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ITM2B cDNA ORF clone, Homo sapiens(Human)

Gene Symbol ITM2B
Entrez Gene ID 9445
Full Name integral membrane protein 2B
Synonyms ABRI,BRI,BRI2,BRICD2B,E25B,E3-16,FBD,RDGCA,imBRI2
General protein information
Preferred Names

integral membrane protein 2B

Names

integral membrane protein 2B
ABri/ADan amyloid peptide
BRICHOS domain containing 2B
immature BRI2
transmembrane protein BRI

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

13

13q14.2

Disorder MIM:

603904

Disorder Html: Dementia, familial British, 176500 (3); Dementia, familial Danish,

mRNA and Protein(s)

mRNA Protein Name
NM_021999.4 NP_068839.1 integral membrane protein 2B



Mus musculus (house mouse) Itm2b NP_032436.1
Danio rerio (zebrafish) itm2ba NP_955940.1
Macaca mulatta (rhesus monkey) ITM2B XP_002800791.1
Bos taurus (cattle) ITM2B NP_001030265.1
Rattus norvegicus (Norway rat) Itm2b NP_001006964.1
Canis lupus familiaris (dog) ITM2B XP_005633935.1
Gallus gallus (chicken) ITM2B NP_990416.1
Homo sapiens (human) ITM2B NP_068839.1
Pan troglodytes (chimpanzee) ITM2B NP_001092017.1
Xenopus tropicalis (tropical clawed frog) itm2b NP_989241.1


Related articles in PubMed

BRI2 and BRI3 are functionally distinct phosphoproteins.
Martins F, Rebelo S, Santos M, Cotrim CZ, da Cruz e Silva EF, da Cruz e Silva OA
Cellular signalling28(1)130-44(2016 Jan)

Oxidative stress and mitochondria-mediated cell death mechanisms triggered by the familial Danish dementia ADan amyloid.
Todd K, Ghiso J, Rostagno A
Neurobiology of disease85130-143(2016 Jan)

Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory.
Biundo F, Ishiwari K, Del Prete D, D'Adamio L
Neurobiology of learning and memory12618-30(2015 Dec)

The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers.
Cantlon A, Frigerio CS, Freir DB, Boland B, Jin M, Walsh DM
The Journal of biological chemistry290(27)16502-16(2015 Jul)

The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases.
Baron BW, Baron RM, Baron JM
Biochimica et biophysica acta1852(5)742-8(2015 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

when BRI2 is phosphorylated a significant increase in neuronal outgrowth and differentiation is evident
Title: BRI2 and BRI3 are functionally distinct phosphoproteins.

familial Danish dementia mutation and pE posttranslational modification are primary elements driving intact ADan into an amyloidogenic/neurotoxic pathway while truncations at the C-terminus eliminate the pro-amyloidogenic characteristics of the molecule
Title: Oxidative stress and mitochondria-mediated cell death mechanisms triggered by the familial Danish dementia ADan amyloid.

Data depict roles for Bri2 and apolipoprotein E4 (ApoE4) proteins in a long-term memory regulation pathway. A single mutation in one Itm2b/Bri2 allele can affect both long-term and working memory, while ApoE4 seems to regulate short-term/working memory.
Title: Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory.

Cystine-linked oligomers of ABri are toxic to neurons and block long-term potentiation.
Title: The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers.

Data indicate integral membrane 2B (ITM2B) as a target of B-cell CLL/lymphoma 6 protein (BCL6) repression in lymphoma.
Title: The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases.

The following ITM2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ITM2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu27275 NM_021999.4
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Homo sapiens integral membrane protein 2B (ITM2B), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
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$199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu27275
Clone ID Related Accession (Same CDS sequence) NM_021999.4
Accession Version NM_021999.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 801bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-12
Organism Homo sapiens(Human)
Product integral membrane protein 2B
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA087198.1, AK130048.1 and AF152462.1. This sequence is a reference standard in the RefSeqGene project. On Jan 24, 2009 this sequence version replaced NM_021999.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF152462.1, SRR1660809.109424.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGTGAAGG TGACGTTCAA CTCCGCTCTG GCCCAGAAGG AGGCCAAGAA GGACGAGCCC 
AAGAGCGGCG AGGAGGCGCT CATCATCCCC CCCGACGCCG TCGCGGTGGA CTGCAAGGAC
CCAGATGATG TGGTACCAGT TGGCCAAAGA AGAGCCTGGT GTTGGTGCAT GTGCTTTGGA
CTAGCATTTA TGCTTGCAGG TGTTATTCTA GGAGGAGCAT ACTTGTACAA ATATTTTGCA
CTTCAACCAG ATGACGTGTA CTACTGTGGA ATAAAGTACA TCAAAGATGA TGTCATCTTA
AATGAGCCCT CTGCAGATGC CCCAGCTGCT CTCTACCAGA CAATTGAAGA AAATATTAAA
ATCTTTGAAG AAGAAGAAGT TGAATTTATC AGTGTGCCTG TCCCAGAGTT TGCAGATAGT
GATCCTGCCA ACATTGTTCA TGACTTTAAC AAGAAACTTA CAGCCTATTT AGATCTTAAC
CTGGATAAGT GCTATGTGAT CCCTCTGAAC ACTTCCATTG TTATGCCACC CAGAAACCTA
CTGGAGTTAC TTATTAACAT CAAGGCTGGA ACCTATTTGC CTCAGTCCTA TCTGATTCAT
GAGCACATGG TTATTACTGA TCGCATTGAA AACATTGATC ACCTGGGTTT CTTTATTTAT
CGACTGTGTC ATGACAAGGA AACTTACAAA CTGCAACGCA GAGAAACTAT TAAAGGTATT
CAGAAACGTG AAGCCAGCAA TTGTTTCGCA ATTCGGCATT TTGAAAACAA ATTTGCCGTG
GAAACTTTAA TTTGTTCTTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_068839.1
CDS224..1024
Misc Feature(1)71..73
Misc Feature(2)386..448
Misc Feature(3)527..625
Misc Feature(4)632..916
Misc Feature(5)950..955
Exon (1)1..340
Exon (2)341..469
Exon (3)470..676
Exon (4)677..787
Exon (5)788..938
Exon (6)939..1896
Translation

Target ORF information:

RefSeq Version NM_021999.4
Organism Homo sapiens(Human)
Definition Homo sapiens integral membrane protein 2B (ITM2B), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_021999.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGTGAAGG TGACGTTCAA CTCCGCTCTG GCCCAGAAGG AGGCCAAGAA GGACGAGCCC 
AAGAGCGGCG AGGAGGCGCT CATCATCCCC CCCGACGCCG TCGCGGTGGA CTGCAAGGAC
CCAGATGATG TGGTACCAGT TGGCCAAAGA AGAGCCTGGT GTTGGTGCAT GTGCTTTGGA
CTAGCATTTA TGCTTGCAGG TGTTATTCTA GGAGGAGCAT ACTTGTACAA ATATTTTGCA
CTTCAACCAG ATGACGTGTA CTACTGTGGA ATAAAGTACA TCAAAGATGA TGTCATCTTA
AATGAGCCCT CTGCAGATGC CCCAGCTGCT CTCTACCAGA CAATTGAAGA AAATATTAAA
ATCTTTGAAG AAGAAGAAGT TGAATTTATC AGTGTGCCTG TCCCAGAGTT TGCAGATAGT
GATCCTGCCA ACATTGTTCA TGACTTTAAC AAGAAACTTA CAGCCTATTT AGATCTTAAC
CTGGATAAGT GCTATGTGAT CCCTCTGAAC ACTTCCATTG TTATGCCACC CAGAAACCTA
CTGGAGTTAC TTATTAACAT CAAGGCTGGA ACCTATTTGC CTCAGTCCTA TCTGATTCAT
GAGCACATGG TTATTACTGA TCGCATTGAA AACATTGATC ACCTGGGTTT CTTTATTTAT
CGACTGTGTC ATGACAAGGA AACTTACAAA CTGCAACGCA GAGAAACTAT TAAAGGTATT
CAGAAACGTG AAGCCAGCAA TTGTTTCGCA ATTCGGCATT TTGAAAACAA ATTTGCCGTG
GAAACTTTAA TTTGTTCTTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

BRI2 and BRI3 are functionally distinct phosphoproteins.
Cellular signalling28(1)130-44(2016 Jan)
Martins F,Rebelo S,Santos M,Cotrim CZ,da Cruz e Silva EF,da Cruz e Silva OA


book

Oxidative stress and mitochondria-mediated cell death mechanisms triggered by the familial Danish dementia ADan amyloid.
Neurobiology of disease85130-143(2016 Jan)
Todd K,Ghiso J,Rostagno A


book

Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory.
Neurobiology of learning and memory12618-30(2015 Dec)
Biundo F,Ishiwari K,Del Prete D,D'Adamio L


book

The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers.
The Journal of biological chemistry290(27)16502-16(2015 Jul)
Cantlon A,Frigerio CS,Freir DB,Boland B,Jin M,Walsh DM


book

The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases.
Biochimica et biophysica acta1852(5)742-8(2015 May)
Baron BW,Baron RM,Baron JM


 
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