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The Heme Oxygenase-Like Diiron Enzyme HrmI Reveals Altered Regulatory Mechanisms for Dioxygen Activation and Substrate N-Oxygenation
Authors: Sydney S Skirboll, Medha Gangopadhyay, Han N Phan, Joshua Hartsell, Aditi Mudireddy, Dalton Hilovsky, Paul D Swartz, Xiaojing Liu, Yisong Guo, Thomas M Makris
Journal: Journal of the American Chemical Society
PubMed ID: 40774922
Doi: doi.org/10.1021/jacs.5c08814
Products & Services: Gene Synthesis   
Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery
Authors: Elias Adriaenssens, Stefan Schaar, Annan S I Cook, Jan F M Stuke, Justyna Sawa-Makarska, Thanh Ngoc Nguyen, Xuefeng Ren, Martina Schuschnig, Julia Romanov, Grace Khuu, Louise Uoselis, Michael Lazarou, Gerhard Hummer, James H Hurley, Sascha Martens
Journal: Nature Cell Biology
PubMed ID: 40715440
Doi: 10.1038/s41556-025-01712-y
Products & Services: Gene Synthesis   
Elevated uric acid induces erectile dysfunction in rats by interacting with MLCK and inhibiting its ubiquitin-mediated degradation
Authors: Gang Shen, Zhenzhen Fang, Fuyan Hong, Mian Wu, Jing Zhang, Jinhong Wang, Chuan Bai, Wencan Chen, Xia Yang, Chunhua Deng, Haibing Chen, Guoquan Gao, Ti Zhou
Journal: Communications Biology
PubMed ID: 40783594
Doi: 10.1038/s42003-025-08607-6.
Products & Services: Protein and Antibody Isolation   
Laodelphax striatellus salivary sheath protein Lsactin triggers defense response in plants
Authors: Liangxuan Qi, Jing Li, Han Wang, Jing Li, Xinyang Tan, Zhichang Zhao, Sicong Zhou, Jichao Fang, Rui Ji
Journal: Insect biochemistry and molecular biology
PubMed ID: 40543628
Doi: 10.1016/j.ibmb.2025.104351
Products & Services: Polyclonal Antibody Services   
Sonodynamic therapy augmented by glycolysis inhibition: a novel metabolic reprogramming strategy for enhanced osteosarcoma treatment
Authors: Zhuorun Song, Shunyi Lu, Yuqi Yang, Zijun Chen, Youdong Chen, Jie Cao, Zimin Zhang, Jun Ge, Huilin Yang, Liang Cheng
Journal: National Science Review
Doi: 10.1093/nsr/nwaf365
Products & Services: Protein and Antibody Isolation   
A Covalent Self-Reporting Peptide Degrader Enables Real-Time Monitoring of Targeted Protein Degradation In Vivo
Authors: Wei Zhang, Lizhen Yuan, Rui Liu, Yanbo Jing, Shijun Lin, Hao Fang, Yuxuan Li, Xiaohui Zhang, Jun Dai, Tao Liu, Fan Xia, Xiaoding Lou
Journal: J Am Chem Soc
PubMed ID: 40717291
Doi: 10.1021/jacs.5c07041
Products & Services: Recombinant Proteins   
Modulation of the PTPRS proteoglycan switch by antibodies binding to the membrane-proximal fibronectin-type III domain
Authors: Thales Hein Da Rosa, Sterling H Ramsey, Judy J Lee, Natalia Y Kozlova, Zixuan Zhao, Jaeyeon Kim, Ava C Schneider, Sheng Li, Madhusudhanarao Katiki, Gary S Firestein, Ramachandran Murali, Eugenio Santelli, Stephanie M Stanford, Nunzio Bottini
Journal: The Journal of Biological Chemistry
PubMed ID: 40651610
Doi: 10.1016/j.jbc.2025.110470
Epitope molecularly imprinted polymers based on host-guest interaction: specific recognition of CD59
Authors: Yitong Xu, Huifeng Zhang, Ying Zhang, Jiutong Ma, Qiong Jia
Journal: Journal of chromatography. A
PubMed ID: 40382882
Doi: doi.org/10.1016/j.chroma.2025.466056
Products & Services: Peptide Synthesis   
Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids
Authors: Kirsten Broderick, Mohamed Taha Moutaoufik, Tatiana Saccon, Ramy Malty, Shahreen Amin, Sadhna Phanse, Thomson Patrick Joseph, Mara Zilocchi, Ali Hosseinnia, Zoe Istace, Maryam Hajikarimlou, Sakib Abrar, Jade Fisher, Raelynn Brassard, Ranawaka Perera, Anil Kumar, Hiroyuki Aoki, Matineh Rahmatbakhsh, Matthew Jessulat, Darwyn Kobasa, Frank Dehne, Bhanu Prasad, Alla Gagarinova, M Joanne Lemieux, Alan Cochrane, Walid A Houry, Khaled A Aly, Ashkan Golshani, Mohan Babu
Journal: Nature Communications
PubMed ID: 40593736
Doi: 10.1038/s41467-025-60949-1
Products & Services: Gene Synthesis   
Bat-specific adaptations in interferon signaling and GBP1 contribute to enhanced antiviral capacity
Authors: Victoria Gonzalez, Briallen Lobb, Jacob Côté, Arkadeb Bhuinya, Adriana G Tubb, Stephen S Nuthalapati, Akarin Asavajaru, Yan Zhou, Vikram Misra, Darryl Falzarano, Trevor R Sweeney, Sophie M C Gobeil, Linfa Wang, Andrew C Doxey, Arinjay Banerjee
Journal: Nature Communications
PubMed ID: 40593754
Doi: 10.1038/s41467-025-61254-7
Products & Services: PCR Cloning and Subcloning   
CryoEM structure of the SLFN14 endoribonuclease reveals insight into RNA binding and cleavage
Authors: Justin Van Riper, Arleth O Martinez-Claros, Lie Wang, Hannah E Schneiderman, Sweta Maheshwari, Monica C Pillon
Journal: Nature Communications
PubMed ID: 40592880
Doi: 10.1038/s41467-025-61091-8
Products & Services: Gene Synthesis   
The human RIF1-Long isoform interacts with BRCA1 to promote recombinational fork repair under DNA replication stress
Authors: Qianqian Dong, Matthew Day, Yuichiro Saito, Emma Parker, Lotte P Watts, Masato T Kanemaki, Antony W Oliver, Laurence H Pearl, Shin-Ichiro Hiraga, Anne D Donaldson
Journal: Nature Communications
PubMed ID: 40595496
Doi: 10.1038/s41467-025-60817-y
Products & Services: Custom Vector Construction   
New molecular components of high and low affinity iron import systems in Drosophila
Authors: Sattar Soltani, Minyi Yan, Qingxuan Yu, Areeg Abd Elhafiz, Erika Pfriem, Samuel M Webb, Thomas Kroll, Jahir Marceliano Bahena Lopez, Fanis Missirlis, Kirst King-Jones
Journal: Nature Communications
PubMed ID: 40592826
Doi: 10.1038/s41467-025-60758-6
Products & Services: PCR Cloning and Subcloning   
Antigen specificity shapes distinct aging trajectories of memory CD8⁺ T cells
Authors: Ines Sturmlechner, Abhinav Jain, Bin Hu, Rohit R Jadhav, Wenqiang Cao, Hirohisa Okuyama, Lu Tian, Cornelia M Weyand, Jörg J Goronzy
Journal: Nature Communications
PubMed ID: 40640147
Doi: 10.1038/s41467-025-61627-y
Products & Services: Peptide Synthesis   
Efficient, cell-type-specific production of flavonols by multiplexed CRISPR activation of a suite of metabolic enzymes
Authors: Anaxi Houbaert, Valérie Denervaud Tendon, Lukas Hoermayer, Nicholas Morffy, Lucia C Strader, Niko Geldner
Journal: Nature Communications
PubMed ID: 40670339
Doi: 10.1038/s41467-025-61742-w
Products & Services: Codon Optimization   
A glyoxal-specific aldehyde signaling axis in Pseudomonas aeruginosa that influences quorum sensing and infection
Authors: Christopher J Corcoran, Bonnie J Cuthbert, David G Glanville, Mailyn Terrado, Diana Valverde Mendez, Benjamin P Bratton, Daniel E Schemenauer, Valerie L Tokars, Thomas G Martin, Lawrence W Rasmussen, Matthew C Madison, Andrew F Maule, Joshua W Shaevitz, Boo Shan Tseng, Julian P Whitelegge, Catherine Putonti, Amit Gaggar, Jordan R Beach, Jonathan A Kirk, Alfonso Mondragón, Abby R Kroken, Jonathan P Allen, Celia W Goulding, Andrew T Ulijasz
Journal: Nature Communications
PubMed ID: 40681494
Doi: 10.1038/s41467-025-61469-8
Products & Services: Protein and Antibody Isolation   
Structural basis of collagen glucosyltransferase function and its serendipitous role in kojibiose synthesis
Authors: Jeong Seon Kim, Zhenhang Chen, Sara Andrea Espinosa Garcia, Christoph Buhlheller, Botao Zhang, Stephen J Richards, Tingfei Chen, Jingjing Wu, Ronald C Bruntz, Marisa E Gilliam, Mitsuo Yamauchi, Bo Liang, Houfu Guo
Journal: Nature Communications
PubMed ID: 40691173
Doi: 10.1038/s41467-025-61973-x
Products & Services: PCR Cloning and Subcloning   
CD19-ReTARGTPR: A Novel Fusion Protein for Physiological Engagement of Anti-CMV Cytotoxic T Cells Against CD19-Expressing Malignancies
Authors: Anne Paulien van Wijngaarden, Isabel Britsch, Matthias Peipp, Douwe Freerk Samplonius, Wijnand Helfrich
Journal: Cancers
PubMed ID: 40723184
Products & Services: Gene Synthesis   
Deficiency of IFNAR1 Increases the Production of Influenza Vaccine Viruses in MDCK Cells
Authors: Qi Wang, Tuanjie Chen, Mengru Feng, Mei Zheng, Feixia Gao, Chenchen Qiu, Jian Luo, Xiuling Li
Journal: Viruses-Basel
Doi: 10.3390/v17081097
Products & Services: Nucleic Acid Purification   
A Carbamoyl N-Methyltransferase Catalyzes N-Methylation of the Primary Amide in Ansacarbamitocin Biosynthesis
Authors: Zhongyue Li, Wanting Yang, Zhonglin Sun, Haoxin Wang, Chunhua Lu, Deyu Zhu, Yuemao Shen
Journal: Journal of the American Chemical Society
PubMed ID: 40601550
Doi: 10.1021/jacs.5c05398
Products & Services: Gene Synthesis   Gene Synthesis   
Optimization of Multiple Combinations of Early Secretion Pathways to Enhance Extracellular Protein Secretion in Komagataella phaffii
Authors: Hai Xu, Shijie Wang, Kang Li, Zhonghu Bai, Yankun Yang
Journal: Journal of Agricultural and Food Chemistry
PubMed ID: 40616507
Doi: doi.org/10.1021/acs.jafc.5c03402
Products & Services: Gene Synthesis   
An integrated electrochemical nanodevice for single-cell MiRNA-155 detection and drug evaluation
Authors: Zhuo Li , Zhaohan Wang , Jun Chen , Yafeng Wu
Journal: BIOSENSORS & BIOELECTRONICS
PubMed ID: 40695112
Doi: 10.1016/j.bios.2025.117804
Products & Services: PCR Cloning and Subcloning   
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI
Authors: Benjamin Bourgeois, Emil Spreitzer, Daniel Platero-Rochart, Margret Paar, Qishun Zhou, Sinem Usluer, Peter L J de Keizer, Boudewijn M T Burgering, Pedro A Sánchez-Murcia, Tobias Madl
Journal: Nature Communications
PubMed ID: 40593617
Doi: 10.1038/s41467-025-60844-9
Products & Services: Bacterial Expression   
Biohybrid-based pyroelectric bio-denitrification driven by temperature fluctuations
Authors: Jie Ye, Shuhui Wang, Chaohui Yang, Zhenhao Zuo, Wenzhi Gu, Baogang Zhang, Shungui Zhou
Journal: Nature Communications
PubMed ID: 40595581
Doi: 10.1038/s41467-025-60908-w
Products & Services: Protein Electrophoresis and Western   
Scalable modulation of CRISPR‒Cas enzyme activity using photocleavable phosphorothioate DNA
Authors: Menglu Hu, Bingni Zhang, Yuanyue Shan, Feng Cao, Yihui Wang, Weiwei Qi, Xue Wang, Yuting Shen, Xinyi Guo, Mengmeng Zhang, Tian Tian, Wei Xie, Mingfeng Zhang, Fang Liang, Duanqing Pei, Xiaoming Zhou
Journal: Nature Communications
PubMed ID: 40593724
Doi: 10.1038/s41467-025-61094-5
Products & Services: Synthetic Guide RNA   
Oropouche virus infects human trophoblasts and placenta explants
Authors: Christina J Megli, Rebecca K Zack, Jackson J McGaughey, Ryan M Hoehl, Taylor Snisky, Amy L Hartman, Cynthia M McMillen
Journal: Nature Communications
PubMed ID: 40593852
Doi: 10.1038/s41467-025-61138-w
Products & Services: Monoclonal Antibody Services   
An adaptive peptide-binding site in ubiquitin receptor hRpn13 revealed by structural studies
Authors: Bakar Hassan, Monika Chandravanshi, Martin Y Ng, Hitendra Negi, Brice A P Wilson, Kylie J Walters
Journal: Nature Communications
PubMed ID: 40595513
Doi: 10.1038/s41467-025-60843-w
Products & Services: Peptide Synthesis   
Pericyte pannexin1 controls cerebral capillary diameter and supports memory function
Authors: Sandra Mai-Morente, Eugenia Isasi, Alberto Rafael, Gonzalo Budelli, Silvia Olivera-Bravo, Nathalia Vitureira, Verónica Abudara
Journal: Nature Communications
PubMed ID: 40610448
Doi: 10.1038/s41467-025-61312-0
Products & Services: Peptide Synthesis   
Tumor site-directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors
Authors: Kevin Sek, Amanda X Y Chen, Thomas Cole, Jesse D Armitage, Junming Tong, Kah Min Yap, Isabelle Munoz, Phoebe A Dunbar, Shiyi Wu, Marit J van Elsas, Olivia Hidajat, Christina Scheffler, Lauren Giuffrida, Melissa A Henderson, Deborah Meyran, Fernando Souza-Fonseca-Guimaraes, Dat Nguyen, Yu-Kuan Huang, Maria N de Menezes, Emily B Derrick, Cheok Weng Chan, Kirsten L Todd, Jack D Chan, Jasmine Li, Junyun Lai, Emma V Petley, Sherly Mardiana, Anthony Bosco, Jason Waithman, Ian A Parish, Christina Mølck, Gregory D Stewart, Lev Kats, Imran G House, Phillip K Darcy, Paul A Beavis
Journal: Nature Communications
PubMed ID: 40610421
Doi: 10.1038/s41467-025-59021-9
Safety and immunogenicity of intranasal parainfluenza virus type 5 (PIV5)-vectored COVID-19 vaccine in adults and teens in an open-label phase 1 trial
Authors: Paul Spearman, Hong Jin, Peng Xiao, Kristeene Knopp, Henry Radziewicz, Marinka Tellier, Sasha E Larsen, Bryan J Berube, Xiao Song, Jamie Kidd, Karnail Singh, Zhuo Li, Maria Cristina Gingerich, Samuel Wu, Susan P John, Angela Branche, Ann R Falsey, Rhea Coler, Francois J Villinger, Biao He
Journal: SCIENCE ADVANCES
PubMed ID: 40614182
Doi: 10.1126/sciadv.adw0896
Products & Services: Peptide Library Services   
Structures of the measles virus polymerase complex with non-nucleoside inhibitors and mechanism of inhibition
Authors: Yiru Wang, Lixia Zhao, Yi Zhang, Xiuxia Gao, Yannan Wang, Wenping Shi, Roger D Kornberg, Heqiao Zhang
Journal: Cell
PubMed ID: 40628260
Doi: 10.1016/j.cell.2025.06.017
Products & Services: Codon Optimization   
Loss of FCoV-23 spike domain 0 enhances fusogenicity and entry kinetics
Authors: M Alejandra Tortorici, Annette Choi, Cecily A Gibson, Jimin Lee, Jack T Brown, Cameron Stewart, Anshu Joshi, Sheri Harari, Isabelle Willoughby, Catherine Treichel, Elizabeth M Leaf, Jesse D Bloom, Neil P King, Christine Tait-Burkard, Gary R Whittaker, David Veesler
Journal: Nature
PubMed ID: 40634609
Doi: 10.1038/s41586-025-09155-z
Products & Services: Gene Synthesis   
API5 Phosphorylation Promotes Antiviral Immunity by Inhibiting Degradation of Cytosolic RNA Sensor RLRs
Authors: Tingjuan Deng, Jianan Xu, Linglong Qin, Xingbo Wang, Chenhe Lu, Yanming Huang, Da Liu, Yan Yan, Weiren Dong, Pinglong Xu, Jiyong Zhou
Journal: Advanced Science
PubMed ID: 40641422
Doi: 10.1002/advs.202505479
Products & Services: Protein and Antibody Isolation   
Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities
Authors: Irafasha C Casmil, Josh J Friesen, Nuthan V Bathula, Anneke Strumpel, Chia Hao Ho, Ilana Guez, Kristen Y S Kong, Andrew J Varley, Shigeki J Miyake-Stoner, Parinaz Aliahmad, Nathaniel S Wang, Andrew J Geall, Anna K Blakney
Journal: Advanced Science
PubMed ID: 40650657
Doi: 10.1002/advs.202508907
Products & Services: Circular RNA synthesis   
Localized Delivery of the mRNAs Encoding CD47 Inhibitor and Interleukins 12, 15, and 21 Elicits Robust Antitumor Immunity
Authors: Tao Jiang, Shuaiyang Jing, Haojun Li, Bao Xiao, Jiahui Jin, Xiu Sun, Juan Wang, Jing Liang, Tongze Cai, Huili Hu, Meilan Wei, Xuanrui Zhong, Yang Ji, Peng George Wang, Jianlong Zhou
Journal: Advanced Science
PubMed ID: 40652522
Doi: 10.1002/advs.202417205
Products & Services: PCR Cloning and Subcloning   
Regulating the N-oxidation selectivity of P450BM3 monooxygenases for N-heterocycles through computer-assisted structure-guided design
Authors: Liu Yang, Zhongji Pu, Jianping Wu, Xiaofeng Liu, Zhe Wang, Haoran Yu, Liuwei Wang, Yan Meng, Gang Xu, Lirong Yang, Wenlong Zheng
Journal: Nature Communications
PubMed ID: 40659637
Doi: 10.1038/s41467-025-61773-3
Products & Services: Protein Electrophoresis and Western   
Regulation of inflammatory responses by pH-dependent transcriptional condensates
Authors: Zhongyang Wu, Scott D Pope, Nasiha S Ahmed, Diana L Leung, Yu Hong, Stephanie Hajjar, Cathleen Krabak, Zhe Zhong, Krishnan Raghunathan, Qiuyu Yue, Diya M Anand, Elizabeth B Kopp, Daniel Okin, Weiyi Ma, Ivan Zanoni, Jonathan C Kagan, Jay R Thiagarajah, Diana C Hargreaves, Ruslan Medzhitov, Xu Zhou
Journal: Cell
PubMed ID: 40680734
Doi: 10.1016/j.cell.2025.06.033
Products & Services: Gene Synthesis   
Single-dose avian influenza A(H5N1) Clade 2.3.4.4b hemagglutinin-Matrix-M® nanoparticle vaccine induces neutralizing responses in nonhuman primates
Authors: Nita Patel, Asma Rehman, Jessica F Trost, Rhonda Flores, Zach Longacre, Mimi Guebre-Xabier, Haixia Zhou, Bin Zhou, Kelsey Jacobson, Desheng Jiang, Xiaoyun Bai, Rafia Khatoon, Thomas Kort, James Norton, M Madhangi, Melinda Hersey, Ann M Greene, Filip Dubovsky, Gale Smith
Journal: Nature Communications
PubMed ID: 40681543
Doi: 10.1038/s41467-025-61964-y
Products & Services: Gene Synthesis   
Potentiating the Efficacy of mRNA Vaccines through NIR-II Imaging-Guided Precise Vaccination
Authors: Mengfei Li, Xue Zheng, Xinyang Yu, Shaolong Qi, Shoujun Zhu, Guocan Yu, Songling Zhang
Journal: Advanced Science
PubMed ID: 40681479
Doi: 10.1002/advs.202413014
Products & Services: Peptide Synthesis   
Remolding Microenvironmental Homeostasis for Enhancing Regenerative Hypertrophic Scar Treatment Based on Functionalized Microneedles
Authors: Shengjie Jiang, Jialiang Zhou, Liyun Wang, Xin Liu, Jiaming Sun, Yu Zhuang, Li Yu, Haiyan Li, Dejian Li, Zhaoyong Zou, Zhen Gao, Kaili Lin
Journal: Interdisciplinary Materials
Doi: doi.org/10.1002/idm2.70000
Products & Services: Protein Electrophoresis and Western   
A Charge-Adhesive Targeted DNA Gel Bandage for the Precision Treatment of Inflammatory Bowel Disease
Authors: Peifen Lu, Hongxiu Yuan, Gang Wang, Tao Cheng, Lie Li, Yixi Dong, Runyu Zhao, Xuerui Zhang, Jianwei Jiao, Jin Jiao
Journal: Advanced Science
PubMed ID: 40685690
Doi: 10.1002/advs.202509419
Products & Services: Protein and Antibody Isolation   
ZEB2 is a master switch controlling the tumor-associated macrophage program
Authors: Fadi Sheban, Truong San Phan, Ken Xie, Florian Ingelfinger, Chamutal Gur, Yuval Shapir Itai, Ronnie Blecher-Gonen, Chunsong Yu, Roberto Avellino, Paulina Chalan, Kiara Freitag, Ido Yofe, Vladimir Yutkin, Pierre Boyeau, Can Ergen, Justin Hong, Kfir Mazuz, Yuxiao Liu, Kangming Chen, Rony Dahan, Marcin Kortylewski, Nir Yosef, Assaf Weiner, Ido Amit
Journal: Cancer Cell
PubMed ID: 40215981
Doi: 10.1016/j.ccell.2025.03.021
Products & Services: Synthetic Guide RNA   
Noninvasive Activation of Local and Systemic Immunity with a Sequential-Targeting Sonodynamic Nanovaccine to Treat Glioblastoma
Authors: Wei Cheng, Jiaojiao Yang, Yuqing Pan, Haijing Qu, Zhiran Duan, Jie Wu, Han Chen, Chao Wang, Xiangdong Xue
Journal: ACS Nano
PubMed ID: 40698543
Doi: 10.1021/acsnano.5c08928
Products & Services: Catalog Antibodies   
BRD9 inhibition overcomes oncolytic virus therapy resistance in glioblastoma
Authors: Chen Guo, Zhilin Long, Peng Lin, Yinan Shen, Yiye Zhong, Jingjing Qian, Jichuan Yu, Weixi Zhao, Fuyi Liu, Yiling Ma, Jian Zheng, Jiayao Yang, Shuai Zhao, Xiaojuan Ran, Zhen Xia, Congying Wu, Yujia Cai, Chen Wang, Qi Xie
Journal: Cell Reports Medicine
PubMed ID: 40744020
Doi: 10.1016/j.xcrm.2025.102258
Products & Services: Catalog Gene Editing   
Erythropoietin decreases apoptosis and promotes Schwann cell repair and phagocytosis following nerve crush injury in mice
Authors: Prem Kumar Govindappa, Govindaraj Ellur, John P Hegarty, Akash Gupta, Rahul V G, John C Elfar
Journal: Cell death & disease
PubMed ID: 40610400
Doi: 10.1038/s41419-025-07825-4
Products & Services: Protein Electrophoresis and Western   
Lysosome-mediated aggregation of galactose-deficient IgA1 with transferrin receptor 1 links to IgA nephropathy
Authors: Meijun Si, Jingpeng Fu, Mengting Fang, Yunfei Lu, Junxuan Huang, Haojie Li, Peiyi Wang, Maofu Liao, Jian Zhu, Peiyao Li, Wenzhao Zhong, Zhifei Guo, Wei Yang, Zhiming Ye, Hongli Hu, Xueqing Yu
Journal: Nature Communications
PubMed ID: 40593574
Doi: 10.1038/s41467-025-60819-w
Products & Services: Protein and Antibody Isolation   
Mice with a diverse human T cell receptor repertoire selected on multiple HLA class I molecules
Authors: Arunraj Dhamodaran, Xiaojing Chen, Niklas Fellmer, Deepti Agrawal, Eric Danner, Ralf Kühn, Thomas Blankenstein
Journal: Nature Communications
PubMed ID: 40593800
Doi: 10.1038/s41467-025-61306-y
Products & Services: Peptide Synthesis   
A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma
Authors: Christophe-Sébastien Arnold, Anna-Maria Alazzi, Serena Shunmugam, Jan Janouškovec, Laurence Berry, Sarah Charital, Thierry Gautier, Samuel Duley, Delphine Jublot, Catherine Lemaire-Vieille, Marie-France Cesbron-Delauw, Pierre Cavailles, Jérôme Govin, Nicholas J Katris, Yoshiki Yamaryo-Botté, Cyrille Y Botté
Journal: Nature Communications
PubMed ID: 40595705
Doi: 10.1038/s41467-025-61155-9
Rim4-seeded stress granules connect temperature sensing to meiotic regulation
Authors: Rudian Zhang, Shunjin Li, Wenzhi Feng, Suhong Qian, Akshay John Chellappa, Fei Wang
Journal: Nature Communications
PubMed ID: 40593583
Doi: 10.1038/s41467-025-60645-0
Products & Services: Protein Electrophoresis and Western   
Myosin-dependent short actin filaments contribute to peripheral widening in developing stereocilia
Authors: Xiayi Liao, Chun-Yu Tung, Jocelyn F Krey, Ghazaleh Behnammanesh, Joseph A Cirilo Jr, Mert Colpan, Christopher M Yengo, Peter G Barr-Gillespie, Jonathan E Bird, Benjamin J Perrin
Journal: Nature Communications
PubMed ID: 40593742
Doi: 10.1038/s41467-025-60976-y
Products & Services: Gene Synthesis   
Pol θ-mediated end-joining uses microhomologies containing mismatches
Authors: Yuzhen Li, Ngoc K Dang, Wei He, Mark Returan, Denisse Carvajal-Maldonado, Adele T Guerin, Han Xu, Bin Liu, Richard D Wood
Journal: Nature Communications
PubMed ID: 40603872
Doi: 10.1038/s41467-025-61258-3
Products & Services: Codon Optimization   
Structural-functional characterization of the MIRO1-TRAK1 complex
Authors: Erika E Ravitch, Elana E Baltrusaitis, Tania A Perez, Kyle R Barrie, Adam R Fenton, Erika L F Holzbaur, Roberto Dominguez
Journal: Nature Communications
PubMed ID: 40615373
Doi: 10.1038/s41467-025-61174-6
Products & Services: Bacterial Expression   
Precision-edited histone tails disrupt polycistronic gene expression controls in trypanosomes
Authors: Markéta Novotná, Michele Tinti, Joana R C Faria, David Horn
Journal: Nature Communications
PubMed ID: 40615444
Doi: 10.1038/s41467-025-61480-z
Products & Services: PCR Cloning and Subcloning   
FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses
Authors: Choah Kim, Katlyn R Gabriel, Dylan Boone, Matthew R Brown, Katherine Oppenheimer, Maria Kost-Alimova, Juan Lorenzo B Pablo, Anna Greka
Journal: SCIENCE ADVANCES
PubMed ID: 40601736
Doi: 10.1126/sciadv.adu9104
Products & Services: Lentivirus Packaging   
Microtubule association induces a Mg-free apo-like ADP pre-release conformation in kinesin-1 that is unaffected by its autoinhibitory tail
Authors: J Atherton, M S Chegkazi, M Leusciatti, M Di Palma, E Peirano, L S Pozzer, M V A Meli, S Pasqualato, T Foran, G Morra, R A Steiner
Journal: Nature Communications
PubMed ID: 40617823
Doi: 10.1038/s41467-025-61498-3
Products & Services: Mammalian Expression   
Continuous in situ synthesis of a complete set of tRNAs sustains steady-state translation in a recombinant cell-free system
Authors: Fanjun Li , Amogh Kumar Baranwal , Sebastian J Maerkl
Journal: Nature Communications
PubMed ID: 40617857
Doi: 10.1038/s41467-025-61671-8
Products & Services: Gene Synthesis   
Subversion of mRNA degradation pathways by EWSR1::FLI1 represents a therapeutic vulnerability in Ewing sarcoma
Authors: Bartimée Galvan, Loïc Ongena, Jonathan Bruyr, Gregory Fettweis, Eva Lucarelli, Arnaud Lavergne, Emeline Mariavelle, Tina M O'Grady, Zahrat El Oula Hassoun, Margaux Claes, Laurence Dubois, Kevin A W Lee, Véronique Kruys, Cyril Gueydan, Jules Durand, Eric Hervouet, Florian H Geyer, Ana Banito, Roland Imle, Lianghao Mao, Ashok K Jayavelu, Thomas G P Grünewald, Florencia Cidre-Aranaz, Jean-Claude Twizere, Franck Dequiedt
Journal: Nature Communications
PubMed ID: 40664627
Doi: 10.1038/s41467-025-61725-x
Products & Services: Custom Vector Construction   
Single-cell RNA sequencing and PANDORA-seq reveal the pivotal role of piRNA in heat stress-induced testicular injury
Authors: Mailin Gan, Jianfeng Ma, Yuhang Lei, Yiting Yang, Yuheng Pan, Shuang Wu, Siyu Chen, Jiaxin Li, Linyuan Shen, Li Zhu
Journal: International Journal of Biological Macromolecules
PubMed ID: 40609925
Doi: 10.1016/j.ijbiomac.2025.145674
Products & Services: Protein and Antibody Isolation   
A novel and sensitive AuNPs/tetracystein-glucose dehydrogenase(GDH)/ screen-printed electrode(SPE)-based electrochemical glucose biosensor
Authors: Ting Zhang , Danni Ma , Fuman Cai
Journal: Microchemical Journal
Doi: doi.org/10.1016/j.microc.2025.114629
Products & Services: Codon Optimization   Gene Synthesis   Molecular Biology Reagents   
Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation
Authors: Rajamanikkam Kamaraj, Ivana Mejdrová, Maria Krutakova, Tomas Smutny, Kryštof Škach, Klara Dohnalova, Lucie Smutna, Dharani Sai Sreekanth Nellore, Jan Dusek, Karel Chalupsky, Jana Hricová, Thales Kronenberger, Aaron Stahl, Markus Templin, Albert Braeuning, Radim Nencka, Petr Pavek
Journal: Journal of Medicinal Chemistry
PubMed ID: 40650588
Doi: 10.1021/acs.jmedchem.4c03134
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The evolution of eukaryotic linear motifs governing the function of androgen receptor from fish to Homo sapiens
Authors: Antonella Falconieri, Giulia Boarolo, Chiara Boschelle, Giovanni Spagnolli, Caterina Marchioretti, Emanuela Zuccaro, Isabella Palazzolo, Laura Tosatto, Adham Kamaleldeen Omara Hegazy, Jessica Rosati, Kenneth Fischbeck, Manuela Basso, Hans Christoph Liedtke, Ivan Gomez-Mestre, Luisa Dalla Valle, Emiliano Biasini, Pietro Faccioli, Alessandro Grapputo, Maria Pennuto
Journal: Nucleic acids research
PubMed ID: 40682815
Doi: 10.1093/nar/gkaf688
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Visualization of a multi-turnover Cas9 after product release
Authors: Kaitlyn A. Kiernan & David W. Taylor
Journal: Nature Communications
PubMed ID: 40593576
Doi: 10.1038/s41467-025-60668-7
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Molecular architecture and catalytic mechanism of human glycogen debranching enzyme
Authors: Huiyi Guan, Huan Chen, He Geng, Ruifang Ma, Zhongmin Liu, Yong Wang, Yifang Chen, Kaige Yan
Journal: Nature Communications
PubMed ID: 40593796
Doi: 10.1038/s41467-025-61077-6
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Single-domain antibodies directed against hemagglutinin and neuraminidase protect against influenza B viruses
Authors: Arne Matthys, Jan Felix, Joao Paulo Portela Catani, Kenny Roose, Wim Nerinckx, Benthe Van Buyten, Daria Fijalkowska, Nico Callewaert, Savvas N Savvides, Xavier Saelens
Journal: Nature Communications
PubMed ID: 40593518
Doi: 10.1038/s41467-025-60232-3
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Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery
Authors: Amanda X Y Chen, Kah Min Yap, Joelle S Kim, Kevin Sek, Yu-Kuan Huang, Phoebe A Dunbar, Volker Wiebking, Jesse D Armitage, Isabelle Munoz, Kirsten L Todd, Emily B Derrick, Dat Nguyen, Junming Tong, Cheok Weng Chan, Thang X Hoang, Katherine M Audsley, Marit J van Elsas, Jim Middelburg, Joel N Lee, Maria N de Menezes, Thomas J Cole, Jasmine Li, Christina Scheffler, Andrew M Scott, Laura K Mackay, Jason Waithman, Jane Oliaro, Simon J Harrison, Ian A Parish, Junyun Lai, Matthew H Porteus, Imran G House, Phillip K Darcy, Paul A Beavis
Journal: Nature
PubMed ID: 40604285
Doi: 10.1038/s41586-025-09212-7
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A single main-chain hydrogen bond required to keep GABAA receptors closed
Authors: Cecilia M Borghese, Jason D Galpin, Samuel Eriksson Lidbrink, Yuxuan Zhuang, Netrang G Desai, Rebecca J Howard, Erik Lindahl, Christopher A Ahern, Marcel P Goldschen-Ohm
Journal: Nature Communications
PubMed ID: 40603861
Doi: 10.1038/s41467-025-61447-0
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NXT2 is a key component of the RNA nuclear export factor complex in the human testis and essential for spermatogenesis
Authors: Ann-Kristin Dicke, Ammar Ahmedani, Lin Ma, Leonie Herrmann, Godfried W van der Heijden, Sophie A Koser, Claudia Krallmann, Oguzhan Kalyon, Miguel J Xavier, Joris A Veltman, Sabine Kliesch, Nina Neuhaus, Noora Kotaja, Frank Tüttelmann, Birgit Stallmeyer
Journal: Nature Communications
PubMed ID: 40624043
Doi: 10.1038/s41467-025-61463-0
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Nucleosome spacing can fine-tune higher-order chromatin assembly
Authors: Lifeng Chen, M Julia Maristany, Stephen E Farr, Jinyue Luo, Bryan A Gibson, Lynda K Doolittle, Jorge R Espinosa, Jan Huertas, Sy Redding, Rosana Collepardo-Guevara, Michael K Rosen
Journal: Nature Communications
PubMed ID: 40628730
Doi: 10.1038/s41467-025-61482-x
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Ion channel structure and function of the MERS coronavirus E protein
Authors: Iva Sučec, Bingqing Xia, Noah H Somberg, Yi Wang, Hyunil Jo, Shuangqu Li, Barbara Perrone, Zhaobing Gao, Mei Hong
Journal: SCIENCE ADVANCES
PubMed ID: 40632851
Doi: 10.1126/sciadv.adx1788
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Human Schlafen 14 Cleavage of Short Double-Stranded RNAs Underpins its Antiviral Activity
Authors: Mengyun Li, Dapeng Sun, Wei Hao, Hua Fu, Yueli Zhang, Zhijian Li, Bo Qin, Yumei Wang, Sheng Cui
Journal: Advanced Science
PubMed ID: 40642785
Doi: 10.1002/advs.202501727
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Boosting RNA nanotherapeutics with V-ATPase activating non-inflammatory lipid nanoparticles to treat chronic lung injury
Authors: Zhiqiang Zhao, Xinzhu Shan, Jing Ding, Bin Ma, Buyao Li, Wendi Huang, Qingqing Yang, Yian Fang, Junhe Chen, Chenglin Song, Chenlong Wei, Shuai Liu, Xingdi Cheng, Shengran Zhang, Yunxuan Liu, Hongkun Wu, Cong Luo, Shaokun Shu, Xue Qiao, Zefeng Wang, Xueguang Lu, Lei Miao
Journal: Nature Communications
PubMed ID: 40659631
Doi: 10.1038/s41467-025-61688-z
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Deep-tissue high-sensitivity multimodal imaging and optogenetic manipulation enabled by biliverdin reductase knockout
Authors: Ludmila A Kasatkina, Chenshuo Ma, Huaxin Sheng, Matthew Lowerison, Luca Menozzi, Mikhail Baloban, Yuqi Tang, Yirui Xu, Lucas Humayun, Tri Vu, Pengfei Song, Junjie Yao, Vladislav V Verkhusha
Journal: Nature Communications
PubMed ID: 40659617
Doi: 10.1038/s41467-025-61532-4
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Adipose tissue-derived PRXL2A suppresses hepatic lipogenesis in a study with male mice
Authors: Zhiyuan Li, Zheng Tian, Xiaoliu Shi, Aijun Long, Yazhuo Wang, Yan Yang, Yaqi Wang, Jingjing Zhang, Yiguo Wang
Journal: Nature Communications
PubMed ID: 40670400
Doi: 10.1038/s41467-025-61963-z
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Supramolecular Lubricating Hydrogel Microspheres Reshape Damaged Matrix Regeneration
Authors: Hui Yuan 1, Pengcheng Xiao 2, Wei Huang 2, Wenguo Cui 1
Journal: Advanced Science
PubMed ID: 40667608
Doi: 10.1002/advs.202504319
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Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ
Authors: K S Beckwith, Ø Ødegård-Fougner, N R Morero, C Barton, F Schueder, W Tang, S Alexander, J-M Peters, R Jungmann, E Birney, J Ellenberg
Journal: Nature Communications
PubMed ID: 40683887
Doi: 10.1038/s41467-025-61689-y
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Rationally Designed TadA-Derived Cytosine Editors Enable Context-Independent Zebrafish Genome Editing
Authors: Wei Qin, Sheng-Jia Lin, Yu Zhang, Kevin Huang, Cassidy Petree, Kevin Boyd, Pratishtha Varshney, Gaurav K Varshney
Journal: Advanced Science
PubMed ID: 40685751
Doi: 10.1002/advs.202509800
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Structural insights into the roles of PARP4 and NAD+ binding in the human vault cage
Authors: Jane E Lodwick, Rong Shen, Satchal Erramilli, Yuan Xie, Karolina Roganowicz, Simone Ritchey, Anthony A Kossiakoff, Minglei Zhao
Journal: Nature Communications
PubMed ID: 40691181
Doi: 10.1038/s41467-025-61981-x
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Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination
Authors: Jaigeeth Deveryshetty, Ayush Mistry, Sushil Pangeni, Mohamed Ghoneim, Monica Tokmina-Lukaszewska, Steven K Gore, Jie Liu, Vikas Kaushik, Simrithaa Karunakaran, Angela Taddei, Wolf-Dietrich Heyer, Taekjip Ha, Brian Bothner, Edwin Antony
Journal: Nature Communications
PubMed ID: 40691144
Doi: 10.1038/s41467-025-61811-0
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A Complementarity-Based Approach to De Novo Binder Design
Authors: Kateryna Maksymenko, Valeriia Hatskovska, Murray Coles, Narges Aghaallaei, Natalia Pashkovskaia, Natalia Borbarán-Bravo, Matteo Pilz, Philip Bucher, Mareike Volz, Joana Pereira, Marcus D Hartmann, Ghazaleh Tabatabai, Judith Feucht, Stefan Liebau, Patrick Müller, Andrei N Lupas, Julia Skokowa, Mohammad ElGamacy
Journal: Advanced Science
PubMed ID: 40686280
Doi: 10.1002/advs.202502015
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Engineered Nano-micro Pyroptosis Generators: A Magnetic-Metallo-Immunotherapeutic Strategy to Reinforce Transarterial Embolization
Authors: Di Wang, Linzhu Zhang, Jihu Nie, Nailin Yang, Shumin Sun, Chunjie Wang, Zifan Pei, Fei Gong, Xingwei Sun, Yong Jin, Liang Cheng
Journal: Journal of the American Chemical Society
PubMed ID: 40644662
Doi: 10.1021/jacs.5c06039
β-catenin functions as a molecular adapter for disordered cBAF interactions
Authors: Yuen San Chan, Qinyu Gao, Sarah A Robinson, Wenzhi Wang, Ruzena Filandrova, Lisa-Maria Weinhold, Mario Loeza Cabrera, Miao Zhang, Chandra Shekar R Ambati, Antonio M Lerario, Nagireddy Putluri, Katja Kiseljak-Vassiliades, Margaret E Wierman, Mouhammed Amir Habra, Gary D Hammer, Vaclav Veverka, Katerina Cermakova, H Courtney Hodges
Journal: Molecular Cell
PubMed ID: 40695292
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Formation and centromere inactivation of fusion chromosomes in two allotetraploid species from the Saccharum complex
Authors: Zehuai Yu, Yongji Huang, Xikai Yu, Zuhu Deng, Jin Chai, Jiarui Liu, Zhiyun Gong, Wei Yao, Jisen Zhang, Muqing Zhang, Fan Yu, Jiming Jiang
Journal: New Phytologist
PubMed ID: 40726300
Doi: 10.1111/nph.70369
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Therapeutic circRNA aptamer alleviates PKR-associated osteoarthritis
Authors: Si-Kun Guo, Jinlong Suo, Youkui Huang, Xubin Yin, Jinghui Wang, Ling Li, Shaokun Sun, Weiguo Zou, Ling-Ling Chen
Journal: Science Bulletin
PubMed ID: 40021383
Doi: 10.1016/j.scib.2025.02.027
Whole-genome identification, evolutionary decipherment, and expression profiling analyses of alcohol dehydrogenase family members in soybean (Glycine max (L.) Merr.)
Authors: Liang Wang, Jing Wang, Xianqin Wen, Wenhua Dongchen, Yumei Dong, Yuanyuan Li, Quan Liang, Yaqiong Zhang
Journal: Plant Stress
Doi: 10.1016/j.stress.2025.100975
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Modifying recombinant purple acid phosphatase using computational design
Authors: Aishwarya Venkatramani, Montader Ali, Olga Predeina, Jennifer C Molloy, Pietro Sormanni, Elizabeth A H Hall
Journal: European Biophysics Journal
PubMed ID: 40650743
Doi: 10.1007/s00249-025-01779-3
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Systemic administration of an RNA binding and cell-­ penetrating antibody targets therapeutic RNA to multiple mouse models of cancer
Authors: Elias Quijano, Diana Martinez-Saucedo, Zaira Ianniello, Natasha Pinto-Medici, Madison Rackear, Haoting Chen, Luiz Lola-Pereira, Yanfeng Liu, Denise Hegan, Xinning Shan, Robert Tseng, Deanne Yugawa, Sumedha Chowdhury, Minsoo Khang, Jay P Singh, Rashed Abdullah, Perisa Azhir, Soki Kashima, Wendy S Woods, Nicholas Gosstola, Bruce C Turner, Stephen Squinto, Dale L Ludwig, Ranjit S Bindra, Marie E Robert, David A Braun, Pablo Perez Pinera, W Mark Saltzman, Luisa F Escobar-Hoyos, Peter M Glazer
Journal: Science Translation Medicine
PubMed ID: 40668891
Doi: 10.1126/scitranslmed.adk1868
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Phosphorylation-activated G protein signaling stabilizes TCP14 and JAZ3 to repress JA signaling and enhance plant immunity
Authors: Haiyan Jia, Natalie Hewitt, Lucía Jordá, Tigran M Abramyan, Josh Tolliver, Janice L Jones, Kinya Nomura, Jing Yang, Sheng-Yang He, Alexander Tropsha, Antonio Molina, Henrik G Dohlman, Alan M Jones
Journal: Molecular Plant
PubMed ID: 40509595
Doi: 10.1016/j.molp.2025.06.004
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Metabotropic glutamate receptor 4-mediated glutamatfergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation
Authors: Xiaoman Ju, Eva Maria Putz, Yaqi Liu, Dongchen Yuan, Guowei Sun, Stephane Koda, Zhuo Fu, Simin Shao, Chunrong Tong, Biping Deng, Jing Hu, Juming Yan
Journal: Nature Communications
PubMed ID: 40593670
Doi: 10.1038/s41467-025-60922-y.
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CRISPRi screen identifies FprB as a synergistic target for gallium therapy in Pseudomonas aeruginosa
Authors: Yu Zhang, Tingting Zhang, Xue Xiao, Yejun Wang, Adam Kawalek, Jinzhao Ou, Anmin Ren, Wenhao Sun, Vincent de Bakker, Yujie Liu, Yuelong Li, Liang Yang, Liang Ye, Ning Jia, Jan-Willem Veening, Xue Liu
Journal: Nature Communications
PubMed ID: 40595632
Doi: 10.1038/s41467-025-61208-z
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DRAM1 promotes the stability of lysosomal VAMP8 to enhance autolysosome formation and facilitates the extravasation
Authors: Rui Zhang, Xin Zhang, Hua Bai, Qiuyu Cheng, Xia Yao, Shi Li, Vincenzo Torraca, Chaojun Yan, Xueying Dong, Siyi Miao, Xueyuan Hu, Yeping Yu, Yueyan Wu, Hongfei Tan, Xin Chen, Shicheng Liu, Hao Lyu, Shuai Xiao, Dong Guo, Qi Zhang, Xing-Zhen Chen, Zhiyin Song, Cefan Zhou, Jingfeng Tang
Journal: Nature Communications
PubMed ID: 40595569
Doi: 10.1038/s41467-025-60887-y
Human neutrophil α-defensin HNP1 interacts with bacterial OmpA to promote Acinetobacter baumannii biofilm formation
Authors: Chongbing Liao, Qihui Liu, Gan Luo, Yinyue Luo, Dan Yao, Qingxia Wang, Jue Zhang, Yang Wu, Jialin Jin, Dan Xu, Wuyuan Lu
Journal: Nature Communications
PubMed ID: 40595622
Doi: 10.1038/s41467-025-60935-7
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Analysis of the Rehmannia chingii geneome identifies RcCYP72H7 as an epoxidase in iridoid glycoside biosynthesis
Authors: Fengqing Wang, Zhennan Jiang, Junge Gao, Chunyan Miao, Ci Song, Yahe Yang, Ning Ding, Yajing Li, Hongzheng Sun, Caixia Xie, Bao Zhang, Pengyu Zhang, Li Gu, Qiuwen Hao, Zhongyi Zhang, Luqi Huang, Yuan Yuan
Journal: Nature Communications
PubMed ID: 40593652
Doi: 10.1038/s41467-025-60909-9
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HIV-1 vif mediates ubiquitination of the proximal protomer in the APOBEC3H dimer to induce degradation
Authors: Katarzyna A Skorupka, Kazuhiro Matsuoka, Bakar Hassan, Rodolfo Ghirlando, Vanivilasini Balachandran, Ting-Hua Chen, Kylie J Walters, Celia A Schiffer, Matthias Wolf, Yasumasa Iwatani, Hiroshi Matsuo
Journal: Nature Communications
PubMed ID: 40593686
Doi: 10.1038/s41467-025-60984-y
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PPP2R1A mutations portend improved survival after cancer immunotherapy
Authors: Yibo Dai, Anne Knisely, Mitsutake Yano, Minghao Dang, Emily M Hinchcliff, Sanghoon Lee, Annalyn Welp, Manoj Chelvanambi, Matthew Lastrapes, Heng Liu, Zhe Yuan, Chen Wang, Hao Nie, Stephanie Jean, Luis J Montaner, Jiakai Hou, Ami Patel, Shrina Patel, Bryan Fellman, Ying Yuan, Baohua Sun, Renganayaki Krishna Pandurengan, Edwin Roger Parra Cuentas, Joseph Celestino, Yan Liu, Jinsong Liu, R Tyler Hillman, Shannon N Westin, Anil K Sood, Pamela T Soliman, Aaron Shafer, Larissa A Meyer, David M Gershenson, David Vining, Dhakshinamoorthy Ganeshan, Karen Lu, Jennifer A Wargo, Weiyi Peng, Rugang Zhang, Linghua Wang, Amir A Jazaeri
Journal: Nature
PubMed ID: 40604275
Doi: 10.1038/s41586-025-09203-8
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Induction of lung mucosal immunity by a next-generation inhaled aerosol COVID-19 vaccine: an open-label, multi-arm phase 1 clinical trial
Authors: Mangalakumari Jeyanathan, Sam Afkhami, Michael R D'Agostino, Imran Satia, Dominik K Fritz, Kate Miyasaki, Jann C Ang, Anna Zganiacz, Karen J Howie, Marilyn Swinton, Emilio Aguirre, Michael B Zheng, Natallia Kazhdan, Anna Dvorkin-Gheva, Lawrence Mbuagbaw, Maria Fe C Medina, Nermin Diab, Danica L Brister, Gail M Gauvreau, Brian D Lichty, Matthew S Miller, Fiona Smaill, Zhou Xing
Journal: Nature Communications
PubMed ID: 40603330
Doi: 10.1038/s41467-025-60726-0
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Discovery of a single-subunit oligosaccharyltransferase that enables glycosylation of full-length IgG antibodies in bacteria
Authors: Belen Sotomayor, Thomas C Donahue, Sai Pooja Mahajan, May N Taw, Sophia W Hulbert, Erik J Bidstrup, D Natasha Owitipana, Alexandra Pang, Xu Yang, Souvik Ghosal, Christopher A Alabi, Parastoo Azadi, Jeffrey J Gray, Michael C Jewett, Lai-Xi Wang, Matthew P DeLisa
Journal: Nature Communications
PubMed ID: 40610439
Doi: 10.1038/s41467-025-61440-7
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Optimizing a human monoclonal antibody for better neutralization of SARS-CoV-2
Authors: Qian Wang, Yicheng Guo, Ryan G Casner, Jian Yu, Manoj S Nair, Jerren Ho, Eswar R Reddem, Ian A Mellis, Madeline Wu, Chih-Chen Tzang, Hsiang Hong, Yaoxing Huang, Lawrence Shapiro, Lihong Liu, David D Ho
Journal: Nature Communications
PubMed ID: 40615407
Doi: 10.1038/s41467-025-61472-z
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Primate retroelement exonization and sexually dimorphic IL13RA1 transcription tune type 2 immune responses
Authors: Tobias Plowman, Tom Hofland, Callum Hall, Rachael Thompson, Judith Pape, Kevin W Ng, Laura Doglio, George Kassiotis
Journal: SCIENCE ADVANCES
PubMed ID: 40614216
Doi: 10.1126/sciimmunol.adr1105
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Staphylococcus aureus LukMF' targets neutrophils to promote skin and soft tissue infection
Authors: Daiane Boff, Ravishankar Chandrasekaran, Gregory Putzel, Rachel M Kratofil, Xuhui Zheng, Ashley Castellaw, Kody Mansfield, Ikjot Sidhu, Avantika Dhabaria, Keenan A Lacey, Sandra Gonzalez, Filadelfia Tadjibaeva, Beatrix Ueberheide, Cynthia Loomis, Alejandro Pironti, Silva Holtfreter, Shruti Naik, Victor J Torres
Journal: SCIENCE ADVANCES
PubMed ID: 40614206
Doi: 10.1126/sciadv.adr5240
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The haplotype-resolved telomere-to-telomere genome and OMICS analyses reveal genetic responses to tapping in rubber tree
Authors: Chaochao Li, Yuan Yuan, Zhiyi Nie, Tingkai Wu, Zhiyuan Wang, Jiangxia Qiao, Zhi Deng, Xiaobo Wang, Dong Xu, Xu Wang, Shuo Cao, Bingqin Li, Zewei An, Wenguan Wu, Zhongxin Jin, Huasun Huang, Wei Hu, Yongfeng Zhou, Han Cheng
Journal: Nature Communications
PubMed ID: 40624070
Doi: 10.1038/s41467-025-61527-1
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