OTX1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OTX1
Entrez Gene ID	5013
Full Name	orthodenticle homeobox 1
General protein information	Preferred Names orthodenticle homeobox 1 Names homeobox protein OTX1 orthodenticle homolog 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p15
Summary	This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mouse is required for proper brain and sensory organ development and can cause epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Disorder MIM:	600036

mRNA and Protein(s)

mRNA	Protein	Name
NM_014562.4	NP_055377.1	homeobox protein OTX1
NM_014562.3	NP_055377.1	homeobox protein OTX1
NM_001199770.2	NP_001186699.1	homeobox protein OTX1
NM_001199770.1	NP_001186699.1	homeobox protein OTX1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Otx1	NP_035153.1
Homo sapiens (human)	OTX1	NP_055377.1
Xenopus tropicalis (tropical clawed frog)	otx1	NP_989216.1
	LOC694175	XP_001084150.1
Canis lupus familiaris (dog)	OTX1	XP_852530.1
Pan troglodytes (chimpanzee)	OTX1	XP_001162799.1
Bos taurus (cattle)	OTX1	NP_001192946.1
Rattus norvegicus (Norway rat)	Otx1	NP_037241.1
Danio rerio (zebrafish)	otx1b	NP_571325.2

Gene Ontology
Bibliography

Related articles in PubMed

Clinical and molecular cytogenetic characterization of four unrelated patients carrying 2p14 microdeletions.
Mathieu ML, Demily C, Chantot-Bastaraud S, Afenjar A, Mignot C, Andrieux J, Gerard M, Catala-Mora J, Jouk PS, Labalme A, Edery P, Sanlaville D, Rossi M
American journal of medical genetics. Part A173(8)2268-2274(2017 Aug)

OTX1 and OTX2 as possible molecular markers of sinonasal carcinomas and olfactory neuroblastomas.
Pirrone C, Chiaravalli AM, Marando A, Conti A, Rainero A, Pistochini A, Lo Curto F, Pasquali F, Castelnuovo P, Capella C, Porta G
European journal of histochemistry : EJH61(1)2730(2017 Feb)

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP
Molecular systems biology12(4)863(2016 Apr)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We speculate that ACTR2 and MEIS1 might respectively play a role in the pathogenesis of the observed deafness and cardiomyopathy...the patient carrying a 2p14p15 deletion including OTX1 had normal kidneys and genitalia, thus confirming that OTX1 haploinsufficiency is not invariably associated with genitourinary defects.
Title: Clinical and molecular cytogenetic characterization of four unrelated patients carrying 2p14 microdeletions.

OTX1 and OTX2 genes might have a role in the pathogenesis of different types of sinonasal neoplasms.
Title: OTX1 and OTX2 as possible molecular markers of sinonasal carcinomas and olfactory neuroblastomas.

Genitalia defects in these patients could result from the effect of OTX1.
Title: Genitourinary defects associated with genomic deletions in 2p15 encompassing OTX1.

overexpression of OTX1 results in accumulation of colorectal cancer (CRC) cell proliferation and invasion in vitro and tumor growth in vivo, whereas ablation of OTX1 expression inhibits the proliferative and invasive capability of CRC cell lines
Title: OTX1 promotes colorectal cancer progression through epithelial-mesenchymal transition.

XPO1 and OXT1 may contribute to ASD in 2p15-p16.1 deletion cases and non-deletion cases of ASD mapping to this chromosome region.
Title: 2p15-p16.1 microdeletion syndrome: molecular characterization and association of the OTX1 and XPO1 genes with autism spectrum disorders.

The following OTX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OTX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16853	NM_014562.4 Latest version!	Homo sapiens orthodenticle homeobox 1 (OTX1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu16853	NM_001199770.2 Latest version!	Homo sapiens orthodenticle homeobox 1 (OTX1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu16853	NM_014562.3	Homo sapiens orthodenticle homeobox 1 (OTX1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu16853	NM_001199770.1	Homo sapiens orthodenticle homeobox 1 (OTX1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OTX1 ( NM_014562.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055377.1 Homo sapiens orthodenticle homeobox 1 (OTX1), transcript variant 1, mRNA.

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CloneID	OHu16853
Clone ID Related Accession (Same CDS sequence)	NM_014562.4 , NM_014562.3 , NM_001199770.2 , NM_001199770.1
Accession Version	NM_014562.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-20
Organism	Homo sapiens(human)
Product	homeobox protein OTX1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK095680.1 and BU689444.1. On Nov 22, 2018 this sequence version replaced NM_014562.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK095680.1, BC007621.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2151887 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000282549.7/ ENSP00000282549.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGTCTT ACCTCAAACA ACCCCCATAC GGCATGAACG GGCTGGGCCT GGCCGGGCCC 
GCCATGGACC TCCTGCACCC ATCCGTGGGC TATCCGGCCA CTCCGCGGAA GCAGCGGCGG 
GAGCGCACCA CCTTCACGCG TTCACAGCTG GACGTGCTCG AGGCGCTCTT CGCCAAGACT 
CGCTACCCTG ACATCTTCAT GCGGGAGGAG GTGGCGCTCA AGATCAACCT GCCGGAGTCT 
AGAGTCCAGG TCTGGTTCAA GAACCGCCGC GCCAAATGCC GCCAGCAGCA GCAGAGCGGG 
AGCGGAACCA AGAGCCGCCC AGCCAAGAAG AAGTCCTCTC CAGTGCGGGA GAGCTCGGGC 
TCCGAAAGCA GTGGCCAATT CACGCCGCCA GCTGTGTCCA GCTCTGCCTC GTCCTCTAGC 
TCGGCGTCCA GCTCTTCCGC CAACCCAGCG GCTGCAGCGG CTGCGGGACT AGGTGGGAAC 
CCGGTGGCGG CCGCGTCGTC GCTGAGTACA CCAGCTGCCT CATCTATCTG GAGCCCGGCC 
TCCATCTCGC CAGGCTCAGC GCCCGCGTCC GTGTCGGTGC CGGAGCCATT GGCCGCGCCT 
AGCAACACCT CGTGTATGCA GCGCTCCGTA GCTGCAGGCG CCGCCACCGC AGCAGCCTCT 
TATCCCATGT CCTACGGCCA GGGCGGCAGC TACGGCCAAG GCTACCCTAC GCCCTCCTCT 
TCCTACTTTG GCGGCGTGGA CTGCAGCTCA TACCTAGCGC CCATGCACTC ACATCACCAC 
CCGCACCAGC TCAGCCCCAT GGCACCCTCC TCCATGGCGG GCCACCATCA TCACCACCCA 
CATGCGCACC ACCCGTTGAG CCAGTCCTCA GGCCACCACC ACCACCATCA CCACCACCAC 
CACCAAGGCT ACGGTGGCTC TGGGCTTGCC TTCAACTCTG CCGACTGCTT GGATTACAAG 
GAGCCTGGCG CCGCTGCTGC TTCCTCCGCC TGGAAACTCA ACTTCAACTC CCCCGACTGT 
CTGGACTATA AGGACCAAGC CTCATGGCGG TTCCAGGTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055377.1
CDS	249..1313
Translation	MMSYLKQPPYGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGSGTKSRPAKKKSSPVRESSGSESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAASSLSTPAASSIWSPASISPGSAPASVSVPEPLAAPSNTSCMQRSVAAGAATAAASYPMSYGQGGSYGQGYPTPSSSYFGGVDCSSYLAPMHSHHHPHQLSPMAPSSMAGHHHHHPHAHHPLSQSSGHHHHHHHHHHQGYGGSGLAFNSADCLDYKEPGAAAASSAWKLNFNSPDCLDYKDQASWRFQVL

Target ORF information:

RefSeq Version	NM_014562.4
Organism	Homo sapiens(human)
Definition	Homo sapiens orthodenticle homeobox 1 (OTX1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014562.4

ORF Insert Sequence:

ATGATGTCTT ACCTCAAACA ACCCCCATAC GGCATGAACG GGCTGGGCCT GGCCGGGCCC 
GCCATGGACC TCCTGCACCC ATCCGTGGGC TATCCGGCCA CTCCGCGGAA GCAGCGGCGG 
GAGCGCACCA CCTTCACGCG TTCACAGCTG GACGTGCTCG AGGCGCTCTT CGCCAAGACT 
CGCTACCCTG ACATCTTCAT GCGGGAGGAG GTGGCGCTCA AGATCAACCT GCCGGAGTCT 
AGAGTCCAGG TCTGGTTCAA GAACCGCCGC GCCAAATGCC GCCAGCAGCA GCAGAGCGGG 
AGCGGAACCA AGAGCCGCCC AGCCAAGAAG AAGTCCTCTC CAGTGCGGGA GAGCTCGGGC 
TCCGAAAGCA GTGGCCAATT CACGCCGCCA GCTGTGTCCA GCTCTGCCTC GTCCTCTAGC 
TCGGCGTCCA GCTCTTCCGC CAACCCAGCG GCTGCAGCGG CTGCGGGACT AGGTGGGAAC 
CCGGTGGCGG CCGCGTCGTC GCTGAGTACA CCAGCTGCCT CATCTATCTG GAGCCCGGCC 
TCCATCTCGC CAGGCTCAGC GCCCGCGTCC GTGTCGGTGC CGGAGCCATT GGCCGCGCCT 
AGCAACACCT CGTGTATGCA GCGCTCCGTA GCTGCAGGCG CCGCCACCGC AGCAGCCTCT 
TATCCCATGT CCTACGGCCA GGGCGGCAGC TACGGCCAAG GCTACCCTAC GCCCTCCTCT 
TCCTACTTTG GCGGCGTGGA CTGCAGCTCA TACCTAGCGC CCATGCACTC ACATCACCAC 
CCGCACCAGC TCAGCCCCAT GGCACCCTCC TCCATGGCGG GCCACCATCA TCACCACCCA 
CATGCGCACC ACCCGTTGAG CCAGTCCTCA GGCCACCACC ACCACCATCA CCACCACCAC 
CACCAAGGCT ACGGTGGCTC TGGGCTTGCC TTCAACTCTG CCGACTGCTT GGATTACAAG 
GAGCCTGGCG CCGCTGCTGC TTCCTCCGCC TGGAAACTCA ACTTCAACTC CCCCGACTGT 
CTGGACTATA AGGACCAAGC CTCATGGCGG TTCCAGGTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OTX1 ( NM_014562.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055377.1 Homo sapiens orthodenticle homeobox 1 (OTX1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16853
Clone ID Related Accession (Same CDS sequence)	NM_014562.4 , NM_014562.3 , NM_001199770.2 , NM_001199770.1
Accession Version	NM_014562.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	homeobox protein OTX1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP310240.1, AK095680.1 and BU689444.1. On Dec 16, 2010 this sequence version replaced NM_014562.2. Transcript Variant: This variant (1) encodes the functional protein. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP310240.1, AK095680.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2151887 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGTCTT ACCTCAAACA ACCCCCATAC GGCATGAACG GGCTGGGCCT GGCCGGGCCC 
GCCATGGACC TCCTGCACCC ATCCGTGGGC TATCCGGCCA CTCCGCGGAA GCAGCGGCGG 
GAGCGCACCA CCTTCACGCG TTCACAGCTG GACGTGCTCG AGGCGCTCTT CGCCAAGACT 
CGCTACCCTG ACATCTTCAT GCGGGAGGAG GTGGCGCTCA AGATCAACCT GCCGGAGTCT 
AGAGTCCAGG TCTGGTTCAA GAACCGCCGC GCCAAATGCC GCCAGCAGCA GCAGAGCGGG 
AGCGGAACCA AGAGCCGCCC AGCCAAGAAG AAGTCCTCTC CAGTGCGGGA GAGCTCGGGC 
TCCGAAAGCA GTGGCCAATT CACGCCGCCA GCTGTGTCCA GCTCTGCCTC GTCCTCTAGC 
TCGGCGTCCA GCTCTTCCGC CAACCCAGCG GCTGCAGCGG CTGCGGGACT AGGTGGGAAC 
CCGGTGGCGG CCGCGTCGTC GCTGAGTACA CCAGCTGCCT CATCTATCTG GAGCCCGGCC 
TCCATCTCGC CAGGCTCAGC GCCCGCGTCC GTGTCGGTGC CGGAGCCATT GGCCGCGCCT 
AGCAACACCT CGTGTATGCA GCGCTCCGTA GCTGCAGGCG CCGCCACCGC AGCAGCCTCT 
TATCCCATGT CCTACGGCCA GGGCGGCAGC TACGGCCAAG GCTACCCTAC GCCCTCCTCT 
TCCTACTTTG GCGGCGTGGA CTGCAGCTCA TACCTAGCGC CCATGCACTC ACATCACCAC 
CCGCACCAGC TCAGCCCCAT GGCACCCTCC TCCATGGCGG GCCACCATCA TCACCACCCA 
CATGCGCACC ACCCGTTGAG CCAGTCCTCA GGCCACCACC ACCACCATCA CCACCACCAC 
CACCAAGGCT ACGGTGGCTC TGGGCTTGCC TTCAACTCTG CCGACTGCTT GGATTACAAG 
GAGCCTGGCG CCGCTGCTGC TTCCTCCGCC TGGAAACTCA ACTTCAACTC CCCCGACTGT 
CTGGACTATA AGGACCAAGC CTCATGGCGG TTCCAGGTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055377.1
CDS	277..1341
Translation	MMSYLKQPPYGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGSGTKSRPAKKKSSPVRESSGSESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAASSLSTPAASSIWSPASISPGSAPASVSVPEPLAAPSNTSCMQRSVAAGAATAAASYPMSYGQGGSYGQGYPTPSSSYFGGVDCSSYLAPMHSHHHPHQLSPMAPSSMAGHHHHHPHAHHPLSQSSGHHHHHHHHHHQGYGGSGLAFNSADCLDYKEPGAAAASSAWKLNFNSPDCLDYKDQASWRFQVL

Target ORF information:

RefSeq Version	NM_014562.3
Organism	Homo sapiens(human)
Definition	Homo sapiens orthodenticle homeobox 1 (OTX1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014562.3

ORF Insert Sequence:

ATGATGTCTT ACCTCAAACA ACCCCCATAC GGCATGAACG GGCTGGGCCT GGCCGGGCCC 
GCCATGGACC TCCTGCACCC ATCCGTGGGC TATCCGGCCA CTCCGCGGAA GCAGCGGCGG 
GAGCGCACCA CCTTCACGCG TTCACAGCTG GACGTGCTCG AGGCGCTCTT CGCCAAGACT 
CGCTACCCTG ACATCTTCAT GCGGGAGGAG GTGGCGCTCA AGATCAACCT GCCGGAGTCT 
AGAGTCCAGG TCTGGTTCAA GAACCGCCGC GCCAAATGCC GCCAGCAGCA GCAGAGCGGG 
AGCGGAACCA AGAGCCGCCC AGCCAAGAAG AAGTCCTCTC CAGTGCGGGA GAGCTCGGGC 
TCCGAAAGCA GTGGCCAATT CACGCCGCCA GCTGTGTCCA GCTCTGCCTC GTCCTCTAGC 
TCGGCGTCCA GCTCTTCCGC CAACCCAGCG GCTGCAGCGG CTGCGGGACT AGGTGGGAAC 
CCGGTGGCGG CCGCGTCGTC GCTGAGTACA CCAGCTGCCT CATCTATCTG GAGCCCGGCC 
TCCATCTCGC CAGGCTCAGC GCCCGCGTCC GTGTCGGTGC CGGAGCCATT GGCCGCGCCT 
AGCAACACCT CGTGTATGCA GCGCTCCGTA GCTGCAGGCG CCGCCACCGC AGCAGCCTCT 
TATCCCATGT CCTACGGCCA GGGCGGCAGC TACGGCCAAG GCTACCCTAC GCCCTCCTCT 
TCCTACTTTG GCGGCGTGGA CTGCAGCTCA TACCTAGCGC CCATGCACTC ACATCACCAC 
CCGCACCAGC TCAGCCCCAT GGCACCCTCC TCCATGGCGG GCCACCATCA TCACCACCCA 
CATGCGCACC ACCCGTTGAG CCAGTCCTCA GGCCACCACC ACCACCATCA CCACCACCAC 
CACCAAGGCT ACGGTGGCTC TGGGCTTGCC TTCAACTCTG CCGACTGCTT GGATTACAAG 
GAGCCTGGCG CCGCTGCTGC TTCCTCCGCC TGGAAACTCA ACTTCAACTC CCCCGACTGT 
CTGGACTATA AGGACCAAGC CTCATGGCGG TTCCAGGTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OTX1 ( NM_001199770.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186699.1 Homo sapiens orthodenticle homeobox 1 (OTX1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16853
Clone ID Related Accession (Same CDS sequence)	NM_014562.4 , NM_014562.3 , NM_001199770.2 , NM_001199770.1
Accession Version	NM_001199770.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-20
Organism	Homo sapiens(human)
Product	homeobox protein OTX1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009501.4. On Aug 2, 2019 this sequence version replaced NM_001199770.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM720707.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGTCTT ACCTCAAACA ACCCCCATAC GGCATGAACG GGCTGGGCCT GGCCGGGCCC 
GCCATGGACC TCCTGCACCC ATCCGTGGGC TATCCGGCCA CTCCGCGGAA GCAGCGGCGG 
GAGCGCACCA CCTTCACGCG TTCACAGCTG GACGTGCTCG AGGCGCTCTT CGCCAAGACT 
CGCTACCCTG ACATCTTCAT GCGGGAGGAG GTGGCGCTCA AGATCAACCT GCCGGAGTCT 
AGAGTCCAGG TCTGGTTCAA GAACCGCCGC GCCAAATGCC GCCAGCAGCA GCAGAGCGGG 
AGCGGAACCA AGAGCCGCCC AGCCAAGAAG AAGTCCTCTC CAGTGCGGGA GAGCTCGGGC 
TCCGAAAGCA GTGGCCAATT CACGCCGCCA GCTGTGTCCA GCTCTGCCTC GTCCTCTAGC 
TCGGCGTCCA GCTCTTCCGC CAACCCAGCG GCTGCAGCGG CTGCGGGACT AGGTGGGAAC 
CCGGTGGCGG CCGCGTCGTC GCTGAGTACA CCAGCTGCCT CATCTATCTG GAGCCCGGCC 
TCCATCTCGC CAGGCTCAGC GCCCGCGTCC GTGTCGGTGC CGGAGCCATT GGCCGCGCCT 
AGCAACACCT CGTGTATGCA GCGCTCCGTA GCTGCAGGCG CCGCCACCGC AGCAGCCTCT 
TATCCCATGT CCTACGGCCA GGGCGGCAGC TACGGCCAAG GCTACCCTAC GCCCTCCTCT 
TCCTACTTTG GCGGCGTGGA CTGCAGCTCA TACCTAGCGC CCATGCACTC ACATCACCAC 
CCGCACCAGC TCAGCCCCAT GGCACCCTCC TCCATGGCGG GCCACCATCA TCACCACCCA 
CATGCGCACC ACCCGTTGAG CCAGTCCTCA GGCCACCACC ACCACCATCA CCACCACCAC 
CACCAAGGCT ACGGTGGCTC TGGGCTTGCC TTCAACTCTG CCGACTGCTT GGATTACAAG 
GAGCCTGGCG CCGCTGCTGC TTCCTCCGCC TGGAAACTCA ACTTCAACTC CCCCGACTGT 
CTGGACTATA AGGACCAAGC CTCATGGCGG TTCCAGGTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186699.1
CDS	599..1663
Translation	MMSYLKQPPYGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGSGTKSRPAKKKSSPVRESSGSESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAASSLSTPAASSIWSPASISPGSAPASVSVPEPLAAPSNTSCMQRSVAAGAATAAASYPMSYGQGGSYGQGYPTPSSSYFGGVDCSSYLAPMHSHHHPHQLSPMAPSSMAGHHHHHPHAHHPLSQSSGHHHHHHHHHHQGYGGSGLAFNSADCLDYKEPGAAAASSAWKLNFNSPDCLDYKDQASWRFQVL

Target ORF information:

RefSeq Version	NM_001199770.2
Organism	Homo sapiens(human)
Definition	Homo sapiens orthodenticle homeobox 1 (OTX1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199770.2

ORF Insert Sequence:

ATGATGTCTT ACCTCAAACA ACCCCCATAC GGCATGAACG GGCTGGGCCT GGCCGGGCCC 
GCCATGGACC TCCTGCACCC ATCCGTGGGC TATCCGGCCA CTCCGCGGAA GCAGCGGCGG 
GAGCGCACCA CCTTCACGCG TTCACAGCTG GACGTGCTCG AGGCGCTCTT CGCCAAGACT 
CGCTACCCTG ACATCTTCAT GCGGGAGGAG GTGGCGCTCA AGATCAACCT GCCGGAGTCT 
AGAGTCCAGG TCTGGTTCAA GAACCGCCGC GCCAAATGCC GCCAGCAGCA GCAGAGCGGG 
AGCGGAACCA AGAGCCGCCC AGCCAAGAAG AAGTCCTCTC CAGTGCGGGA GAGCTCGGGC 
TCCGAAAGCA GTGGCCAATT CACGCCGCCA GCTGTGTCCA GCTCTGCCTC GTCCTCTAGC 
TCGGCGTCCA GCTCTTCCGC CAACCCAGCG GCTGCAGCGG CTGCGGGACT AGGTGGGAAC 
CCGGTGGCGG CCGCGTCGTC GCTGAGTACA CCAGCTGCCT CATCTATCTG GAGCCCGGCC 
TCCATCTCGC CAGGCTCAGC GCCCGCGTCC GTGTCGGTGC CGGAGCCATT GGCCGCGCCT 
AGCAACACCT CGTGTATGCA GCGCTCCGTA GCTGCAGGCG CCGCCACCGC AGCAGCCTCT 
TATCCCATGT CCTACGGCCA GGGCGGCAGC TACGGCCAAG GCTACCCTAC GCCCTCCTCT 
TCCTACTTTG GCGGCGTGGA CTGCAGCTCA TACCTAGCGC CCATGCACTC ACATCACCAC 
CCGCACCAGC TCAGCCCCAT GGCACCCTCC TCCATGGCGG GCCACCATCA TCACCACCCA 
CATGCGCACC ACCCGTTGAG CCAGTCCTCA GGCCACCACC ACCACCATCA CCACCACCAC 
CACCAAGGCT ACGGTGGCTC TGGGCTTGCC TTCAACTCTG CCGACTGCTT GGATTACAAG 
GAGCCTGGCG CCGCTGCTGC TTCCTCCGCC TGGAAACTCA ACTTCAACTC CCCCGACTGT 
CTGGACTATA AGGACCAAGC CTCATGGCGG TTCCAGGTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OTX1 ( NM_001199770.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001186699.1 Homo sapiens orthodenticle homeobox 1 (OTX1), transcript variant 2, mRNA.

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CloneID	OHu16853
Clone ID Related Accession (Same CDS sequence)	NM_014562.4 , NM_014562.3 , NM_001199770.2 , NM_001199770.1
Accession Version	NM_001199770.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1065bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-24
Organism	Homo sapiens(human)
Product	homeobox protein OTX1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM720707.1, AC009501.4, AK095680.1 and BU689444.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM720707.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151887, SAMEA2153427 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGTCTT ACCTCAAACA ACCCCCATAC GGCATGAACG GGCTGGGCCT GGCCGGGCCC 
GCCATGGACC TCCTGCACCC ATCCGTGGGC TATCCGGCCA CTCCGCGGAA GCAGCGGCGG 
GAGCGCACCA CCTTCACGCG TTCACAGCTG GACGTGCTCG AGGCGCTCTT CGCCAAGACT 
CGCTACCCTG ACATCTTCAT GCGGGAGGAG GTGGCGCTCA AGATCAACCT GCCGGAGTCT 
AGAGTCCAGG TCTGGTTCAA GAACCGCCGC GCCAAATGCC GCCAGCAGCA GCAGAGCGGG 
AGCGGAACCA AGAGCCGCCC AGCCAAGAAG AAGTCCTCTC CAGTGCGGGA GAGCTCGGGC 
TCCGAAAGCA GTGGCCAATT CACGCCGCCA GCTGTGTCCA GCTCTGCCTC GTCCTCTAGC 
TCGGCGTCCA GCTCTTCCGC CAACCCAGCG GCTGCAGCGG CTGCGGGACT AGGTGGGAAC 
CCGGTGGCGG CCGCGTCGTC GCTGAGTACA CCAGCTGCCT CATCTATCTG GAGCCCGGCC 
TCCATCTCGC CAGGCTCAGC GCCCGCGTCC GTGTCGGTGC CGGAGCCATT GGCCGCGCCT 
AGCAACACCT CGTGTATGCA GCGCTCCGTA GCTGCAGGCG CCGCCACCGC AGCAGCCTCT 
TATCCCATGT CCTACGGCCA GGGCGGCAGC TACGGCCAAG GCTACCCTAC GCCCTCCTCT 
TCCTACTTTG GCGGCGTGGA CTGCAGCTCA TACCTAGCGC CCATGCACTC ACATCACCAC 
CCGCACCAGC TCAGCCCCAT GGCACCCTCC TCCATGGCGG GCCACCATCA TCACCACCCA 
CATGCGCACC ACCCGTTGAG CCAGTCCTCA GGCCACCACC ACCACCATCA CCACCACCAC 
CACCAAGGCT ACGGTGGCTC TGGGCTTGCC TTCAACTCTG CCGACTGCTT GGATTACAAG 
GAGCCTGGCG CCGCTGCTGC TTCCTCCGCC TGGAAACTCA ACTTCAACTC CCCCGACTGT 
CTGGACTATA AGGACCAAGC CTCATGGCGG TTCCAGGTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001186699.1
CDS	277..1341
Translation	MMSYLKQPPYGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQSGSGTKSRPAKKKSSPVRESSGSESSGQFTPPAVSSSASSSSSASSSSANPAAAAAAGLGGNPVAAASSLSTPAASSIWSPASISPGSAPASVSVPEPLAAPSNTSCMQRSVAAGAATAAASYPMSYGQGGSYGQGYPTPSSSYFGGVDCSSYLAPMHSHHHPHQLSPMAPSSMAGHHHHHPHAHHPLSQSSGHHHHHHHHHHQGYGGSGLAFNSADCLDYKEPGAAAASSAWKLNFNSPDCLDYKDQASWRFQVL

Target ORF information:

RefSeq Version	NM_001199770.1
Organism	Homo sapiens(human)
Definition	Homo sapiens orthodenticle homeobox 1 (OTX1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001199770.1

ORF Insert Sequence:

ATGATGTCTT ACCTCAAACA ACCCCCATAC GGCATGAACG GGCTGGGCCT GGCCGGGCCC 
GCCATGGACC TCCTGCACCC ATCCGTGGGC TATCCGGCCA CTCCGCGGAA GCAGCGGCGG 
GAGCGCACCA CCTTCACGCG TTCACAGCTG GACGTGCTCG AGGCGCTCTT CGCCAAGACT 
CGCTACCCTG ACATCTTCAT GCGGGAGGAG GTGGCGCTCA AGATCAACCT GCCGGAGTCT 
AGAGTCCAGG TCTGGTTCAA GAACCGCCGC GCCAAATGCC GCCAGCAGCA GCAGAGCGGG 
AGCGGAACCA AGAGCCGCCC AGCCAAGAAG AAGTCCTCTC CAGTGCGGGA GAGCTCGGGC 
TCCGAAAGCA GTGGCCAATT CACGCCGCCA GCTGTGTCCA GCTCTGCCTC GTCCTCTAGC 
TCGGCGTCCA GCTCTTCCGC CAACCCAGCG GCTGCAGCGG CTGCGGGACT AGGTGGGAAC 
CCGGTGGCGG CCGCGTCGTC GCTGAGTACA CCAGCTGCCT CATCTATCTG GAGCCCGGCC 
TCCATCTCGC CAGGCTCAGC GCCCGCGTCC GTGTCGGTGC CGGAGCCATT GGCCGCGCCT 
AGCAACACCT CGTGTATGCA GCGCTCCGTA GCTGCAGGCG CCGCCACCGC AGCAGCCTCT 
TATCCCATGT CCTACGGCCA GGGCGGCAGC TACGGCCAAG GCTACCCTAC GCCCTCCTCT 
TCCTACTTTG GCGGCGTGGA CTGCAGCTCA TACCTAGCGC CCATGCACTC ACATCACCAC 
CCGCACCAGC TCAGCCCCAT GGCACCCTCC TCCATGGCGG GCCACCATCA TCACCACCCA 
CATGCGCACC ACCCGTTGAG CCAGTCCTCA GGCCACCACC ACCACCATCA CCACCACCAC 
CACCAAGGCT ACGGTGGCTC TGGGCTTGCC TTCAACTCTG CCGACTGCTT GGATTACAAG 
GAGCCTGGCG CCGCTGCTGC TTCCTCCGCC TGGAAACTCA ACTTCAACTC CCCCGACTGT 
CTGGACTATA AGGACCAAGC CTCATGGCGG TTCCAGGTCT TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Clinical and molecular cytogenetic characterization of four unrelated patients carrying 2p14 microdeletions.
American journal of medical genetics. Part A173(8)2268-2274(2017 Aug)
Mathieu ML,Demily C,Chantot-Bastaraud S,Afenjar A,Mignot C,Andrieux J,Gerard M,Catala-Mora J,Jouk PS,Labalme A,Edery P,Sanlaville D,Rossi M

OTX1 and OTX2 as possible molecular markers of sinonasal carcinomas and olfactory neuroblastomas.
European journal of histochemistry : EJH61(1)2730(2017 Feb)
Pirrone C,Chiaravalli AM,Marando A,Conti A,Rainero A,Pistochini A,Lo Curto F,Pasquali F,Castelnuovo P,Capella C,Porta G

Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Molecular systems biology12(4)863(2016 Apr)
Yachie N,Petsalaki E,Mellor JC,Weile J,Jacob Y,Verby M,Ozturk SB,Li S,Cote AG,Mosca R,Knapp JJ,Ko M,Yu A,Gebbia M,Sahni N,Yi S,Tyagi T,Sheykhkarimli D,Roth JF,Wong C,Musa L,Snider J,Liu YC,Yu H,Braun P,Stagljar I,Hao T,Calderwood MA,Pelletier L,Aloy P,Hill DE,Vidal M,Roth FP

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

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OTX1 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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