Gene Symbol | Prox1 |
Entrez Gene ID | 305066 |
Full Name | prospero homeobox 1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Prox1 cDNA ORF clone
Gene Symbol | Prox1 |
Entrez Gene ID | 305066 |
Full Name | prospero homeobox 1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006250454.3 | XP_006250516.1 | prospero homeobox protein 1 isoform X1 |
XM_006250455.3 | XP_006250517.1 | prospero homeobox protein 1 isoform X1 |
XM_017598838.1 | XP_017454327.1 | prospero homeobox protein 1 isoform X1 |
XM_006250458.3 | XP_006250520.1 | prospero homeobox protein 1 isoform X2 |
XM_006250456.3 | XP_006250518.1 | prospero homeobox protein 1 isoform X1 |
NM_001107201.1 | NP_001100671.1 | prospero homeobox protein 1 |
PROX1 | XP_001106666.1 | |
Gallus gallus (chicken) | PROX1 | NP_001005616.1 |
Pan troglodytes (chimpanzee) | PROX1 | XP_003949740.1 |
Canis lupus familiaris (dog) | PROX1 | XP_005622419.1 |
Homo sapiens (human) | PROX1 | NP_001257545.1 |
Bos taurus (cattle) | PROX1 | NP_001180161.1 |
Rattus norvegicus (Norway rat) | Prox1 | NP_001100671.1 |
Mus musculus (house mouse) | Prox1 | NP_032963.1 |
Danio rerio (zebrafish) | prox1a | NP_571480.2 |
Xenopus tropicalis (tropical clawed frog) | prox1 | XP_004914836.1 |
The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation.
Kivel? R, Salmela I, Nguyen YH, Petrova TV, Koistinen HA, Wiener Z, Alitalo K
Nature communications713124(2016 Oct)
Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors ?- and ?-mediated transactivation.
Takeda Y, Jetten AM
Nucleic acids research41(14)6992-7008(2013 Aug)
Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas.
Westmoreland JJ, Kilic G, Sartain C, Sirma S, Blain J, Rehg J, Harvey N, Sosa-Pineda B
Gastroenterology142(4)999-1009.e6(2012 Apr)
Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development.
Tateya T, Imayoshi I, Tateya I, Ito J, Kageyama R
Developmental biology352(2)329-40(2011 Apr)
Regulation of the lymphatic endothelial cell cycle by the PROX1 homeodomain protein.
Baxter SA, Cheung DY, Bocangel P, Kim HK, Herbert K, Douville JM, Jangamreddy JR, Zhang S, Eisenstat DD, Wigle JT
Biochimica et biophysica acta1813(1)201-12(2011 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Prox1 synergizes with the p50 of NF-kappaB to control VEGFR-3 expression.
Title: Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1.
Our studies suggest that Prox1 is a multifunctional regulator of liver morphogenesis and of hepatocyte function and commitment.
Title: Gene regulation by homeobox transcription factor Prox1 in murine hepatoblasts.
At embryonal stage of rat liver development (embryonal days 14-16) hepatoblasts were found to be Prox1(+)/Cytokeratin (CK) 19(+) and alpha-fetoprotein (AFP)(+), at this stage Prox1(-)/CK19(+)/AFP(-) small cells (early cholangiocytes?) were identified.
Title: Prospero-related homeobox 1 (Prox1) is a stable hepatocyte marker during liver development, injury and regeneration, and is absent from "oval cells".
Prox1 is a highly conserved transcription factor, expressed in hepatocytes from the earliest stages of development into adulthood and over-expressed in hepatoma cell lines.
Title: The homeobox transcription factor Prox1 is highly conserved in embryonic hepatoblasts and in adult and transformed hepatocytes, but is absent from bile duct epithelium.
Prox1 activity is both necessary and sufficient for progenitor-cell proliferation and cell-fate determination in the vertebrate retina
Title: Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina.
The following Prox1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prox1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa11132 | |
Clone ID Related Accession (Same CDS sequence) | NM_001107201.1 | |
Accession Version | NM_001107201.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1752bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-09-15 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | prospero homeobox protein 1 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473985.1. On or before Oct 4, 2007 this sequence version replaced XM_001067440.1, XM_223067.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGCCTGACC ATGACAGCAC AGCCCTCTTA AGCCGGCAAA CCAAGAGGAG AAGGGTTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001100671.1 |
CDS | 478..2229 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001107201.1 |
1 | ATGCCTGACC ATGACAGCAC AGCCCTCTTA AGCCGGCAAA CCAAGAGGAG AAGGGTTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa35727 | |
Clone ID Related Accession (Same CDS sequence) | XM_006250454.3 , XM_006250455.3 , XM_017598838.1 , XM_006250456.3 | |
Accession Version | XM_006250454.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2217bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | prospero homeobox protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006250454.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCTGACC ATGACAGCAC AGCCCTCTTA AGCCGGCAAA CCAAGAGGAG AAGGGTTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006250516.1 |
CDS | 604..2820 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006250454.3 |
1 | ATGCCTGACC ATGACAGCAC AGCCCTCTTA AGCCGGCAAA CCAAGAGGAG AAGGGTTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa35727 | |
Clone ID Related Accession (Same CDS sequence) | XM_006250454.3 , XM_006250455.3 , XM_017598838.1 , XM_006250456.3 | |
Accession Version | XM_006250455.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2217bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | prospero homeobox protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006250455.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCTGACC ATGACAGCAC AGCCCTCTTA AGCCGGCAAA CCAAGAGGAG AAGGGTTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006250517.1 |
CDS | 298..2514 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006250455.3 |
1 | ATGCCTGACC ATGACAGCAC AGCCCTCTTA AGCCGGCAAA CCAAGAGGAG AAGGGTTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa35727 | |
Clone ID Related Accession (Same CDS sequence) | XM_006250454.3 , XM_006250455.3 , XM_017598838.1 , XM_006250456.3 | |
Accession Version | XM_017598838.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2217bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | prospero homeobox protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCTGACC ATGACAGCAC AGCCCTCTTA AGCCGGCAAA CCAAGAGGAG AAGGGTTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017454327.1 |
CDS | 732..2948 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017598838.1 |
1 | ATGCCTGACC ATGACAGCAC AGCCCTCTTA AGCCGGCAAA CCAAGAGGAG AAGGGTTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa35727 | |
Clone ID Related Accession (Same CDS sequence) | XM_006250454.3 , XM_006250455.3 , XM_017598838.1 , XM_006250456.3 | |
Accession Version | XM_006250456.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2217bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | prospero homeobox protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006250456.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCTGACC ATGACAGCAC AGCCCTCTTA AGCCGGCAAA CCAAGAGGAG AAGGGTTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006250518.1 |
CDS | 923..3139 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006250456.3 |
1 | ATGCCTGACC ATGACAGCAC AGCCCTCTTA AGCCGGCAAA CCAAGAGGAG AAGGGTTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa35728 | |
Clone ID Related Accession (Same CDS sequence) | XM_006250458.3 | |
Accession Version | XM_006250458.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2214bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | prospero homeobox protein 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006250458.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCTGACC ATGACAGCAC AGCCCTCTTA AGCCGGCAAA CCAAGAGGAG AAGGGTTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006250520.1 |
CDS | 604..2817 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006250458.3 |
1 | ATGCCTGACC ATGACAGCAC AGCCCTCTTA AGCCGGCAAA CCAAGAGGAG AAGGGTTGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation. |
Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors ?- and ?-mediated transactivation. |
Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas. |
Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development. |
Regulation of the lymphatic endothelial cell cycle by the PROX1 homeodomain protein. |