crkl cDNA ORF clone, Danio rerio(zebrafish)

Gene
Clones
gRNAs

Gene Symbol	crkl
Entrez Gene ID	556443
Full Name	v-crk avian sarcoma virus CT10 oncogene homolog-like
Synonyms	wu:fa55g05,wu:fj60e01,zgc:63469
General protein information	Preferred Names v-crk avian sarcoma virus CT10 oncogene homolog-like Names crk-like protein v-crk sarcoma virus CT10 oncogene homolog-like
Gene Type	protein-coding
Organism	Danio rerio(zebrafish)

mRNA and Protein(s)

mRNA Protein Name

NM_213538.1 NP_998703.1 crk-like protein
Pathways from BioSystems

mRNA	Protein	Name
NM_213538.1	NP_998703.1	crk-like protein

Homologies

	CRKL	XP_001086123.1
Gallus gallus (chicken)	CRKL	XP_415233.1
Pan troglodytes (chimpanzee)	CRKL	XP_525530.2
Canis lupus familiaris (dog)	CRKL	XP_849949.1
Xenopus tropicalis (tropical clawed frog)	crkl	NP_989060.1
Mus musculus (house mouse)	Crkl	NP_031790.2
Homo sapiens (human)	CRKL	NP_005198.1
Rattus norvegicus (Norway rat)	Crkl	NP_001008285.1
Rattus norvegicus (Norway rat)	LOC100911248	XP_003751143.1
Danio rerio (zebrafish)	crkl	NP_998703.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic Drivers of Kidney Defects in the DiGeorge Syndrome.
Lopez-Rivera E, Liu YP, Verbitsky M, Anderson BR, Capone VP, Otto EA, Yan Z, Mitrotti A, Martino J, Steers NJ, Fasel DA, Vukojevic K, Deng R, Racedo SE, Liu Q, Werth M, Westland R, Vivante A, Makar GS, Bodria M, Sampson MG, Gillies CE, Vega-Warner V, Maiorana M, Petrey DS, Honig B, Lozanovski VJ, Salomon R, Heidet L, Carpentier W, Gaillard D, Carrea A, Gesualdo L, Cusi D, Izzi C, Scolari F, van Wijk JA, Arapovic A, Saraga-Babic M, Saraga M, Kunac N, Samii A, McDonald-McGinn DM, Crowley TB, Zackai EH, Drozdz D, Miklaszewska M, Tkaczyk M, Sikora P, Szczepanska M, Mizerska-Wasiak M, Krzemien G, Szmigielska A, Zaniew M, Darlow JM, Puri P, Barton D, Casolari E, Furth SL, Warady BA, Gucev Z, Hakonarson H, Flogelova H, Tasic V, Latos-Bielenska A, Materna-Kiryluk A, Allegri L, Wong CS, Drummond IA, D'Agati V, Imamoto A, Barasch JM, Hildebrandt F, Kiryluk K, Lifton RP, Morrow BE, Jeanpierre C, Papaioannou VE, Ghiggeri GM, Gharavi AG, Katsanis N, Sanna-Cherchi S
The New England journal of medicine376(8)742-754(2017 02)

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
Pasquier J, Cabau C, Nguyen T, Jouanno E, Severac D, Braasch I, Journot L, Pontarotti P, Klopp C, Postlethwait JH, Guiguen Y, Bobe J
BMC genomics17368(2016 05)

RFX transcription factors are essential for hearing in mice.
Elkon R, Milon B, Morrison L, Shah M, Vijayakumar S, Racherla M, Leitch CC, Silipino L, Hadi S, Weiss-Gayet M, Barras E, Schmid CD, Ait-Lounis A, Barnes A, Song Y, Eisenman DJ, Eliyahu E, Frolenkov GI, Strome SE, Durand B, Zaghloul NA, Jones SM, Reith W, Hertzano R
Nature communications68549(2015 Oct)

Comparative mapping of the 22q11.2 deletion region and the potential of simple model organisms.
Guna A, Butcher NJ, Bassett AS
Journal of neurodevelopmental disorders7(1)18(2015)

Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation.
Anelli V, Santoriello C, Distel M, K?ster RW, Ciccarelli FD, Mione M
Zebrafish6(4)417-24(2009 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The adaptor proteins Crk and Crk-like (Crkl), with which Dock proteins are known to interact physically, are also required for myoblast fusion.
Title: A role for the Myoblast city homologues Dock1 and Dock5 and the adaptor proteins Crk and Crk-like in zebrafish myoblast fusion.

The following crkl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the crkl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ODa03874	NM_213538.1 Latest version!	Danio rerio v-crk avian sarcoma virus CT10 oncogene homolog-like (crkl), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

crkl ( NM_213538.1 ) cDNA ORF clone, Danio rerio(zebrafish) -> NP_998703.1 Danio rerio v-crk avian sarcoma virus CT10 oncogene homolog-like (crkl), mRNA.

Price & Availability↑

CloneID	ODa03874
Clone ID Related Accession (Same CDS sequence)	NM_213538.1
Accession Version	NM_213538.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-23
Organism	Danio rerio(zebrafish)
Product	crk-like protein
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC056763.1. On Dec 28, 2007 this sequence version replaced XM_679259.2. ##Evidence-Data-START## Transcript exon combination :: BC056763.1, BC171398.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2168446, SAMEA2168447 [ECO:0000348] ##Evidence-Data-END##

ATGTCGTCTG CACGGTTCGA CTCCTCAGAC CGAGCCAGCT GGTATTTCGG GCCGGTTTCG 
AGACAGGAGG CGCAGAATAG GCTACAGGGA CAGAGACACG GGATGTTTTT GGTGCGAGAT 
TCGTCCACTT GTCCTGGTGA TTATGTACTT TCAGTGTCCG AAAACTCCAA AGTTTCGCAC 
TATATCATCA ACTCTTTGCC AAGCAAGAGA TTCAAGATAG GCGATCAAGA GTTTGATAAT 
CTACCCGGCC TTTTGGAGTT CTATAAAATA CATTATTTGG ATACGACCAC CCTCATAGAA 
CCAGCACCAA GGTACCCCAG TACTGCTCTG CCCAGTGGTC CTATTCAGCC ATCTGGAGGA 
CTGGGTGATG AGAACCAGGA GTATGTGCGG ACTCTTTATG ACTTCACTGG CAGCGATGCT 
GAAGACCTTC CTTTCAAGAA GGGTGAAATC CTAATAATTA TGGACAAGCC TGAGGAGCAG 
TGGTGGAGTG CCAAGAACAA AGAAGGCCGA ACAGGCATGA TTCCTGTTCC CTATGTAGAA 
AAGCTTGTGA GATCTTCGCC TCATCCTGGT CAGTCCATCC ATGGTTCACG GAATTCCAAT 
AGCTATGGCA TCCCTGAGCC ATCACACGCC TATGCCCAGC CTCAGACTCC ATCTCCCATT 
CCTCCTGGTA CACCCGGCGC TGTCATCAAC CCGCTACCTT CTGTGCAGAA TGGGCCAGTG 
TTGGCGAAGG CGATCCAGAA ACGAGTGCCA TGCGCATATG ACAAAACTGC TTTAGCACTG 
GAGGTGGGTG ACATTGTGAA GGTGACTAGG ATGAACATCA GTGGTCAGTG GGAAGGGGAG 
GTAAACAACC GGAGAGGTTT ATTCCCTTTC ACTCATGTGA AAATACTGGA CCCCCAAAAC 
CCAGACGAGA GTGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_998703.1
CDS	285..1202
Translation	MSSARFDSSDRASWYFGPVSRQEAQNRLQGQRHGMFLVRDSSTCPGDYVLSVSENSKVSHYIINSLPSKRFKIGDQEFDNLPGLLEFYKIHYLDTTTLIEPAPRYPSTALPSGPIQPSGGLGDENQEYVRTLYDFTGSDAEDLPFKKGEILIIMDKPEEQWWSAKNKEGRTGMIPVPYVEKLVRSSPHPGQSIHGSRNSNSYGIPEPSHAYAQPQTPSPIPPGTPGAVINPLPSVQNGPVLAKAIQKRVPCAYDKTALALEVGDIVKVTRMNISGQWEGEVNNRRGLFPFTHVKILDPQNPDESE

Target ORF information:

RefSeq Version	NM_213538.1
Organism	Danio rerio(zebrafish)
Definition	Danio rerio v-crk avian sarcoma virus CT10 oncogene homolog-like (crkl), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_213538.1

ORF Insert Sequence:

ATGTCGTCTG CACGGTTCGA CTCCTCAGAC CGAGCCAGCT GGTATTTCGG GCCGGTTTCG 
AGACAGGAGG CGCAGAATAG GCTACAGGGA CAGAGACACG GGATGTTTTT GGTGCGAGAT 
TCGTCCACTT GTCCTGGTGA TTATGTACTT TCAGTGTCCG AAAACTCCAA AGTTTCGCAC 
TATATCATCA ACTCTTTGCC AAGCAAGAGA TTCAAGATAG GCGATCAAGA GTTTGATAAT 
CTACCCGGCC TTTTGGAGTT CTATAAAATA CATTATTTGG ATACGACCAC CCTCATAGAA 
CCAGCACCAA GGTACCCCAG TACTGCTCTG CCCAGTGGTC CTATTCAGCC ATCTGGAGGA 
CTGGGTGATG AGAACCAGGA GTATGTGCGG ACTCTTTATG ACTTCACTGG CAGCGATGCT 
GAAGACCTTC CTTTCAAGAA GGGTGAAATC CTAATAATTA TGGACAAGCC TGAGGAGCAG 
TGGTGGAGTG CCAAGAACAA AGAAGGCCGA ACAGGCATGA TTCCTGTTCC CTATGTAGAA 
AAGCTTGTGA GATCTTCGCC TCATCCTGGT CAGTCCATCC ATGGTTCACG GAATTCCAAT 
AGCTATGGCA TCCCTGAGCC ATCACACGCC TATGCCCAGC CTCAGACTCC ATCTCCCATT 
CCTCCTGGTA CACCCGGCGC TGTCATCAAC CCGCTACCTT CTGTGCAGAA TGGGCCAGTG 
TTGGCGAAGG CGATCCAGAA ACGAGTGCCA TGCGCATATG ACAAAACTGC TTTAGCACTG 
GAGGTGGGTG ACATTGTGAA GGTGACTAGG ATGAACATCA GTGGTCAGTG GGAAGGGGAG 
GTAAACAACC GGAGAGGTTT ATTCCCTTTC ACTCATGTGA AAATACTGGA CCCCCAAAAC 
CCAGACGAGA GTGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic Drivers of Kidney Defects in the DiGeorge Syndrome.
The New England journal of medicine376(8)742-754(2017 02)
Lopez-Rivera E,Liu YP,Verbitsky M,Anderson BR,Capone VP,Otto EA,Yan Z,Mitrotti A,Martino J,Steers NJ,Fasel DA,Vukojevic K,Deng R,Racedo SE,Liu Q,Werth M,Westland R,Vivante A,Makar GS,Bodria M,Sampson MG,Gillies CE,Vega-Warner V,Maiorana M,Petrey DS,Honig B,Lozanovski VJ,Salomon R,Heidet L,Carpentier W,Gaillard D,Carrea A,Gesualdo L,Cusi D,Izzi C,Scolari F,van Wijk JA,Arapovic A,Saraga-Babic M,Saraga M,Kunac N,Samii A,McDonald-McGinn DM,Crowley TB,Zackai EH,Drozdz D,Miklaszewska M,Tkaczyk M,Sikora P,Szczepanska M,Mizerska-Wasiak M,Krzemien G,Szmigielska A,Zaniew M,Darlow JM,Puri P,Barton D,Casolari E,Furth SL,Warady BA,Gucev Z,Hakonarson H,Flogelova H,Tasic V,Latos-Bielenska A,Materna-Kiryluk A,Allegri L,Wong CS,Drummond IA,D'Agati V,Imamoto A,Barasch JM,Hildebrandt F,Kiryluk K,Lifton RP,Morrow BE,Jeanpierre C,Papaioannou VE,Ghiggeri GM,Gharavi AG,Katsanis N,Sanna-Cherchi S

Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database.
BMC genomics17368(2016 05)
Pasquier J,Cabau C,Nguyen T,Jouanno E,Severac D,Braasch I,Journot L,Pontarotti P,Klopp C,Postlethwait JH,Guiguen Y,Bobe J

RFX transcription factors are essential for hearing in mice.
Nature communications68549(2015 Oct)
Elkon R,Milon B,Morrison L,Shah M,Vijayakumar S,Racherla M,Leitch CC,Silipino L,Hadi S,Weiss-Gayet M,Barras E,Schmid CD,Ait-Lounis A,Barnes A,Song Y,Eisenman DJ,Eliyahu E,Frolenkov GI,Strome SE,Durand B,Zaghloul NA,Jones SM,Reith W,Hertzano R

Comparative mapping of the 22q11.2 deletion region and the potential of simple model organisms.
Journal of neurodevelopmental disorders7(1)18(2015)
Guna A,Butcher NJ,Bassett AS

Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation.
Zebrafish6(4)417-24(2009 Dec)
Anelli V,Santoriello C,Distel M,K?ster RW,Ciccarelli FD,Mione M

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crkl cDNA ORF clone, Danio rerio(zebrafish)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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