Gene Symbol | PIK3AP1 |
Entrez Gene ID | 118788 |
Full Name | phosphoinositide-3-kinase adaptor protein 1 |
Synonyms | BCAP |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » PIK3AP1 cDNA ORF clone
Gene Symbol | PIK3AP1 |
Entrez Gene ID | 118788 |
Full Name | phosphoinositide-3-kinase adaptor protein 1 |
Synonyms | BCAP |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_011539248.1 | XP_011537550.1 | phosphoinositide 3-kinase adapter protein 1 isoform X1 |
XM_005269498.1 | XP_005269555.1 | phosphoinositide 3-kinase adapter protein 1 isoform X3 |
NM_152309.3 | NP_689522.2 | phosphoinositide 3-kinase adapter protein 1 |
NM_152309.2 | NP_689522.2 | phosphoinositide 3-kinase adapter protein 1 |
XM_005269499.1 | XP_005269556.1 | phosphoinositide 3-kinase adapter protein 1 isoform X3 |
XM_011539249.1 | XP_011537551.1 | phosphoinositide 3-kinase adapter protein 1 isoform X2 |
Canis lupus familiaris (dog) | PIK3AP1 | XP_850837.1 |
Rattus norvegicus (Norway rat) | Pik3ap1 | NP_001099838.1 |
Homo sapiens (human) | PIK3AP1 | NP_689522.2 |
Bos taurus (cattle) | PIK3AP1 | XP_002698457.2 |
Danio rerio (zebrafish) | pik3ap1 | XP_005156973.1 |
Xenopus tropicalis (tropical clawed frog) | pik3ap1 | XP_002936021.2 |
Pan troglodytes (chimpanzee) | PIK3AP1 | XP_507955.2 |
PIK3AP1 | XP_001101530.1 | |
Mus musculus (house mouse) | Pik3ap1 | NP_113553.1 |
Gallus gallus (chicken) | PIK3AP1 | NP_989681.1 |
Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)
Structure of the Toll/Interleukin-1 Receptor (TIR) Domain of the B-cell Adaptor That Links Phosphoinositide Metabolism with the Negative Regulation of the Toll-like Receptor (TLR) Signalosome.
Halabi S, Sekine E, Verstak B, Gay NJ, Moncrieffe MC
The Journal of biological chemistry292(2)652-660(2017 Jan)
Genome-wide association study of orthostatic hypotension and supine-standing blood pressure changes in two korean populations.
Hong KW, Kim SS, Kim Y
Genomics & informatics11(3)129-34(2013 Sep)
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Lauc G, Huffman JE, Pu?i? M, Zgaga L, Adamczyk B, Mu?ini? A, Novokmet M, Pola?ek O, Gornik O, Kri?ti? J, Keser T, Vitart V, Scheijen B, Uh HW, Molokhia M, Patrick AL, McKeigue P, Kol?i? I, Luki? IK, Swann O, van Leeuwen FN, Ruhaak LR, Houwing-Duistermaat JJ, Slagboom PE, Beekman M, de Craen AJ, Deelder AM, Zeng Q, Wang W, Hastie ND, Gyllensten U, Wilson JF, Wuhrer M, Wright AF, Rudd PM, Hayward C, Aulchenko Y, Campbell H, Rudan I
PLoS genetics9(1)e1003225(2013)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Dimeric BCAP associates with the TIR domains of TLR2/4 and MAL/TIRAP, suggesting that it is recruited to the TLR signalosome by multitypic TIR-TIR interactions.
Title: Structure of the Toll/Interleukin-1 Receptor (TIR) Domain of the B-cell Adaptor That Links Phosphoinositide Metabolism with the Negative Regulation of the Toll-like Receptor (TLR) Signalosome.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Pooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer.
Observational study of gene-disease association. (HuGE Navigator)
Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Abi-1 promotes Abl-mediated BCAP phosphorylation and suggest that Abi-1 in general coordinates kinase-substrate interactions
Title: Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases.
The following PIK3AP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PIK3AP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu13969 | |
Clone ID Related Accession (Same CDS sequence) | NM_152309.3 , NM_152309.2 | |
Accession Version | NM_152309.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2418bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-09 | |
Organism | Homo sapiens(human) | |
Product | phosphoinositide 3-kinase adapter protein 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK125635.1, BX648550.1, AK092883.1, AK122584.1 and AI826732.1. On Nov 22, 2018 this sequence version replaced NM_152309.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK125635.1, SRR1803616.75811.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000339364.10/ ENSP00000339826.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGCAGCCT CAGGGGTGCC CAGAGGATGC GACATCCTCA TCGTCTACAG CCCGGATGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_689522.2 |
CDS | 121..2538 |
Translation |
Target ORF information:
Target ORF information:
|
NM_152309.3 |
1 | ATGGCAGCCT CAGGGGTGCC CAGAGGATGC GACATCCTCA TCGTCTACAG CCCGGATGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu13969 | |
Clone ID Related Accession (Same CDS sequence) | NM_152309.3 , NM_152309.2 | |
Accession Version | NM_152309.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2418bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-26 | |
Organism | Homo sapiens(human) | |
Product | phosphoinositide 3-kinase adapter protein 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB990570.1, AK125635.1, BX648550.1, AK092883.1, AK122584.1 and AI826732.1. On Mar 17, 2004 this sequence version replaced NM_152309.1. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.517072.1, SRR1803616.75811.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGCAGCCT CAGGGGTGCC CAGAGGATGC GACATCCTCA TCGTCTACAG CCCGGATGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_689522.2 |
CDS | 129..2546 |
Translation |
Target ORF information:
Target ORF information:
|
NM_152309.2 |
1 | ATGGCAGCCT CAGGGGTGCC CAGAGGATGC GACATCCTCA TCGTCTACAG CCCGGATGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu44019 | |
Clone ID Related Accession (Same CDS sequence) | XM_005269498.1 , XM_005269499.1 | |
Accession Version | XM_005269498.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1884bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | phosphoinositide 3-kinase adapter protein 1 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGTGGTGC AGCCGGACCG CATTCGCTGT GGGGCAGAAA CCACTGTCTA TGTTATTGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005269555.1 |
CDS | 186..2069 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005269498.1 |
1 | ATGGTGGTGC AGCCGGACCG CATTCGCTGT GGGGCAGAAA CCACTGTCTA TGTTATTGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu44019 | |
Clone ID Related Accession (Same CDS sequence) | XM_005269498.1 , XM_005269499.1 | |
Accession Version | XM_005269499.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1884bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | phosphoinositide 3-kinase adapter protein 1 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGTGGTGC AGCCGGACCG CATTCGCTGT GGGGCAGAAA CCACTGTCTA TGTTATTGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005269556.1 |
CDS | 210..2093 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005269499.1 |
1 | ATGGTGGTGC AGCCGGACCG CATTCGCTGT GGGGCAGAAA CCACTGTCTA TGTTATTGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu75080 | |
Clone ID Related Accession (Same CDS sequence) | XM_011539248.1 | |
Accession Version | XM_011539248.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2391bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | phosphoinositide 3-kinase adapter protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGCCT CAGGGGTGCC CAGAGGATGC GACATCCTCA TCGTCTACAG CCCGGATGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011537550.1 |
CDS | 121..2511 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011539248.1 |
1 | ATGGCAGCCT CAGGGGTGCC CAGAGGATGC GACATCCTCA TCGTCTACAG CCCGGATGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu75081 | |
Clone ID Related Accession (Same CDS sequence) | XM_011539249.1 | |
Accession Version | XM_011539249.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2262bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | phosphoinositide 3-kinase adapter protein 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCAGCCT CAGGGGTGCC CAGAGGATGC GACATCCTCA TCGTCTACAG CCCGGATGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011537551.1 |
CDS | 121..2382 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011539249.1 |
1 | ATGGCAGCCT CAGGGGTGCC CAGAGGATGC GACATCCTCA TCGTCTACAG CCCGGATGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Architecture of the human interactome defines protein communities and disease networks. |
Structure of the Toll/Interleukin-1 Receptor (TIR) Domain of the B-cell Adaptor That Links Phosphoinositide Metabolism with the Negative Regulation of the Toll-like Receptor (TLR) Signalosome. |
Genome-wide association study of orthostatic hypotension and supine-standing blood pressure changes in two korean populations. |
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. |