Gene Symbol | Eif2a |
Entrez Gene ID | 229317 |
Full Name | eukaryotic translation initiation factor 2A |
Synonyms | D030048D22,D3Ertd194e |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Eif2a cDNA ORF clone
gRNAs
Gene Symbol | Eif2a |
Entrez Gene ID | 229317 |
Full Name | eukaryotic translation initiation factor 2A |
Synonyms | D030048D22,D3Ertd194e |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006501321.3 | XP_006501384.1 | eukaryotic translation initiation factor 2A isoform X1 |
NM_001005509.2 | NP_001005509.1 | eukaryotic translation initiation factor 2A |
XM_006501321.4 | XP_006501384.1 | eukaryotic translation initiation factor 2A isoform X1 |
Homo sapiens (human) | EIF2A | NP_114414.2 |
Pan troglodytes (chimpanzee) | EIF2A | XP_001143578.1 |
Canis lupus familiaris (dog) | EIF2A | XP_534306.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002525 | XP_312412.4 |
Caenorhabditis elegans (roundworm) | E04D5.1 | NP_496239.2 |
Schizosaccharomyces pombe (fission yeast) | SPBC4B4.04 | NP_596421.1 |
Bos taurus (cattle) | EIF2A | NP_001095753.1 |
Drosophila melanogaster (fruit fly) | CG7414 | NP_649365.1 |
EIF2A | XP_001108004.2 | |
Mus musculus (house mouse) | Eif2a | NP_001005509.1 |
Saccharomyces cerevisiae (baker's yeast) | YGR054W | NP_011568.3 |
Eremothecium gossypii | AGOS_AEL286C | NP_984574.2 |
Arabidopsis thaliana (thale cress) | AT1G73180 | NP_565058.1 |
Kluyveromyces lactis | KLLA0A02761g | XP_451122.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_00847 | XP_003718132.1 |
Neurospora crassa | NCU06099 | XP_959961.1 |
Xenopus tropicalis (tropical clawed frog) | eif2a | NP_001120561.1 |
Rattus norvegicus (Norway rat) | Eif2a | NP_001102809.1 |
Gallus gallus (chicken) | EIF2A | NP_001026494.1 |
Danio rerio (zebrafish) | eif2a | NP_001020341.1 |
HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF2? ubiquitylation and degradation.
Huang Y, Sun Y, Cao Y, Sun H, Li M, You H, Su D, Li Y, Liang X
Cell death & disease8(12)3202(2017 Dec)
Neuroprotection by eIF2?-CHOP inhibition and XBP-1 activation in EAE/optic neuritiss.
Huang H, Miao L, Liang F, Liu X, Xu L, Teng X, Wang Q, Ridder WH 3rd, Shindler KS, Sun Y, Hu Y
Cell death & disease8(7)e2936(2017 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
results further extended the understanding of Heme-regulated eIF2alpha kinase on the regulation of non-erythroid lineages and might provide new aspects for preventing and treating Cd-induced detrimental effects
Title: A protective role of Heme-regulated eIF2? kinase in cadmium-induced liver and kidney injuries.
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a phosphorylation by inhibiting PPP1CA via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 expression. (eIF2a = eukaryotic initiation factor-2alpha; PPP1CA = protein phosphatase 1 catalytic subunit alpha; Atf4 = activating transcription factor 4)
Title: Hydrogen sulfide modulates eukaryotic translation initiation factor 2? (eIF2?) phosphorylation status in the integrated stress-response pathway.
stress granule formation is a downstream event of eIF2alpha phosphorylation that may not directly protect cells from apoptosis, at least in spermatocytes of seminiferous tubules in early stages.
Title: Importance of eIF2? phosphorylation as a protective mechanism against heat stress in mouse male germ cells.
Results mechanistically link multiple forms of dystonia and put forth a new overall cellular mechanism for dystonia pathogenesis, impairment of eIF2alpha signaling, a pathway known for its roles in cellular stress responses and synaptic plasticity.
Title: Functional Genomic Analyses of Mendelian and Sporadic Disease Identify Impaired eIF2? Signaling as a Generalizable Mechanism for Dystonia.
The eIF2A knock out mice strain is viable and to date displays no apparent phenotype.
Title: The eIF2A knockout mouse.
The following Eif2a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Eif2a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu31804 | |
Clone ID Related Accession (Same CDS sequence) | XM_006501321.3 , XM_006501321.4 | |
Accession Version | XM_006501321.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1569bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | eukaryotic translation initiation factor 2A isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006501321.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACCACC ACACTTCACA GAAAGCACGG TGCTTCCCAG AGAATCTGGA AGAAATTGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006501384.1 |
CDS | 207..1775 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGACCACC ACACTTCACA GAAAGCACGG TGCTTCCCAG AGAATCTGGA AGAAATTGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu18130 | |
Clone ID Related Accession (Same CDS sequence) | NM_001005509.2 | |
Accession Version | NM_001005509.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1746bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | eukaryotic translation initiation factor 2A | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY035972.1 and BC082557.1. On Jun 20, 2009 this sequence version replaced NM_001005509.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC082557.1, AK145275.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCGCCGT CCACACCGCT GTTGACAGTC AGAGGATCAG AGGGACTGTA CATGGTGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001005509.1 |
CDS | 239..1984 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCGCCGT CCACACCGCT GTTGACAGTC AGAGGATCAG AGGGACTGTA CATGGTGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu31804 | |
Clone ID Related Accession (Same CDS sequence) | XM_006501321.3 , XM_006501321.4 | |
Accession Version | XM_006501321.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1569bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | eukaryotic translation initiation factor 2A isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006501321.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACCACC ACACTTCACA GAAAGCACGG TGCTTCCCAG AGAATCTGGA AGAAATTGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006501384.1 |
CDS | 287..1855 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGACCACC ACACTTCACA GAAAGCACGG TGCTTCCCAG AGAATCTGGA AGAAATTGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF2? ubiquitylation and degradation. |
Neuroprotection by eIF2?-CHOP inhibition and XBP-1 activation in EAE/optic neuritiss. |