Gene Symbol | Sv2c |
Entrez Gene ID | 75209 |
Full Name | synaptic vesicle glycoprotein 2c |
Synonyms | 4930527L09Rik,AI841971 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Sv2c cDNA ORF clone
Gene Symbol | Sv2c |
Entrez Gene ID | 75209 |
Full Name | synaptic vesicle glycoprotein 2c |
Synonyms | 4930527L09Rik,AI841971 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_030247440.1 | XP_030103300.1 | synaptic vesicle glycoprotein 2C isoform X1 |
NM_029210.1 | NP_083486.1 | synaptic vesicle glycoprotein 2C |
Pan troglodytes (chimpanzee) | SV2C | XP_526889.2 |
SV2C | XP_001105846.1 | |
Canis lupus familiaris (dog) | LOC488943 | XP_546060.2 |
Mus musculus (house mouse) | Sv2c | NP_083486.1 |
Danio rerio (zebrafish) | sv2c | NP_001121811.1 |
Rattus norvegicus (Norway rat) | Sv2c | NP_113781.1 |
Homo sapiens (human) | SV2C | NP_055794.1 |
Bos taurus (cattle) | SV2C | NP_001178948.1 |
Gallus gallus (chicken) | SV2C | XP_004937396.1 |
Xenopus tropicalis (tropical clawed frog) | sv2c | XP_002934873.1 |
Immunochemical analysis of the expression of SV2C in mouse, macaque and human brain.
Dunn AR, Hoffman CA, Stout KA, Ozawa M, Dhamsania RK, Miller GW
Brain research(2017 Dec)
Multiple roles of integrin-?3 at the neuromuscular junction.
Ross JA, Webster RG, Lechertier T, Reynolds LE, Turmaine M, Bencze M, Jamshidi Y, Cetin H, Muntoni F, Beeson D, Hodilvala-Dilke K, Conti FJ
Journal of cell science130(10)1772-1784(2017 May)
Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.
Dunn AR, Stout KA, Ozawa M, Lohr KM, Hoffman CA, Bernstein AI, Li Y, Wang M, Sgobio C, Sastry N, Cai H, Caudle WM, Miller GW
Proceedings of the National Academy of Sciences of the United States of America114(11)E2253-E2262(2017 Mar)
Expression of SV2 isoforms during rodent brain development.
Cr?vec?ur J, Foerch P, Doupagne M, Thielen C, Vandenplas C, Moonen G, Deprez M, Rogister B
BMC neuroscience1487(2013 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Results showed that SV2C, a poorly functionally characterized protein is strongly involved in normal operation of the basal ganglia network and could be also involved in system adaptation in basal ganglia pathological conditions.
Title: A role for Sv2c in basal ganglia functions.
SV2C protein was expressed in a small subset of brain regions including the olfactory bulb, olfactory tubercle, nucleus accumbens, caudate-putamen, ventral pallidum, globus pallidus, substantia nigra and the ventral tegmental area.
Title: Distribution of SV2C mRNA and protein expression in the mouse brain with a particular emphasis on the basal ganglia system.
Botulinum neurotoxin A also interacts with a synaptic vesicle protein, the synaptic vesicle glycoprotein 2C (SV2C), but not with the homologous proteins SV2A and SV2B.
Title: The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves.
findings show that botulinum neurotoxin (BoNT/A) enters neurons by binding to the synaptic vesicle protein SV2 (isoforms A, B, and C);SV2 acts as the protein receptor for BoNT/A
Title: SV2 is the protein receptor for botulinum neurotoxin A.
The following Sv2c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sv2c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu86285 | |
Clone ID Related Accession (Same CDS sequence) | XM_030247440.1 | |
Accession Version | XM_030247440.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | synaptic vesicle glycoprotein 2C isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000079.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTAGCAG TGGCCATATG CACATATGTT ACAGATACCA GAAAAGACCA CTGGATTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030103300.1 |
CDS | 33..956 |
Translation |
Target ORF information:
Target ORF information:
|
XM_030247440.1 |
1 | ATGCTAGCAG TGGCCATATG CACATATGTT ACAGATACCA GAAAAGACCA CTGGATTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu19284 | |
Clone ID Related Accession (Same CDS sequence) | NM_029210.1 | |
Accession Version | NM_029210.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-18 | |
Organism | Mus musculus(house mouse) | |
Product | synaptic vesicle glycoprotein 2C | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC153134.5 and AC129327.4. On or before Apr 10, 2009 this sequence version replaced XM_914033.2, XM_923035.2, XM_991257.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK173092.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGAAGACT CCTACAAGGA TAGGACTTCA CTGATGAAGG GTGCCAAGGA CATTGCCAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_083486.1 |
CDS | 232..2415 |
Translation |
Target ORF information:
Target ORF information:
|
NM_029210.1 |
1 | ATGGAAGACT CCTACAAGGA TAGGACTTCA CTGATGAAGG GTGCCAAGGA CATTGCCAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Immunochemical analysis of the expression of SV2C in mouse, macaque and human brain. |
Multiple roles of integrin-?3 at the neuromuscular junction. |
Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease. |
Expression of SV2 isoforms during rodent brain development. |