Ptafr cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Ptafr |
| Entrez Gene ID | 19204 |
| Full Name | platelet-activating factor receptor |
| Synonyms | PAFR |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome | |
| Summary | This gene encodes a member of the G-protein coupled receptor 1 family of proteins. Binding of the encoded protein to its phospholipid ligand, platelet-activating factor (PAF), may regulate the inflammatory response and the perception of pain. Homozygous knockout mice for this gene exhibit impaired anaphylactic response, resistance to bacterial infection, and reduced pain-related behavior. [provided by RefSeq, Aug 2015]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001081211.2 | NP_001074680.1 | platelet-activating factor receptor |
| PTAFR | XP_001112942.2 | |
| Canis lupus familiaris (dog) | PTAFR | XP_005617766.1 |
| Rattus norvegicus (Norway rat) | Ptafr | NP_445773.1 |
| Xenopus tropicalis (tropical clawed frog) | ptafr | NP_001008003.1 |
| Homo sapiens (human) | PTAFR | NP_000943.1 |
| Pan troglodytes (chimpanzee) | PTAFR | XP_001151906.1 |
| Bos taurus (cattle) | PTAFR | NP_001035628.1 |
| Mus musculus (house mouse) | Ptafr | NP_001074680.1 |
| Danio rerio (zebrafish) | LOC100002627 | XP_001342372.1 |
| Gallus gallus (chicken) | PTAFR | XP_004947758.1 |
Related articles in PubMed
PAFR-deficiency alleviates myocardial ischemia/reperfusion injury in mice via suppressing inflammation, oxidative stress and apoptosis.
Wang EW, Han YY, Jia XS
Biochemical and biophysical research communications495(4)2475-2481(2018 Jan)
CD36 and Platelet-Activating Factor Receptor Promote House Dust Mite Allergy Development.
Patel PS, Kearney JF
Journal of immunology (Baltimore, Md. : 1950)199(3)1184-1195(2017 Aug)
Loss of PAFR prevents neuroinflammation and brain dysfunction after traumatic brain injury.
Yin XJ, Chen ZY, Zhu XN, Hu JJ
Scientific reports740614(2017 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Results show that CD36 and Platelet-Activating Factor Receptor are important mediators of house dust mites (HDM) allergy development and that inhibiting HDM engagement with phosphorylcholine receptors in the lung protects against allergic airway disease.
Title: CD36 and Platelet-Activating Factor Receptor Promote House Dust Mite Allergy Development.
PAFR null mutant mice showed a better functional recovery in grip and rotarod performances than wild-type mice.
Title: Attenuated Reactive Gliosis and Enhanced Functional Recovery Following Spinal Cord Injury in Null Mutant Mice of Platelet-Activating Factor Receptor.
In the absence of PAFR signalling, monocytes and macrophages acquire a pro-inflammatory phenotype, resulting in adipose tissue inflammation and metabolic dysfunction.
Title: PAFR in adipose tissue macrophages is associated with anti-inflammatory phenotype and metabolic homoeostasis.
Study demonstrated that PAFR has a compelling involvement in Brucella abortus uptake as a promoter of phagocytosis, which is associated with JAK2 signaling activation.
Title: Influence of platelet-activating factor receptor (PAFR) on Brucella abortus infection: implications for manipulating the phagocytic strategy of B. abortus.
Data (including data from studies in knockout mice) suggest that signal transduction via platelet-activating factor (PAF) and PAF receptor is involved in regulation of lipid metabolism/inflammation in liver of mice on high-refined carbohydrate diet.
Title: Platelet-activating factor modulates fat storage in the liver induced by a high-refined carbohydrate-containing diet.
The following Ptafr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ptafr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu22094 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001081211.2 | |
| Accession Version | NM_001081211.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1026bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-09-14 | |
| Organism | Mus musculus(house mouse) | |
| Product | platelet-activating factor receptor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY194666.1, AK032547.1, BY203963.1, CR931794.3 and AA960103.1. On Aug 19, 2015 this sequence version replaced NM_001081211.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK032547.1, BY203963.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGAGCACA ATGGCTCCTT TCGTGTGGAT TCTGAGTTTC GATACACGCT CTTTCCGATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001074680.1 |
| CDS | 255..1280 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001081211.2 |
ORF Insert Sequence:
1 | ATGGAGCACA ATGGCTCCTT TCGTGTGGAT TCTGAGTTTC GATACACGCT CTTTCCGATT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
PAFR-deficiency alleviates myocardial ischemia/reperfusion injury in mice via suppressing inflammation, oxidative stress and apoptosis. |
|
CD36 and Platelet-Activating Factor Receptor Promote House Dust Mite Allergy Development. |
|
Loss of PAFR prevents neuroinflammation and brain dysfunction after traumatic brain injury. |