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Itgb3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Summary

Gene Symbol Itgb3
Entrez Gene ID 29302
Full Name integrin subunit beta 3
General protein information
Preferred Names

integrin subunit beta 3

Names

integrin beta-3
integrin beta 3 (Cd61)
integrin, beta 3
Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

10

10q32.1
Summary beta chain of integrin; involved in cardiac remodeling after myocardial infarction [RGD, Feb 2006].

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_153720.1 NP_714942.1 integrin beta-3 precursor

Pathways from BioSystems


Homologies


Pan troglodytes (chimpanzee) ITGB3 XP_523684.2
Mus musculus (house mouse) Itgb3 NP_058060.2
Homo sapiens (human) ITGB3 NP_000203.2
ITGB3 XP_001116013.1
Bos taurus (cattle) ITGB3 NP_001193419.1
Xenopus tropicalis (tropical clawed frog) itgb3 XP_002942401.2
Canis lupus familiaris (dog) ITGB3 NP_001003162.1
Rattus norvegicus (Norway rat) Itgb3 NP_714942.1
Gallus gallus (chicken) ITGB3 NP_989646.1
Danio rerio (zebrafish) itgb3b NP_001076417.1

Gene Ontology


Bibliography

Related articles in PubMed

The Gain-of-Function Integrin ?3 Pro33 Variant Alters the Serotonin System in the Mouse Brain.
Dohn MR, Kooker CG, Bastarache L, Jessen T, Rinaldi C, Varney S, Mazalouskas MD, Pan H, Oliver KH, Velez Edwards DR, Sutcliffe JS, Denny JC, Carneiro AMD
The Journal of neuroscience : the official journal of the Society for Neuroscience37(46)11271-11284(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This is the first study to detail the signaling pathway triggered by alphavbeta3, the endogenous Thy-1 ligand, highlighting the role of membrane-bound integrins as trans acting ligands in astrocyte-neuron communication
Title: Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway.

These findings uncover a hitherto unrecognized role for hemichannels in the regulation of astrocyte migration via P2X7R transactivation induced by integrin-mediated ATP release.
Title: Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration.

Taken together, our results reveal that ND-1 is a novel antagonist of alphaIIb3 with strong antithrombotic effect and lower bleeding risk
Title: A Naphthalenic Derivative ND-1 Inhibits Thrombus Formation by Interfering the Binding of Fibrinogen to Integrin

Integrin alphaVbeta3 facilitates Ca(2+) wave generation through a signaling cascade, involving phospholipase Cgamma1, inositol 1,3,4 triphosphate production, and inositol 1, 4, 5-triphosphate receptor activation.
Title: Implications of ?v?3 Integrin Signaling in the Regulation of Ca2+ Waves and Myogenic Tone in Cerebral Arteries.

Propose that a reduction in beta3 integrin expression in osteocytes might impair mechanosensation by bone cells during estrogen deficiency.
Title: Differential ?3 and ?1 Integrin Expression in Bone Marrow and Cortical Bone of Estrogen Deficient Rats.

The following Itgb3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Itgb3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa13522 NM_153720.1
Latest version!		 Rattus norvegicus integrin subunit beta 3 (Itgb3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $461.30
$659.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ORa13522
Clone ID Related Accession (Same CDS sequence) NM_153720.1
Accession Version NM_153720.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 2364bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-25
Organism Rattus norvegicus(Norway rat)
Product integrin beta-3 precursor
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ440952.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ440952.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2689594, SAMEA2689598 [ECO:0000350] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
ATGCGAACGC GGCGGCCGGG ACAGCTCTGG GCCACTCTGC TGGCGCTGGG GGCGCTGGCG 
GGCGTTGTCG TCGGAGAGTC CAACATCTGT ACCACGAGAG GTGTGAACTC CTGCCAGCAG 
TGTCTGGCCG TAAGTCCCGT GTGTGCCTGG TGCTCGGATG AGTCTCTGCC TCAGAACTCG 
CCCCGCTGTA ACCTGAAAAA GAACCTGCTG AAGGATAAGT GCTCCCCAGA GTCTATTGAG 
TTCCCAGTCA GCGAGGCCCA GATCCTGGAA GCTCTTCCGC TCAGCAGCAA GGGCTCAGGA 
GACAGCGCCC AGATCACTCA GGTCAGCCCC CAGAGGATCG CCCTTCGGCT GCGGCCAGAT 
GATTCGAAGA TCTTTTCACT CCAAGTGCGG CAGGTGGAGG ATTACCCTGT AGACATCTAC 
TACTTGATGG ATCTGTCTTT CTCCATGAAG GATGATCTGT CCAGCATCCA GACCCTGGGT 
ACCAAGTTGG CCTCTCAGAT GCGCAAGCTT ACCAGCAACC TTCGGATTGG CTTTGGGGCC 
TTTGTGGACA AGCCCGTGTC TCCATACATG TTCATCTCCC CACCACAGGC GATCAAAAAC 
CCCTGTTACA CTATGAAGAG TACCTGCTTG CCCATGTTTG GCTACAAACA TGTGCTAACA 
CTAACCGACC AGGTGACCCG CTTCAATGAC GAAGTGAAGA AGCAGAGTGT GTCACGTAAC 
CGAGATGCCC CAGAGGGCGG CTTTGACGCC ATCATGCAGG CTACAGTCTG TGATGAAAAA 
ATTGGCTGGA GGAATGATGC ATCCCATTTG CTGGTGTTTA CCACTGATGC CAAGACCCAT 
ATTGCCCTGG ACGGAAGGCT GGCAGGCATT GTCTTGCCCA ATGATGGGCG CTGCCACATT 
GGCCCGGACA ACCACTACTC TGCTTCCACT ACTATGGATT ACCCATCTCT GGGGCTGATG 
ACTGAGAAAC TATCCCAGAA GAACATTAAC TTGATCTTTG CAGTGACCGA AAATGTCGTC 
AGCCTTTACC AGAATTACAG TGAGCTCATC CCGGGGACCA CAGTGGGAGT CCTGTCTGAT 
GACTCAAGCA ATGTCCTTCA GCTCATCGTT GATGCTTACG GGAAAATCCG TTCTAAAGTG 
GAGCTGGAAG TGCGTGATCT CCCCGAAGAG CTGTCGCTGT CCTTCAATGC CACCTGCCTC 
AACAACGAGG TCATCCCAGG CCTCAAGTCT TGTGTGGGCC TCAAGATTGG AGACACGGTG 
AGCTTCAGCA TCGAGGCCAA GGTGCGTGGC TGCCCCCAGC AGAAGGAGCA ATCTTTCACT 
ATTAAGCCTG TGGGCTTTAA GGACAGCCTT ACAGTCCAGG TGACCTTCGA CTGTGACTGT 
GACTGCCAGG CCTTTGCCCA GCCTCTCAGC CCACGCTGCA ACAATGGTAA CGGAACCTTT 
GAGTGTGGGG TGTGCCGCTG TGACCAGGGC TGGCTGGGCT CCATGTGTGA GTGCTCCGAG 
GAGGACTATC GACCCTCTCA GCAGGAAGAG TGCAGCCCCA AGGAAGGCCA GCCCATCTGC 
AGCCAGCGGG GCGAGTGCCT CTGTGGCCAG TGCGTCTGCC ACAGCAGTGA CTTTGGCAAG 
ATCACCGGCA AGTACTGTGA GTGTGATGAC TTCTCCTGTG TCCGCTACAA AGGGGAGATG 
TGCTCTGGCC ATGGCCAGTG CAACTGTGGG GACTGCGTGT GTGACTCGGA CTGGACTGGC 
TACTACTGCA ACTGCACAAC ACGCACCGAC ACCTGCATGT CCACCAACGG GCTGCTGTGC 
AGCGGCCGGG GCAACTGTGA GTGTGGCAGC TGTGTGTGCG TCCAGCCAGG CTCCTATGGA 
GACACCTGCG AGAAGTGTCC CACCTGCCCA GATGCCTGCT CATTTAAGAA GGACTGTGTG 
GAGTGTAAGA AGTTCAACCG GGGAAAGCTA CATGAAGAAA ACAACTGCAA CCGTTTCTGC 
CGAGATGACA TCGAGCTGGT GAAAGAACTG ACGGATACTG GCAAAAACGC GGTGAACTGT 
ACCTACAAGA ATGAGGACGA CTGTGTCGTC AGATTCCAGT ACTATGAAGA CTCCAGTGGA 
AGGGCTGTCC TGTATGTGGT AGAAGAGCCT GAGTGTCCTA AGGGTCCTGA TATCCTGGTG 
GTCCTGCTGT CAGTGATGGG GGCGATTCTG CTCATTGGCC TTGCTACTCT GCTCATCTGG 
AAGCTACTCA TCACCATTCA TGACCGGAAG GAATTTGCTA AATTTGAGGA AGAACGAGCC 
AGAGCCAAAT GGGACACAGC AAACAACCCA TTGTATAAAG AGGCCACCTC CACCTTCACC 
AATATCACCT ACCGGGGCAC TTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_714942.1
CDS12..2375
Translation

Target ORF information:

RefSeq Version NM_153720.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus integrin subunit beta 3 (Itgb3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_153720.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
ATGCGAACGC GGCGGCCGGG ACAGCTCTGG GCCACTCTGC TGGCGCTGGG GGCGCTGGCG 
GGCGTTGTCG TCGGAGAGTC CAACATCTGT ACCACGAGAG GTGTGAACTC CTGCCAGCAG 
TGTCTGGCCG TAAGTCCCGT GTGTGCCTGG TGCTCGGATG AGTCTCTGCC TCAGAACTCG 
CCCCGCTGTA ACCTGAAAAA GAACCTGCTG AAGGATAAGT GCTCCCCAGA GTCTATTGAG 
TTCCCAGTCA GCGAGGCCCA GATCCTGGAA GCTCTTCCGC TCAGCAGCAA GGGCTCAGGA 
GACAGCGCCC AGATCACTCA GGTCAGCCCC CAGAGGATCG CCCTTCGGCT GCGGCCAGAT 
GATTCGAAGA TCTTTTCACT CCAAGTGCGG CAGGTGGAGG ATTACCCTGT AGACATCTAC 
TACTTGATGG ATCTGTCTTT CTCCATGAAG GATGATCTGT CCAGCATCCA GACCCTGGGT 
ACCAAGTTGG CCTCTCAGAT GCGCAAGCTT ACCAGCAACC TTCGGATTGG CTTTGGGGCC 
TTTGTGGACA AGCCCGTGTC TCCATACATG TTCATCTCCC CACCACAGGC GATCAAAAAC 
CCCTGTTACA CTATGAAGAG TACCTGCTTG CCCATGTTTG GCTACAAACA TGTGCTAACA 
CTAACCGACC AGGTGACCCG CTTCAATGAC GAAGTGAAGA AGCAGAGTGT GTCACGTAAC 
CGAGATGCCC CAGAGGGCGG CTTTGACGCC ATCATGCAGG CTACAGTCTG TGATGAAAAA 
ATTGGCTGGA GGAATGATGC ATCCCATTTG CTGGTGTTTA CCACTGATGC CAAGACCCAT 
ATTGCCCTGG ACGGAAGGCT GGCAGGCATT GTCTTGCCCA ATGATGGGCG CTGCCACATT 
GGCCCGGACA ACCACTACTC TGCTTCCACT ACTATGGATT ACCCATCTCT GGGGCTGATG 
ACTGAGAAAC TATCCCAGAA GAACATTAAC TTGATCTTTG CAGTGACCGA AAATGTCGTC 
AGCCTTTACC AGAATTACAG TGAGCTCATC CCGGGGACCA CAGTGGGAGT CCTGTCTGAT 
GACTCAAGCA ATGTCCTTCA GCTCATCGTT GATGCTTACG GGAAAATCCG TTCTAAAGTG 
GAGCTGGAAG TGCGTGATCT CCCCGAAGAG CTGTCGCTGT CCTTCAATGC CACCTGCCTC 
AACAACGAGG TCATCCCAGG CCTCAAGTCT TGTGTGGGCC TCAAGATTGG AGACACGGTG 
AGCTTCAGCA TCGAGGCCAA GGTGCGTGGC TGCCCCCAGC AGAAGGAGCA ATCTTTCACT 
ATTAAGCCTG TGGGCTTTAA GGACAGCCTT ACAGTCCAGG TGACCTTCGA CTGTGACTGT 
GACTGCCAGG CCTTTGCCCA GCCTCTCAGC CCACGCTGCA ACAATGGTAA CGGAACCTTT 
GAGTGTGGGG TGTGCCGCTG TGACCAGGGC TGGCTGGGCT CCATGTGTGA GTGCTCCGAG 
GAGGACTATC GACCCTCTCA GCAGGAAGAG TGCAGCCCCA AGGAAGGCCA GCCCATCTGC 
AGCCAGCGGG GCGAGTGCCT CTGTGGCCAG TGCGTCTGCC ACAGCAGTGA CTTTGGCAAG 
ATCACCGGCA AGTACTGTGA GTGTGATGAC TTCTCCTGTG TCCGCTACAA AGGGGAGATG 
TGCTCTGGCC ATGGCCAGTG CAACTGTGGG GACTGCGTGT GTGACTCGGA CTGGACTGGC 
TACTACTGCA ACTGCACAAC ACGCACCGAC ACCTGCATGT CCACCAACGG GCTGCTGTGC 
AGCGGCCGGG GCAACTGTGA GTGTGGCAGC TGTGTGTGCG TCCAGCCAGG CTCCTATGGA 
GACACCTGCG AGAAGTGTCC CACCTGCCCA GATGCCTGCT CATTTAAGAA GGACTGTGTG 
GAGTGTAAGA AGTTCAACCG GGGAAAGCTA CATGAAGAAA ACAACTGCAA CCGTTTCTGC 
CGAGATGACA TCGAGCTGGT GAAAGAACTG ACGGATACTG GCAAAAACGC GGTGAACTGT 
ACCTACAAGA ATGAGGACGA CTGTGTCGTC AGATTCCAGT ACTATGAAGA CTCCAGTGGA 
AGGGCTGTCC TGTATGTGGT AGAAGAGCCT GAGTGTCCTA AGGGTCCTGA TATCCTGGTG 
GTCCTGCTGT CAGTGATGGG GGCGATTCTG CTCATTGGCC TTGCTACTCT GCTCATCTGG 
AAGCTACTCA TCACCATTCA TGACCGGAAG GAATTTGCTA AATTTGAGGA AGAACGAGCC 
AGAGCCAAAT GGGACACAGC AAACAACCCA TTGTATAAAG AGGCCACCTC CACCTTCACC 
AATATCACCT ACCGGGGCAC TTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

The Gain-of-Function Integrin ?3 Pro33 Variant Alters the Serotonin System in the Mouse Brain.
The Journal of neuroscience : the official journal of the Society for Neuroscience37(46)11271-11284(2017 Nov)
Dohn MR,Kooker CG,Bastarache L,Jessen T,Rinaldi C,Varney S,Mazalouskas MD,Pan H,Oliver KH,Velez Edwards DR,Sutcliffe JS,Denny JC,Carneiro AMD