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Srp54a cDNA ORF clone, Rattus norvegicus(Norway rat)

Summary

Gene Symbol Srp54a
Entrez Gene ID 116650
Full Name signal recognition particle 54A
Synonyms Srp54
General protein information
Preferred Names

signal recognition particle 54A

Names

signal recognition particle 54 kDa protein
Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

6

6q23
Summary may recognize signal sequences of secretory proteins and may retard them in the endoplasmic reticulum; may regulate synthesis of the secretory protein osteopontin [RGD, Feb 2006].

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_006240097.3 XP_006240159.1 signal recognition particle 54 kDa protein isoform X1
NM_053871.1 NP_446323.1 signal recognition particle 54 kDa protein

Pathways from BioSystems


Homologies


Mus musculus (house mouse) Srp54a NP_036029.2
Danio rerio (zebrafish) srp54 NP_957282.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP004610 XP_315212.2
Caenorhabditis elegans (roundworm) F21D5.7 NP_501507.1
Saccharomyces cerevisiae (baker's yeast) SRP54 NP_015413.1
Kluyveromyces lactis KLLA0D09020g XP_453464.1
Homo sapiens (human) SRP54 NP_003127.1
Rattus norvegicus (Norway rat) Srp54a NP_446323.1
Magnaporthe oryzae (rice blast fungus) MGG_05977 XP_003711822.1
Arabidopsis thaliana (thale cress) AT1G48900 NP_564535.1
Canis lupus familiaris (dog) SRP54 NP_001003272.1
Bos taurus (cattle) SRP54 NP_001033290.1
Gallus gallus (chicken) SRP54 XP_421238.1
Schizosaccharomyces pombe (fission yeast) srp54 NP_588209.1
Neurospora crassa NCU09696 XP_960643.1
Oryza sativa (rice) Os01g0772800 NP_001044395.1
Pan troglodytes (chimpanzee) SRP54 XP_001136048.1
SRP54 XP_001082531.1
Mus musculus (house mouse) Srp54b NP_001093579.1
Drosophila melanogaster (fruit fly) Srp54k NP_523931.1
Eremothecium gossypii AGOS_AAR041W NP_982582.2
Xenopus tropicalis (tropical clawed frog) srp54 NP_988977.1

Gene Ontology


Bibliography

Related articles in PubMed

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads.
Yoshida M, Kabe Y, Wada T, Asai A, Handa H
Molecular pharmacology73(3)987-94(2008 Mar)

Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages.
R?misch K, Miller FW, Dobberstein B, High S
Arthritis research & therapy8(2)R39(2006)

Signal recognition particle components in the nucleolus.
Politz JC, Yarovoi S, Kilroy SM, Gowda K, Zwieb C, Pederson T
Proceedings of the National Academy of Sciences of the United States of America97(1)55-60(2000 Jan)

Protein SRP54 of human signal recognition particle: cloning, expression, and comparative analysis of functional sites.
Gowda K, Black SD, Moeller I, Sakakibara Y, Liu MC, Zwieb C
Gene207(2)197-207(1998 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Srp54a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Srp54a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa10914 NM_053871.1
Latest version!		 Rattus norvegicus signal recognition particle 54A (Srp54a), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $307.30
$439.00
ORa29340 XM_006240097.3
Latest version!		 Rattus norvegicus signal recognition particle 54A (Srp54a), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00

ORF Online Only Promotion

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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ORa10914
Clone ID Related Accession (Same CDS sequence) NM_053871.1
Accession Version NM_053871.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1515bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-06-06
Organism Rattus norvegicus(Norway rat)
Product signal recognition particle 54 kDa protein
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC079117.1. On Apr 27, 2005 this sequence version replaced XM_343063.2. ##Evidence-Data-START## Transcript exon combination :: BC079117.1, FQ211580.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## 

1
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361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGGTTCTAG CAGATCTTGG AAGAAAAATA ACATCAGCAT TACGCTCACT GAGCAATGCC 
ACCATTATCA ATGAAGAGGT ACTAAATGCT ATGCTGAAGG AAGTGTGTAC AGCACTATTG 
GAAGCAGATG TTAATATTAA ACTAGTGAAG CAGCTGAGAG AAAATGTTAA GTCTGCGATT 
GATCTTGAGG AGATGGCGTC CGGTCTGAAC AAAAGGAAGA TGATTCAGCA TGCTGTGTTT 
AAAGAACTTG TAAAGCTTGT AGACCCTGGA GTTAAAGCAT GGACACCGAC TAAGGGAAAG 
CAAAATGTGA TCATGTTTGT TGGATTGCAA GGGAGTGGTA AAACAACAAC GTGTTCAAAG 
TTAGCATATT TTTACCAGAG GAAAGGTTGG AAGACCTGTT TGATATGTGC AGATACATTC 
AGAGCAGGAG CTTTTGACCA GCTTAAACAG AACGCCACCA AAGCAAGAAT TCCGTTCTAT 
GGAAGCTATA CCGAAATGGA TCCTGTCATC ATTGCTTCTG AAGGAGTGGA GAAATTCAAA 
AATGAAAATT TTGAAATTAT TATTGTTGAT ACAAGTGGTC GTCACAAACA AGAAGACTCC 
TTGTTTGAAG AAATGCTTCA AGTTTCTAAC GCTATACAAC CTGATAACAT TGTTTATGTG 
ATGGACGCAT CCATTGGACA GGCTTGTGAG GCCCAGGCAA AGGCCTTCAA AGATAAAGTA 
GATGTAGCTT CAGTAATAGT GACGAAACTT GATGGTCATG CAAAAGGAGG TGGTGCTCTC 
AGTGCAGTTG CTGCCACAAA AAGTCCAATT ATTTTCATTG GTACAGGAGA ACATATAGAT 
GACTTTGAAC CTTTCAAAAC ACAACCTTTC ATTAGTAAAC TTCTTGGAAT GGGTGACATT 
GAAGGACTGA TTGATAAAGT CAATGAGTTG AAGTTGGATG ATAACGAGGC ACTTATAGAG 
AAGCTGAAGC ACGGTCAGTT TACATTGCGA GACATGTATG AACAGTTTCA GAATATTATG 
AAAATGGGCC CATTCAGTCA GATCTTGGGG ATGATTCCTG GTTTTGGCAC AGATTTTATG 
AGCAAAGGAA ATGAGCAGGA GTCAATGGCA AGGCTAAAGA AGCTGATGAC GATAATGGAC 
AGTATGAATG ATCAAGAACT GGACAGTACA GATGGTGCCA AGGTTTTTAG TAAGCAACCA 
GGCAGAATCC AAAGAGTTGC CCGGGGATCA GGTGTGTCAA CAAGAGATGT GCAAGAACTT 
CTCACACAGT ATACCAAGTT TGCCCAGATG GTCAAAAAGA TGGGAGGTAT CAAAGGGCTT 
TTTAAAGGTG GTGATATGTC AAAGAATGTG AGTCAGTCAC AGATGGCAAA ATTAAATCAA 
CAAATGGCCA AAATGATGGA CCCACGAGTT CTTCATCACA TGGGTGGCAT GGCCGGCCTT 
CAGTCGATGA TGCGGCAGTT TCAGCAGGGT GCTGCTGGCA ATATGAAAGG CATGATGGGA 
TTCAATAACA TGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_446323.1
CDS244..1758
Translation

Target ORF information:

RefSeq Version NM_053871.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus signal recognition particle 54A (Srp54a), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_053871.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGGTTCTAG CAGATCTTGG AAGAAAAATA ACATCAGCAT TACGCTCACT GAGCAATGCC 
ACCATTATCA ATGAAGAGGT ACTAAATGCT ATGCTGAAGG AAGTGTGTAC AGCACTATTG 
GAAGCAGATG TTAATATTAA ACTAGTGAAG CAGCTGAGAG AAAATGTTAA GTCTGCGATT 
GATCTTGAGG AGATGGCGTC CGGTCTGAAC AAAAGGAAGA TGATTCAGCA TGCTGTGTTT 
AAAGAACTTG TAAAGCTTGT AGACCCTGGA GTTAAAGCAT GGACACCGAC TAAGGGAAAG 
CAAAATGTGA TCATGTTTGT TGGATTGCAA GGGAGTGGTA AAACAACAAC GTGTTCAAAG 
TTAGCATATT TTTACCAGAG GAAAGGTTGG AAGACCTGTT TGATATGTGC AGATACATTC 
AGAGCAGGAG CTTTTGACCA GCTTAAACAG AACGCCACCA AAGCAAGAAT TCCGTTCTAT 
GGAAGCTATA CCGAAATGGA TCCTGTCATC ATTGCTTCTG AAGGAGTGGA GAAATTCAAA 
AATGAAAATT TTGAAATTAT TATTGTTGAT ACAAGTGGTC GTCACAAACA AGAAGACTCC 
TTGTTTGAAG AAATGCTTCA AGTTTCTAAC GCTATACAAC CTGATAACAT TGTTTATGTG 
ATGGACGCAT CCATTGGACA GGCTTGTGAG GCCCAGGCAA AGGCCTTCAA AGATAAAGTA 
GATGTAGCTT CAGTAATAGT GACGAAACTT GATGGTCATG CAAAAGGAGG TGGTGCTCTC 
AGTGCAGTTG CTGCCACAAA AAGTCCAATT ATTTTCATTG GTACAGGAGA ACATATAGAT 
GACTTTGAAC CTTTCAAAAC ACAACCTTTC ATTAGTAAAC TTCTTGGAAT GGGTGACATT 
GAAGGACTGA TTGATAAAGT CAATGAGTTG AAGTTGGATG ATAACGAGGC ACTTATAGAG 
AAGCTGAAGC ACGGTCAGTT TACATTGCGA GACATGTATG AACAGTTTCA GAATATTATG 
AAAATGGGCC CATTCAGTCA GATCTTGGGG ATGATTCCTG GTTTTGGCAC AGATTTTATG 
AGCAAAGGAA ATGAGCAGGA GTCAATGGCA AGGCTAAAGA AGCTGATGAC GATAATGGAC 
AGTATGAATG ATCAAGAACT GGACAGTACA GATGGTGCCA AGGTTTTTAG TAAGCAACCA 
GGCAGAATCC AAAGAGTTGC CCGGGGATCA GGTGTGTCAA CAAGAGATGT GCAAGAACTT 
CTCACACAGT ATACCAAGTT TGCCCAGATG GTCAAAAAGA TGGGAGGTAT CAAAGGGCTT 
TTTAAAGGTG GTGATATGTC AAAGAATGTG AGTCAGTCAC AGATGGCAAA ATTAAATCAA 
CAAATGGCCA AAATGATGGA CCCACGAGTT CTTCATCACA TGGGTGGCAT GGCCGGCCTT 
CAGTCGATGA TGCGGCAGTT TCAGCAGGGT GCTGCTGGCA ATATGAAAGG CATGATGGGA 
TTCAATAACA TGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa29340
Clone ID Related Accession (Same CDS sequence) XM_006240097.3
Accession Version XM_006240097.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1344bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product signal recognition particle 54 kDa protein isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005105.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006240097.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGTTCTAG CAGATCTTGG AAGAAAAATA ACATCAGCAT TACGCTCACT GAGCAATGCC 
ACCATTATCA ATGAAGAGGT ACTAAATGCT ATGCTGAAGG AAGTGTGTAC AGCACTATTG 
GAAGCAGATG TTAATATTAA ACTAGTGAAG CAGCTGAGAG AAAATGTTAA GTCTGCGATT 
GATCTTGAGG AGATGGCGTC CGGTCTGAAC AAAAGGAAGA TGATTCAGCA TGCTGTGTTT 
AAAGAACTTG TAAAGCTTGT AGACCCTGGA GTTAAAGCAT GGACACCGAC TAAGGGAAAG 
CAAAATGTGA TCATGTTTGT TGGATTGCAA GGGAGTGGTA AAACAACAAC GTGTTCAAAG 
TTAGCATATT TTTACCAGAG GAAAGGTTGG AAGACCTGTT TGATATGTGC AGATACATTC 
AGAGCAGGAG CTTTTGACCA GCTTAAACAG AACGCCACCA AAGCAAGAAT TCCGTTCTAT 
GGAAGCTATA CCGAAATGGA TCCTGTCATC ATTGCTTCTG AAGGAGTGGA GAAATTCAAA 
AATGAAAATT TTGAAATTAT TATTGTTGAT ACAAGTGGTC GTCACAAACA AGAAGACTCC 
TTGTTTGAAG AAATGCTTCA AGTTTCTAAC GCTATACAAC CTGATAACAT TGTTTATGTG 
ATGGACGCAT CCATTGGACA GGCTTGTGAG GCCCAGGCAA AGGCCTTCAA AGATAAAGTA 
GATGTAGCTT CAGTAATAGT GACGAAACTT GATGGTCATG CAAAAGGAGG TGGTGCTCTC 
AGTGCAGTTG CTGCCACAAA AAGTCCAATT ATTTTCATTG GTACAGGAGA ACATATAGAT 
GACTTTGAAC CTTTCAAAAC ACAACCTTTC ATTAGTAAAC TTCTTGGAAT GGGTGACATT 
GAAGGACTGA TTGATAAAGT CAATGAGTTG AAGTTGGATG ATAACGAGGC ACTTATAGAG 
AAGCTGAAGC ACGGTCAGTT TACATTGCGA GACATGTATG AACAGTTTCA GAATATTATG 
AAAATGGGCC CATTCAGTCA GATCTTGGGG ATGATTCCTG GTTTTGGCAC AGATTTTATG 
AGCAAAGGAA ATGAGCAGGA GTCAATGGCA AGGCTAAAGA AGCTGATGAC GATAATGGAC 
AGTATGAATG ATCAAGGTGG TGATATGTCA AAGAATGTGA GTCAGTCACA GATGGCAAAA 
TTAAATCAAC AAATGGCCAA AATGATGGAC CCACGAGTTC TTCATCACAT GGGTGGCATG 
GCCGGCCTTC AGTCGATGAT GCGGCAGTTT CAGCAGGGTG CTGCTGGCAA TATGAAAGGC 
ATGATGGGAT TCAATAACAT GTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006240159.1
CDS258..1601
Translation

Target ORF information:

RefSeq Version XM_006240097.3
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus signal recognition particle 54A (Srp54a), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_006240097.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGTTCTAG CAGATCTTGG AAGAAAAATA ACATCAGCAT TACGCTCACT GAGCAATGCC 
ACCATTATCA ATGAAGAGGT ACTAAATGCT ATGCTGAAGG AAGTGTGTAC AGCACTATTG 
GAAGCAGATG TTAATATTAA ACTAGTGAAG CAGCTGAGAG AAAATGTTAA GTCTGCGATT 
GATCTTGAGG AGATGGCGTC CGGTCTGAAC AAAAGGAAGA TGATTCAGCA TGCTGTGTTT 
AAAGAACTTG TAAAGCTTGT AGACCCTGGA GTTAAAGCAT GGACACCGAC TAAGGGAAAG 
CAAAATGTGA TCATGTTTGT TGGATTGCAA GGGAGTGGTA AAACAACAAC GTGTTCAAAG 
TTAGCATATT TTTACCAGAG GAAAGGTTGG AAGACCTGTT TGATATGTGC AGATACATTC 
AGAGCAGGAG CTTTTGACCA GCTTAAACAG AACGCCACCA AAGCAAGAAT TCCGTTCTAT 
GGAAGCTATA CCGAAATGGA TCCTGTCATC ATTGCTTCTG AAGGAGTGGA GAAATTCAAA 
AATGAAAATT TTGAAATTAT TATTGTTGAT ACAAGTGGTC GTCACAAACA AGAAGACTCC 
TTGTTTGAAG AAATGCTTCA AGTTTCTAAC GCTATACAAC CTGATAACAT TGTTTATGTG 
ATGGACGCAT CCATTGGACA GGCTTGTGAG GCCCAGGCAA AGGCCTTCAA AGATAAAGTA 
GATGTAGCTT CAGTAATAGT GACGAAACTT GATGGTCATG CAAAAGGAGG TGGTGCTCTC 
AGTGCAGTTG CTGCCACAAA AAGTCCAATT ATTTTCATTG GTACAGGAGA ACATATAGAT 
GACTTTGAAC CTTTCAAAAC ACAACCTTTC ATTAGTAAAC TTCTTGGAAT GGGTGACATT 
GAAGGACTGA TTGATAAAGT CAATGAGTTG AAGTTGGATG ATAACGAGGC ACTTATAGAG 
AAGCTGAAGC ACGGTCAGTT TACATTGCGA GACATGTATG AACAGTTTCA GAATATTATG 
AAAATGGGCC CATTCAGTCA GATCTTGGGG ATGATTCCTG GTTTTGGCAC AGATTTTATG 
AGCAAAGGAA ATGAGCAGGA GTCAATGGCA AGGCTAAAGA AGCTGATGAC GATAATGGAC 
AGTATGAATG ATCAAGGTGG TGATATGTCA AAGAATGTGA GTCAGTCACA GATGGCAAAA 
TTAAATCAAC AAATGGCCAA AATGATGGAC CCACGAGTTC TTCATCACAT GGGTGGCATG 
GCCGGCCTTC AGTCGATGAT GCGGCAGTTT CAGCAGGGTG CTGCTGGCAA TATGAAAGGC 
ATGATGGGAT TCAATAACAT GTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW


book

A new mechanism of 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride (TAS-103) action discovered by target screening with drug-immobilized affinity beads.
Molecular pharmacology73(3)987-94(2008 Mar)
Yoshida M,Kabe Y,Wada T,Asai A,Handa H


book

Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages.
Arthritis research & therapy8(2)R39(2006)
R?misch K,Miller FW,Dobberstein B,High S


book

Signal recognition particle components in the nucleolus.
Proceedings of the National Academy of Sciences of the United States of America97(1)55-60(2000 Jan)
Politz JC,Yarovoi S,Kilroy SM,Gowda K,Zwieb C,Pederson T


book

Protein SRP54 of human signal recognition particle: cloning, expression, and comparative analysis of functional sites.
Gene207(2)197-207(1998 Jan)
Gowda K,Black SD,Moeller I,Sakakibara Y,Liu MC,Zwieb C