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NDUFB7 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol NDUFB7
Entrez Gene ID 4713
Full Name NADH:ubiquinone oxidoreductase subunit B7
Synonyms B18,CI-B18
General protein information
Preferred Names

NADH:ubiquinone oxidoreductase subunit B7

Names

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
NADH-ubiquinone oxidoreductase B18 subunit
cell adhesion protein SQM1
complex I B18 subunit
complex I-B18
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

19

19p13.12
Summary The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [provided by RefSeq, Jul 2008].
Disorder MIM:

603842


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_004146.5 NP_004137.2 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
NM_004146.6 NP_004137.2 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
XM_011528039.2 XP_011526341.1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 isoform X1
XM_011528039.3 XP_011526341.1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 isoform X1

Pathways from BioSystems


Homologies


Rattus norvegicus (Norway rat) Ndufb7 NP_001101912.1
Drosophila melanogaster (fruit fly) CG5548 NP_572993.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP007574 XP_308300.3
Danio rerio (zebrafish) ndufb7 NP_957142.1
Homo sapiens (human) NDUFB7 NP_004137.2
Bos taurus (cattle) NDUFB7 NP_788833.1
Xenopus tropicalis (tropical clawed frog) ndufb7 NP_001017236.1
Pan troglodytes (chimpanzee) NDUFB7 NP_001065270.1
NDUFB7 XP_001111436.1
Mus musculus (house mouse) Ndufb7 NP_080119.1
Canis lupus familiaris (dog) NDUFB7 XP_533892.2

Gene Ontology


Bibliography

Related articles in PubMed

Accessory subunits are integral for assembly and function of human mitochondrial complex I.
Stroud DA, Surgenor EE, Formosa LE, Reljic B, Frazier AE, Dibley MG, Osellame LD, Stait T, Beilharz TH, Thorburn DR, Salim A, Ryan MT
Nature538(7623)123-126(2016 Oct)

NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I.
Szklarczyk R, Wanschers BF, Nabuurs SB, Nouws J, Nijtmans LG, Huynen MA
FEBS letters585(5)737-43(2011 Mar)

Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.
Zhao X, Le?n IR, Bak S, Mogensen M, Wrzesinski K, H?jlund K, Jensen ON
Molecular & cellular proteomics : MCP10(1)M110.000299(2011 Jan)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
Saito A, Kawamoto M, Kamatani N
Journal of human genetics54(6)317-23(2009 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Intra-molecular disulfide bridges and the inter-membrane space localization of three Cx(9)C-containing subunits in human: NDUFS5, NDUFB7 and NDUFA8, are proposed.
Title: NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.

Observational study of gene-disease association. (HuGE Navigator)
Title: Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.

Observational study of gene-disease association. (HuGE Navigator)
Title: A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

The following NDUFB7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NDUFB7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu59232 XM_011528039.3
Latest version!		 Homo sapiens NADH:ubiquinone oxidoreductase subunit B7 (NDUFB7), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $69.30
$99.00
OHu09432 NM_004146.6
Latest version!		 Homo sapiens NADH:ubiquinone oxidoreductase subunit B7 (NDUFB7), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
View Old Accession Versions >>
OHu09432 NM_004146.5 Homo sapiens NADH:ubiquinone oxidoreductase subunit B7 (NDUFB7), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu59232 XM_011528039.2 Homo sapiens NADH:ubiquinone oxidoreductase subunit B7 (NDUFB7), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $69.30
$99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu59232
Clone ID Related Accession (Same CDS sequence) XM_011528039.2 , XM_011528039.3
Accession Version XM_011528039.2 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 300bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011528039.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
ATGGTGGCCA CACAGCAGGA GATGATGGAC GCGCAGCTGA GGCTCCAGCT GCGGGACTAC 
TGCGCCCACC ACCTCATCCG GCTGCTCAAG TGCAAGCGTG ACAGCTTCCC CAACTTCCTG 
GCCTGCAAGC AGGAGCGGCA CGACTGGGAC TACTGCGAGC ACCGCGACTA TGTGATGCGC 
ATGAAGGAGT TTGAGCGGGA GCGGAGGCTG CTCCAGCGGA AGAAGCGGCG GGAGAAGAAG 
GCGGCAGAGT TGGCCAAAGG CCAGGGACCC GGGGAAGTGG ACCCCAAGGT GGCCCTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011526341.1
CDS784..1083
Translation

Target ORF information:

RefSeq Version XM_011528039.2
Organism Homo sapiens(human)
Definition Homo sapiens NADH:ubiquinone oxidoreductase subunit B7 (NDUFB7), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011528039.2

ORF Insert Sequence:

1
61
121
181
241
ATGGTGGCCA CACAGCAGGA GATGATGGAC GCGCAGCTGA GGCTCCAGCT GCGGGACTAC 
TGCGCCCACC ACCTCATCCG GCTGCTCAAG TGCAAGCGTG ACAGCTTCCC CAACTTCCTG 
GCCTGCAAGC AGGAGCGGCA CGACTGGGAC TACTGCGAGC ACCGCGACTA TGTGATGCGC 
ATGAAGGAGT TTGAGCGGGA GCGGAGGCTG CTCCAGCGGA AGAAGCGGCG GGAGAAGAAG 
GCGGCAGAGT TGGCCAAAGG CCAGGGACCC GGGGAAGTGG ACCCCAAGGT GGCCCTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu59232
Clone ID Related Accession (Same CDS sequence) XM_011528039.2 , XM_011528039.3
Accession Version XM_011528039.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 300bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011528039.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
ATGGTGGCCA CACAGCAGGA GATGATGGAC GCGCAGCTGA GGCTCCAGCT GCGGGACTAC 
TGCGCCCACC ACCTCATCCG GCTGCTCAAG TGCAAGCGTG ACAGCTTCCC CAACTTCCTG 
GCCTGCAAGC AGGAGCGGCA CGACTGGGAC TACTGCGAGC ACCGCGACTA TGTGATGCGC 
ATGAAGGAGT TTGAGCGGGA GCGGAGGCTG CTCCAGCGGA AGAAGCGGCG GGAGAAGAAG 
GCGGCAGAGT TGGCCAAAGG CCAGGGACCC GGGGAAGTGG ACCCCAAGGT GGCCCTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011526341.1
CDS785..1084
Translation

Target ORF information:

RefSeq Version XM_011528039.3
Organism Homo sapiens(human)
Definition Homo sapiens NADH:ubiquinone oxidoreductase subunit B7 (NDUFB7), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011528039.3

ORF Insert Sequence:

1
61
121
181
241
ATGGTGGCCA CACAGCAGGA GATGATGGAC GCGCAGCTGA GGCTCCAGCT GCGGGACTAC 
TGCGCCCACC ACCTCATCCG GCTGCTCAAG TGCAAGCGTG ACAGCTTCCC CAACTTCCTG 
GCCTGCAAGC AGGAGCGGCA CGACTGGGAC TACTGCGAGC ACCGCGACTA TGTGATGCGC 
ATGAAGGAGT TTGAGCGGGA GCGGAGGCTG CTCCAGCGGA AGAAGCGGCG GGAGAAGAAG 
GCGGCAGAGT TGGCCAAAGG CCAGGGACCC GGGGAAGTGG ACCCCAAGGT GGCCCTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu09432
Clone ID Related Accession (Same CDS sequence) NM_004146.5 , NM_004146.6
Accession Version NM_004146.5 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 414bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-10-01
Organism Homo sapiens(human)
Product NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB124371.1 and BC002595.2. On Jan 5, 2011 this sequence version replaced NM_004146.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.221643.1, SRR1163658.407215.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2147920 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
ATGGGGGCCC ACCTGGTCCG GCGCTACCTG GGCGATGCCT CGGTGGAGCC CGACCCCCTG 
CAGATGCCAA CCTTCCCGCC AGACTACGGC TTCCCCGAAC GCAAGGAGCG CGAGATGGTG 
GCCACACAGC AGGAGATGAT GGACGCGCAG CTGAGGCTCC AGCTGCGGGA CTACTGCGCC 
CACCACCTCA TCCGGCTGCT CAAGTGCAAG CGTGACAGCT TCCCCAACTT CCTGGCCTGC 
AAGCAGGAGC GGCACGACTG GGACTACTGC GAGCACCGCG ACTATGTGAT GCGCATGAAG 
GAGTTTGAGC GGGAGCGGAG GCTGCTCCAG CGGAAGAAGC GGCGGGAGAA GAAGGCGGCA 
GAGTTGGCCA AAGGCCAGGG ACCCGGGGAA GTGGACCCCA AGGTGGCCCT GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004137.2
CDS78..491
Translation

Target ORF information:

RefSeq Version NM_004146.5
Organism Homo sapiens(human)
Definition Homo sapiens NADH:ubiquinone oxidoreductase subunit B7 (NDUFB7), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_004146.5

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGGGGGCCC ACCTGGTCCG GCGCTACCTG GGCGATGCCT CGGTGGAGCC CGACCCCCTG 
CAGATGCCAA CCTTCCCGCC AGACTACGGC TTCCCCGAAC GCAAGGAGCG CGAGATGGTG 
GCCACACAGC AGGAGATGAT GGACGCGCAG CTGAGGCTCC AGCTGCGGGA CTACTGCGCC 
CACCACCTCA TCCGGCTGCT CAAGTGCAAG CGTGACAGCT TCCCCAACTT CCTGGCCTGC 
AAGCAGGAGC GGCACGACTG GGACTACTGC GAGCACCGCG ACTATGTGAT GCGCATGAAG 
GAGTTTGAGC GGGAGCGGAG GCTGCTCCAG CGGAAGAAGC GGCGGGAGAA GAAGGCGGCA 
GAGTTGGCCA AAGGCCAGGG ACCCGGGGAA GTGGACCCCA AGGTGGCCCT GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu09432
Clone ID Related Accession (Same CDS sequence) NM_004146.5 , NM_004146.6
Accession Version NM_004146.6 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 414bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-30
Organism Homo sapiens(human)
Product NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB124371.1 and BC002595.2. On Nov 22, 2018 this sequence version replaced NM_004146.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.221643.1, SRR1163658.407215.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000215565.3/ ENSP00000215565.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
ATGGGGGCCC ACCTGGTCCG GCGCTACCTG GGCGATGCCT CGGTGGAGCC CGACCCCCTG 
CAGATGCCAA CCTTCCCGCC AGACTACGGC TTCCCCGAAC GCAAGGAGCG CGAGATGGTG 
GCCACACAGC AGGAGATGAT GGACGCGCAG CTGAGGCTCC AGCTGCGGGA CTACTGCGCC 
CACCACCTCA TCCGGCTGCT CAAGTGCAAG CGTGACAGCT TCCCCAACTT CCTGGCCTGC 
AAGCAGGAGC GGCACGACTG GGACTACTGC GAGCACCGCG ACTATGTGAT GCGCATGAAG 
GAGTTTGAGC GGGAGCGGAG GCTGCTCCAG CGGAAGAAGC GGCGGGAGAA GAAGGCGGCA 
GAGTTGGCCA AAGGCCAGGG ACCCGGGGAA GTGGACCCCA AGGTGGCCCT GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004137.2
CDS67..480
Translation

Target ORF information:

RefSeq Version NM_004146.6
Organism Homo sapiens(human)
Definition Homo sapiens NADH:ubiquinone oxidoreductase subunit B7 (NDUFB7), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_004146.6

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGGGGGCCC ACCTGGTCCG GCGCTACCTG GGCGATGCCT CGGTGGAGCC CGACCCCCTG 
CAGATGCCAA CCTTCCCGCC AGACTACGGC TTCCCCGAAC GCAAGGAGCG CGAGATGGTG 
GCCACACAGC AGGAGATGAT GGACGCGCAG CTGAGGCTCC AGCTGCGGGA CTACTGCGCC 
CACCACCTCA TCCGGCTGCT CAAGTGCAAG CGTGACAGCT TCCCCAACTT CCTGGCCTGC 
AAGCAGGAGC GGCACGACTG GGACTACTGC GAGCACCGCG ACTATGTGAT GCGCATGAAG 
GAGTTTGAGC GGGAGCGGAG GCTGCTCCAG CGGAAGAAGC GGCGGGAGAA GAAGGCGGCA 
GAGTTGGCCA AAGGCCAGGG ACCCGGGGAA GTGGACCCCA AGGTGGCCCT GTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Accessory subunits are integral for assembly and function of human mitochondrial complex I.
Nature538(7623)123-126(2016 Oct)
Stroud DA,Surgenor EE,Formosa LE,Reljic B,Frazier AE,Dibley MG,Osellame LD,Stait T,Beilharz TH,Thorburn DR,Salim A,Ryan MT


book

NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I.
FEBS letters585(5)737-43(2011 Mar)
Szklarczyk R,Wanschers BF,Nabuurs SB,Nouws J,Nijtmans LG,Huynen MA


book

Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.
Molecular & cellular proteomics : MCP10(1)M110.000299(2011 Jan)
Zhao X,Le?n IR,Bak S,Mogensen M,Wrzesinski K,H?jlund K,Jensen ON


book

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
PloS one5(9)e12862(2010 Sep)
Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ


book

Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
Journal of human genetics54(6)317-23(2009 Jun)
Saito A,Kawamoto M,Kamatani N