DUOX2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DUOX2
Entrez Gene ID	50506
Full Name	dual oxidase 2
Synonyms	LNOX2,NOXEF2,P138-TOX,TDH6,THOX2
General protein information	Preferred Names dual oxidase 2 Names dual oxidase 2 NADH/NADPH thyroid oxidase p138-tox NADPH oxidase/peroxidase DUOX2 NADPH thyroid oxidase 2 dual oxidase-like domains 2 flavoprotein NADPH oxidase large NOX 2 long NOX 2 nicotinamide adenine dinucleotide phosphate oxidase p138 thyroid oxidase thyroid oxidase 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q21.1
Summary	The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008].
Disorder MIM:	606759
Disorder Html:	Thyroid dyshormonogenesis 6, 607200 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001363711.1	NP_001350640.1	dual oxidase 2 precursor
XM_005254421.2	XP_005254478.1	dual oxidase 2 isoform X1
NM_014080.4	NP_054799.4	dual oxidase 2 precursor
NM_001363711.2	NP_001350640.1	dual oxidase 2 precursor

Pathways from BioSystems

Homologies

	LOC713906	XP_001103398.2
Canis lupus familiaris (dog)	DUOX2	XP_005638424.1
Rattus norvegicus (Norway rat)	Duox2	NP_077055.1
Bos taurus (cattle)	DUOX2	XP_002690988.2
Homo sapiens (human)	DUOX2	NP_054799.4
Drosophila melanogaster (fruit fly)	Duox	NP_001259968.1
Anopheles gambiae (African malaria mosquito)	DUOX	XP_319115.4
Caenorhabditis elegans (roundworm)	bli-3	NP_490686.3
Pan troglodytes (chimpanzee)	DUOX2	XP_510367.3
Arabidopsis thaliana (thale cress)	RBOHB	NP_973799.1
Mus musculus (house mouse)	Duox2	NP_808278.2
Caenorhabditis elegans (roundworm)	duox-2	NP_490684.1
Xenopus tropicalis (tropical clawed frog)	duox2	XP_002937935.1

Gene Ontology
Bibliography

Related articles in PubMed

Association between monoallelic
Abe K, Narumi S, Suwanai AS, Adachi M, Muroya K, Asakura Y, Nagasaki K, Abe T, Hasegawa T
European journal of endocrinology178(2)137-144(2018 Feb)

Myocardium of patients with dilated cardiomyopathy presents altered expression of genes involved in thyroid hormone biosynthesis.
Gil-Cayuela C, Ortega A, Taraz?n E, Mart?nez-Dolz L, Cinca J, Gonz?lez-Juanatey JR, Lago F, Rosell?-Llet? E, Rivera M, Portol?s M
PloS one13(1)e0190987(2018)

DUOX2 Mutations Are Associated With Congenital Hypothyroidism With Ectopic Thyroid Gland.
Kizys MML, Louzada RA, Mitne-Neto M, Jara JR, Furuzawa GK, de Carvalho DP, Dias-da-Silva MR, Nesi-Fran?a S, Dupuy C, Maciel RMB
The Journal of clinical endocrinology and metabolism102(11)4060-4071(2017 Nov)

First Identification of Biallelic Inherited DUOX2 Inactivating Mutations as a Cause of Very Early Onset Inflammatory Bowel Disease.
Parlato M, Charbit-Henrion F, Hayes P, Tiberti A, Aloi M, Cucchiara S, B?gue B, Bras M, Pouliet A, Rakotobe S, Ruemmele F, Knaus UG, Cerf-Bensussan N
Gastroenterology153(2)609-611.e3(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Monoallelic TSHR mutations are significantly associated with positive newborn screen for congenital hypothyroidism, and the association is further strengthened by the coexistence of monoallelic DUOX2 mutations.
Title: Association between monoallelic

In addition to thyroid hormonogenesis, the DUOX2 N-terminal domain may play a role in thyroid development.
Title: DUOX2 Mutations Are Associated With Congenital Hypothyroidism With Ectopic Thyroid Gland.

DUOX2 nonsense mutation plays a role in the pathogenesis of congenital hypothyroidism.
Title: Digenic DUOX1 and DUOX2 Mutations in Cases With Congenital Hypothyroidism.

This study reports the pedigree with goitrous congenital hypothyroidism (GCH) due to the coexistence of heterozygous mutations in the DUOX2 and DUOXA2 genes.
Title: Compound Heterozygous Mutations in the DUOX2/DUOXA2 Genes Cause Congenital Hypothyroidism.

DUOX2 Mutation is associated with Congenital Hypothyroidism.
Title: The Prevalence, Clinical, and Molecular Characteristics of Congenital Hypothyroidism Caused by DUOX2 Mutations: A Population-Based Cohort Study in Guangzhou.

The following DUOX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DUOX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25833	NM_014080.4 Latest version!	Homo sapiens dual oxidase 2 (DUOX2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$923.30 $1319.00
OHu48347	NM_001363711.2 Latest version!	Homo sapiens dual oxidase 2 (DUOX2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$811.30 $1159.00
OHu48347	XM_005254421.2 Latest version!	Homo sapiens dual oxidase 2 (DUOX2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$811.30 $1159.00
View Old Accession Versions >>
OHu48347	NM_001363711.1	Homo sapiens dual oxidase 2 (DUOX2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$811.30 $1159.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DUOX2 ( NM_014080.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_054799.4 Homo sapiens dual oxidase 2 (DUOX2), transcript variant 1, mRNA.

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CloneID	OHu25833
Clone ID Related Accession (Same CDS sequence)	NM_014080.4
Accession Version	NM_014080.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4647bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-27
Organism	Homo sapiens(human)
Product	dual oxidase 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI045475.1, AF230496.1 and AC091117.5. This sequence is a reference standard in the RefSeqGene project. On Mar 15, 2007 this sequence version replaced NM_014080.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTCCGTG CAAGACCAGA GGCACTGATG CTCCTGGGAG CTCTTCTGAC TGGATCCCTG 
GGTCCATCGG GCAATCAGGA CGCACTCTCA CTGCCCTGGG AAGTGCAGCG CTATGACGGC 
TGGTTTAACA ACCTGAGGCA CCACGAGCGT GGTGCTGTTG GCTGCCGGTT GCAGCGCCGC 
GTACCAGCCA ATTACGCCGA CGGTGTGTAT CAGGCTCTGG AGGAGCCGCA GCTGCCCAAC 
CCGCGCCGGC TCAGCAACGC AGCCACGCGG GGCATAGCCG GCCTGCCGTC GCTCCACAAC 
CGCACCGTAC TGGGGGTCTT CTTTGGCTAC CATGTTCTTT CCGACGTGGT GAGCGTGGAA 
ACGCCCGGTT GCCCCGCCGA GTTCCTCAAC ATCCGCATCC CACCTGGAGA CCCCGTGTTC 
GACCCCGACC AGCGCGGGGA CGTGGTGCTG CCCTTCCAGA GGAGCCGCTG GGACCCCGAG 
ACCGGACGGA GTCCCAGCAA CCCCCGGGAC CTGGCCAACC AGGTGACGGG CTGGCTGGAC 
GGCAGCGCCA TCTATGGCTC CTCGCACTCC TGGAGCGACG CGCTGCGGAG CTTCTCGGGG 
GGACAGCTGG CGTCGGGGCC CGACCCCGCT TTCCCCCGAG ACTCGCAGAA CCCCCTGCTC 
ATGTGGGCGG CGCCCGACCC CGCCACCGGG CAGAACGGGC CCCGGGGGCT GTACGCCTTC 
GGGGCAGAGA GAGGGAACCG GGAACCCTTC CTGCAGGCGC TGGGCCTGCT CTGGTTCCGC 
TACCACAACC TGTGGGCGCA GAGGCTGGCC CGCCAGCACC CAGACTGGGA GGACGAGGAG 
CTGTTCCAGC ACGCACGCAA GAGGGTCATC GCCACCTACC AGAACATCGC TGTGTATGAG 
TGGCTGCCCA GCTTCCTGCA GAAAACACTC CCGGAGTATA CAGGATACCG TCCTTTCCTA 
GACCCCAGCA TCTCCCCGGA ATTTGTGGTG GCCTCTGAGC AGTTCTTCTC TACCATGGTG 
CCCCCTGGTG TCTACATGAG AAATGCCAGC TGTCATTTCC GGAAGGTCCT GAACAAGGGT 
TTTCAAAGCT CCCAAGCTCT CAGGGTCTGC AACAACTACT GGATTCGGGA GAACCCCAAT 
CTGAACAGTA CCCAGGAGGT GAATGAGCTG CTGCTGGGAA TGGCCTCCCA GATTTCGGAG 
TTGGAGGACA ACATAGTGGT TGAAGATCTG AGGGATTACT GGCCTGGCCC TGGCAAATTC 
TCCCGTACAG ACTATGTGGC CAGCAGCATC CAACGTGGCC GAGATATGGG GCTGCCCAGC 
TATAGCCAGG CCCTGCTGGC CTTTGGGCTG GACATCCCAA GGAACTGGAG TGATCTCAAC 
CCTAATGTGG ACCCCCAGGT GCTGGAGGCC ACAGCTGCCC TGTACAACCA GGACCTATCC 
CAGCTAGAGC TGCTCCTTGG GGGGCTCCTG GAGAGCCATG GGGACCCTGG ACCCCTGTTC 
AGTGCCATTG TCCTCGACCA GTTTGTACGG CTGCGGGATG GTGACCGCTA CTGGTTTGAG 
AACACCAGGA ATGGGCTGTT CTCCAAGAAG GAGATTGAAG ACATCCGAAA TACCACCCTG 
CGGGACGTGC TGGTCGCTGT TATCAACATT GACCCCAGTG CCCTGCAGCC CAATGTCTTT 
GTCTGGCATA AAGGTGCACC CTGCCCTCAA CCTAAGCAGC TCACAACTGA CGGCCTGCCC 
CAGTGTGCAC CCCTGACTGT GCTTGACTTC TTTGAAGGCA GCAGCCCTGG TTTTGCCATC 
ACCATCATTG CTCTCTGCTG CCTTCCCTTA GTGAGTCTGC TTCTCTCTGG AGTGGTGGCC 
TATTTCCGGG GCCGAGAACA CAAGAAGCTA CAAAAGAAAC TCAAAGAGAG CGTGAAGAAG 
GAAGCAGCCA AAGATGGAGT GCCAGCGATG GAGTGGCCAG GCCCCAAGGA GAGGAGCAGT 
CCCATCATCA TCCAGCTGCT GTCAGACAGG TGTCTGCAGG TCCTGAACAG GCATCTCACT 
GTGCTCCGTG TGGTCCAGCT GCAGCCTCTG CAGCAGGTCA ACCTCATCCT GTCCAACAAC 
CGAGGATGCC GCACCCTGCT GCTCAAGATC CCTAAGGAGT ATGACCTGGT GCTGCTGTTT 
AGTTCTGAAG AGGAACGGGG CGCCTTTGTG CAGCAGCTAT GGGACTTCTG CGTGCGCTGG 
GCTCTGGGCC TCCATGTGGC TGAGATGAGC GAGAAGGAGC TATTTAGGAA GGCTGTGACA 
AAGCAGCAGC GGGAACGCAT CCTGGAGATC TTCTTCAGAC ACCTTTTTGC TCAGGTGCTG 
GACATCAACC AGGCCGACGC AGGGACCCTG CCCCTGGACT CCTCCCAGAA GGTGCGGGAG 
GCCCTGACCT GCGAGCTGAG CAGGGCCGAG TTTGCCGAGT CCCTGGGCCT CAAGCCCCAG 
GACATGTTTG TGGAGTCCAT GTTCTCTCTG GCTGACAAGG ATGGCAATGG CTACCTGTCC 
TTCCGAGAGT TCCTGGACAT CCTGGTGGTC TTCATGAAAG GCTCCCCAGA GGATAAGTCC 
CGTCTAATGT TTACCATGTA TGACCTGGAT GAGAATGGCT TCCTCTCCAA GGACGAATTC 
TTCACCATGA TGCGATCCTT CATCGAGATC TCCAACAACT GCCTGTCCAA GGCCCAGCTG 
GCCGAGGTGG TGGAGTCTAT GTTCCGGGAG TCGGGATTCC AGGACAAGGA GGAGCTGACA 
TGGGAGGATT TTCACTTCAT GCTGCGGGAC CATGACAGCG AGCTCCGCTT CACGCAGCTC 
TGTGTCAAAG GTGGAGGTGG AGGTGGAAAT GGTATTAGAG ATATCTTTAA ACAAAACATC 
AGCTGTCGAG TCTCGTTCAT CACTCGGACA CCTGGGGAGC GCTCCCACCC CCAGGGACTG 
GGGCCCCCTG CCCCAGAAGC CCCAGAGCTG GGAGGCCCTG GACTGAAGAA GAGGTTTGGC 
AAAAAGGCAG CAGTGCCCAC TCCCCGGCTG TACACAGAGG CGCTGCAAGA GAAGATGCAG 
CGAGGCTTCC TAGCCCAAAA GCTGCAGCAG TACAAGCGCT TCGTGGAGAA CTACCGGAGG 
CACATCGTGT GTGTGGCAAT CTTCTCGGCC ATCTGTGTTG GCGTGTTTGC AGATCGTGCT 
TACTACTATG GCTTTGCCTC GCCACCCTCG GACATTGCAC AGACCACCCT CGTGGGCATC 
ATCCTGTCAC GAGGCACGGC GGCCAGCGTC TCCTTCATGT TCTCTTATAT CTTGCTCACC 
ATGTGCCGCA ACCTCATAAC CTTCCTGCGA GAGACTTTCC TCAACCGCTA TGTGCCTTTT 
GATGCCGCAG TGGACTTCCA CCGCTGGATC GCCATGGCTG CTGTTGTCCT GGCCATTTTG 
CACAGTGCTG GCCACGCAGT CAATGTCTAC ATCTTCTCAG TCAGCCCACT CAGCCTGCTG 
GCCTGCATAT TCCCCAACGT CTTTGTGAAT GATGGGTCCA AGCTTCCCCA GAAGTTCTAT 
TGGTGGTTCT TCCAGACCGT CCCAGGTATG ACAGGTGTGC TTCTGCTCCT GGTCCTGGCC 
ATCATGTATG TCTTCGCCTC CCACCACTTC CGCCGCCGCA GCTTCCGGGG CTTCTGGCTG 
ACCCACCACC TCTACATCCT GCTCTATGCC CTGCTCATCA TCCATGGCAG CTATGCTCTG 
ATCCAGCTGC CCACTTTCCA CATCTACTTC CTGGTCCCGG CAATCATCTA TGGAGGTGAC 
AAGCTGGTGA GCCTGAGCCG GAAGAAGGTG GAGATCAGCG TGGTGAAGGC GGAGCTGCTG 
CCCTCAGGAG TGACCTACCT GCAATTCCAG AGGCCCCAAG GCTTTGAGTA CAAGTCAGGA 
CAGTGGGTGC GGATCGCCTG CCTGGCTCTG GGGACCACCG AGTACCACCC CTTCACACTG 
ACCTCCGCGC CCCATGAGGA CACACTCAGC CTGCACATCC GGGCAGTGGG GCCCTGGACC 
ACTCGCCTCA GGGAGATCTA CTCATCCCCA AAGGGCAATG GCTGTGCTGG ATACCCAAAG 
CTGTACCTTG ATGGACCGTT TGGAGAGGGC CATCAGGAGT GGCATAAATT TGAGGTGTCA 
GTGTTGGTGG GAGGGGGCAT TGGGGTCACC CCCTTTGCCT CCATCCTCAA AGACCTGGTC 
TTCAAGTCAT CCTTGGGCAG CCAAATGCTG TGTAAGAAGA TCTACTTCAT CTGGGTGACA 
CGGACCCAGC GTCAGTTTGA GTGGCTGGCT GACATCATCC AAGAGGTGGA GGAGAACGAC 
CACCAGGACC TGGTGTCTGT GCACATTTAT GTCACCCAGC TGGCTGAGAA GTTCGACCTC 
AGGACCACCA TGCTATACAT CTGCGAGCGG CACTTCCAGA AAGTGCTGAA CCGGAGTCTG 
TTCACGGGCC TGCGCTCCAT CACCCACTTT GGCCGTCCCC CCTTCGAGCC CTTCTTCAAC 
TCCCTGCAGG AGGTCCACCC ACAGGTGCGC AAGATCGGGG TGTTCAGCTG CGGCCCTCCA 
GGAATGACCA AGAATGTAGA GAAGGCCTGT CAGCTCGTCA ACAGGCAGGA CCGAGCCCAC 
TTCATGCACC ACTATGAGAA CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054799.4
CDS	204..4850
Translation	MLRARPEALMLLGALLTGSLGPSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVETPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLSQLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTLRDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAITIIALCCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSSPIIIQLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLFSSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVLDINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNISCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQRGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAILHSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEENDHQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF

Target ORF information:

RefSeq Version	NM_014080.4
Organism	Homo sapiens(human)
Definition	Homo sapiens dual oxidase 2 (DUOX2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014080.4

ORF Insert Sequence:

ATGCTCCGTG CAAGACCAGA GGCACTGATG CTCCTGGGAG CTCTTCTGAC TGGATCCCTG 
GGTCCATCGG GCAATCAGGA CGCACTCTCA CTGCCCTGGG AAGTGCAGCG CTATGACGGC 
TGGTTTAACA ACCTGAGGCA CCACGAGCGT GGTGCTGTTG GCTGCCGGTT GCAGCGCCGC 
GTACCAGCCA ATTACGCCGA CGGTGTGTAT CAGGCTCTGG AGGAGCCGCA GCTGCCCAAC 
CCGCGCCGGC TCAGCAACGC AGCCACGCGG GGCATAGCCG GCCTGCCGTC GCTCCACAAC 
CGCACCGTAC TGGGGGTCTT CTTTGGCTAC CATGTTCTTT CCGACGTGGT GAGCGTGGAA 
ACGCCCGGTT GCCCCGCCGA GTTCCTCAAC ATCCGCATCC CACCTGGAGA CCCCGTGTTC 
GACCCCGACC AGCGCGGGGA CGTGGTGCTG CCCTTCCAGA GGAGCCGCTG GGACCCCGAG 
ACCGGACGGA GTCCCAGCAA CCCCCGGGAC CTGGCCAACC AGGTGACGGG CTGGCTGGAC 
GGCAGCGCCA TCTATGGCTC CTCGCACTCC TGGAGCGACG CGCTGCGGAG CTTCTCGGGG 
GGACAGCTGG CGTCGGGGCC CGACCCCGCT TTCCCCCGAG ACTCGCAGAA CCCCCTGCTC 
ATGTGGGCGG CGCCCGACCC CGCCACCGGG CAGAACGGGC CCCGGGGGCT GTACGCCTTC 
GGGGCAGAGA GAGGGAACCG GGAACCCTTC CTGCAGGCGC TGGGCCTGCT CTGGTTCCGC 
TACCACAACC TGTGGGCGCA GAGGCTGGCC CGCCAGCACC CAGACTGGGA GGACGAGGAG 
CTGTTCCAGC ACGCACGCAA GAGGGTCATC GCCACCTACC AGAACATCGC TGTGTATGAG 
TGGCTGCCCA GCTTCCTGCA GAAAACACTC CCGGAGTATA CAGGATACCG TCCTTTCCTA 
GACCCCAGCA TCTCCCCGGA ATTTGTGGTG GCCTCTGAGC AGTTCTTCTC TACCATGGTG 
CCCCCTGGTG TCTACATGAG AAATGCCAGC TGTCATTTCC GGAAGGTCCT GAACAAGGGT 
TTTCAAAGCT CCCAAGCTCT CAGGGTCTGC AACAACTACT GGATTCGGGA GAACCCCAAT 
CTGAACAGTA CCCAGGAGGT GAATGAGCTG CTGCTGGGAA TGGCCTCCCA GATTTCGGAG 
TTGGAGGACA ACATAGTGGT TGAAGATCTG AGGGATTACT GGCCTGGCCC TGGCAAATTC 
TCCCGTACAG ACTATGTGGC CAGCAGCATC CAACGTGGCC GAGATATGGG GCTGCCCAGC 
TATAGCCAGG CCCTGCTGGC CTTTGGGCTG GACATCCCAA GGAACTGGAG TGATCTCAAC 
CCTAATGTGG ACCCCCAGGT GCTGGAGGCC ACAGCTGCCC TGTACAACCA GGACCTATCC 
CAGCTAGAGC TGCTCCTTGG GGGGCTCCTG GAGAGCCATG GGGACCCTGG ACCCCTGTTC 
AGTGCCATTG TCCTCGACCA GTTTGTACGG CTGCGGGATG GTGACCGCTA CTGGTTTGAG 
AACACCAGGA ATGGGCTGTT CTCCAAGAAG GAGATTGAAG ACATCCGAAA TACCACCCTG 
CGGGACGTGC TGGTCGCTGT TATCAACATT GACCCCAGTG CCCTGCAGCC CAATGTCTTT 
GTCTGGCATA AAGGTGCACC CTGCCCTCAA CCTAAGCAGC TCACAACTGA CGGCCTGCCC 
CAGTGTGCAC CCCTGACTGT GCTTGACTTC TTTGAAGGCA GCAGCCCTGG TTTTGCCATC 
ACCATCATTG CTCTCTGCTG CCTTCCCTTA GTGAGTCTGC TTCTCTCTGG AGTGGTGGCC 
TATTTCCGGG GCCGAGAACA CAAGAAGCTA CAAAAGAAAC TCAAAGAGAG CGTGAAGAAG 
GAAGCAGCCA AAGATGGAGT GCCAGCGATG GAGTGGCCAG GCCCCAAGGA GAGGAGCAGT 
CCCATCATCA TCCAGCTGCT GTCAGACAGG TGTCTGCAGG TCCTGAACAG GCATCTCACT 
GTGCTCCGTG TGGTCCAGCT GCAGCCTCTG CAGCAGGTCA ACCTCATCCT GTCCAACAAC 
CGAGGATGCC GCACCCTGCT GCTCAAGATC CCTAAGGAGT ATGACCTGGT GCTGCTGTTT 
AGTTCTGAAG AGGAACGGGG CGCCTTTGTG CAGCAGCTAT GGGACTTCTG CGTGCGCTGG 
GCTCTGGGCC TCCATGTGGC TGAGATGAGC GAGAAGGAGC TATTTAGGAA GGCTGTGACA 
AAGCAGCAGC GGGAACGCAT CCTGGAGATC TTCTTCAGAC ACCTTTTTGC TCAGGTGCTG 
GACATCAACC AGGCCGACGC AGGGACCCTG CCCCTGGACT CCTCCCAGAA GGTGCGGGAG 
GCCCTGACCT GCGAGCTGAG CAGGGCCGAG TTTGCCGAGT CCCTGGGCCT CAAGCCCCAG 
GACATGTTTG TGGAGTCCAT GTTCTCTCTG GCTGACAAGG ATGGCAATGG CTACCTGTCC 
TTCCGAGAGT TCCTGGACAT CCTGGTGGTC TTCATGAAAG GCTCCCCAGA GGATAAGTCC 
CGTCTAATGT TTACCATGTA TGACCTGGAT GAGAATGGCT TCCTCTCCAA GGACGAATTC 
TTCACCATGA TGCGATCCTT CATCGAGATC TCCAACAACT GCCTGTCCAA GGCCCAGCTG 
GCCGAGGTGG TGGAGTCTAT GTTCCGGGAG TCGGGATTCC AGGACAAGGA GGAGCTGACA 
TGGGAGGATT TTCACTTCAT GCTGCGGGAC CATGACAGCG AGCTCCGCTT CACGCAGCTC 
TGTGTCAAAG GTGGAGGTGG AGGTGGAAAT GGTATTAGAG ATATCTTTAA ACAAAACATC 
AGCTGTCGAG TCTCGTTCAT CACTCGGACA CCTGGGGAGC GCTCCCACCC CCAGGGACTG 
GGGCCCCCTG CCCCAGAAGC CCCAGAGCTG GGAGGCCCTG GACTGAAGAA GAGGTTTGGC 
AAAAAGGCAG CAGTGCCCAC TCCCCGGCTG TACACAGAGG CGCTGCAAGA GAAGATGCAG 
CGAGGCTTCC TAGCCCAAAA GCTGCAGCAG TACAAGCGCT TCGTGGAGAA CTACCGGAGG 
CACATCGTGT GTGTGGCAAT CTTCTCGGCC ATCTGTGTTG GCGTGTTTGC AGATCGTGCT 
TACTACTATG GCTTTGCCTC GCCACCCTCG GACATTGCAC AGACCACCCT CGTGGGCATC 
ATCCTGTCAC GAGGCACGGC GGCCAGCGTC TCCTTCATGT TCTCTTATAT CTTGCTCACC 
ATGTGCCGCA ACCTCATAAC CTTCCTGCGA GAGACTTTCC TCAACCGCTA TGTGCCTTTT 
GATGCCGCAG TGGACTTCCA CCGCTGGATC GCCATGGCTG CTGTTGTCCT GGCCATTTTG 
CACAGTGCTG GCCACGCAGT CAATGTCTAC ATCTTCTCAG TCAGCCCACT CAGCCTGCTG 
GCCTGCATAT TCCCCAACGT CTTTGTGAAT GATGGGTCCA AGCTTCCCCA GAAGTTCTAT 
TGGTGGTTCT TCCAGACCGT CCCAGGTATG ACAGGTGTGC TTCTGCTCCT GGTCCTGGCC 
ATCATGTATG TCTTCGCCTC CCACCACTTC CGCCGCCGCA GCTTCCGGGG CTTCTGGCTG 
ACCCACCACC TCTACATCCT GCTCTATGCC CTGCTCATCA TCCATGGCAG CTATGCTCTG 
ATCCAGCTGC CCACTTTCCA CATCTACTTC CTGGTCCCGG CAATCATCTA TGGAGGTGAC 
AAGCTGGTGA GCCTGAGCCG GAAGAAGGTG GAGATCAGCG TGGTGAAGGC GGAGCTGCTG 
CCCTCAGGAG TGACCTACCT GCAATTCCAG AGGCCCCAAG GCTTTGAGTA CAAGTCAGGA 
CAGTGGGTGC GGATCGCCTG CCTGGCTCTG GGGACCACCG AGTACCACCC CTTCACACTG 
ACCTCCGCGC CCCATGAGGA CACACTCAGC CTGCACATCC GGGCAGTGGG GCCCTGGACC 
ACTCGCCTCA GGGAGATCTA CTCATCCCCA AAGGGCAATG GCTGTGCTGG ATACCCAAAG 
CTGTACCTTG ATGGACCGTT TGGAGAGGGC CATCAGGAGT GGCATAAATT TGAGGTGTCA 
GTGTTGGTGG GAGGGGGCAT TGGGGTCACC CCCTTTGCCT CCATCCTCAA AGACCTGGTC 
TTCAAGTCAT CCTTGGGCAG CCAAATGCTG TGTAAGAAGA TCTACTTCAT CTGGGTGACA 
CGGACCCAGC GTCAGTTTGA GTGGCTGGCT GACATCATCC AAGAGGTGGA GGAGAACGAC 
CACCAGGACC TGGTGTCTGT GCACATTTAT GTCACCCAGC TGGCTGAGAA GTTCGACCTC 
AGGACCACCA TGCTATACAT CTGCGAGCGG CACTTCCAGA AAGTGCTGAA CCGGAGTCTG 
TTCACGGGCC TGCGCTCCAT CACCCACTTT GGCCGTCCCC CCTTCGAGCC CTTCTTCAAC 
TCCCTGCAGG AGGTCCACCC ACAGGTGCGC AAGATCGGGG TGTTCAGCTG CGGCCCTCCA 
GGAATGACCA AGAATGTAGA GAAGGCCTGT CAGCTCGTCA ACAGGCAGGA CCGAGCCCAC 
TTCATGCACC ACTATGAGAA CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DUOX2 ( NM_001363711.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001350640.1 Homo sapiens dual oxidase 2 (DUOX2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu48347
Clone ID Related Accession (Same CDS sequence)	NM_001363711.1 , XM_005254421.2 , NM_001363711.2
Accession Version	NM_001363711.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4647bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-26
Organism	Homo sapiens(human)
Product	dual oxidase 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC091117.5. On May 29, 2018 this sequence version replaced XM_005254421.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF267981.1, AF230496.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGCTCCGTG CAAGACCAGA GGCACTGATG CTCCTGGGAG CTCTTCTGAC TGGATCCCTG 
GGTCCATCGG GCAGTCAGGA CGCACTCTCA CTGCCCTGGG AAGTGCAGCG CTATGACGGC 
TGGTTTAACA ACCTGAGGCA CCACGAGCGT GGTGCTGTTG GCTGCCGGTT GCAGCGCCGC 
GTACCAGCCA ATTACGCCGA CGGTGTGTAT CAGGCTCTGG AGGAGCCGCA GCTGCCCAAC 
CCGCGCCGGC TCAGCAACGC AGCCACGCGG GGCATAGCCG GCCTGCCGTC GCTCCACAAC 
CGCACCGTAC TGGGGGTCTT CTTTGGCTAC CATGTTCTTT CCGACGTGGT GAGCGTGGAA 
ACGCCCGGTT GCCCCGCCGA GTTCCTCAAC ATCCGCATCC CACCTGGAGA CCCCGTGTTC 
GACCCCGACC AGCGCGGGGA CGTGGTGCTG CCCTTCCAGA GGAGCCGCTG GGACCCCGAG 
ACCGGACGGA GTCCCAGCAA CCCCCGGGAC CTGGCCAACC AGGTGACGGG CTGGCTGGAC 
GGCAGCGCCA TCTATGGCTC CTCGCACTCC TGGAGCGACG CGCTGCGGAG CTTCTCGGGG 
GGACAGCTGG CGTCGGGGCC CGACCCCGCT TTCCCCCGAG ACTCGCAGAA CCCCCTGCTC 
ATGTGGGCGG CGCCCGACCC CGCCACCGGG CAGAACGGGC CCCGGGGGCT GTACGCCTTC 
GGGGCAGAGA GAGGGAACCG GGAACCCTTC CTGCAGGCGC TGGGCCTGCT CTGGTTCCGC 
TACCACAACC TGTGGGCGCA GAGGCTGGCC CGCCAGCACC CAGACTGGGA GGACGAGGAG 
CTGTTCCAGC ACGCACGCAA GAGGGTCATC GCCACCTACC AGAACATCGC TGTGTATGAG 
TGGCTGCCCA GCTTCCTGCA GAAAACACTC CCGGAGTATA CAGGATACCG TCCTTTCCTA 
GACCCCAGCA TCTCCCCGGA ATTTGTGGTG GCCTCTGAGC AGTTCTTCTC TACCATGGTG 
CCCCCTGGTG TCTACATGAG AAATGCCAGC TGTCATTTCC GGAAGGTCCT GAACAAGGGT 
TTTCAAAGCT CCCAAGCTCT CAGGGTCTGC AACAACTACT GGATTCGGGA GAACCCCAAT 
CTGAACAGTA CCCAGGAGGT GAATGAGCTG CTGCTGGGAA TGGCCTCCCA GATTTCGGAG 
TTGGAGGACA ACATAGTGGT TGAAGATCTG AGGGATTACT GGCCTGGCCC TGGCAAATTC 
TCCCGTACAG ACTATGTGGC CAGCAGCATC CAACGTGGCC GAGATATGGG GCTGCCCAGC 
TATAGCCAGG CCCTGCTGGC CTTTGGGCTG GACATCCCAA GGAACTGGAG TGATCTCAAC 
CCTAATGTGG ACCCCCAGGT GCTGGAGGCC ACAGCTGCCC TGTACAACCA GGACCTATCC 
CAGCTAGAGC TGCTCCTTGG GGGGCTCCTG GAGAGCCATG GGGACCCTGG ACCCCTGTTC 
AGTGCCATTG TCCTCGACCA GTTTGTACGG CTGCGGGATG GTGACCGCTA CTGGTTTGAG 
AACACCAGGA ATGGGCTGTT CTCCAAGAAG GAGATTGAAG ACATCCGAAA TACCACCCTG 
CGGGACGTGC TGGTCGCTGT TATCAACATT GACCCCAGTG CCCTGCAGCC CAATGTCTTT 
GTCTGGCATA AAGGTGCACC CTGCCCTCAA CCTAAGCAGC TCACAACTGA CGGCCTGCCC 
CAGTGTGCAC CCCTGACTGT GCTTGACTTC TTTGAAGGCA GCAGCCCTGG TTTTGCCATC 
ACCATCATTG CTCTCTGCTG CCTTCCCTTA GTGAGTCTGC TTCTCTCTGG AGTGGTGGCC 
TATTTCCGGG GCCGAGAACA CAAGAAGCTA CAAAAGAAAC TCAAAGAGAG CGTGAAGAAG 
GAAGCAGCCA AAGATGGAGT GCCAGCGATG GAGTGGCCAG GCCCCAAGGA GAGGAGCAGT 
CCCATCATCA TCCAGCTGCT GTCAGACAGG TGTCTGCAGG TCCTGAACAG GCATCTCACT 
GTGCTCCGTG TGGTCCAGCT GCAGCCTCTG CAGCAGGTCA ACCTCATCCT GTCCAACAAC 
CGAGGATGCC GCACCCTGCT GCTCAAGATC CCTAAGGAGT ATGACCTGGT GCTGCTGTTT 
AGTTCTGAAG AGGAACGGGG CGCCTTTGTG CAGCAGCTAT GGGACTTCTG CGTGCGCTGG 
GCTCTGGGCC TCCATGTGGC TGAGATGAGC GAGAAGGAGC TATTTAGGAA GGCTGTGACA 
AAGCAGCAGC GGGAACGCAT CCTGGAGATC TTCTTCAGAC ACCTTTTTGC TCAGGTGCTG 
GACATCAACC AGGCCGACGC AGGGACCCTG CCCCTGGACT CCTCCCAGAA GGTGCGGGAG 
GCCCTGACCT GCGAGCTGAG CAGGGCCGAG TTTGCCGAGT CCCTGGGCCT CAAGCCCCAG 
GACATGTTTG TGGAGTCCAT GTTCTCTCTG GCTGACAAGG ATGGCAATGG CTACCTGTCC 
TTCCGAGAGT TCCTGGACAT CCTGGTGGTC TTCATGAAAG GCTCCCCAGA GGATAAGTCC 
CGTCTAATGT TTACCATGTA TGACCTGGAT GAGAATGGCT TCCTCTCCAA GGACGAATTC 
TTCACCATGA TGCGATCCTT CATCGAGATC TCCAACAACT GCCTGTCCAA GGCCCAGCTG 
GCCGAGGTGG TGGAGTCTAT GTTCCGGGAG TCGGGATTCC AGGACAAGGA GGAGCTGACA 
TGGGAGGATT TTCACTTCAT GCTGCGGGAC CATGACAGCG AGCTCCGCTT CACGCAGCTC 
TGTGTCAAAG GTGGAGGTGG AGGTGGAAAT GGTATTAGAG ATATCTTTAA ACAAAACATC 
AGCTGTCGAG TCTCGTTCAT CACTCGGACA CCTGGGGAGC GCTCCCACCC CCAGGGACTG 
GGGCCCCCTG CCCCAGAAGC CCCAGAGCTG GGAGGCCCTG GACTGAAGAA GAGGTTTGGC 
AAAAAGGCAG CAGTGCCCAC TCCCCGGCTG TACACAGAGG CGCTGCAAGA GAAGATGCAG 
CGAGGCTTCC TAGCCCAAAA GCTGCAGCAG TACAAGCGCT TCGTGGAGAA CTACCGGAGG 
CACATCGTGT GTGTGGCAAT CTTCTCGGCC ATCTGTGTTG GCGTGTTTGC AGATCGTGCT 
TACTACTATG GCTTTGCCTC GCCACCCTCG GACATTGCAC AGACCACCCT CGTGGGCATC 
ATCCTGTCAC GAGGCACGGC GGCCAGCGTC TCCTTCATGT TCTCTTATAT CTTGCTCACC 
ATGTGCCGCA ACCTCATAAC CTTCCTGCGA GAGACTTTCC TCAACCGCTA TGTGCCTTTT 
GATGCCGCAG TGGACTTCCA CCGCTGGATC GCCATGGCTG CTGTTGTCCT GGCCATTTTG 
CACAGTGCTG GCCACGCAGT CAATGTCTAC ATCTTCTCAG TCAGCCCACT CAGCCTGCTG 
GCCTGCATAT TCCCCAACGT CTTTGTGAAT GATGGGTCCA AGCTTCCCCA GAAGTTCTAT 
TGGTGGTTCT TCCAGACCGT CCCAGGTATG ACAGGTGTGC TTCTGCTCCT GGTCCTGGCC 
ATCATGTATG TCTTCGCCTC CCACCACTTC CGCCGCCGCA GCTTCCGGGG CTTCTGGCTG 
ACCCACCACC TCTACATCCT GCTCTATGCC CTGCTCATCA TCCATGGCAG CTATGCTCTG 
ATCCAGCTGC CCACTTTCCA CATCTACTTC CTGGTCCCGG CAATCATCTA TGGAGGTGAC 
AAGCTGGTGA GCCTGAGCCG GAAGAAGGTG GAGATCAGCG TGGTGAAGGC GGAGCTGCTG 
CCCTCAGGAG TGACCTACCT GCAATTCCAG AGGCCCCAAG GCTTTGAGTA CAAGTCAGGA 
CAGTGGGTGC GGATCGCCTG CCTGGCTCTG GGGACCACCG AGTACCACCC CTTCACACTG 
ACCTCCGCGC CCCATGAGGA CACACTCAGC CTGCACATCC GGGCAGTGGG GCCCTGGACC 
ACTCGCCTCA GGGAGATCTA CTCATCCCCA AAGGGCAATG GCTGTGCTGG ATACCCAAAG 
CTGTACCTTG ATGGACCGTT TGGAGAGGGC CATCAGGAGT GGCATAAATT TGAGGTGTCA 
GTGTTGGTGG GAGGGGGCAT TGGGGTCACC CCCTTTGCCT CCATCCTCAA AGACCTGGTC 
TTCAAGTCAT CCTTGGGCAG CCAAATGCTG TGTAAGAAGA TCTACTTCAT CTGGGTGACA 
CGGACCCAGC GTCAGTTTGA GTGGCTGGCT GACATCATCC AAGAGGTGGA GGAGAACGAC 
CACCAGGACC TGGTGTCTGT GCACATTTAT GTCACCCAGC TGGCTGAGAA GTTCGACCTC 
AGGACCACCA TGCTATACAT CTGCGAGCGG CACTTCCAGA AAGTGCTGAA CCGGAGTCTG 
TTCACGGGCC TGCGCTCCAT CACCCACTTT GGCCGTCCCC CCTTCGAGCC CTTCTTCAAC 
TCCCTGCAGG AGGTCCACCC ACAGGTGCGC AAGATCGGGG TGTTCAGCTG CGGCCCTCCA 
GGAATGACCA AGAATGTAGA GAAGGCCTGT CAGCTCGTCA ACAGGCAGGA CCGAGCCCAC 
TTCATGCACC ACTATGAGAA CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350640.1
CDS	204..4850
Translation	MLRARPEALMLLGALLTGSLGPSGSQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVETPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLSQLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTLRDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAITIIALCCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSSPIIIQLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLFSSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVLDINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNISCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQRGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAILHSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEENDHQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF

Target ORF information:

RefSeq Version	NM_001363711.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dual oxidase 2 (DUOX2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363711.1

ORF Insert Sequence:

ATGCTCCGTG CAAGACCAGA GGCACTGATG CTCCTGGGAG CTCTTCTGAC TGGATCCCTG 
GGTCCATCGG GCAGTCAGGA CGCACTCTCA CTGCCCTGGG AAGTGCAGCG CTATGACGGC 
TGGTTTAACA ACCTGAGGCA CCACGAGCGT GGTGCTGTTG GCTGCCGGTT GCAGCGCCGC 
GTACCAGCCA ATTACGCCGA CGGTGTGTAT CAGGCTCTGG AGGAGCCGCA GCTGCCCAAC 
CCGCGCCGGC TCAGCAACGC AGCCACGCGG GGCATAGCCG GCCTGCCGTC GCTCCACAAC 
CGCACCGTAC TGGGGGTCTT CTTTGGCTAC CATGTTCTTT CCGACGTGGT GAGCGTGGAA 
ACGCCCGGTT GCCCCGCCGA GTTCCTCAAC ATCCGCATCC CACCTGGAGA CCCCGTGTTC 
GACCCCGACC AGCGCGGGGA CGTGGTGCTG CCCTTCCAGA GGAGCCGCTG GGACCCCGAG 
ACCGGACGGA GTCCCAGCAA CCCCCGGGAC CTGGCCAACC AGGTGACGGG CTGGCTGGAC 
GGCAGCGCCA TCTATGGCTC CTCGCACTCC TGGAGCGACG CGCTGCGGAG CTTCTCGGGG 
GGACAGCTGG CGTCGGGGCC CGACCCCGCT TTCCCCCGAG ACTCGCAGAA CCCCCTGCTC 
ATGTGGGCGG CGCCCGACCC CGCCACCGGG CAGAACGGGC CCCGGGGGCT GTACGCCTTC 
GGGGCAGAGA GAGGGAACCG GGAACCCTTC CTGCAGGCGC TGGGCCTGCT CTGGTTCCGC 
TACCACAACC TGTGGGCGCA GAGGCTGGCC CGCCAGCACC CAGACTGGGA GGACGAGGAG 
CTGTTCCAGC ACGCACGCAA GAGGGTCATC GCCACCTACC AGAACATCGC TGTGTATGAG 
TGGCTGCCCA GCTTCCTGCA GAAAACACTC CCGGAGTATA CAGGATACCG TCCTTTCCTA 
GACCCCAGCA TCTCCCCGGA ATTTGTGGTG GCCTCTGAGC AGTTCTTCTC TACCATGGTG 
CCCCCTGGTG TCTACATGAG AAATGCCAGC TGTCATTTCC GGAAGGTCCT GAACAAGGGT 
TTTCAAAGCT CCCAAGCTCT CAGGGTCTGC AACAACTACT GGATTCGGGA GAACCCCAAT 
CTGAACAGTA CCCAGGAGGT GAATGAGCTG CTGCTGGGAA TGGCCTCCCA GATTTCGGAG 
TTGGAGGACA ACATAGTGGT TGAAGATCTG AGGGATTACT GGCCTGGCCC TGGCAAATTC 
TCCCGTACAG ACTATGTGGC CAGCAGCATC CAACGTGGCC GAGATATGGG GCTGCCCAGC 
TATAGCCAGG CCCTGCTGGC CTTTGGGCTG GACATCCCAA GGAACTGGAG TGATCTCAAC 
CCTAATGTGG ACCCCCAGGT GCTGGAGGCC ACAGCTGCCC TGTACAACCA GGACCTATCC 
CAGCTAGAGC TGCTCCTTGG GGGGCTCCTG GAGAGCCATG GGGACCCTGG ACCCCTGTTC 
AGTGCCATTG TCCTCGACCA GTTTGTACGG CTGCGGGATG GTGACCGCTA CTGGTTTGAG 
AACACCAGGA ATGGGCTGTT CTCCAAGAAG GAGATTGAAG ACATCCGAAA TACCACCCTG 
CGGGACGTGC TGGTCGCTGT TATCAACATT GACCCCAGTG CCCTGCAGCC CAATGTCTTT 
GTCTGGCATA AAGGTGCACC CTGCCCTCAA CCTAAGCAGC TCACAACTGA CGGCCTGCCC 
CAGTGTGCAC CCCTGACTGT GCTTGACTTC TTTGAAGGCA GCAGCCCTGG TTTTGCCATC 
ACCATCATTG CTCTCTGCTG CCTTCCCTTA GTGAGTCTGC TTCTCTCTGG AGTGGTGGCC 
TATTTCCGGG GCCGAGAACA CAAGAAGCTA CAAAAGAAAC TCAAAGAGAG CGTGAAGAAG 
GAAGCAGCCA AAGATGGAGT GCCAGCGATG GAGTGGCCAG GCCCCAAGGA GAGGAGCAGT 
CCCATCATCA TCCAGCTGCT GTCAGACAGG TGTCTGCAGG TCCTGAACAG GCATCTCACT 
GTGCTCCGTG TGGTCCAGCT GCAGCCTCTG CAGCAGGTCA ACCTCATCCT GTCCAACAAC 
CGAGGATGCC GCACCCTGCT GCTCAAGATC CCTAAGGAGT ATGACCTGGT GCTGCTGTTT 
AGTTCTGAAG AGGAACGGGG CGCCTTTGTG CAGCAGCTAT GGGACTTCTG CGTGCGCTGG 
GCTCTGGGCC TCCATGTGGC TGAGATGAGC GAGAAGGAGC TATTTAGGAA GGCTGTGACA 
AAGCAGCAGC GGGAACGCAT CCTGGAGATC TTCTTCAGAC ACCTTTTTGC TCAGGTGCTG 
GACATCAACC AGGCCGACGC AGGGACCCTG CCCCTGGACT CCTCCCAGAA GGTGCGGGAG 
GCCCTGACCT GCGAGCTGAG CAGGGCCGAG TTTGCCGAGT CCCTGGGCCT CAAGCCCCAG 
GACATGTTTG TGGAGTCCAT GTTCTCTCTG GCTGACAAGG ATGGCAATGG CTACCTGTCC 
TTCCGAGAGT TCCTGGACAT CCTGGTGGTC TTCATGAAAG GCTCCCCAGA GGATAAGTCC 
CGTCTAATGT TTACCATGTA TGACCTGGAT GAGAATGGCT TCCTCTCCAA GGACGAATTC 
TTCACCATGA TGCGATCCTT CATCGAGATC TCCAACAACT GCCTGTCCAA GGCCCAGCTG 
GCCGAGGTGG TGGAGTCTAT GTTCCGGGAG TCGGGATTCC AGGACAAGGA GGAGCTGACA 
TGGGAGGATT TTCACTTCAT GCTGCGGGAC CATGACAGCG AGCTCCGCTT CACGCAGCTC 
TGTGTCAAAG GTGGAGGTGG AGGTGGAAAT GGTATTAGAG ATATCTTTAA ACAAAACATC 
AGCTGTCGAG TCTCGTTCAT CACTCGGACA CCTGGGGAGC GCTCCCACCC CCAGGGACTG 
GGGCCCCCTG CCCCAGAAGC CCCAGAGCTG GGAGGCCCTG GACTGAAGAA GAGGTTTGGC 
AAAAAGGCAG CAGTGCCCAC TCCCCGGCTG TACACAGAGG CGCTGCAAGA GAAGATGCAG 
CGAGGCTTCC TAGCCCAAAA GCTGCAGCAG TACAAGCGCT TCGTGGAGAA CTACCGGAGG 
CACATCGTGT GTGTGGCAAT CTTCTCGGCC ATCTGTGTTG GCGTGTTTGC AGATCGTGCT 
TACTACTATG GCTTTGCCTC GCCACCCTCG GACATTGCAC AGACCACCCT CGTGGGCATC 
ATCCTGTCAC GAGGCACGGC GGCCAGCGTC TCCTTCATGT TCTCTTATAT CTTGCTCACC 
ATGTGCCGCA ACCTCATAAC CTTCCTGCGA GAGACTTTCC TCAACCGCTA TGTGCCTTTT 
GATGCCGCAG TGGACTTCCA CCGCTGGATC GCCATGGCTG CTGTTGTCCT GGCCATTTTG 
CACAGTGCTG GCCACGCAGT CAATGTCTAC ATCTTCTCAG TCAGCCCACT CAGCCTGCTG 
GCCTGCATAT TCCCCAACGT CTTTGTGAAT GATGGGTCCA AGCTTCCCCA GAAGTTCTAT 
TGGTGGTTCT TCCAGACCGT CCCAGGTATG ACAGGTGTGC TTCTGCTCCT GGTCCTGGCC 
ATCATGTATG TCTTCGCCTC CCACCACTTC CGCCGCCGCA GCTTCCGGGG CTTCTGGCTG 
ACCCACCACC TCTACATCCT GCTCTATGCC CTGCTCATCA TCCATGGCAG CTATGCTCTG 
ATCCAGCTGC CCACTTTCCA CATCTACTTC CTGGTCCCGG CAATCATCTA TGGAGGTGAC 
AAGCTGGTGA GCCTGAGCCG GAAGAAGGTG GAGATCAGCG TGGTGAAGGC GGAGCTGCTG 
CCCTCAGGAG TGACCTACCT GCAATTCCAG AGGCCCCAAG GCTTTGAGTA CAAGTCAGGA 
CAGTGGGTGC GGATCGCCTG CCTGGCTCTG GGGACCACCG AGTACCACCC CTTCACACTG 
ACCTCCGCGC CCCATGAGGA CACACTCAGC CTGCACATCC GGGCAGTGGG GCCCTGGACC 
ACTCGCCTCA GGGAGATCTA CTCATCCCCA AAGGGCAATG GCTGTGCTGG ATACCCAAAG 
CTGTACCTTG ATGGACCGTT TGGAGAGGGC CATCAGGAGT GGCATAAATT TGAGGTGTCA 
GTGTTGGTGG GAGGGGGCAT TGGGGTCACC CCCTTTGCCT CCATCCTCAA AGACCTGGTC 
TTCAAGTCAT CCTTGGGCAG CCAAATGCTG TGTAAGAAGA TCTACTTCAT CTGGGTGACA 
CGGACCCAGC GTCAGTTTGA GTGGCTGGCT GACATCATCC AAGAGGTGGA GGAGAACGAC 
CACCAGGACC TGGTGTCTGT GCACATTTAT GTCACCCAGC TGGCTGAGAA GTTCGACCTC 
AGGACCACCA TGCTATACAT CTGCGAGCGG CACTTCCAGA AAGTGCTGAA CCGGAGTCTG 
TTCACGGGCC TGCGCTCCAT CACCCACTTT GGCCGTCCCC CCTTCGAGCC CTTCTTCAAC 
TCCCTGCAGG AGGTCCACCC ACAGGTGCGC AAGATCGGGG TGTTCAGCTG CGGCCCTCCA 
GGAATGACCA AGAATGTAGA GAAGGCCTGT CAGCTCGTCA ACAGGCAGGA CCGAGCCCAC 
TTCATGCACC ACTATGAGAA CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DUOX2 ( NM_001363711.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001350640.1 Homo sapiens dual oxidase 2 (DUOX2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu48347
Clone ID Related Accession (Same CDS sequence)	NM_001363711.1 , XM_005254421.2 , NM_001363711.2
Accession Version	NM_001363711.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4647bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	dual oxidase 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC091117.5. On Jun 2, 2019 this sequence version replaced NM_001363711.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF230496.1, AF267981.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGCTCCGTG CAAGACCAGA GGCACTGATG CTCCTGGGAG CTCTTCTGAC TGGATCCCTG 
GGTCCATCGG GCAGTCAGGA CGCACTCTCA CTGCCCTGGG AAGTGCAGCG CTATGACGGC 
TGGTTTAACA ACCTGAGGCA CCACGAGCGT GGTGCTGTTG GCTGCCGGTT GCAGCGCCGC 
GTACCAGCCA ATTACGCCGA CGGTGTGTAT CAGGCTCTGG AGGAGCCGCA GCTGCCCAAC 
CCGCGCCGGC TCAGCAACGC AGCCACGCGG GGCATAGCCG GCCTGCCGTC GCTCCACAAC 
CGCACCGTAC TGGGGGTCTT CTTTGGCTAC CATGTTCTTT CCGACGTGGT GAGCGTGGAA 
ACGCCCGGTT GCCCCGCCGA GTTCCTCAAC ATCCGCATCC CACCTGGAGA CCCCGTGTTC 
GACCCCGACC AGCGCGGGGA CGTGGTGCTG CCCTTCCAGA GGAGCCGCTG GGACCCCGAG 
ACCGGACGGA GTCCCAGCAA CCCCCGGGAC CTGGCCAACC AGGTGACGGG CTGGCTGGAC 
GGCAGCGCCA TCTATGGCTC CTCGCACTCC TGGAGCGACG CGCTGCGGAG CTTCTCGGGG 
GGACAGCTGG CGTCGGGGCC CGACCCCGCT TTCCCCCGAG ACTCGCAGAA CCCCCTGCTC 
ATGTGGGCGG CGCCCGACCC CGCCACCGGG CAGAACGGGC CCCGGGGGCT GTACGCCTTC 
GGGGCAGAGA GAGGGAACCG GGAACCCTTC CTGCAGGCGC TGGGCCTGCT CTGGTTCCGC 
TACCACAACC TGTGGGCGCA GAGGCTGGCC CGCCAGCACC CAGACTGGGA GGACGAGGAG 
CTGTTCCAGC ACGCACGCAA GAGGGTCATC GCCACCTACC AGAACATCGC TGTGTATGAG 
TGGCTGCCCA GCTTCCTGCA GAAAACACTC CCGGAGTATA CAGGATACCG TCCTTTCCTA 
GACCCCAGCA TCTCCCCGGA ATTTGTGGTG GCCTCTGAGC AGTTCTTCTC TACCATGGTG 
CCCCCTGGTG TCTACATGAG AAATGCCAGC TGTCATTTCC GGAAGGTCCT GAACAAGGGT 
TTTCAAAGCT CCCAAGCTCT CAGGGTCTGC AACAACTACT GGATTCGGGA GAACCCCAAT 
CTGAACAGTA CCCAGGAGGT GAATGAGCTG CTGCTGGGAA TGGCCTCCCA GATTTCGGAG 
TTGGAGGACA ACATAGTGGT TGAAGATCTG AGGGATTACT GGCCTGGCCC TGGCAAATTC 
TCCCGTACAG ACTATGTGGC CAGCAGCATC CAACGTGGCC GAGATATGGG GCTGCCCAGC 
TATAGCCAGG CCCTGCTGGC CTTTGGGCTG GACATCCCAA GGAACTGGAG TGATCTCAAC 
CCTAATGTGG ACCCCCAGGT GCTGGAGGCC ACAGCTGCCC TGTACAACCA GGACCTATCC 
CAGCTAGAGC TGCTCCTTGG GGGGCTCCTG GAGAGCCATG GGGACCCTGG ACCCCTGTTC 
AGTGCCATTG TCCTCGACCA GTTTGTACGG CTGCGGGATG GTGACCGCTA CTGGTTTGAG 
AACACCAGGA ATGGGCTGTT CTCCAAGAAG GAGATTGAAG ACATCCGAAA TACCACCCTG 
CGGGACGTGC TGGTCGCTGT TATCAACATT GACCCCAGTG CCCTGCAGCC CAATGTCTTT 
GTCTGGCATA AAGGTGCACC CTGCCCTCAA CCTAAGCAGC TCACAACTGA CGGCCTGCCC 
CAGTGTGCAC CCCTGACTGT GCTTGACTTC TTTGAAGGCA GCAGCCCTGG TTTTGCCATC 
ACCATCATTG CTCTCTGCTG CCTTCCCTTA GTGAGTCTGC TTCTCTCTGG AGTGGTGGCC 
TATTTCCGGG GCCGAGAACA CAAGAAGCTA CAAAAGAAAC TCAAAGAGAG CGTGAAGAAG 
GAAGCAGCCA AAGATGGAGT GCCAGCGATG GAGTGGCCAG GCCCCAAGGA GAGGAGCAGT 
CCCATCATCA TCCAGCTGCT GTCAGACAGG TGTCTGCAGG TCCTGAACAG GCATCTCACT 
GTGCTCCGTG TGGTCCAGCT GCAGCCTCTG CAGCAGGTCA ACCTCATCCT GTCCAACAAC 
CGAGGATGCC GCACCCTGCT GCTCAAGATC CCTAAGGAGT ATGACCTGGT GCTGCTGTTT 
AGTTCTGAAG AGGAACGGGG CGCCTTTGTG CAGCAGCTAT GGGACTTCTG CGTGCGCTGG 
GCTCTGGGCC TCCATGTGGC TGAGATGAGC GAGAAGGAGC TATTTAGGAA GGCTGTGACA 
AAGCAGCAGC GGGAACGCAT CCTGGAGATC TTCTTCAGAC ACCTTTTTGC TCAGGTGCTG 
GACATCAACC AGGCCGACGC AGGGACCCTG CCCCTGGACT CCTCCCAGAA GGTGCGGGAG 
GCCCTGACCT GCGAGCTGAG CAGGGCCGAG TTTGCCGAGT CCCTGGGCCT CAAGCCCCAG 
GACATGTTTG TGGAGTCCAT GTTCTCTCTG GCTGACAAGG ATGGCAATGG CTACCTGTCC 
TTCCGAGAGT TCCTGGACAT CCTGGTGGTC TTCATGAAAG GCTCCCCAGA GGATAAGTCC 
CGTCTAATGT TTACCATGTA TGACCTGGAT GAGAATGGCT TCCTCTCCAA GGACGAATTC 
TTCACCATGA TGCGATCCTT CATCGAGATC TCCAACAACT GCCTGTCCAA GGCCCAGCTG 
GCCGAGGTGG TGGAGTCTAT GTTCCGGGAG TCGGGATTCC AGGACAAGGA GGAGCTGACA 
TGGGAGGATT TTCACTTCAT GCTGCGGGAC CATGACAGCG AGCTCCGCTT CACGCAGCTC 
TGTGTCAAAG GTGGAGGTGG AGGTGGAAAT GGTATTAGAG ATATCTTTAA ACAAAACATC 
AGCTGTCGAG TCTCGTTCAT CACTCGGACA CCTGGGGAGC GCTCCCACCC CCAGGGACTG 
GGGCCCCCTG CCCCAGAAGC CCCAGAGCTG GGAGGCCCTG GACTGAAGAA GAGGTTTGGC 
AAAAAGGCAG CAGTGCCCAC TCCCCGGCTG TACACAGAGG CGCTGCAAGA GAAGATGCAG 
CGAGGCTTCC TAGCCCAAAA GCTGCAGCAG TACAAGCGCT TCGTGGAGAA CTACCGGAGG 
CACATCGTGT GTGTGGCAAT CTTCTCGGCC ATCTGTGTTG GCGTGTTTGC AGATCGTGCT 
TACTACTATG GCTTTGCCTC GCCACCCTCG GACATTGCAC AGACCACCCT CGTGGGCATC 
ATCCTGTCAC GAGGCACGGC GGCCAGCGTC TCCTTCATGT TCTCTTATAT CTTGCTCACC 
ATGTGCCGCA ACCTCATAAC CTTCCTGCGA GAGACTTTCC TCAACCGCTA TGTGCCTTTT 
GATGCCGCAG TGGACTTCCA CCGCTGGATC GCCATGGCTG CTGTTGTCCT GGCCATTTTG 
CACAGTGCTG GCCACGCAGT CAATGTCTAC ATCTTCTCAG TCAGCCCACT CAGCCTGCTG 
GCCTGCATAT TCCCCAACGT CTTTGTGAAT GATGGGTCCA AGCTTCCCCA GAAGTTCTAT 
TGGTGGTTCT TCCAGACCGT CCCAGGTATG ACAGGTGTGC TTCTGCTCCT GGTCCTGGCC 
ATCATGTATG TCTTCGCCTC CCACCACTTC CGCCGCCGCA GCTTCCGGGG CTTCTGGCTG 
ACCCACCACC TCTACATCCT GCTCTATGCC CTGCTCATCA TCCATGGCAG CTATGCTCTG 
ATCCAGCTGC CCACTTTCCA CATCTACTTC CTGGTCCCGG CAATCATCTA TGGAGGTGAC 
AAGCTGGTGA GCCTGAGCCG GAAGAAGGTG GAGATCAGCG TGGTGAAGGC GGAGCTGCTG 
CCCTCAGGAG TGACCTACCT GCAATTCCAG AGGCCCCAAG GCTTTGAGTA CAAGTCAGGA 
CAGTGGGTGC GGATCGCCTG CCTGGCTCTG GGGACCACCG AGTACCACCC CTTCACACTG 
ACCTCCGCGC CCCATGAGGA CACACTCAGC CTGCACATCC GGGCAGTGGG GCCCTGGACC 
ACTCGCCTCA GGGAGATCTA CTCATCCCCA AAGGGCAATG GCTGTGCTGG ATACCCAAAG 
CTGTACCTTG ATGGACCGTT TGGAGAGGGC CATCAGGAGT GGCATAAATT TGAGGTGTCA 
GTGTTGGTGG GAGGGGGCAT TGGGGTCACC CCCTTTGCCT CCATCCTCAA AGACCTGGTC 
TTCAAGTCAT CCTTGGGCAG CCAAATGCTG TGTAAGAAGA TCTACTTCAT CTGGGTGACA 
CGGACCCAGC GTCAGTTTGA GTGGCTGGCT GACATCATCC AAGAGGTGGA GGAGAACGAC 
CACCAGGACC TGGTGTCTGT GCACATTTAT GTCACCCAGC TGGCTGAGAA GTTCGACCTC 
AGGACCACCA TGCTATACAT CTGCGAGCGG CACTTCCAGA AAGTGCTGAA CCGGAGTCTG 
TTCACGGGCC TGCGCTCCAT CACCCACTTT GGCCGTCCCC CCTTCGAGCC CTTCTTCAAC 
TCCCTGCAGG AGGTCCACCC ACAGGTGCGC AAGATCGGGG TGTTCAGCTG CGGCCCTCCA 
GGAATGACCA AGAATGTAGA GAAGGCCTGT CAGCTCGTCA ACAGGCAGGA CCGAGCCCAC 
TTCATGCACC ACTATGAGAA CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001350640.1
CDS	215..4861
Translation	MLRARPEALMLLGALLTGSLGPSGSQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVETPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLSQLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTLRDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAITIIALCCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSSPIIIQLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLFSSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVLDINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNISCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQRGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAILHSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEENDHQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF

Target ORF information:

RefSeq Version	NM_001363711.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dual oxidase 2 (DUOX2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001363711.2

ORF Insert Sequence:

ATGCTCCGTG CAAGACCAGA GGCACTGATG CTCCTGGGAG CTCTTCTGAC TGGATCCCTG 
GGTCCATCGG GCAGTCAGGA CGCACTCTCA CTGCCCTGGG AAGTGCAGCG CTATGACGGC 
TGGTTTAACA ACCTGAGGCA CCACGAGCGT GGTGCTGTTG GCTGCCGGTT GCAGCGCCGC 
GTACCAGCCA ATTACGCCGA CGGTGTGTAT CAGGCTCTGG AGGAGCCGCA GCTGCCCAAC 
CCGCGCCGGC TCAGCAACGC AGCCACGCGG GGCATAGCCG GCCTGCCGTC GCTCCACAAC 
CGCACCGTAC TGGGGGTCTT CTTTGGCTAC CATGTTCTTT CCGACGTGGT GAGCGTGGAA 
ACGCCCGGTT GCCCCGCCGA GTTCCTCAAC ATCCGCATCC CACCTGGAGA CCCCGTGTTC 
GACCCCGACC AGCGCGGGGA CGTGGTGCTG CCCTTCCAGA GGAGCCGCTG GGACCCCGAG 
ACCGGACGGA GTCCCAGCAA CCCCCGGGAC CTGGCCAACC AGGTGACGGG CTGGCTGGAC 
GGCAGCGCCA TCTATGGCTC CTCGCACTCC TGGAGCGACG CGCTGCGGAG CTTCTCGGGG 
GGACAGCTGG CGTCGGGGCC CGACCCCGCT TTCCCCCGAG ACTCGCAGAA CCCCCTGCTC 
ATGTGGGCGG CGCCCGACCC CGCCACCGGG CAGAACGGGC CCCGGGGGCT GTACGCCTTC 
GGGGCAGAGA GAGGGAACCG GGAACCCTTC CTGCAGGCGC TGGGCCTGCT CTGGTTCCGC 
TACCACAACC TGTGGGCGCA GAGGCTGGCC CGCCAGCACC CAGACTGGGA GGACGAGGAG 
CTGTTCCAGC ACGCACGCAA GAGGGTCATC GCCACCTACC AGAACATCGC TGTGTATGAG 
TGGCTGCCCA GCTTCCTGCA GAAAACACTC CCGGAGTATA CAGGATACCG TCCTTTCCTA 
GACCCCAGCA TCTCCCCGGA ATTTGTGGTG GCCTCTGAGC AGTTCTTCTC TACCATGGTG 
CCCCCTGGTG TCTACATGAG AAATGCCAGC TGTCATTTCC GGAAGGTCCT GAACAAGGGT 
TTTCAAAGCT CCCAAGCTCT CAGGGTCTGC AACAACTACT GGATTCGGGA GAACCCCAAT 
CTGAACAGTA CCCAGGAGGT GAATGAGCTG CTGCTGGGAA TGGCCTCCCA GATTTCGGAG 
TTGGAGGACA ACATAGTGGT TGAAGATCTG AGGGATTACT GGCCTGGCCC TGGCAAATTC 
TCCCGTACAG ACTATGTGGC CAGCAGCATC CAACGTGGCC GAGATATGGG GCTGCCCAGC 
TATAGCCAGG CCCTGCTGGC CTTTGGGCTG GACATCCCAA GGAACTGGAG TGATCTCAAC 
CCTAATGTGG ACCCCCAGGT GCTGGAGGCC ACAGCTGCCC TGTACAACCA GGACCTATCC 
CAGCTAGAGC TGCTCCTTGG GGGGCTCCTG GAGAGCCATG GGGACCCTGG ACCCCTGTTC 
AGTGCCATTG TCCTCGACCA GTTTGTACGG CTGCGGGATG GTGACCGCTA CTGGTTTGAG 
AACACCAGGA ATGGGCTGTT CTCCAAGAAG GAGATTGAAG ACATCCGAAA TACCACCCTG 
CGGGACGTGC TGGTCGCTGT TATCAACATT GACCCCAGTG CCCTGCAGCC CAATGTCTTT 
GTCTGGCATA AAGGTGCACC CTGCCCTCAA CCTAAGCAGC TCACAACTGA CGGCCTGCCC 
CAGTGTGCAC CCCTGACTGT GCTTGACTTC TTTGAAGGCA GCAGCCCTGG TTTTGCCATC 
ACCATCATTG CTCTCTGCTG CCTTCCCTTA GTGAGTCTGC TTCTCTCTGG AGTGGTGGCC 
TATTTCCGGG GCCGAGAACA CAAGAAGCTA CAAAAGAAAC TCAAAGAGAG CGTGAAGAAG 
GAAGCAGCCA AAGATGGAGT GCCAGCGATG GAGTGGCCAG GCCCCAAGGA GAGGAGCAGT 
CCCATCATCA TCCAGCTGCT GTCAGACAGG TGTCTGCAGG TCCTGAACAG GCATCTCACT 
GTGCTCCGTG TGGTCCAGCT GCAGCCTCTG CAGCAGGTCA ACCTCATCCT GTCCAACAAC 
CGAGGATGCC GCACCCTGCT GCTCAAGATC CCTAAGGAGT ATGACCTGGT GCTGCTGTTT 
AGTTCTGAAG AGGAACGGGG CGCCTTTGTG CAGCAGCTAT GGGACTTCTG CGTGCGCTGG 
GCTCTGGGCC TCCATGTGGC TGAGATGAGC GAGAAGGAGC TATTTAGGAA GGCTGTGACA 
AAGCAGCAGC GGGAACGCAT CCTGGAGATC TTCTTCAGAC ACCTTTTTGC TCAGGTGCTG 
GACATCAACC AGGCCGACGC AGGGACCCTG CCCCTGGACT CCTCCCAGAA GGTGCGGGAG 
GCCCTGACCT GCGAGCTGAG CAGGGCCGAG TTTGCCGAGT CCCTGGGCCT CAAGCCCCAG 
GACATGTTTG TGGAGTCCAT GTTCTCTCTG GCTGACAAGG ATGGCAATGG CTACCTGTCC 
TTCCGAGAGT TCCTGGACAT CCTGGTGGTC TTCATGAAAG GCTCCCCAGA GGATAAGTCC 
CGTCTAATGT TTACCATGTA TGACCTGGAT GAGAATGGCT TCCTCTCCAA GGACGAATTC 
TTCACCATGA TGCGATCCTT CATCGAGATC TCCAACAACT GCCTGTCCAA GGCCCAGCTG 
GCCGAGGTGG TGGAGTCTAT GTTCCGGGAG TCGGGATTCC AGGACAAGGA GGAGCTGACA 
TGGGAGGATT TTCACTTCAT GCTGCGGGAC CATGACAGCG AGCTCCGCTT CACGCAGCTC 
TGTGTCAAAG GTGGAGGTGG AGGTGGAAAT GGTATTAGAG ATATCTTTAA ACAAAACATC 
AGCTGTCGAG TCTCGTTCAT CACTCGGACA CCTGGGGAGC GCTCCCACCC CCAGGGACTG 
GGGCCCCCTG CCCCAGAAGC CCCAGAGCTG GGAGGCCCTG GACTGAAGAA GAGGTTTGGC 
AAAAAGGCAG CAGTGCCCAC TCCCCGGCTG TACACAGAGG CGCTGCAAGA GAAGATGCAG 
CGAGGCTTCC TAGCCCAAAA GCTGCAGCAG TACAAGCGCT TCGTGGAGAA CTACCGGAGG 
CACATCGTGT GTGTGGCAAT CTTCTCGGCC ATCTGTGTTG GCGTGTTTGC AGATCGTGCT 
TACTACTATG GCTTTGCCTC GCCACCCTCG GACATTGCAC AGACCACCCT CGTGGGCATC 
ATCCTGTCAC GAGGCACGGC GGCCAGCGTC TCCTTCATGT TCTCTTATAT CTTGCTCACC 
ATGTGCCGCA ACCTCATAAC CTTCCTGCGA GAGACTTTCC TCAACCGCTA TGTGCCTTTT 
GATGCCGCAG TGGACTTCCA CCGCTGGATC GCCATGGCTG CTGTTGTCCT GGCCATTTTG 
CACAGTGCTG GCCACGCAGT CAATGTCTAC ATCTTCTCAG TCAGCCCACT CAGCCTGCTG 
GCCTGCATAT TCCCCAACGT CTTTGTGAAT GATGGGTCCA AGCTTCCCCA GAAGTTCTAT 
TGGTGGTTCT TCCAGACCGT CCCAGGTATG ACAGGTGTGC TTCTGCTCCT GGTCCTGGCC 
ATCATGTATG TCTTCGCCTC CCACCACTTC CGCCGCCGCA GCTTCCGGGG CTTCTGGCTG 
ACCCACCACC TCTACATCCT GCTCTATGCC CTGCTCATCA TCCATGGCAG CTATGCTCTG 
ATCCAGCTGC CCACTTTCCA CATCTACTTC CTGGTCCCGG CAATCATCTA TGGAGGTGAC 
AAGCTGGTGA GCCTGAGCCG GAAGAAGGTG GAGATCAGCG TGGTGAAGGC GGAGCTGCTG 
CCCTCAGGAG TGACCTACCT GCAATTCCAG AGGCCCCAAG GCTTTGAGTA CAAGTCAGGA 
CAGTGGGTGC GGATCGCCTG CCTGGCTCTG GGGACCACCG AGTACCACCC CTTCACACTG 
ACCTCCGCGC CCCATGAGGA CACACTCAGC CTGCACATCC GGGCAGTGGG GCCCTGGACC 
ACTCGCCTCA GGGAGATCTA CTCATCCCCA AAGGGCAATG GCTGTGCTGG ATACCCAAAG 
CTGTACCTTG ATGGACCGTT TGGAGAGGGC CATCAGGAGT GGCATAAATT TGAGGTGTCA 
GTGTTGGTGG GAGGGGGCAT TGGGGTCACC CCCTTTGCCT CCATCCTCAA AGACCTGGTC 
TTCAAGTCAT CCTTGGGCAG CCAAATGCTG TGTAAGAAGA TCTACTTCAT CTGGGTGACA 
CGGACCCAGC GTCAGTTTGA GTGGCTGGCT GACATCATCC AAGAGGTGGA GGAGAACGAC 
CACCAGGACC TGGTGTCTGT GCACATTTAT GTCACCCAGC TGGCTGAGAA GTTCGACCTC 
AGGACCACCA TGCTATACAT CTGCGAGCGG CACTTCCAGA AAGTGCTGAA CCGGAGTCTG 
TTCACGGGCC TGCGCTCCAT CACCCACTTT GGCCGTCCCC CCTTCGAGCC CTTCTTCAAC 
TCCCTGCAGG AGGTCCACCC ACAGGTGCGC AAGATCGGGG TGTTCAGCTG CGGCCCTCCA 
GGAATGACCA AGAATGTAGA GAAGGCCTGT CAGCTCGTCA ACAGGCAGGA CCGAGCCCAC 
TTCATGCACC ACTATGAGAA CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DUOX2 ( XM_005254421.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005254478.1 Homo sapiens dual oxidase 2 (DUOX2), transcript variant X1, mRNA.

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CloneID	OHu48347
Clone ID Related Accession (Same CDS sequence)	NM_001363711.1 , XM_005254421.2 , NM_001363711.2
Accession Version	XM_005254421.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4647bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	dual oxidase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 3, 2014 this sequence version replaced XM_005254421.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCCGTG CAAGACCAGA GGCACTGATG CTCCTGGGAG CTCTTCTGAC TGGATCCCTG 
GGTCCATCGG GCAGTCAGGA CGCACTCTCA CTGCCCTGGG AAGTGCAGCG CTATGACGGC 
TGGTTTAACA ACCTGAGGCA CCACGAGCGT GGTGCTGTTG GCTGCCGGTT GCAGCGCCGC 
GTACCAGCCA ATTACGCCGA CGGTGTGTAT CAGGCTCTGG AGGAGCCGCA GCTGCCCAAC 
CCGCGCCGGC TCAGCAACGC AGCCACGCGG GGCATAGCCG GCCTGCCGTC GCTCCACAAC 
CGCACCGTAC TGGGGGTCTT CTTTGGCTAC CATGTTCTTT CCGACGTGGT GAGCGTGGAA 
ACGCCCGGTT GCCCCGCCGA GTTCCTCAAC ATCCGCATCC CACCTGGAGA CCCCGTGTTC 
GACCCCGACC AGCGCGGGGA CGTGGTGCTG CCCTTCCAGA GGAGCCGCTG GGACCCCGAG 
ACCGGACGGA GTCCCAGCAA CCCCCGGGAC CTGGCCAACC AGGTGACGGG CTGGCTGGAC 
GGCAGCGCCA TCTATGGCTC CTCGCACTCC TGGAGCGACG CGCTGCGGAG CTTCTCGGGG 
GGACAGCTGG CGTCGGGGCC CGACCCCGCT TTCCCCCGAG ACTCGCAGAA CCCCCTGCTC 
ATGTGGGCGG CGCCCGACCC CGCCACCGGG CAGAACGGGC CCCGGGGGCT GTACGCCTTC 
GGGGCAGAGA GAGGGAACCG GGAACCCTTC CTGCAGGCGC TGGGCCTGCT CTGGTTCCGC 
TACCACAACC TGTGGGCGCA GAGGCTGGCC CGCCAGCACC CAGACTGGGA GGACGAGGAG 
CTGTTCCAGC ACGCACGCAA GAGGGTCATC GCCACCTACC AGAACATCGC TGTGTATGAG 
TGGCTGCCCA GCTTCCTGCA GAAAACACTC CCGGAGTATA CAGGATACCG TCCTTTCCTA 
GACCCCAGCA TCTCCCCGGA ATTTGTGGTG GCCTCTGAGC AGTTCTTCTC TACCATGGTG 
CCCCCTGGTG TCTACATGAG AAATGCCAGC TGTCATTTCC GGAAGGTCCT GAACAAGGGT 
TTTCAAAGCT CCCAAGCTCT CAGGGTCTGC AACAACTACT GGATTCGGGA GAACCCCAAT 
CTGAACAGTA CCCAGGAGGT GAATGAGCTG CTGCTGGGAA TGGCCTCCCA GATTTCGGAG 
TTGGAGGACA ACATAGTGGT TGAAGATCTG AGGGATTACT GGCCTGGCCC TGGCAAATTC 
TCCCGTACAG ACTATGTGGC CAGCAGCATC CAACGTGGCC GAGATATGGG GCTGCCCAGC 
TATAGCCAGG CCCTGCTGGC CTTTGGGCTG GACATCCCAA GGAACTGGAG TGATCTCAAC 
CCTAATGTGG ACCCCCAGGT GCTGGAGGCC ACAGCTGCCC TGTACAACCA GGACCTATCC 
CAGCTAGAGC TGCTCCTTGG GGGGCTCCTG GAGAGCCATG GGGACCCTGG ACCCCTGTTC 
AGTGCCATTG TCCTCGACCA GTTTGTACGG CTGCGGGATG GTGACCGCTA CTGGTTTGAG 
AACACCAGGA ATGGGCTGTT CTCCAAGAAG GAGATTGAAG ACATCCGAAA TACCACCCTG 
CGGGACGTGC TGGTCGCTGT TATCAACATT GACCCCAGTG CCCTGCAGCC CAATGTCTTT 
GTCTGGCATA AAGGTGCACC CTGCCCTCAA CCTAAGCAGC TCACAACTGA CGGCCTGCCC 
CAGTGTGCAC CCCTGACTGT GCTTGACTTC TTTGAAGGCA GCAGCCCTGG TTTTGCCATC 
ACCATCATTG CTCTCTGCTG CCTTCCCTTA GTGAGTCTGC TTCTCTCTGG AGTGGTGGCC 
TATTTCCGGG GCCGAGAACA CAAGAAGCTA CAAAAGAAAC TCAAAGAGAG CGTGAAGAAG 
GAAGCAGCCA AAGATGGAGT GCCAGCGATG GAGTGGCCAG GCCCCAAGGA GAGGAGCAGT 
CCCATCATCA TCCAGCTGCT GTCAGACAGG TGTCTGCAGG TCCTGAACAG GCATCTCACT 
GTGCTCCGTG TGGTCCAGCT GCAGCCTCTG CAGCAGGTCA ACCTCATCCT GTCCAACAAC 
CGAGGATGCC GCACCCTGCT GCTCAAGATC CCTAAGGAGT ATGACCTGGT GCTGCTGTTT 
AGTTCTGAAG AGGAACGGGG CGCCTTTGTG CAGCAGCTAT GGGACTTCTG CGTGCGCTGG 
GCTCTGGGCC TCCATGTGGC TGAGATGAGC GAGAAGGAGC TATTTAGGAA GGCTGTGACA 
AAGCAGCAGC GGGAACGCAT CCTGGAGATC TTCTTCAGAC ACCTTTTTGC TCAGGTGCTG 
GACATCAACC AGGCCGACGC AGGGACCCTG CCCCTGGACT CCTCCCAGAA GGTGCGGGAG 
GCCCTGACCT GCGAGCTGAG CAGGGCCGAG TTTGCCGAGT CCCTGGGCCT CAAGCCCCAG 
GACATGTTTG TGGAGTCCAT GTTCTCTCTG GCTGACAAGG ATGGCAATGG CTACCTGTCC 
TTCCGAGAGT TCCTGGACAT CCTGGTGGTC TTCATGAAAG GCTCCCCAGA GGATAAGTCC 
CGTCTAATGT TTACCATGTA TGACCTGGAT GAGAATGGCT TCCTCTCCAA GGACGAATTC 
TTCACCATGA TGCGATCCTT CATCGAGATC TCCAACAACT GCCTGTCCAA GGCCCAGCTG 
GCCGAGGTGG TGGAGTCTAT GTTCCGGGAG TCGGGATTCC AGGACAAGGA GGAGCTGACA 
TGGGAGGATT TTCACTTCAT GCTGCGGGAC CATGACAGCG AGCTCCGCTT CACGCAGCTC 
TGTGTCAAAG GTGGAGGTGG AGGTGGAAAT GGTATTAGAG ATATCTTTAA ACAAAACATC 
AGCTGTCGAG TCTCGTTCAT CACTCGGACA CCTGGGGAGC GCTCCCACCC CCAGGGACTG 
GGGCCCCCTG CCCCAGAAGC CCCAGAGCTG GGAGGCCCTG GACTGAAGAA GAGGTTTGGC 
AAAAAGGCAG CAGTGCCCAC TCCCCGGCTG TACACAGAGG CGCTGCAAGA GAAGATGCAG 
CGAGGCTTCC TAGCCCAAAA GCTGCAGCAG TACAAGCGCT TCGTGGAGAA CTACCGGAGG 
CACATCGTGT GTGTGGCAAT CTTCTCGGCC ATCTGTGTTG GCGTGTTTGC AGATCGTGCT 
TACTACTATG GCTTTGCCTC GCCACCCTCG GACATTGCAC AGACCACCCT CGTGGGCATC 
ATCCTGTCAC GAGGCACGGC GGCCAGCGTC TCCTTCATGT TCTCTTATAT CTTGCTCACC 
ATGTGCCGCA ACCTCATAAC CTTCCTGCGA GAGACTTTCC TCAACCGCTA TGTGCCTTTT 
GATGCCGCAG TGGACTTCCA CCGCTGGATC GCCATGGCTG CTGTTGTCCT GGCCATTTTG 
CACAGTGCTG GCCACGCAGT CAATGTCTAC ATCTTCTCAG TCAGCCCACT CAGCCTGCTG 
GCCTGCATAT TCCCCAACGT CTTTGTGAAT GATGGGTCCA AGCTTCCCCA GAAGTTCTAT 
TGGTGGTTCT TCCAGACCGT CCCAGGTATG ACAGGTGTGC TTCTGCTCCT GGTCCTGGCC 
ATCATGTATG TCTTCGCCTC CCACCACTTC CGCCGCCGCA GCTTCCGGGG CTTCTGGCTG 
ACCCACCACC TCTACATCCT GCTCTATGCC CTGCTCATCA TCCATGGCAG CTATGCTCTG 
ATCCAGCTGC CCACTTTCCA CATCTACTTC CTGGTCCCGG CAATCATCTA TGGAGGTGAC 
AAGCTGGTGA GCCTGAGCCG GAAGAAGGTG GAGATCAGCG TGGTGAAGGC GGAGCTGCTG 
CCCTCAGGAG TGACCTACCT GCAATTCCAG AGGCCCCAAG GCTTTGAGTA CAAGTCAGGA 
CAGTGGGTGC GGATCGCCTG CCTGGCTCTG GGGACCACCG AGTACCACCC CTTCACACTG 
ACCTCCGCGC CCCATGAGGA CACACTCAGC CTGCACATCC GGGCAGTGGG GCCCTGGACC 
ACTCGCCTCA GGGAGATCTA CTCATCCCCA AAGGGCAATG GCTGTGCTGG ATACCCAAAG 
CTGTACCTTG ATGGACCGTT TGGAGAGGGC CATCAGGAGT GGCATAAATT TGAGGTGTCA 
GTGTTGGTGG GAGGGGGCAT TGGGGTCACC CCCTTTGCCT CCATCCTCAA AGACCTGGTC 
TTCAAGTCAT CCTTGGGCAG CCAAATGCTG TGTAAGAAGA TCTACTTCAT CTGGGTGACA 
CGGACCCAGC GTCAGTTTGA GTGGCTGGCT GACATCATCC AAGAGGTGGA GGAGAACGAC 
CACCAGGACC TGGTGTCTGT GCACATTTAT GTCACCCAGC TGGCTGAGAA GTTCGACCTC 
AGGACCACCA TGCTATACAT CTGCGAGCGG CACTTCCAGA AAGTGCTGAA CCGGAGTCTG 
TTCACGGGCC TGCGCTCCAT CACCCACTTT GGCCGTCCCC CCTTCGAGCC CTTCTTCAAC 
TCCCTGCAGG AGGTCCACCC ACAGGTGCGC AAGATCGGGG TGTTCAGCTG CGGCCCTCCA 
GGAATGACCA AGAATGTAGA GAAGGCCTGT CAGCTCGTCA ACAGGCAGGA CCGAGCCCAC 
TTCATGCACC ACTATGAGAA CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005254478.1
CDS	204..4850
Translation	MLRARPEALMLLGALLTGSLGPSGSQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLPNPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVSVETPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALRSFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCHFRKVLNKGFQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDNIVVEDLRDYWPGPGKFSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLEATAALYNQDLSQLELLLGGLLESHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGLFSKKEIEDIRNTTLRDVLVAVINIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLDFFEGSSPGFAITIIALCCLPLVSLLLSGVVAYFRGREHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSSPIIIQLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGCRTLLLKIPKEYDLVLLFSSEEERGAFVQQLWDFCVRWALGLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVLDINQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEDKSRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKAQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRFTQLCVKGGGGGGNGIRDIFKQNISCRVSFITRTPGERSHPQGLGPPAPEAPELGGPGLKKRFGKKAAVPTPRLYTEALQEKMQRGFLAQKLQQYKRFVENYRRHIVCVAIFSAICVGVFADRAYYYGFASPPSDIAQTTLVGIILSRGTAASVSFMFSYILLTMCRNLITFLRETFLNRYVPFDAAVDFHRWIAMAAVVLAILHSAGHAVNVYIFSVSPLSLLACIFPNVFVNDGSKLPQKFYWWFFQTVPGMTGVLLLLVLAIMYVFASHHFRRRSFRGFWLTHHLYILLYALLIIHGSYALIQLPTFHIYFLVPAIIYGGDKLVSLSRKKVEISVVKAELLPSGVTYLQFQRPQGFEYKSGQWVRIACLALGTTEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSSPKGNGCAGYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSLGSQMLCKKIYFIWVTRTQRQFEWLADIIQEVEENDHQDLVSVHIYVTQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCGPPGMTKNVEKACQLVNRQDRAHFMHHYENF

Target ORF information:

RefSeq Version	XM_005254421.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dual oxidase 2 (DUOX2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005254421.2

ORF Insert Sequence:

ATGCTCCGTG CAAGACCAGA GGCACTGATG CTCCTGGGAG CTCTTCTGAC TGGATCCCTG 
GGTCCATCGG GCAGTCAGGA CGCACTCTCA CTGCCCTGGG AAGTGCAGCG CTATGACGGC 
TGGTTTAACA ACCTGAGGCA CCACGAGCGT GGTGCTGTTG GCTGCCGGTT GCAGCGCCGC 
GTACCAGCCA ATTACGCCGA CGGTGTGTAT CAGGCTCTGG AGGAGCCGCA GCTGCCCAAC 
CCGCGCCGGC TCAGCAACGC AGCCACGCGG GGCATAGCCG GCCTGCCGTC GCTCCACAAC 
CGCACCGTAC TGGGGGTCTT CTTTGGCTAC CATGTTCTTT CCGACGTGGT GAGCGTGGAA 
ACGCCCGGTT GCCCCGCCGA GTTCCTCAAC ATCCGCATCC CACCTGGAGA CCCCGTGTTC 
GACCCCGACC AGCGCGGGGA CGTGGTGCTG CCCTTCCAGA GGAGCCGCTG GGACCCCGAG 
ACCGGACGGA GTCCCAGCAA CCCCCGGGAC CTGGCCAACC AGGTGACGGG CTGGCTGGAC 
GGCAGCGCCA TCTATGGCTC CTCGCACTCC TGGAGCGACG CGCTGCGGAG CTTCTCGGGG 
GGACAGCTGG CGTCGGGGCC CGACCCCGCT TTCCCCCGAG ACTCGCAGAA CCCCCTGCTC 
ATGTGGGCGG CGCCCGACCC CGCCACCGGG CAGAACGGGC CCCGGGGGCT GTACGCCTTC 
GGGGCAGAGA GAGGGAACCG GGAACCCTTC CTGCAGGCGC TGGGCCTGCT CTGGTTCCGC 
TACCACAACC TGTGGGCGCA GAGGCTGGCC CGCCAGCACC CAGACTGGGA GGACGAGGAG 
CTGTTCCAGC ACGCACGCAA GAGGGTCATC GCCACCTACC AGAACATCGC TGTGTATGAG 
TGGCTGCCCA GCTTCCTGCA GAAAACACTC CCGGAGTATA CAGGATACCG TCCTTTCCTA 
GACCCCAGCA TCTCCCCGGA ATTTGTGGTG GCCTCTGAGC AGTTCTTCTC TACCATGGTG 
CCCCCTGGTG TCTACATGAG AAATGCCAGC TGTCATTTCC GGAAGGTCCT GAACAAGGGT 
TTTCAAAGCT CCCAAGCTCT CAGGGTCTGC AACAACTACT GGATTCGGGA GAACCCCAAT 
CTGAACAGTA CCCAGGAGGT GAATGAGCTG CTGCTGGGAA TGGCCTCCCA GATTTCGGAG 
TTGGAGGACA ACATAGTGGT TGAAGATCTG AGGGATTACT GGCCTGGCCC TGGCAAATTC 
TCCCGTACAG ACTATGTGGC CAGCAGCATC CAACGTGGCC GAGATATGGG GCTGCCCAGC 
TATAGCCAGG CCCTGCTGGC CTTTGGGCTG GACATCCCAA GGAACTGGAG TGATCTCAAC 
CCTAATGTGG ACCCCCAGGT GCTGGAGGCC ACAGCTGCCC TGTACAACCA GGACCTATCC 
CAGCTAGAGC TGCTCCTTGG GGGGCTCCTG GAGAGCCATG GGGACCCTGG ACCCCTGTTC 
AGTGCCATTG TCCTCGACCA GTTTGTACGG CTGCGGGATG GTGACCGCTA CTGGTTTGAG 
AACACCAGGA ATGGGCTGTT CTCCAAGAAG GAGATTGAAG ACATCCGAAA TACCACCCTG 
CGGGACGTGC TGGTCGCTGT TATCAACATT GACCCCAGTG CCCTGCAGCC CAATGTCTTT 
GTCTGGCATA AAGGTGCACC CTGCCCTCAA CCTAAGCAGC TCACAACTGA CGGCCTGCCC 
CAGTGTGCAC CCCTGACTGT GCTTGACTTC TTTGAAGGCA GCAGCCCTGG TTTTGCCATC 
ACCATCATTG CTCTCTGCTG CCTTCCCTTA GTGAGTCTGC TTCTCTCTGG AGTGGTGGCC 
TATTTCCGGG GCCGAGAACA CAAGAAGCTA CAAAAGAAAC TCAAAGAGAG CGTGAAGAAG 
GAAGCAGCCA AAGATGGAGT GCCAGCGATG GAGTGGCCAG GCCCCAAGGA GAGGAGCAGT 
CCCATCATCA TCCAGCTGCT GTCAGACAGG TGTCTGCAGG TCCTGAACAG GCATCTCACT 
GTGCTCCGTG TGGTCCAGCT GCAGCCTCTG CAGCAGGTCA ACCTCATCCT GTCCAACAAC 
CGAGGATGCC GCACCCTGCT GCTCAAGATC CCTAAGGAGT ATGACCTGGT GCTGCTGTTT 
AGTTCTGAAG AGGAACGGGG CGCCTTTGTG CAGCAGCTAT GGGACTTCTG CGTGCGCTGG 
GCTCTGGGCC TCCATGTGGC TGAGATGAGC GAGAAGGAGC TATTTAGGAA GGCTGTGACA 
AAGCAGCAGC GGGAACGCAT CCTGGAGATC TTCTTCAGAC ACCTTTTTGC TCAGGTGCTG 
GACATCAACC AGGCCGACGC AGGGACCCTG CCCCTGGACT CCTCCCAGAA GGTGCGGGAG 
GCCCTGACCT GCGAGCTGAG CAGGGCCGAG TTTGCCGAGT CCCTGGGCCT CAAGCCCCAG 
GACATGTTTG TGGAGTCCAT GTTCTCTCTG GCTGACAAGG ATGGCAATGG CTACCTGTCC 
TTCCGAGAGT TCCTGGACAT CCTGGTGGTC TTCATGAAAG GCTCCCCAGA GGATAAGTCC 
CGTCTAATGT TTACCATGTA TGACCTGGAT GAGAATGGCT TCCTCTCCAA GGACGAATTC 
TTCACCATGA TGCGATCCTT CATCGAGATC TCCAACAACT GCCTGTCCAA GGCCCAGCTG 
GCCGAGGTGG TGGAGTCTAT GTTCCGGGAG TCGGGATTCC AGGACAAGGA GGAGCTGACA 
TGGGAGGATT TTCACTTCAT GCTGCGGGAC CATGACAGCG AGCTCCGCTT CACGCAGCTC 
TGTGTCAAAG GTGGAGGTGG AGGTGGAAAT GGTATTAGAG ATATCTTTAA ACAAAACATC 
AGCTGTCGAG TCTCGTTCAT CACTCGGACA CCTGGGGAGC GCTCCCACCC CCAGGGACTG 
GGGCCCCCTG CCCCAGAAGC CCCAGAGCTG GGAGGCCCTG GACTGAAGAA GAGGTTTGGC 
AAAAAGGCAG CAGTGCCCAC TCCCCGGCTG TACACAGAGG CGCTGCAAGA GAAGATGCAG 
CGAGGCTTCC TAGCCCAAAA GCTGCAGCAG TACAAGCGCT TCGTGGAGAA CTACCGGAGG 
CACATCGTGT GTGTGGCAAT CTTCTCGGCC ATCTGTGTTG GCGTGTTTGC AGATCGTGCT 
TACTACTATG GCTTTGCCTC GCCACCCTCG GACATTGCAC AGACCACCCT CGTGGGCATC 
ATCCTGTCAC GAGGCACGGC GGCCAGCGTC TCCTTCATGT TCTCTTATAT CTTGCTCACC 
ATGTGCCGCA ACCTCATAAC CTTCCTGCGA GAGACTTTCC TCAACCGCTA TGTGCCTTTT 
GATGCCGCAG TGGACTTCCA CCGCTGGATC GCCATGGCTG CTGTTGTCCT GGCCATTTTG 
CACAGTGCTG GCCACGCAGT CAATGTCTAC ATCTTCTCAG TCAGCCCACT CAGCCTGCTG 
GCCTGCATAT TCCCCAACGT CTTTGTGAAT GATGGGTCCA AGCTTCCCCA GAAGTTCTAT 
TGGTGGTTCT TCCAGACCGT CCCAGGTATG ACAGGTGTGC TTCTGCTCCT GGTCCTGGCC 
ATCATGTATG TCTTCGCCTC CCACCACTTC CGCCGCCGCA GCTTCCGGGG CTTCTGGCTG 
ACCCACCACC TCTACATCCT GCTCTATGCC CTGCTCATCA TCCATGGCAG CTATGCTCTG 
ATCCAGCTGC CCACTTTCCA CATCTACTTC CTGGTCCCGG CAATCATCTA TGGAGGTGAC 
AAGCTGGTGA GCCTGAGCCG GAAGAAGGTG GAGATCAGCG TGGTGAAGGC GGAGCTGCTG 
CCCTCAGGAG TGACCTACCT GCAATTCCAG AGGCCCCAAG GCTTTGAGTA CAAGTCAGGA 
CAGTGGGTGC GGATCGCCTG CCTGGCTCTG GGGACCACCG AGTACCACCC CTTCACACTG 
ACCTCCGCGC CCCATGAGGA CACACTCAGC CTGCACATCC GGGCAGTGGG GCCCTGGACC 
ACTCGCCTCA GGGAGATCTA CTCATCCCCA AAGGGCAATG GCTGTGCTGG ATACCCAAAG 
CTGTACCTTG ATGGACCGTT TGGAGAGGGC CATCAGGAGT GGCATAAATT TGAGGTGTCA 
GTGTTGGTGG GAGGGGGCAT TGGGGTCACC CCCTTTGCCT CCATCCTCAA AGACCTGGTC 
TTCAAGTCAT CCTTGGGCAG CCAAATGCTG TGTAAGAAGA TCTACTTCAT CTGGGTGACA 
CGGACCCAGC GTCAGTTTGA GTGGCTGGCT GACATCATCC AAGAGGTGGA GGAGAACGAC 
CACCAGGACC TGGTGTCTGT GCACATTTAT GTCACCCAGC TGGCTGAGAA GTTCGACCTC 
AGGACCACCA TGCTATACAT CTGCGAGCGG CACTTCCAGA AAGTGCTGAA CCGGAGTCTG 
TTCACGGGCC TGCGCTCCAT CACCCACTTT GGCCGTCCCC CCTTCGAGCC CTTCTTCAAC 
TCCCTGCAGG AGGTCCACCC ACAGGTGCGC AAGATCGGGG TGTTCAGCTG CGGCCCTCCA 
GGAATGACCA AGAATGTAGA GAAGGCCTGT CAGCTCGTCA ACAGGCAGGA CCGAGCCCAC 
TTCATGCACC ACTATGAGAA CTTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association between monoallelic
European journal of endocrinology178(2)137-144(2018 Feb)
Abe K,Narumi S,Suwanai AS,Adachi M,Muroya K,Asakura Y,Nagasaki K,Abe T,Hasegawa T

Myocardium of patients with dilated cardiomyopathy presents altered expression of genes involved in thyroid hormone biosynthesis.
PloS one13(1)e0190987(2018)
Gil-Cayuela C,Ortega A,Taraz?n E,Mart?nez-Dolz L,Cinca J,Gonz?lez-Juanatey JR,Lago F,Rosell?-Llet? E,Rivera M,Portol?s M

DUOX2 Mutations Are Associated With Congenital Hypothyroidism With Ectopic Thyroid Gland.
The Journal of clinical endocrinology and metabolism102(11)4060-4071(2017 Nov)
Kizys MML,Louzada RA,Mitne-Neto M,Jara JR,Furuzawa GK,de Carvalho DP,Dias-da-Silva MR,Nesi-Fran?a S,Dupuy C,Maciel RMB

First Identification of Biallelic Inherited DUOX2 Inactivating Mutations as a Cause of Very Early Onset Inflammatory Bowel Disease.
Gastroenterology153(2)609-611.e3(2017 Aug)
Parlato M,Charbit-Henrion F,Hayes P,Tiberti A,Aloi M,Cucchiara S,B?gue B,Bras M,Pouliet A,Rakotobe S,Ruemmele F,Knaus UG,Cerf-Bensussan N

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DUOX2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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