Gene Symbol | Snx5 |
Entrez Gene ID | 69178 |
Full Name | sorting nexin 5 |
Synonyms | 0910001N05Rik,1810032P22Rik,AU019504,D2Ertd52e |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Snx5 cDNA ORF clone
Gene Symbol | Snx5 |
Entrez Gene ID | 69178 |
Full Name | sorting nexin 5 |
Synonyms | 0910001N05Rik,1810032P22Rik,AU019504,D2Ertd52e |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001199188.1 | NP_001186117.1 | sorting nexin-5 |
NM_024225.5 | NP_077187.1 | sorting nexin-5 |
SNX5 | XP_001087384.2 | |
Canis lupus familiaris (dog) | SNX5 | XP_005634809.1 |
Gallus gallus (chicken) | SNX5 | NP_001006178.1 |
Bos taurus (cattle) | SNX5 | NP_001029636.1 |
Mus musculus (house mouse) | Snx5 | NP_077187.1 |
Xenopus tropicalis (tropical clawed frog) | snx5 | NP_001016081.1 |
Homo sapiens (human) | SNX5 | NP_055241.1 |
Pan troglodytes (chimpanzee) | SNX5 | XP_003316879.2 |
Danio rerio (zebrafish) | snx5 | NP_999934.1 |
Loss of sorting nexin 5 stabilizes internalized growth factor receptors to promote thyroid cancer progression.
Jitsukawa S, Kamekura R, Kawata K, Ito F, Sato A, Matsumiya H, Nagaya T, Yamashita K, Kubo T, Kikuchi T, Sato N, Hasegawa T, Kiyonari H, Mukumoto Y, Takano KI, Himi T, Ichimiya S
The Journal of pathology243(3)342-353(2017 Nov)
Elwell CA, Czudnochowski N, von Dollen J, Johnson JR, Nakagawa R, Mirrashidi K, Krogan NJ, Engel JN, Rosenberg OS
eLife6(2017 Mar)
Sorting nexin 5 selectively regulates dorsal-ruffle-mediated macropinocytosis in primary macrophages.
Lim JP, Gosavi P, Mintern JD, Ross EM, Gleeson PA
Journal of cell science128(23)4407-19(2015 Dec)
Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice.
Im SK, Jeong H, Jeong HW, Kim KT, Hwang D, Ikegami M, Kong YY
PloS one8(3)e58511(2013)
Sorting nexin 5 of a new diagnostic marker of papillary thyroid carcinoma regulates Caspase-2.
Ara S, Kikuchi T, Matsumiya H, Kojima T, Kubo T, Ye RC, Sato A, Kon S, Honma T, Asakura K, Hasegawa T, Himi T, Sato N, Ichimiya S
Cancer science103(7)1356-62(2012 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
thyroid cancer model using carcinogen and an anti-thyroidal agent revealed that Snx5(-/-) mice developed metastasizing thyroid tumors with activation of MAP kinase and AKT pathways
Title: Loss of sorting nexin 5 stabilizes internalized growth factor receptors to promote thyroid cancer progression.
findings reveal the important contribution of dorsal ruffing to receptor-activated macropinocytosis in primary macrophages and show that SNX5 selectively regulates macropinosomes derived from the dorsal ruffles.
Title: Sorting nexin 5 selectively regulates dorsal-ruffle-mediated macropinocytosis in primary macrophages.
Histological analysis revealed that Snx5(-/-) mice exhibited thickened alveolar walls associated with undifferentiated alveolar epithelial type I cells. In contrast, type II cells were intact, exhibiting normal surfactant synthesis and secretion.
Title: Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice.
Data indicate high expression of sorting nexin 5 (Snx5) in chemically induced papillary thyroid carcinoma.
Title: Sorting nexin 5 of a new diagnostic marker of papillary thyroid carcinoma regulates Caspase-2.
The following Snx5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Snx5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu02086 | |
Clone ID Related Accession (Same CDS sequence) | NM_001199188.1 , NM_024225.5 | |
Accession Version | NM_001199188.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1215bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-06-06 | |
Organism | Mus musculus(house mouse) | |
Product | sorting nexin-5 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL808123.9, AK031873.1 and BM120064.2. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK169786.1, AK144710.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCCGCGG TTCCCGAGTT GCTGGAGCAG CAGGAGGAGG ACCGCAGCAA GTTAAGATCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001186117.1 |
CDS | 235..1449 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001199188.1 |
1 | ATGGCCGCGG TTCCCGAGTT GCTGGAGCAG CAGGAGGAGG ACCGCAGCAA GTTAAGATCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu02086 | |
Clone ID Related Accession (Same CDS sequence) | NM_001199188.1 , NM_024225.5 | |
Accession Version | NM_024225.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1215bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-06-06 | |
Organism | Mus musculus(house mouse) | |
Product | sorting nexin-5 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK169545.1, AK029463.1 and BM120064.2. On Nov 24, 2010 this sequence version replaced NM_024225.4. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.114747.1, AK029463.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCCGCGG TTCCCGAGTT GCTGGAGCAG CAGGAGGAGG ACCGCAGCAA GTTAAGATCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_077187.1 |
CDS | 146..1360 |
Translation |
Target ORF information:
Target ORF information:
|
NM_024225.5 |
1 | ATGGCCGCGG TTCCCGAGTT GCTGGAGCAG CAGGAGGAGG ACCGCAGCAA GTTAAGATCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Loss of sorting nexin 5 stabilizes internalized growth factor receptors to promote thyroid cancer progression. |
|
Sorting nexin 5 selectively regulates dorsal-ruffle-mediated macropinocytosis in primary macrophages. |
Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice. |
Sorting nexin 5 of a new diagnostic marker of papillary thyroid carcinoma regulates Caspase-2. |