.5 , NM_019686.6
Accession Version	NM_019686.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	calcium and integrin-binding family member 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DN175059.1, AB016080.1, AK013240.1 and AI842389.1. On Jun 19, 2018 this sequence version replaced NM_019686.5. ##Evidence-Data-START## Transcript exon combination :: AK013240.1, BY705508.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGGAACA AGCAGACCAT CTTCACTGAA GAGCAGCTGG ACAACTACCA GGACTGCACT 
TTCTTCAATA AGAAGGACAT CCTCAAGCTT CATGCACGGT TCTATGAGCT GGCTCCCAAC 
CTCGTCCCGA TGGACTACAG GAAGAGTCCC ATCGTCCATG TACCCATGAG CCTCATCATT 
CAGATGCCGG AGCTCCGGGA GAATCCCTTC AAAGAGAGGA TTGTGGAGGC TTTCTCCGAG 
GATGGCGAGG GGAACCTCAC CTTCAATGAC TTTGTGGACA TGTTCTCTGT GCTCTGCGAA 
TCAGCGCCTC GGGAGCTCAA GGCAAACTAT GCCTTCAAGA TCTATGACTT CAACACTGAC 
AATTTCATCT GTAAAGAAGA CTTAGAGATG ACGCTGGCCC GACTCACCAA GTCTGAGTTG 
GAAGAGGATG AGGTAGTGCT TGTGTGTGAC AAAGTCATTG AAGAGGCTGA CCTGGATGGT 
GACGGCAAGC TGGGCTTTGC TGACTTTGAG GACATGATCG CCAAGGCCCC TGATTTTCTC 
AGCACCTTCC ACATTCGAAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062660.1
CDS	173..736
Translation	MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHARFYELAPNLVPMDYRKSPIVHVPMSLIIQMPELRENPFKERIVEAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLEMTLARLTKSELEEDEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFLSTFHIRI

Target ORF information:

RefSeq Version	NM_019686.6
Organism	Mus musculus(house mouse)
Definition	Mus musculus calcium and integrin binding family member 2 (Cib2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019686.6

ORF Insert Sequence:

ATGGGGAACA AGCAGACCAT CTTCACTGAA GAGCAGCTGG ACAACTACCA GGACTGCACT 
TTCTTCAATA AGAAGGACAT CCTCAAGCTT CATGCACGGT TCTATGAGCT GGCTCCCAAC 
CTCGTCCCGA TGGACTACAG GAAGAGTCCC ATCGTCCATG TACCCATGAG CCTCATCATT 
CAGATGCCGG AGCTCCGGGA GAATCCCTTC AAAGAGAGGA TTGTGGAGGC TTTCTCCGAG 
GATGGCGAGG GGAACCTCAC CTTCAATGAC TTTGTGGACA TGTTCTCTGT GCTCTGCGAA 
TCAGCGCCTC GGGAGCTCAA GGCAAACTAT GCCTTCAAGA TCTATGACTT CAACACTGAC 
AATTTCATCT GTAAAGAAGA CTTAGAGATG ACGCTGGCCC GACTCACCAA GTCTGAGTTG 
GAAGAGGATG AGGTAGTGCT TGTGTGTGAC AAAGTCATTG AAGAGGCTGA CCTGGATGGT 
GACGGCAAGC TGGGCTTTGC TGACTTTGAG GACATGATCG CCAAGGCCCC TGATTTTCTC 
AGCACCTTCC ACATTCGAAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival.
EMBO molecular medicine9(12)1711-1731(2017 Dec)
Michel V,Booth KT,Patni P,Cortese M,Azaiez H,Bahloul A,Kahrizi K,Labb? M,Emptoz A,Lelli A,D?gardin J,Dupont T,Aghaie A,Oficjalska-Pham D,Picaud S,Najmabadi H,Smith RJ,Bowl MR,Brown SD,Avan P,Petit C,El-Amraoui A

Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.
Development (Cambridge, England)144(17)3177-3188(2017 09)
Rutledge EA,Benazet JD,McMahon AP

CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells.
Nature communications8(1)43(2017 06)
Giese APJ,Tang YQ,Sinha GP,Bowl MR,Goldring AC,Parker A,Freeman MJ,Brown SDM,Riazuddin S,Fettiplace R,Schafer WR,Frolenkov GI,Ahmed ZM

The roles of USH1 proteins and PDZ domain-containing USH proteins in USH2 complex integrity in cochlear hair cells.
Human molecular genetics26(3)624-636(2017 02)
Zou J,Chen Q,Almishaal A,Mathur PD,Zheng T,Tian C,Zheng QY,Yang J

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

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Cib2 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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