MED31 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MED31
Entrez Gene ID	51003
Full Name	mediator complex subunit 31
Synonyms	3110004H13Rik,CGI-125,Soh1
General protein information	Preferred Names mediator complex subunit 31 Names mediator of RNA polymerase II transcription subunit 31 hSOH1 mediator complex subunit SOH1 mediator of RNA polymerase II transcription, subunit 31 homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_016060.3	NP_057144.1	mediator of RNA polymerase II transcription subunit 31
NM_016060.2	NP_057144.1	mediator of RNA polymerase II transcription subunit 31
XM_017024710.1	XP_016880199.1	mediator of RNA polymerase II transcription subunit 31 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MED31	XP_848597.2
Arabidopsis thaliana (thale cress)	MED31	NP_197491.2
Homo sapiens (human)	MED31	NP_057144.1
	MED31	XP_001103338.2
Rattus norvegicus (Norway rat)	Med31	NP_001129285.1
Oryza sativa (rice)	Os10g0564100	NP_001065408.1
Gallus gallus (chicken)	MED31	XP_415924.1
Danio rerio (zebrafish)	med31	NP_001002417.2
Xenopus tropicalis (tropical clawed frog)	med31	NP_001004826.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002258	XP_307924.5
Oryza sativa (rice)	Os07g0164600	NP_001058961.1
Pan troglodytes (chimpanzee)	MED31	XP_003953012.1
Bos taurus (cattle)	MED31	NP_001071457.1
Mus musculus (house mouse)	Med31	NP_080344.2
Caenorhabditis elegans (roundworm)	mdt-31	NP_001250947.1

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNA-1 functions as a potential tumor suppressor in osteosarcoma by targeting Med1 and Med31.
Jiang C, Chen H, Shao L, Wang Q
Oncology reports32(3)1249-56(2014 Sep)

A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toks?z E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell122(6)957-68(2005 Sep)

A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, B?ssow K, Buessow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H, Wanker EE
Molecular cell15(6)853-65(2004 Sep)

A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.
Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC
Molecular cell14(5)685-91(2004 Jun)

A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.
Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW
The Journal of biological chemistry279(7)5846-51(2004 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that miR-1 is downregulated in osteosarcoma cells but both of its targets Med1 and Med31 were overexpressed suggesting that MiR-1 plays an important role on the proliferation of osteosarcoma cells through regulation of Med1 and Med31.
Title: MicroRNA-1 functions as a potential tumor suppressor in osteosarcoma by targeting Med1 and Med31.

The following MED31 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MED31 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31112	NM_016060.3 Latest version!	Homo sapiens mediator complex subunit 31 (MED31), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu86907	XM_017024710.1 Latest version!	Homo sapiens mediator complex subunit 31 (MED31), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu31112	NM_016060.2	Homo sapiens mediator complex subunit 31 (MED31), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MED31 ( NM_016060.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057144.1 Homo sapiens mediator complex subunit 31 (MED31), mRNA.

Price & Availability↑

CloneID	OHu31112
Clone ID Related Accession (Same CDS sequence)	NM_016060.3 , NM_016060.2
Accession Version	NM_016060.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	mediator of RNA polymerase II transcription subunit 31
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF151883.1 and AC004706.1. On Nov 23, 2018 this sequence version replaced NM_016060.2. ##Evidence-Data-START## Transcript exon combination :: DA511624.1, SRR1660807.55598.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146411, SAMEA2467147 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000225728.8/ ENSP00000225728.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCGCTG CTGTCGCTAT GGAGACAGAT GATGCTGGAA ATCGACTTCG GTTTCAGTTG 
GAGTTGGAAT TTGTGCAATG TTTAGCCAAC CCAAATTACC TTAATTTTCT TGCCCAAAGA 
GGTTACTTCA AAGACAAAGC TTTTGTTAAT TATCTTAAAT ACTTGCTTTA CTGGAAAGAC 
CCAGAATATG CCAAGTATCT AAAGTACCCT CAGTGTTTAC ACATGTTAGA GCTGCTCCAA 
TATGAACACT TCCGAAAGGA GCTGGTGAAT GCTCAGTGTG CGAAATTTAT TGATGAACAG 
CAGATTCTAC ATTGGCAGCA CTATTCCCGG AAGCGGATGC GCCTTCAGCA AGCCTTGGCA 
GAGCAGCAAC AGCAAAATAA CACATCGGGA AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057144.1
CDS	78..473
Translation	MAAAVAMETDDAGNRLRFQLELEFVQCLANPNYLNFLAQRGYFKDKAFVNYLKYLLYWKDPEYAKYLKYPQCLHMLELLQYEHFRKELVNAQCAKFIDEQQILHWQHYSRKRMRLQQALAEQQQQNNTSGK

Target ORF information:

RefSeq Version	NM_016060.3
Organism	Homo sapiens(human)
Definition	Homo sapiens mediator complex subunit 31 (MED31), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016060.3

ORF Insert Sequence:

ATGGCCGCTG CTGTCGCTAT GGAGACAGAT GATGCTGGAA ATCGACTTCG GTTTCAGTTG 
GAGTTGGAAT TTGTGCAATG TTTAGCCAAC CCAAATTACC TTAATTTTCT TGCCCAAAGA 
GGTTACTTCA AAGACAAAGC TTTTGTTAAT TATCTTAAAT ACTTGCTTTA CTGGAAAGAC 
CCAGAATATG CCAAGTATCT AAAGTACCCT CAGTGTTTAC ACATGTTAGA GCTGCTCCAA 
TATGAACACT TCCGAAAGGA GCTGGTGAAT GCTCAGTGTG CGAAATTTAT TGATGAACAG 
CAGATTCTAC ATTGGCAGCA CTATTCCCGG AAGCGGATGC GCCTTCAGCA AGCCTTGGCA 
GAGCAGCAAC AGCAAAATAA CACATCGGGA AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MED31 ( NM_016060.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_057144.1 Homo sapiens mediator complex subunit 31 (MED31), mRNA.

Price & Availability↑

CloneID	OHu31112
Clone ID Related Accession (Same CDS sequence)	NM_016060.3 , NM_016060.2
Accession Version	NM_016060.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-13
Organism	Homo sapiens(human)
Product	mediator of RNA polymerase II transcription subunit 31
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK130946.1, AF151883.1 and AC004706.1. On Jul 25, 2007 this sequence version replaced NM_016060.1. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.71056.1, SRR1803614.93630.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2146411, SAMEA2467147 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGCTG CTGTCGCTAT GGAGACAGAT GATGCTGGAA ATCGACTTCG GTTTCAGTTG 
GAGTTGGAAT TTGTGCAATG TTTAGCCAAC CCAAATTACC TTAATTTTCT TGCCCAAAGA 
GGTTACTTCA AAGACAAAGC TTTTGTTAAT TATCTTAAAT ACTTGCTTTA CTGGAAAGAC 
CCAGAATATG CCAAGTATCT AAAGTACCCT CAGTGTTTAC ACATGTTAGA GCTGCTCCAA 
TATGAACACT TCCGAAAGGA GCTGGTGAAT GCTCAGTGTG CGAAATTTAT TGATGAACAG 
CAGATTCTAC ATTGGCAGCA CTATTCCCGG AAGCGGATGC GCCTTCAGCA AGCCTTGGCA 
GAGCAGCAAC AGCAAAATAA CACATCGGGA AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057144.1
CDS	107..502
Translation	MAAAVAMETDDAGNRLRFQLELEFVQCLANPNYLNFLAQRGYFKDKAFVNYLKYLLYWKDPEYAKYLKYPQCLHMLELLQYEHFRKELVNAQCAKFIDEQQILHWQHYSRKRMRLQQALAEQQQQNNTSGK

Target ORF information:

RefSeq Version	NM_016060.2
Organism	Homo sapiens(human)
Definition	Homo sapiens mediator complex subunit 31 (MED31), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016060.2

ORF Insert Sequence:

ATGGCCGCTG CTGTCGCTAT GGAGACAGAT GATGCTGGAA ATCGACTTCG GTTTCAGTTG 
GAGTTGGAAT TTGTGCAATG TTTAGCCAAC CCAAATTACC TTAATTTTCT TGCCCAAAGA 
GGTTACTTCA AAGACAAAGC TTTTGTTAAT TATCTTAAAT ACTTGCTTTA CTGGAAAGAC 
CCAGAATATG CCAAGTATCT AAAGTACCCT CAGTGTTTAC ACATGTTAGA GCTGCTCCAA 
TATGAACACT TCCGAAAGGA GCTGGTGAAT GCTCAGTGTG CGAAATTTAT TGATGAACAG 
CAGATTCTAC ATTGGCAGCA CTATTCCCGG AAGCGGATGC GCCTTCAGCA AGCCTTGGCA 
GAGCAGCAAC AGCAAAATAA CACATCGGGA AAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MED31 ( XM_017024710.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880199.1 Homo sapiens mediator complex subunit 31 (MED31), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu86907
Clone ID Related Accession (Same CDS sequence)	XM_017024710.1
Accession Version	XM_017024710.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 387bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	mediator of RNA polymerase II transcription subunit 31 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCCTTC GAAGGCTAAA ACACTGGACT CCTGCCCCTC AGGCGCTCCC ACGGCCCGGG 
CCCCGCCCCC TCGCTATTTT GGAGCCAGCG CGGGTGGAGC CATCCCAGGG CTGGTCGGGG 
ATGGGCGGAG CCGCCCCGCC CCATATCCCA CAGTGCCCCG GGACCGGAAG AGGGAGCCGT 
GGTTTCCGGA ACTTCGCCCG CGTCTCTGGG CTTTTGCTCT GTCAGGCTGG TGGCGTTTTG 
GTGTCTTCGT TTGTTATGGC CGCTGCTGTC GCTATGGAGA CAGATGATGC TGGAAATCGA 
CTTCGGTTTC AGTTGGAGTT GGAATTTGTG CAATGTTTAG CCAACCCAAA TTACCTTAAT 
TGTACCCTCA GTGTTTACAC ATGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016880199.1
CDS	22..408
Translation	MVLRRLKHWTPAPQALPRPGPRPLAILEPARVEPSQGWSGMGGAAPPHIPQCPGTGRGSRGFRNFARVSGLLLCQAGGVLVSSFVMAAAVAMETDDAGNRLRFQLELEFVQCLANPNYLNCTLSVYTC

Target ORF information:

RefSeq Version	XM_017024710.1
Organism	Homo sapiens(human)
Definition	Homo sapiens mediator complex subunit 31 (MED31), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017024710.1

ORF Insert Sequence:

ATGGTCCTTC GAAGGCTAAA ACACTGGACT CCTGCCCCTC AGGCGCTCCC ACGGCCCGGG 
CCCCGCCCCC TCGCTATTTT GGAGCCAGCG CGGGTGGAGC CATCCCAGGG CTGGTCGGGG 
ATGGGCGGAG CCGCCCCGCC CCATATCCCA CAGTGCCCCG GGACCGGAAG AGGGAGCCGT 
GGTTTCCGGA ACTTCGCCCG CGTCTCTGGG CTTTTGCTCT GTCAGGCTGG TGGCGTTTTG 
GTGTCTTCGT TTGTTATGGC CGCTGCTGTC GCTATGGAGA CAGATGATGC TGGAAATCGA 
CTTCGGTTTC AGTTGGAGTT GGAATTTGTG CAATGTTTAG CCAACCCAAA TTACCTTAAT 
TGTACCCTCA GTGTTTACAC ATGTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNA-1 functions as a potential tumor suppressor in osteosarcoma by targeting Med1 and Med31.
Oncology reports32(3)1249-56(2014 Sep)
Jiang C,Chen H,Shao L,Wang Q

A human protein-protein interaction network: a resource for annotating the proteome.
Cell122(6)957-68(2005 Sep)
Stelzl U,Worm U,Lalowski M,Haenig C,Brembeck FH,Goehler H,Stroedicke M,Zenkner M,Schoenherr A,Koeppen S,Timm J,Mintzlaff S,Abraham C,Bock N,Kietzmann S,Goedde A,Toks?z E,Droege A,Krobitsch S,Korn B,Birchmeier W,Lehrach H,Wanker EE

A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
Molecular cell15(6)853-65(2004 Sep)
Goehler H,Lalowski M,Stelzl U,Waelter S,Stroedicke M,Worm U,Droege A,Lindenberg KS,Knoblich M,Haenig C,Herbst M,Suopanki J,Scherzinger E,Abraham C,Bauer B,Hasenbank R,Fritzsche A,Ludewig AH,B?ssow K,Buessow K,Coleman SH,Gutekunst CA,Landwehrmeyer BG,Lehrach H,Wanker EE

A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.
Molecular cell14(5)685-91(2004 Jun)
Sato S,Tomomori-Sato C,Parmely TJ,Florens L,Zybailov B,Swanson SK,Banks CA,Jin J,Cai Y,Washburn MP,Conaway JW,Conaway RC

A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2.
The Journal of biological chemistry279(7)5846-51(2004 Feb)
Tomomori-Sato C,Sato S,Parmely TJ,Banks CA,Sorokina I,Florens L,Zybailov B,Washburn MP,Brower CS,Conaway RC,Conaway JW

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MED31 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

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Target ORF information:

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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