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COX6A1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol COX6A1
Entrez Gene ID 1337
Full Name cytochrome c oxidase subunit VIa polypeptide 1
Synonyms CMTRID, COX6A, COX6AL
General protein information
Preferred Names
cytochrome c oxidase subunit 6A1, mitochondrial
Names
cytochrome c oxidase subunit 6A1, mitochondrial
COX VIa-L
cytochrome c oxidase subunit VIA-liver
cytochrome C oxidase subunit VIa homolog
cytochrome c oxidase polypeptide VIa-liver
NP_004364.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q24.2|12q24.2

Summary Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

602072


mRNA and Protein(s)

mRNA Protein Name
NM_004373 NP_004364 cytochrome c oxidase subunit 6A1, mitochondrial



Homo sapiens (human) COX6A1 NP_004364.2
Pan troglodytes (chimpanzee) LOC100616508 XP_003339284.1
Macaca mulatta (Rhesus monkey) LOC696956 XP_002808040.1
Canis lupus familiaris (dog) LOC477508 XP_534704.3
Mus musculus (house mouse) Cox6a1 NP_031774.1
Rattus norvegicus (Norway rat) Cox6a1 NP_036946.1
Gallus gallus (chicken) COX6A1 NP_001264438.1
Danio rerio (zebrafish) cox6a1 NP_001005592.1
Drosophila melanogaster (fruit fly) levy NP_611805.1
Xenopus (Silurana) tropicalis (western clawed frog) cox6a1 NP_001016543.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following COX6A1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX6A1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu55939
NM_004373 Homo sapiens cytochrome c oxidase subunit VIa polypeptide 1 (COX6A1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu55939
Clone ID Related Accession (Same CDS sequence) NM_004373
Accession Version NM_004373.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 330bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product cytochrome c oxidase subunit 6A1, mitochondrial
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK312009.1, BC107861.1 and BP378295.1. This sequence is a reference standard in the RefSeqGene project. On Dec 31, 2011 this sequence version replaced gi:17999527. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: BP378295.1, BP342628.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
ATGGCGGTAG TTGGTGTGTC CTCGGTTTCT CGGCTGCTGG GTCGGTCCCG CCCACAGCTG 
GGGCGGCCTA TGTCGAGTGG CGCCCATGGC GAAGAGGGCT CAGCTCGCAT GTGGAAGACT
CTCACCTTCT TCGTCGCGCT CCCCGGGGTG GCAGTCAGCA TGCTGAATGT GTACCTGAAG
TCGCACCACG GAGAGCACGA GAGACCCGAG TTCATCGCCT ACCCCCATCT CCGCATCAGG
ACCAAGCCGT TTCCCTGGGG AGATGGTAAC CATACTCTAT TCCATAACCC TCATGTGAAT
CCACTTCCAA CTGGCTACGA AGATGAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004364.2
CDS38..367
Misc Feature(1)101..358(+)
Misc Feature(2)107..169(+)
Misc Feature(3)137..337(+)
Misc Feature(4)152..154(+)
Misc Feature(5)251..262(+)
Misc Feature(6)263..289(+)
Exon (1)1..140
Gene:COX6A1
Gene Synonym:
Exon (2)141..283
Gene:COX6A1
Gene Synonym:
Exon (3)284..572
Gene:COX6A1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_004373
Organism Homo sapiens (human)
Definition Homo sapiens cytochrome c oxidase subunit VIa polypeptide 1 (COX6A1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004373

ORF Insert Sequence:

1
61
121
181
241
301
ATGGCGGTAG TTGGTGTGTC CTCGGTTTCT CGGCTGCTGG GTCGGTCCCG CCCACAGCTG 
GGGCGGCCTA TGTCGAGTGG CGCCCATGGC GAAGAGGGCT CAGCTCGCAT GTGGAAGACT
CTCACCTTCT TCGTCGCGCT CCCCGGGGTG GCAGTCAGCA TGCTGAATGT GTACCTGAAG
TCGCACCACG GAGAGCACGA GAGACCCGAG TTCATCGCCT ACCCCCATCT CCGCATCAGG
ACCAAGCCGT TTCCCTGGGG AGATGGTAAC CATACTCTAT TCCATAACCC TCATGTGAAT
CCACTTCCAA CTGGCTACGA AGATGAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 4, 5a, 6a, 7a and 7b
Biochem. J. 428 (3), 363-374 (2010)
Fornuskova D, Stiburek L, Wenchich L, Vinsova K, Hansikova H and Zeman J.


book

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression
PLoS ONE 5 (9), E12862 (2010)
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL and O'Brien SJ.


book

Assembly of nuclear DNA-encoded subunits into mitochondrial complex IV, and their preferential integration into supercomplex forms in patient mitochondria
FEBS J. 276 (22), 6701-6713 (2009)
Lazarou M, Smith SM, Thorburn DR, Ryan MT and McKenzie M.


book

Identification of cytochrome c oxidase subunit 6A1 as a suppressor of Bax-induced cell death by yeast-based functional screening
Biochem. Biophys. Res. Commun. 373 (1), 58-63 (2008)
Eun SY, Woo IS, Jang HS, Jin H, Kim MY, Kim HJ, Lee JH, Chang KC, Kim JH and Seo HG.


book

The finished DNA sequence of human chromosome 12
Nature 440 (7082), 346-351 (2006)
Scherer SE, Muzny DM, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Montgomery KT, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Lovering RC, Wheeler DA, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clerc-Blankenburg KP, Davis C, Delgado O, Dinh HH, Draper H, Gonzalez-Garay ML, Havlak P, Jackson LR, Jacob LS, Kelly SH, Li L, Li Z, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Pasternak S, Perez LM, Plopper FJ, Santibanez J, Shen H, Tabor PE, Verduzco D, Waldron L, Wang Q, Williams GA, Zhang J, Zhou J, Allen CC, Amin AG, Anyalebechi V, Bailey M, Barbaria JA, Bimage KE, Bryant NP, Burch PE, Burkett CE, Burrell KL, Calderon E, Cardenas V, Carter K, Casias K, Cavazos I, Cavazos SR, Ceasar H, Chacko J, Chan SN, Chavez D, Christopoulos C, Chu J, Cockrell R, Cox CD, Dang M, Dathorne SR, David R, Davis CM, Davy-Carroll L, Deshazo DR, Donlin JE, D'Souza L, Eaves KA, Egan A, Emery-Cohen AJ, Escotto M, Flagg N, Forbes LD, Gabisi AM, Garza M, Hamilton C, Henderson N, Hernandez O, Hines S, Hogues ME, Huang M, Idlebird DG, Johnson R, Jolivet A, Jones S, Kagan R, King LM, Leal B, Lebow H, Lee S, LeVan JM, Lewis LC, London P, Lorensuhewa LM, Loulseged H, Lovett DA, Lucier A, Lucier RL, Ma J, Madu RC, Mapua P, Martindale AD, Martinez E, Massey E, Mawhiney S, Meador MG, Mendez S, Mercado C, Mercado IC, Merritt CE, Miner ZL, Minja E, Mitchell T, Mohabbat F, Mohabbat K, Montgomery B, Moore N, Morris S, Munidasa M, Ngo RN, Nguyen NB, Nickerson E, Nwaokelemeh OO, Nwokenkwo S, Obregon M, Oguh M, Oragunye N, Oviedo RJ, Parish BJ, Parker DN, Parrish J, Parks KL, Paul HA, Payton BA, Perez A, Perrin W, Pickens A, Primus EL, Pu LL, Puazo M, Quiles MM, Quiroz JB, Rabata D, Reeves K, Ruiz SJ, Shao H, Sisson I, Sonaike T, Sorelle RP, Sutton AE, Svatek AF, Svetz LA, Tamerisa KS, Taylor TR, Teague B, Thomas N, Thorn RD, Trejos ZY, Trevino BK, Ukegbu ON, Urban JB, Vasquez LI, Vera VA, Villasana DM, Wang L, Ward-Moore S, Warren JT, Wei X, White F, Williamson AL, Wleczyk R, Wooden HS, Wooden SH, Yen J, Yoon L, Yoon V, Zorrilla SE, Nelson D, Kucherlapati R, Weinstock G and Gibbs RA.


book

Molecular evolution of cytochrome c oxidase: rate variation among subunit VIa isoforms
Mol. Biol. Evol. 14 (6), 595-601 (1997)
Schmidt TR, Jaradat SA, Goodman M, Lomax MI and Grossman LI.


book

Tissue distribution of cytochrome c oxidase isoforms in mammals. Characterization with monoclonal and polyclonal antibodies
Biochim. Biophys. Acta 1225 (1), 95-100 (1993)
Taanman JW, Hall RE, Tang C, Marusich MF, Kennaway NG and Capaldi RA.


book

Human liver protein map: a reference database established by microsequencing and gel comparison
Electrophoresis 13 (12), 992-1001 (1992)
Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B and Vargas R.


book

Differential expression of genes specifying two isoforms of subunit VIa of human cytochrome c oxidase
Gene 119 (2), 307-312 (1992)
Fabrizi GM, Sadlock J, Hirano M, Mita S, Koga Y, Rizzuto R, Zeviani M and Schon EA.


book

Sequence of a cDNA specifying subunit VIa of human cytochrome c oxidase
Nucleic Acids Res. 17 (15), 6409 (1989)
Fabrizi GM, Rizzuto R, Nakase H, Mita S, Kadenbach B and Schon EA.


 
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