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Akirin2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Summary

Gene Symbol Akirin2
Entrez Gene ID 297968
Full Name akirin 2
Synonyms FBI1,RGD1307791
General protein information
Preferred Names

akirin 2

Names

akirin-2
fourteen-three-three beta interactant 1
fourteen-three-three beta interacting-protein 1
Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

5

5q21

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_001039914.2 NP_001035003.1 akirin-2
XM_008763614.2 XP_008761836.1 akirin-2 isoform X1

Pathways from BioSystems


Homologies


LOC700914 XP_001089230.1
Gallus gallus (chicken) AKIRIN2 NP_001180524.1
Danio rerio (zebrafish) akirin2 NP_998459.2
Canis lupus familiaris (dog) AKIRIN2 XP_542340.3
Drosophila melanogaster (fruit fly) akirin NP_729249.1
Xenopus tropicalis (tropical clawed frog) akirin2 NP_988914.1
Bos taurus (cattle) AKIRIN2 NP_001103557.1
Mus musculus (house mouse) Akirin2 NP_001007590.2
Anopheles gambiae (African malaria mosquito) AgaP_AGAP006809 XP_308938.4
Homo sapiens (human) AKIRIN2 NP_060534.1
Pan troglodytes (chimpanzee) AKIRIN2 NP_001238836.1
Rattus norvegicus (Norway rat) Akirin2 NP_001035003.1

Gene Ontology


Bibliography

Related articles in PubMed

FBI1/Akirin2 promotes tumorigenicity and metastasis of Lewis lung carcinoma cells.
Komiya Y, Akiyama H, Sakumoto R, Tashiro F
Biochemical and biophysical research communications444(3)382-6(2014 Feb)

A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA
Molecular and cellular biology33(8)1487-502(2013 Apr)

The FBI1/Akirin2 target gene, BCAM, acts as a suppressive oncogene.
Akiyama H, Iwahana Y, Suda M, Yoshimura A, Kogai H, Nagashima A, Ohtsuka H, Komiya Y, Tashiro F
PloS one8(11)e78716(2013)

A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis.
Komiya Y, Kurabe N, Katagiri K, Ogawa M, Sugiyama A, Kawasaki Y, Tashiro F
The Journal of biological chemistry283(27)18753-64(2008 Jul)

Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.
Goto A, Matsushita K, Gesellchen V, El Chamy L, Kuttenkeuler D, Takeuchi O, Hoffmann JA, Akira S, Boutros M, Reichhart JM
Nature immunology9(1)97-104(2008 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Akirin2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Akirin2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa13396 NM_001039914.2
Latest version!		 Rattus norvegicus akirin 2 (Akirin2), mRNA. pcDNA3.1-C-(k)DYK or customized vector TBD $139.30
$199.00
ORa45485 XM_008763614.2
Latest version!		 Rattus norvegicus akirin 2 (Akirin2), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK or customized vector TBD $139.30
$199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone 40% OFF
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30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ORa13396
Clone ID Related Accession (Same CDS sequence) NM_001039914.2
Accession Version NM_001039914.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 606bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-02-16
Organism Rattus norvegicus(Norway rat)
Product akirin-2
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB234867.1. On Feb 23, 2013 this sequence version replaced NM_001039914.1. ##Evidence-Data-START## Transcript exon combination :: AB234867.1, FM074314.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
ATGGCGTGCG GAGCCACTCT GAAAAGGACT CTGGATTTCG ACCCACTGCT TAGCCCGGCA 
TCTCCGAAGC GGAGGCGGTG CGCGCCTTTG TCGGCACCGG CTTCGGCTGC CGCCTCCCCT 
GCCGCCGCTA CCGCCGCCGC CGCTGCCTCT GCCGCGGCCG CTTCGCCGCA GAAGTATCTC 
CGGATGGAGC CTTCCCCCTT CGGCGACGTC TCCTCCCGTC TCACCACAGA ACAAATTCTG 
TACAACATAA AACAGGAATA TAAACGTATG CAGAAGAGGA GACATTTAGA AGCTAGTTTT 
CAGCAGACAG ACCCAGGTTG TAGTTCCGAT TCACAGCCAC ATGCATTTCT CATCAGTGGA 
CCAGCATCAC CAGGGACTTC ATCTGCAACA TCCTCACCAT TAAAAAAAGA ACAGCCCTTA 
TTTACTCTAA GGCAGGTTGG GATGATCTGT GAACGTTTGT TGAAAGAACG GGAAGAGAAG 
GTTCGAGAAG AATATGAAGA AATACTGAAC ACAAAACTTG CAGAACAATA CGATGCATTT 
GTGAAGTTTA CGCATGATCA GATAATGCGG CGATATGGAG AACAGCCTGC TAGTTATGTT 
TCATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001035003.1
CDS199..804
Translation

Target ORF information:

RefSeq Version NM_001039914.2
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus akirin 2 (Akirin2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001039914.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGGCGTGCG GAGCCACTCT GAAAAGGACT CTGGATTTCG ACCCACTGCT TAGCCCGGCA 
TCTCCGAAGC GGAGGCGGTG CGCGCCTTTG TCGGCACCGG CTTCGGCTGC CGCCTCCCCT 
GCCGCCGCTA CCGCCGCCGC CGCTGCCTCT GCCGCGGCCG CTTCGCCGCA GAAGTATCTC 
CGGATGGAGC CTTCCCCCTT CGGCGACGTC TCCTCCCGTC TCACCACAGA ACAAATTCTG 
TACAACATAA AACAGGAATA TAAACGTATG CAGAAGAGGA GACATTTAGA AGCTAGTTTT 
CAGCAGACAG ACCCAGGTTG TAGTTCCGAT TCACAGCCAC ATGCATTTCT CATCAGTGGA 
CCAGCATCAC CAGGGACTTC ATCTGCAACA TCCTCACCAT TAAAAAAAGA ACAGCCCTTA 
TTTACTCTAA GGCAGGTTGG GATGATCTGT GAACGTTTGT TGAAAGAACG GGAAGAGAAG 
GTTCGAGAAG AATATGAAGA AATACTGAAC ACAAAACTTG CAGAACAATA CGATGCATTT 
GTGAAGTTTA CGCATGATCA GATAATGCGG CGATATGGAG AACAGCCTGC TAGTTATGTT 
TCATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa45485
Clone ID Related Accession (Same CDS sequence) XM_008763614.2
Accession Version XM_008763614.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 621bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product akirin-2 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008763614.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
ATGGCGTGCG GAGCCACTCT GAAAAGGACT CTGGATTTCG ACCCACTGCT TAGCCCGGCA 
TCTCCGAAGC GGAGGCGGTG CGCGCCTTTG TCGGCACCGG CTTCGGCTGC CGCCTCCCCT 
GCCGCCGCTA CCGCCGCCGC CGCTGCCTCT GCCGCGGCCG CTTCGCCGCA GAAGTATCTC 
CGGATGGAGC CTTCCCCCTT CGGCGACGTC TCCTCCCGTC TCACCACAGA ACAAATTCTG 
TACAACATAA AACAGGAATA TAAACGTATG CAGAAGAGGA GACATTTAGA AGCTAGTTTT 
CAGCAGACAG ACCCAGGTTG TAGTTCCGAT TCACAGCCAC ATGCATTTCT CATCAGTGGA 
CCAGCATCAC CAGGGACTTC ATCTGCAACA TCCTCACCAT TAAAAAAAGA ACAGCCCTTA 
TTTACTCTAA GGCAGGTTGG GATGATCTGT GAACGTTTGT TGAAAGAACG GGAAGAGAAG 
GTTCGAGAAG AATATGAAGA AATACTGAAC ACAAAACTTG CAGAACAATA CGATGCATTT 
GTGAAGTTTA CGCATGATCA GATAATGCGG CGATATGGAG AACAGCCTGC TAGTTGTAAG 
TATTTGACCT TTGAACTATA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_008761836.1
CDS449..1069
Translation

Target ORF information:

RefSeq Version XM_008763614.2
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus akirin 2 (Akirin2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_008763614.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGGCGTGCG GAGCCACTCT GAAAAGGACT CTGGATTTCG ACCCACTGCT TAGCCCGGCA 
TCTCCGAAGC GGAGGCGGTG CGCGCCTTTG TCGGCACCGG CTTCGGCTGC CGCCTCCCCT 
GCCGCCGCTA CCGCCGCCGC CGCTGCCTCT GCCGCGGCCG CTTCGCCGCA GAAGTATCTC 
CGGATGGAGC CTTCCCCCTT CGGCGACGTC TCCTCCCGTC TCACCACAGA ACAAATTCTG 
TACAACATAA AACAGGAATA TAAACGTATG CAGAAGAGGA GACATTTAGA AGCTAGTTTT 
CAGCAGACAG ACCCAGGTTG TAGTTCCGAT TCACAGCCAC ATGCATTTCT CATCAGTGGA 
CCAGCATCAC CAGGGACTTC ATCTGCAACA TCCTCACCAT TAAAAAAAGA ACAGCCCTTA 
TTTACTCTAA GGCAGGTTGG GATGATCTGT GAACGTTTGT TGAAAGAACG GGAAGAGAAG 
GTTCGAGAAG AATATGAAGA AATACTGAAC ACAAAACTTG CAGAACAATA CGATGCATTT 
GTGAAGTTTA CGCATGATCA GATAATGCGG CGATATGGAG AACAGCCTGC TAGTTGTAAG 
TATTTGACCT TTGAACTATA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

FBI1/Akirin2 promotes tumorigenicity and metastasis of Lewis lung carcinoma cells.
Biochemical and biophysical research communications444(3)382-6(2014 Feb)
Komiya Y,Akiyama H,Sakumoto R,Tashiro F


book

A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.
Molecular and cellular biology33(8)1487-502(2013 Apr)
Armour SM,Bennett EJ,Braun CR,Zhang XY,McMahon SB,Gygi SP,Harper JW,Sinclair DA


book

The FBI1/Akirin2 target gene, BCAM, acts as a suppressive oncogene.
PloS one8(11)e78716(2013)
Akiyama H,Iwahana Y,Suda M,Yoshimura A,Kogai H,Nagashima A,Ohtsuka H,Komiya Y,Tashiro F


book

A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis.
The Journal of biological chemistry283(27)18753-64(2008 Jul)
Komiya Y,Kurabe N,Katagiri K,Ogawa M,Sugiyama A,Kawasaki Y,Tashiro F


book

Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice.
Nature immunology9(1)97-104(2008 Jan)
Goto A,Matsushita K,Gesellchen V,El Chamy L,Kuttenkeuler D,Takeuchi O,Hoffmann JA,Akira S,Boutros M,Reichhart JM


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