Lyz1 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Lyz1
Entrez Gene ID	17110
Full Name	lysozyme 1
Synonyms	Lyz,Lyzf3,Lzp-s
General protein information	Preferred Names lysozyme 1 Names lysozyme C-1 1,4-beta-N-acetylmuramidase C P lysozyme structural lysozyme C type P lysozyme f3 renal amyloidosis
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 D2

mRNA and Protein(s)

mRNA Protein Name

NM_013590.4 NP_038618.1 lysozyme C-1 precursor
Pathways from BioSystems

mRNA	Protein	Name
NM_013590.4	NP_038618.1	lysozyme C-1 precursor

Homologies

Canis lupus familiaris (dog)	LYZ	XP_531672.1
Rattus norvegicus (Norway rat)	Lyz2	NP_036903.2
	LYZ	NP_001095203.1
Gallus gallus (chicken)	LYZ	NP_990612.1
Xenopus tropicalis (tropical clawed frog)	LOC100492798	XP_002938553.1
Pan troglodytes (chimpanzee)	LYZ	NP_001009073.1
Mus musculus (house mouse)	Lyz2	NP_059068.1
Bos taurus (cattle)	LYZ	NP_001071627.1
Mus musculus (house mouse)	Lyz1	NP_038618.1
Homo sapiens (human)	LYZ	NP_000230.1

Gene Ontology
Bibliography

Related articles in PubMed

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.
Mario Gonzalez-Meljem J, Haston S, Carreno G, Apps JR, Pozzi S, Stache C, Kaushal G, Virasami A, Panousopoulos L, Neda Mousavy-Gharavy S, Guerrero A, Rashid M, Jani N, Goding CR, Jacques TS, Adams DJ, Gil J, Andoniadou CL, Pedro Martinez-Barbera J
Nature communications8(1)1819(2017 Nov)

YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme.
Cotton JL, Li Q, Ma L, Park JS, Wang J, Ou J, Zhu LJ, Ip YT, Johnson RL, Mao J
Developmental cell43(1)35-47.e4(2017 10)

Intestinal stem cells contribute to the maturation of the neonatal small intestine and colon independently of digestive activity.
Yanai H, Atsumi N, Tanaka T, Nakamura N, Komai Y, Omachi T, Tanaka K, Ishigaki K, Saiga K, Ohsugi H, Tokuyama Y, Imahashi Y, Ohe S, Hisha H, Yoshida N, Kumano K, Kon M, Ueno H
Scientific reports7(1)9891(2017 Aug)

Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland.
Farmer DT, Nathan S, Finley JK, Shengyang Yu K, Emmerson E, Byrnes LE, Sneddon JB, McManus MT, Tward AD, Knox SM
Development (Cambridge, England)144(13)2517-2528(2017 07)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results show that lysozyme (LYSO) - induced Staphylococcus aureus bacteriostasis increased with increasing concentrations of baicalin, and that baicalin binding to LYSO synergistically increased the antibacterial activity of LYSO.
Title: Baicalin promotes the bacteriostatic activity of lysozyme on S. aureus in mammary glands and neutrophilic granulocytes in mice.

These observations demonstrate that phagocytosis and lysozyme-based cell wall degradation of S. aureus are functionally coupled to NLRP3 inflammasome activation and IL-1beta secretion.
Title: Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion.

These observations demonstrate that phagocytosis and lysozyme-based cell wall degradation of S. aureus are functionally coupled to NLRP3 inflammasome activation and IL-1beta secretion.
Title: Inflammasome activation: how macrophages watch what they eat.

The following Lyz1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lyz1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu09662	NM_013590.4 Latest version!	Mus musculus lysozyme 1 (Lyz1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lyz1 ( NM_013590.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_038618.1 Mus musculus lysozyme 1 (Lyz1), mRNA.

Price & Availability↑

CloneID	OMu09662
Clone ID Related Accession (Same CDS sequence)	NM_013590.4
Accession Version	NM_013590.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 447bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Mus musculus(house mouse)
Product	lysozyme C-1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC061129.1 and CD742179.1. On Apr 11, 2009 this sequence version replaced NM_013590.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC061129.1, BB610427.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377, SAMN00849378 [ECO:0000348] ##Evidence-Data-END##

ATGAAGGCTC TCCTGACTCT GGGACTCCTC CTGCTTTCTG TCACTGCCCA GGCCAAGGTC 
TACAATCGTT GTGAGTTGGC CAGAATTCTG AAAAGGAATG GAATGGATGG CTACCGTGGT 
GTCAAGCTGG CTGACTGGGT GTGTTTAGCT CAGCATGAGA GCAATTATAA CACACGAGCT 
ACAAACTACA ACCGTGGAGA CCGAAGCACC GACTATGGGA TATTTCAGAT CAATAGCCGA 
TACTGGTGTA ATGATGGCAA AACCCCAAGA TCTAAGAATG CCTGTGGGAT CAATTGCAGT 
GCTCTGCTGC AGGATGACAT CACTGCAGCC ATACAATGTG CAAAGAGGGT GGTGAGAGAT 
CCCCAAGGCA TTCGAGCATG GGTGGCATGG CGAACACAAT GTCAAAACCG AGATCTGTCC 
CAGTATATTC GGAACTGCGG AGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_038618.1
CDS	31..477
Translation	MKALLTLGLLLLSVTAQAKVYNRCELARILKRNGMDGYRGVKLADWVCLAQHESNYNTRATNYNRGDRSTDYGIFQINSRYWCNDGKTPRSKNACGINCSALLQDDITAAIQCAKRVVRDPQGIRAWVAWRTQCQNRDLSQYIRNCGV

Target ORF information:

RefSeq Version	NM_013590.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus lysozyme 1 (Lyz1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_013590.4

ORF Insert Sequence:

ATGAAGGCTC TCCTGACTCT GGGACTCCTC CTGCTTTCTG TCACTGCCCA GGCCAAGGTC 
TACAATCGTT GTGAGTTGGC CAGAATTCTG AAAAGGAATG GAATGGATGG CTACCGTGGT 
GTCAAGCTGG CTGACTGGGT GTGTTTAGCT CAGCATGAGA GCAATTATAA CACACGAGCT 
ACAAACTACA ACCGTGGAGA CCGAAGCACC GACTATGGGA TATTTCAGAT CAATAGCCGA 
TACTGGTGTA ATGATGGCAA AACCCCAAGA TCTAAGAATG CCTGTGGGAT CAATTGCAGT 
GCTCTGCTGC AGGATGACAT CACTGCAGCC ATACAATGTG CAAAGAGGGT GGTGAGAGAT 
CCCCAAGGCA TTCGAGCATG GGTGGCATGG CGAACACAAT GTCAAAACCG AGATCTGTCC 
CAGTATATTC GGAACTGCGG AGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma.
Nature communications8(1)1819(2017 Nov)
Mario Gonzalez-Meljem J,Haston S,Carreno G,Apps JR,Pozzi S,Stache C,Kaushal G,Virasami A,Panousopoulos L,Neda Mousavy-Gharavy S,Guerrero A,Rashid M,Jani N,Goding CR,Jacques TS,Adams DJ,Gil J,Andoniadou CL,Pedro Martinez-Barbera J

YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme.
Developmental cell43(1)35-47.e4(2017 10)
Cotton JL,Li Q,Ma L,Park JS,Wang J,Ou J,Zhu LJ,Ip YT,Johnson RL,Mao J

Intestinal stem cells contribute to the maturation of the neonatal small intestine and colon independently of digestive activity.
Scientific reports7(1)9891(2017 Aug)
Yanai H,Atsumi N,Tanaka T,Nakamura N,Komai Y,Omachi T,Tanaka K,Ishigaki K,Saiga K,Ohsugi H,Tokuyama Y,Imahashi Y,Ohe S,Hisha H,Yoshida N,Kumano K,Kon M,Ueno H

Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland.
Development (Cambridge, England)144(13)2517-2528(2017 07)
Farmer DT,Nathan S,Finley JK,Shengyang Yu K,Emmerson E,Byrnes LE,Sneddon JB,McManus MT,Tward AD,Knox SM

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Lyz1 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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