Gene Symbol | Fancl |
Entrez Gene ID | 305600 |
Full Name | Fanconi anemia, complementation group L |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Fancl cDNA ORF clone
gRNAs
Gene Symbol | Fancl |
Entrez Gene ID | 305600 |
Full Name | Fanconi anemia, complementation group L |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006251597.3 | XP_006251659.1 | E3 ubiquitin-protein ligase FANCL isoform X1 |
NM_001191684.1 | NP_001178613.1 | E3 ubiquitin-protein ligase FANCL |
Homo sapiens (human) | FANCL | NP_001108108.1 |
Pan troglodytes (chimpanzee) | FANCL | XP_001157414.1 |
Mus musculus (house mouse) | Fancl | NP_080199.1 |
LOC717528 | XP_001115119.2 | |
Rattus norvegicus (Norway rat) | Fancl | NP_001178613.1 |
Oryza sativa (rice) | Os03g0726900 | NP_001051138.1 |
Bos taurus (cattle) | FANCL | NP_001069800.1 |
Xenopus tropicalis (tropical clawed frog) | fancl | NP_001007482.1 |
Canis lupus familiaris (dog) | FANCL | XP_005626177.1 |
Gallus gallus (chicken) | FANCL | NP_001029113.1 |
Danio rerio (zebrafish) | fancl | NP_998147.1 |
Arabidopsis thaliana (thale cress) | AT5G65740 | NP_001032152.1 |
Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection.
Hodson C, Purkiss A, Miles JA, Walden H
Structure (London, England : 1993)22(2)337-44(2014 Feb)
FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway.
Ali AM, Pradhan A, Singh TR, Du C, Li J, Wahengbam K, Grassman E, Auerbach AD, Pang Q, Meetei AR
Blood119(14)3285-94(2012 Apr)
UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2.
Zhang Y, Zhou X, Zhao L, Li C, Zhu H, Xu L, Shan L, Liao X, Guo Z, Huang P
Molecules and cells31(2)113-22(2011 Feb)
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.
Yan Z, Delannoy M, Ling C, Daee D, Osman F, Muniandy PA, Shen X, Oostra AB, Du H, Steltenpool J, Lin T, Schuster B, D?caillet C, Stasiak A, Stasiak AZ, Stone S, Hoatlin ME, Schindler D, Woodcock CL, Joenje H, Sen R, de Winter JP, Li L, Seidman MM, Whitby MC, Myung K, Constantinou A, Wang W
Molecular cell37(6)865-78(2010 Mar)
FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL.
Longerich S, San Filippo J, Liu D, Sung P
The Journal of biological chemistry284(35)23182-6(2009 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following Fancl gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fancl cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa07393 | |
Clone ID Related Accession (Same CDS sequence) | NM_001191684.1 | |
Accession Version | NM_001191684.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1128bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-06-02 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | E3 ubiquitin-protein ligase FANCL | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07016690.1. On Jul 17, 2010 this sequence version replaced XM_223701.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCGGACA CGGAAGCAAA CCTGTTGCGC CATTTCCCGC TGCTGCTTCC TCAGAATCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001178613.1 |
CDS | 3..1130 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGGACA CGGAAGCAAA CCTGTTGCGC CATTTCCCGC TGCTGCTTCC TCAGAATCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa36468 | |
Clone ID Related Accession (Same CDS sequence) | XM_006251597.3 | |
Accession Version | XM_006251597.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1404bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | E3 ubiquitin-protein ligase FANCL isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005113.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006251597.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGTCAGG TTCAGGGTAA AGACAGGATG CTATGGGCAT ACTGTAAAAG CTATGTCAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006251659.1 |
CDS | 442..1845 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGTCAGG TTCAGGGTAA AGACAGGATG CTATGGGCAT ACTGTAAAAG CTATGTCAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection. |
FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway. |
UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2. |
A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. |
FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL. |