Tesc cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tesc
Entrez Gene ID	57816
Full Name	tescalcin
Synonyms	1010001A17Rik,2410011K10Rik,TE-1
General protein information	Preferred Names tescalcin Names calcineurin B homologous protein 3 CHP3 TSC
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 5 Map Location: 5 F\|5 57.84 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_021344.3	NP_067319.2	calcineurin B homologous protein 3
NM_021344.4	NP_067319.2	calcineurin B homologous protein 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TESC	XP_001155277.3
Rattus norvegicus (Norway rat)	Tesc	XP_213790.6
Danio rerio (zebrafish)	tesca	NP_998493.1
Homo sapiens (human)	TESC	NP_060369.3
Gallus gallus (chicken)	TESC	NP_001074353.1
Canis lupus familiaris (dog)	TESC	XP_005636574.1
Xenopus tropicalis (tropical clawed frog)	tesc	NP_001072423.1
	TESC	XP_001082221.1
Bos taurus (cattle)	TESC	XP_002694632.3
Mus musculus (house mouse)	Tesc	NP_067319.2
Danio rerio (zebrafish)	tescb	NP_991256.1

Gene Ontology
Bibliography

Related articles in PubMed

Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons.
Takamatsu G, Katagiri C, Tomoyuki T, Shimizu-Okabe C, Nakamura W, Nakamura-Higa M, Hayakawa T, Wakabayashi S, Kondo T, Takayama C, Matsushita M
Biochemical and biophysical research communications482(4)1327-1333(2017 Jan)

Transcription Factor MafB Coordinates Epidermal Keratinocyte Differentiation.
Miyai M, Hamada M, Moriguchi T, Hiruma J, Kamitani-Kawamoto A, Watanabe H, Hara-Chikuma M, Takahashi K, Takahashi S, Kataoka K
The Journal of investigative dermatology136(9)1848-57(2016 Sep)

A hypomorphic lsd1 allele results in heart development defects in mice.
Nicholson TB, Singh AK, Su H, Hevi S, Wang J, Bajko J, Li M, Valdez R, Goetschkes M, Capodieci P, Loureiro J, Cheng X, Li E, Kinzel B, Labow M, Chen T
PloS one8(4)e60913(2013)

Megakaryocyte development is normal in mice with targeted disruption of Tescalcin.
Ukarapong S, Bao Y, Perera EM, Berkovitz GD
Experimental cell research318(5)662-9(2012 Mar)

Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways.
Thiagarajan RD, Georgas KM, Rumballe BA, Lesieur E, Chiu HS, Taylor D, Tang DT, Grimmond SM, Little MH
PloS one6(2)e17286(2011 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TESC has an important role in mediating the neuroprotective effect of class I histone deacetylase inhibitors, and may also be involved in the development of brain and neurodegenerative diseases through epigenetic mechanisms
Title: Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons.

Tescalcin does not appear to be necessary for normal megakaryocyte development
Title: Megakaryocyte development is normal in mice with targeted disruption of Tescalcin.

the data demonstrated that Sp1 and Sp3 transcription factors cooperate positively in the regulation of Tesc promoter, and that the putative ZF5 motif is critical for its activation.
Title: Structural and functional characterization of the mouse tescalcin promoter.

CIB1 functions as a previously undescribed regulator of cardiac hypertrophy through its ability to regulate the association of calcineurin with the sarcolemma and its activation.
Title: CIB1 is a regulator of pathological cardiac hypertrophy.

Studies indicate very specific expression of Tesc in various tissues in chicken and mouse during embryologic development, and conservation of Tesc expression in both species.
Title: Expression and evolutionary conservation of the tescalcin gene during development.

The following Tesc gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tesc cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu12208	NM_021344.4 Latest version!	Mus musculus tescalcin (Tesc), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OMu12208	NM_021344.3	Mus musculus tescalcin (Tesc), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tesc ( NM_021344.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_067319.2 Mus musculus tescalcin (Tesc), mRNA.

Price & Availability↑

CloneID	OMu12208
Clone ID Related Accession (Same CDS sequence)	NM_021344.3 , NM_021344.4
Accession Version	NM_021344.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 645bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-04-22
Organism	Mus musculus(House mouse)
Product	calcineurin B homologous protein 3
Comment	PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC114993.18. On Nov 17, 2006 this sequence version replaced NM_021344.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC019492.1, GQ856259.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END##

ATGGGCGCTG CCCACTCGGC GTCCGAGGAG GTGCGGGAGC TCGAGGGCAA GACCGGCTTC 
TCCTCGGACC AGATAGAGCA GCTGCATCGG AGGTTCAAGC AGCTAAGCGG GGACCAGCCC 
ACCATTCGCA AGGAGAACTT CAACAATGTC CCTGACCTGG AGCTCAACCC GATCCGATCC 
AAAATCGTCC GTGCCTTCTT CGACAACAGG AACCTGCGAA AGGGATCCAG CGGTCTGGCC 
GATGAGATCA ACTTTGAGGA CTTCCTGACT ATCATGTCCT ACTTCCGGCC CATCGACACC 
ACCCTGGGCG AGGAACAGGT GGAGCTGTCA CGAAAGGAGA AGCTGAAATT TCTGTTTCAT 
ATGTATGATT CGGACAGTGA CGGCCGCATC ACCCTGGAAG AGTATAGAAA TGTGGTGGAG 
GAGCTGCTCT CGGGAAACCC TCACATTGAA AAGGAGTCGG CTCGGTCCAT TGCAGACGGG 
GCCATGATGG AGGCGGCCAG CGTGTGCGTG GGGCAGATGG AACCGGACCA GGTGTACGAG 
GGGATCACCT TTGAGGACTT CCTGAAGATC TGGCAGGGCA TCGACATCGA GACCAAGATG 
CACATTCGTT TCCTCAACAT GGAGACCATC GCCCTCTGCC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067319.2
CDS	107..751
Translation	MGAAHSASEEVRELEGKTGFSSDQIEQLHRRFKQLSGDQPTIRKENFNNVPDLELNPIRSKIVRAFFDNRNLRKGSSGLADEINFEDFLTIMSYFRPIDTTLGEEQVELSRKEKLKFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADGAMMEAASVCVGQMEPDQVYEGITFEDFLKIWQGIDIETKMHIRFLNMETIALCH

Target ORF information:

RefSeq Version	NM_021344.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus tescalcin (Tesc), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021344.3

ORF Insert Sequence:

ATGGGCGCTG CCCACTCGGC GTCCGAGGAG GTGCGGGAGC TCGAGGGCAA GACCGGCTTC 
TCCTCGGACC AGATAGAGCA GCTGCATCGG AGGTTCAAGC AGCTAAGCGG GGACCAGCCC 
ACCATTCGCA AGGAGAACTT CAACAATGTC CCTGACCTGG AGCTCAACCC GATCCGATCC 
AAAATCGTCC GTGCCTTCTT CGACAACAGG AACCTGCGAA AGGGATCCAG CGGTCTGGCC 
GATGAGATCA ACTTTGAGGA CTTCCTGACT ATCATGTCCT ACTTCCGGCC CATCGACACC 
ACCCTGGGCG AGGAACAGGT GGAGCTGTCA CGAAAGGAGA AGCTGAAATT TCTGTTTCAT 
ATGTATGATT CGGACAGTGA CGGCCGCATC ACCCTGGAAG AGTATAGAAA TGTGGTGGAG 
GAGCTGCTCT CGGGAAACCC TCACATTGAA AAGGAGTCGG CTCGGTCCAT TGCAGACGGG 
GCCATGATGG AGGCGGCCAG CGTGTGCGTG GGGCAGATGG AACCGGACCA GGTGTACGAG 
GGGATCACCT TTGAGGACTT CCTGAAGATC TGGCAGGGCA TCGACATCGA GACCAAGATG 
CACATTCGTT TCCTCAACAT GGAGACCATC GCCCTCTGCC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Tesc ( NM_021344.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_067319.2 Mus musculus tescalcin (Tesc), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu12208
Clone ID Related Accession (Same CDS sequence)	NM_021344.3 , NM_021344.4
Accession Version	NM_021344.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 645bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Mus musculus(house mouse)
Product	calcineurin B homologous protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BE979843.1, CX242767.1 and AC114993.18. On Oct 12, 2017 this sequence version replaced NM_021344.3. Transcript Variant: This variant (1) represents the protein-coding transcript. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC107679.1, BC019492.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCGCTG CCCACTCGGC GTCCGAGGAG GTGCGGGAGC TCGAGGGCAA GACCGGCTTC 
TCCTCGGACC AGATAGAGCA GCTGCATCGG AGGTTCAAGC AGCTAAGCGG GGACCAGCCC 
ACCATTCGCA AGGAGAACTT CAACAATGTC CCTGACCTGG AGCTCAACCC GATCCGATCC 
AAAATCGTCC GTGCCTTCTT CGACAACAGG AACCTGCGAA AGGGATCCAG CGGTCTGGCC 
GATGAGATCA ACTTTGAGGA CTTCCTGACT ATCATGTCCT ACTTCCGGCC CATCGACACC 
ACCCTGGGCG AGGAACAGGT GGAGCTGTCA CGAAAGGAGA AGCTGAAATT TCTGTTTCAT 
ATGTATGATT CGGACAGTGA CGGCCGCATC ACCCTGGAAG AGTATAGAAA TGTGGTGGAG 
GAGCTGCTCT CGGGAAACCC TCACATTGAA AAGGAGTCGG CTCGGTCCAT TGCAGACGGG 
GCCATGATGG AGGCGGCCAG CGTGTGCGTG GGGCAGATGG AACCGGACCA GGTGTACGAG 
GGGATCACCT TTGAGGACTT CCTGAAGATC TGGCAGGGCA TCGACATCGA GACCAAGATG 
CACATTCGTT TCCTCAACAT GGAGACCATC GCCCTCTGCC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067319.2
CDS	188..832
Translation	MGAAHSASEEVRELEGKTGFSSDQIEQLHRRFKQLSGDQPTIRKENFNNVPDLELNPIRSKIVRAFFDNRNLRKGSSGLADEINFEDFLTIMSYFRPIDTTLGEEQVELSRKEKLKFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADGAMMEAASVCVGQMEPDQVYEGITFEDFLKIWQGIDIETKMHIRFLNMETIALCH

Target ORF information:

RefSeq Version	NM_021344.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus tescalcin (Tesc), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021344.4

ORF Insert Sequence:

ATGGGCGCTG CCCACTCGGC GTCCGAGGAG GTGCGGGAGC TCGAGGGCAA GACCGGCTTC 
TCCTCGGACC AGATAGAGCA GCTGCATCGG AGGTTCAAGC AGCTAAGCGG GGACCAGCCC 
ACCATTCGCA AGGAGAACTT CAACAATGTC CCTGACCTGG AGCTCAACCC GATCCGATCC 
AAAATCGTCC GTGCCTTCTT CGACAACAGG AACCTGCGAA AGGGATCCAG CGGTCTGGCC 
GATGAGATCA ACTTTGAGGA CTTCCTGACT ATCATGTCCT ACTTCCGGCC CATCGACACC 
ACCCTGGGCG AGGAACAGGT GGAGCTGTCA CGAAAGGAGA AGCTGAAATT TCTGTTTCAT 
ATGTATGATT CGGACAGTGA CGGCCGCATC ACCCTGGAAG AGTATAGAAA TGTGGTGGAG 
GAGCTGCTCT CGGGAAACCC TCACATTGAA AAGGAGTCGG CTCGGTCCAT TGCAGACGGG 
GCCATGATGG AGGCGGCCAG CGTGTGCGTG GGGCAGATGG AACCGGACCA GGTGTACGAG 
GGGATCACCT TTGAGGACTT CCTGAAGATC TGGCAGGGCA TCGACATCGA GACCAAGATG 
CACATTCGTT TCCTCAACAT GGAGACCATC GCCCTCTGCC ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons.
Biochemical and biophysical research communications482(4)1327-1333(2017 Jan)
Takamatsu G,Katagiri C,Tomoyuki T,Shimizu-Okabe C,Nakamura W,Nakamura-Higa M,Hayakawa T,Wakabayashi S,Kondo T,Takayama C,Matsushita M

Transcription Factor MafB Coordinates Epidermal Keratinocyte Differentiation.
The Journal of investigative dermatology136(9)1848-57(2016 Sep)
Miyai M,Hamada M,Moriguchi T,Hiruma J,Kamitani-Kawamoto A,Watanabe H,Hara-Chikuma M,Takahashi K,Takahashi S,Kataoka K

A hypomorphic lsd1 allele results in heart development defects in mice.
PloS one8(4)e60913(2013)
Nicholson TB,Singh AK,Su H,Hevi S,Wang J,Bajko J,Li M,Valdez R,Goetschkes M,Capodieci P,Loureiro J,Cheng X,Li E,Kinzel B,Labow M,Chen T

Megakaryocyte development is normal in mice with targeted disruption of Tescalcin.
Experimental cell research318(5)662-9(2012 Mar)
Ukarapong S,Bao Y,Perera EM,Berkovitz GD

Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways.
PloS one6(2)e17286(2011 Feb)
Thiagarajan RD,Georgas KM,Rumballe BA,Lesieur E,Chiu HS,Taylor D,Tang DT,Grimmond SM,Little MH

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Tesc cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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