cnot8 cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Summary

Gene Symbol	cnot8
Entrez Gene ID	406788
Full Name	CCR4-NOT transcription complex, subunit 8
Synonyms	wu:fe49a05,zgc:63844
General protein information	Preferred Names CCR4-NOT transcription complex, subunit 8 Names CCR4-NOT transcription complex subunit 8
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA	Protein	Name
NM_213479.1	NP_998644.1	CCR4-NOT transcription complex subunit 8
XM_005173877.3	XP_005173934.1	CCR4-NOT transcription complex subunit 8 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	CNOT8	XP_546280.1
Danio rerio (zebrafish)	cnot8	NP_998644.1
Pan troglodytes (chimpanzee)	CNOT8	NP_001233465.1
	CNOT8	XP_001112661.1
Rattus norvegicus (Norway rat)	Cnot8	NP_001008383.1
Homo sapiens (human)	CNOT8	NP_004770.4
Bos taurus (cattle)	CNOT8	NP_001179703.1
Oryza sativa (rice)	Os09g0416800	NP_001063181.1
Gallus gallus (chicken)	CNOT8	NP_001025789.1
Mus musculus (house mouse)	Cnot8	NP_081225.1
Xenopus tropicalis (tropical clawed frog)	cnot8	NP_001016578.1

Gene Ontology
Bibliography

Related articles in PubMed

Transcriptome dynamics in early zebrafish embryogenesis determined by high-resolution time course analysis of 180 successive, individual zebrafish embryos.
Rauwerda H, Pagano JF, de Leeuw WC, Ensink W, Nehrdich U, de Jong M, Jonker M, Spaink HP, Breit TM
BMC genomics18(1)287(2017 04)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

Normalization of RNA-sequencing data from samples with varying mRNA levels.
Aanes H, Winata C, Moen LF, ?strup O, Mathavan S, Collas P, Rognes T, Alestr?m P
PloS one9(2)e89158(2014)

A mutation in cnot8, component of the Ccr4-not complex regulating transcript stability, affects expression levels of developmental regulators and reveals a role of Fgf3 in development of caudal hypothalamic dopaminergic neurons.
Koch P, L?hr HB, Driever W
PloS one9(12)e113829(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pharmacological inhibition of FGF signaling or a mutation in the fgf3 gene can compensate the gain of caudal hypothalamic dopaminergic neurons in cnot8m1061 mutants, indicating a role for Fgf3 in control of development of this dopaminergic population
Title: A mutation in cnot8, component of the Ccr4-not complex regulating transcript stability, affects expression levels of developmental regulators and reveals a role of Fgf3 in development of caudal hypothalamic dopaminergic neurons.

The following cnot8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the cnot8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa33656	NM_213479.1 Latest version!	Danio rerio CCR4-NOT transcription complex, subunit 8 (cnot8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
ODa26124	XM_005173877.3 Latest version!	Danio rerio CCR4-NOT transcription complex, subunit 8 (cnot8), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

cnot8 ( NM_213479.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_998644.1 Danio rerio CCR4-NOT transcription complex, subunit 8 (cnot8), mRNA.

Price & Availability↑

CloneID	ODa33656
Clone ID Related Accession (Same CDS sequence)	NM_213479.1
Accession Version	NM_213479.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 858bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-23
Organism	Danio rerio(zebrafish)
Product	CCR4-NOT transcription complex subunit 8
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC055263.1. ##Evidence-Data-START## Transcript exon combination :: BC055263.1, EG566460.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2168446, SAMEA2168447 [ECO:0000350] ##Evidence-Data-END##

ATGCCAGCCG CACTTGCAGA TACCAGTCAA ATTATCTGCG AGGTCTGGGC CAGCAATGTG 
GAGGAGGAGA TGAGGAAGAT ACGACAGATC ATTCAGAACT ACAACTACAT TGCCATGGAC 
ACTGAGTTTC CCGGTGTCGT GGTCCGTCCC ATTGGAGAAT TTCGCAGTAC TGTTGACTAT 
CAGTACCAGC TCTTAAGGTG CAACGTGGAC CTTTTAAAAA TCGTTCAGCT GGGTTTGACA 
TTTATGAATG AAGATGGAGA CTACCCTCCA GGAACCACAA CATGGCAGTT CAACTTCAAG 
TTTAATCTGA CAGAGGACAT GTACTCGCAG GACTCTATAG ATCTCCTCCA GAACTCTGGG 
CTGCAGTTTA AGAAGCACGA GGAGGAAGGA ATCGACACAC TTTACTTCGC AGAGCTTCTC 
ATGACTTCAG GCCTGGTGCT CTGTGAAAAT GTCAAGTGGC TCTCCTTTCA CAGCGGGTAT 
GATTTTGGTT ACCTGGTGAA GCTTCTCACG GACTCCCGGC TGCCAGAGGA AGAACACGAG 
TTCTTCCAGA TCTTAAATCT TTTCTTTCCT GCAATCTACG ATGTCAAATA TCTGATGAAG 
AGCTGTAAAA ACCTTAAGGG TGGACTTCAG GAAGTGGCGG ACCAGTTGGA GCTCAAAAGA 
ATCGGCAGGC AGCATCAGGC CGGCTCAGAC TCTCTGCTCA CTGGAATGGC TTTCTTCCGC 
ATGAAAGAGC TGTTTTTTGA AGACAACATC GATGACGCCA AGTACTGCGG GCGACTCTAC 
GGCCTGGGAT CGGGTTCTAC TCAAAGTCAG AACGGGATCT CCAACTCCTC GCAGGAAGAG 
ACCAACAACA AGCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_998644.1
CDS	115..972
Translation	MPAALADTSQIICEVWASNVEEEMRKIRQIIQNYNYIAMDTEFPGVVVRPIGEFRSTVDYQYQLLRCNVDLLKIVQLGLTFMNEDGDYPPGTTTWQFNFKFNLTEDMYSQDSIDLLQNSGLQFKKHEEEGIDTLYFAELLMTSGLVLCENVKWLSFHSGYDFGYLVKLLTDSRLPEEEHEFFQILNLFFPAIYDVKYLMKSCKNLKGGLQEVADQLELKRIGRQHQAGSDSLLTGMAFFRMKELFFEDNIDDAKYCGRLYGLGSGSTQSQNGISNSSQEETNNKH

Target ORF information:

RefSeq Version	NM_213479.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio CCR4-NOT transcription complex, subunit 8 (cnot8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_213479.1

ORF Insert Sequence:

ATGCCAGCCG CACTTGCAGA TACCAGTCAA ATTATCTGCG AGGTCTGGGC CAGCAATGTG 
GAGGAGGAGA TGAGGAAGAT ACGACAGATC ATTCAGAACT ACAACTACAT TGCCATGGAC 
ACTGAGTTTC CCGGTGTCGT GGTCCGTCCC ATTGGAGAAT TTCGCAGTAC TGTTGACTAT 
CAGTACCAGC TCTTAAGGTG CAACGTGGAC CTTTTAAAAA TCGTTCAGCT GGGTTTGACA 
TTTATGAATG AAGATGGAGA CTACCCTCCA GGAACCACAA CATGGCAGTT CAACTTCAAG 
TTTAATCTGA CAGAGGACAT GTACTCGCAG GACTCTATAG ATCTCCTCCA GAACTCTGGG 
CTGCAGTTTA AGAAGCACGA GGAGGAAGGA ATCGACACAC TTTACTTCGC AGAGCTTCTC 
ATGACTTCAG GCCTGGTGCT CTGTGAAAAT GTCAAGTGGC TCTCCTTTCA CAGCGGGTAT 
GATTTTGGTT ACCTGGTGAA GCTTCTCACG GACTCCCGGC TGCCAGAGGA AGAACACGAG 
TTCTTCCAGA TCTTAAATCT TTTCTTTCCT GCAATCTACG ATGTCAAATA TCTGATGAAG 
AGCTGTAAAA ACCTTAAGGG TGGACTTCAG GAAGTGGCGG ACCAGTTGGA GCTCAAAAGA 
ATCGGCAGGC AGCATCAGGC CGGCTCAGAC TCTCTGCTCA CTGGAATGGC TTTCTTCCGC 
ATGAAAGAGC TGTTTTTTGA AGACAACATC GATGACGCCA AGTACTGCGG GCGACTCTAC 
GGCCTGGGAT CGGGTTCTAC TCAAAGTCAG AACGGGATCT CCAACTCCTC GCAGGAAGAG 
ACCAACAACA AGCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

cnot8 ( XM_005173877.3 ) cDNA ORF clone, Danio rerio(zebrafish) -> XP_005173934.1 Danio rerio CCR4-NOT transcription complex, subunit 8 (cnot8), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ODa26124
Clone ID Related Accession (Same CDS sequence)	XM_005173877.3
Accession Version	XM_005173877.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 858bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-06-14
Organism	Danio rerio(zebrafish)
Product	CCR4-NOT transcription complex subunit 8 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_007132.7) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 24, 2016 this sequence version replaced XM_005173877.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Danio rerio Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCAGCCG CACTTGCAGA TACCAGTCAA ATTATCTGCG AGGTCTGGGC CAGCAATGTG 
GAGGAGGAGA TGAGGAAGAT ACGACAGATC ATTCAGAACT ACAACTACAT TGCCATGGAC 
ACTGAGTTTC CCGGTGTCGT GGTCCGTCCC ATTGGAGAAT TTCGCAGTAC TGTTGACTAT 
CAGTACCAGC TCTTAAGGTG CAACGTGGAC CTTTTAAAAA TCATTCAGCT GGGTTTGACA 
TTTATGAATG AAGATGGAGA CTACCCTCCA GGAACCACAA CATGGCAGTT CAACTTCAAG 
TTTAATCTGA CAGAGGACAT GTACTCGCAG GACTCTATAG ATCTCCTCCA GAACTCTGGG 
CTGCAGTTTA AGAAGCACGA GGAGGAAGGA ATCGACACAC TTTACTTCGC AGAGCTTCTA 
ATGACTTCAG GCCTGGTGCT CTGTGAAAAT GTCAAGTGGC TCTCCTTTCA CAGCGGGTAT 
GATTTTGGTT ACCTGGTGAA GCTTCTCACA GACTCCCGGC TGCCAGAGGA AGAACACGAG 
TTCTTCCAGA TCTTAAATCT TTTCTTTCCT GCAATCTATG ATGTCAAATA TCTGATGAAG 
AGCTGTAAAA ACCTTAAGGG TGGACTTCAG GAAGTGGCGG ACCAGTTGGA GCTCAAAAGA 
ATCGGCAGGC AGCATCAGGC CGGCTCAGAC TCTCTGCTCA CTGGAATGGC TTTCTTCCGC 
ATGAAAGAGC TGTTTTTTGA AGACAACATC GATGACGCCA AGTACTGCGG GCGACTCTAC 
GGCCTGGGAT CGGGTTCTAC TCAAAGTCAG AATGGGATCT CCAACTCCTC GCAGGAAGAG 
ACCAACAACA AGCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005173934.1
CDS	233..1090
Translation	MPAALADTSQIICEVWASNVEEEMRKIRQIIQNYNYIAMDTEFPGVVVRPIGEFRSTVDYQYQLLRCNVDLLKIIQLGLTFMNEDGDYPPGTTTWQFNFKFNLTEDMYSQDSIDLLQNSGLQFKKHEEEGIDTLYFAELLMTSGLVLCENVKWLSFHSGYDFGYLVKLLTDSRLPEEEHEFFQILNLFFPAIYDVKYLMKSCKNLKGGLQEVADQLELKRIGRQHQAGSDSLLTGMAFFRMKELFFEDNIDDAKYCGRLYGLGSGSTQSQNGISNSSQEETNNKH

Target ORF information:

RefSeq Version	XM_005173877.3
Organism	Danio rerio(zebrafish)
Definition	Danio rerio CCR4-NOT transcription complex, subunit 8 (cnot8), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005173877.3

ORF Insert Sequence:

ATGCCAGCCG CACTTGCAGA TACCAGTCAA ATTATCTGCG AGGTCTGGGC CAGCAATGTG 
GAGGAGGAGA TGAGGAAGAT ACGACAGATC ATTCAGAACT ACAACTACAT TGCCATGGAC 
ACTGAGTTTC CCGGTGTCGT GGTCCGTCCC ATTGGAGAAT TTCGCAGTAC TGTTGACTAT 
CAGTACCAGC TCTTAAGGTG CAACGTGGAC CTTTTAAAAA TCATTCAGCT GGGTTTGACA 
TTTATGAATG AAGATGGAGA CTACCCTCCA GGAACCACAA CATGGCAGTT CAACTTCAAG 
TTTAATCTGA CAGAGGACAT GTACTCGCAG GACTCTATAG ATCTCCTCCA GAACTCTGGG 
CTGCAGTTTA AGAAGCACGA GGAGGAAGGA ATCGACACAC TTTACTTCGC AGAGCTTCTA 
ATGACTTCAG GCCTGGTGCT CTGTGAAAAT GTCAAGTGGC TCTCCTTTCA CAGCGGGTAT 
GATTTTGGTT ACCTGGTGAA GCTTCTCACA GACTCCCGGC TGCCAGAGGA AGAACACGAG 
TTCTTCCAGA TCTTAAATCT TTTCTTTCCT GCAATCTATG ATGTCAAATA TCTGATGAAG 
AGCTGTAAAA ACCTTAAGGG TGGACTTCAG GAAGTGGCGG ACCAGTTGGA GCTCAAAAGA 
ATCGGCAGGC AGCATCAGGC CGGCTCAGAC TCTCTGCTCA CTGGAATGGC TTTCTTCCGC 
ATGAAAGAGC TGTTTTTTGA AGACAACATC GATGACGCCA AGTACTGCGG GCGACTCTAC 
GGCCTGGGAT CGGGTTCTAC TCAAAGTCAG AATGGGATCT CCAACTCCTC GCAGGAAGAG 
ACCAACAACA AGCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Transcriptome dynamics in early zebrafish embryogenesis determined by high-resolution time course analysis of 180 successive, individual zebrafish embryos.
BMC genomics18(1)287(2017 04)
Rauwerda H,Pagano JF,de Leeuw WC,Ensink W,Nehrdich U,de Jong M,Jonker M,Spaink HP,Breit TM

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

Normalization of RNA-sequencing data from samples with varying mRNA levels.
PloS one9(2)e89158(2014)
Aanes H,Winata C,Moen LF,?strup O,Mathavan S,Collas P,Rognes T,Alestr?m P

A mutation in cnot8, component of the Ccr4-not complex regulating transcript stability, affects expression levels of developmental regulators and reveals a role of Fgf3 in development of caudal hypothalamic dopaminergic neurons.
PloS one9(12)e113829(2014)
Koch P,L?hr HB,Driever W

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cnot8 cDNA ORF clone, Danio rerio(zebrafish)

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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