Gene Symbol
TUFM
Entrez Gene ID
7284
Full Name
Tu translation elongation factor, mitochondrial
Synonyms
COXPD4,EF-TuMT,EFTU,P43
General protein information
Preferred NamesTu translation elongation factor, mitochondrial
Nameselongation factor Tu, mitochondrial EF-Tu
Gene Type
protein-coding
Organism
Homo sapiens(human)
Genome
Chromosome: 16
Map Location: 16p11.2
Summary
This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008].
Disorder MIM:
602389
Disorder Html:
Combined oxidative phosphorylation deficiency 4, 610678 (3)
mRNA and Protein(s)
mRNA
Protein
Name
XM_011545928.2
XP_011544230.1
elongation factor Tu, mitochondrial isoform X2
NM_003321.4
NP_003312.3
elongation factor Tu, mitochondrial precursor
XM_017023619.1
XP_016879108.1
elongation factor Tu, mitochondrial isoform X1
NM_001365360.1
NP_001352289.1
elongation factor Tu, mitochondrial isoform 2 precursor
NM_001365360.2
NP_001352289.1
elongation factor Tu, mitochondrial isoform 2 precursor
NM_003321.5
NP_003312.3
elongation factor Tu, mitochondrial isoform 1 precursor
TUFM
XP_001103519.1
Homo sapiens (human)
TUFM
NP_003312.3
Saccharomyces cerevisiae (baker's yeast)
TUF1
NP_014830.1
Kluyveromyces lactis
KLLA0A04587g
XP_451201.1
Kluyveromyces lactis
KLLA0C05214g
XP_452433.1
Eremothecium gossypii
AGOS_AAR143W
NP_982685.1
Magnaporthe oryzae (rice blast fungus)
MGG_08162
XP_003715132.1
Canis lupus familiaris (dog)
TUFM
XP_536924.3
Bos taurus (cattle)
TUFM
NP_776632.1
Rattus norvegicus (Norway rat)
Tufm
NP_001099765.1
Danio rerio (zebrafish)
tufm
NP_001013523.1
Anopheles gambiae (African malaria mosquito)
AgaP_AGAP006996
XP_308774.4
Neurospora crassa
NCU03737
XP_961513.1
Pan troglodytes (chimpanzee)
TUFM
XP_510904.2
Drosophila melanogaster (fruit fly)
EfTuM
NP_001163144.1
Schizosaccharomyces pombe (fission yeast)
tuf1
NP_595746.1
Arabidopsis thaliana (thale cress)
AT4G02930
NP_192202.1
Oryza sativa (rice)
Os03g0851100
NP_001051912.1
Mus musculus (house mouse)
Tufm
NP_766333.1
Caenorhabditis elegans (roundworm)
tufm-1
NP_497623.1
Related articles in PubMed
Inhibition of Avian Influenza A Virus Replication in Human Cells by Host Restriction Factor TUFM Is Correlated with Autophagy.
Kuo SM, Chen CJ, Chang SC, Liu TJ, Chen YH, Huang SY, Shih SR mBio8(3)(2017 Jun)
Novel mutation in mitochondrial Elongation Factor EF-Tu associated to dysplastic leukoencephalopathy and defective mitochondrial DNA translation.
Di Nottia M, Montanari A, Verrigni D, Oliva R, Torraco A, Fernandez-Vizarra E, Diodato D, Rizza T, Bianchi M, Catteruccia M, Zeviani M, Dionisi-Vici C, Francisci S, Bertini E, Carrozzo R Biochimica et biophysica acta1863(4)961-967(2017 Apr)
Expression and clinicopathologic significance of TUFM and p53 for the normal-adenoma-carcinoma sequence in colorectal epithelia.
Xi HQ, Zhang KC, Li JY, Cui JX, Zhao P, Chen L World journal of surgical oncology15(1)90(2017 Apr)
EGFR-targeted mAb therapy modulates autophagy in head and neck squamous cell carcinoma through NLRX1-TUFM protein complex.
Lei Y, Kansy BA, Li J, Cong L, Liu Y, Trivedi S, Wen H, Ting JP, Ouyang H, Ferris RL Oncogene35(36)4698-707(2016 Sep)
TUFM downregulation induces epithelial-mesenchymal transition and invasion in lung cancer cells via a mechanism involving AMPK-GSK3? signaling.
He K, Guo X, Liu Y, Li J, Hu Y, Wang D, Song J Cellular and molecular life sciences : CMLS73(10)2105-21(2016 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The following TUFM gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TUFM cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+ /C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID
OHu18903
Clone ID Related Accession (Same CDS sequence)
NM_003321.4
, XM_017023619.1
, NM_003321.5
Accession Version
NM_003321.5 Latest version!
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 1368bp)
Protein sequence
SNP
Vector
pcDNA3.1+ /C-(K)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2019-12-30
Organism
Homo sapiens(human)
Product
elongation factor Tu, mitochondrial isoform 1 precursor
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC133550.2, BC010041.2 and CA420396.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_003321.4.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1660805.291522.1, SRR1803613.251890.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145313 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: reported by MitoCarta
MANE Ensembl match :: ENST00000313511.8/ ENSP00000322439.3
RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein
##RefSeq-Attributes-END##
COMPLETENESS: full length.
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 ATGACCACAA TGGCGGCCGC CACCCTGCTG CGCGCGACGC CCCACTTCAG CGGTCTCGCC GCCGGCCGGA CCTTCCTGCT GCAGGGTCTG TTGCGGCTGC TGAAAGCCCC GGCATTGCCT CTCTTGTGCC GCGGCCTGGC CGTGGAGGCC AAGAAGACTT ACGTGCGCGA CAAGCCACAT GTGAATGTGG GTACCATCGG CCATGTGGAC CACGGGAAGA CCACGCTGAC TGCAGCCATC ACGAAGATTC TAGCTGAGGG AGGTGGGGCT AAGTTCAAGA AGTACGAGGA GATTGACAAT GCCCCGGAGG AGCGAGCTCG GGGTATCACC ATCAATGCGG CTCATGTGGA GTATAGCACT GCCGCCCGCC ACTACGCCCA CACAGACTGC CCGGGTCATG CAGATTATGT TAAGAATATG ATCACAGGCA CTGCACCCCT CGACGGCTGC ATCCTGGTGG TAGCAGCCAA TGACGGCCCC ATGCCCCAGA CCCGAGAGCA CTTATTACTG GCCAGACAGA TTGGGGTGGA GCATGTGGTG GTGTATGTGA ACAAGGCTGA CGCTGTCCAG GACTCTGAGA TGGTGGAACT GGTGGAACTG GAGATCCGGG AGCTGCTCAC CGAGTTTGGC TATAAAGGGG AGGAGACCCC AGTCATCGTA GGCTCTGCTC TCTGTGCCCT TGAGGGTCGG GACCCTGAGT TAGGCCTGAA GTCTGTGCAG AAGCTACTGG ATGCTGTGGA CACTTACATC CCAGTGCCCG CCCGGGACCT GGAGAAGCCT TTCCTGCTGC CTGTGGAGGC GGTGTACTCC GTCCCTGGCC GTGGCACCGT GGTGACAGGT ACACTAGAGC GTGGCATTTT AAAGAAGGGA GACGAGTGTG AGCTCCTAGG ACATAGCAAG AACATCCGCA CTGTGGTGAC AGGCATTGAG ATGTTCCACA AGAGCCTGGA GAGGGCCGAG GCCGGAGATA ACCTCGGGGC CCTGGTCCGA GGCTTGAAGC GGGAGGACTT GCGGCGGGGC CTGGTCATGG TCAAGCCAGG TTCCATCAAG CCCCACCAGA AGGTGGAGGC CCAGGTTTAC ATCCTCAGCA AGGAGGAAGG TGGCCGCCAC AAGCCCTTTG TGTCCCACTT CATGCCTGTC ATGTTCTCCC TGACTTGGGA CATGGCCTGT CGGATTATCC TGCCCCCAGA GAAGGAGCTT GCCATGCCCG GGGAGGACCT GAAGTTCAAC CTAATCTTGC GGCAGCCAAT GATCTTAGAG AAAGGCCAGC GTTTCACCCT GCGAGATGGC AACCGGACTA TTGGCACCGG TCTAGTCACC AACACGCTGG CCATGACTGA GGAGGAGAAG AATATCAAAT GGGGTTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
NP_003312.3
CDS 80..1447
Translation
Target ORF information:
RefSeq Version NM_003321.5
Organism Homo sapiens(human)
Definition Homo sapiens Tu translation elongation factor, mitochondrial (TUFM), transcript variant 1, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
NM_003321.5
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 1321 ATGACCACAA TGGCGGCCGC CACCCTGCTG CGCGCGACGC CCCACTTCAG CGGTCTCGCC GCCGGCCGGA CCTTCCTGCT GCAGGGTCTG TTGCGGCTGC TGAAAGCCCC GGCATTGCCT CTCTTGTGCC GCGGCCTGGC CGTGGAGGCC AAGAAGACTT ACGTGCGCGA CAAGCCACAT GTGAATGTGG GTACCATCGG CCATGTGGAC CACGGGAAGA CCACGCTGAC TGCAGCCATC ACGAAGATTC TAGCTGAGGG AGGTGGGGCT AAGTTCAAGA AGTACGAGGA GATTGACAAT GCCCCGGAGG AGCGAGCTCG GGGTATCACC ATCAATGCGG CTCATGTGGA GTATAGCACT GCCGCCCGCC ACTACGCCCA CACAGACTGC CCGGGTCATG CAGATTATGT TAAGAATATG ATCACAGGCA CTGCACCCCT CGACGGCTGC ATCCTGGTGG TAGCAGCCAA TGACGGCCCC ATGCCCCAGA CCCGAGAGCA CTTATTACTG GCCAGACAGA TTGGGGTGGA GCATGTGGTG GTGTATGTGA ACAAGGCTGA CGCTGTCCAG GACTCTGAGA TGGTGGAACT GGTGGAACTG GAGATCCGGG AGCTGCTCAC CGAGTTTGGC TATAAAGGGG AGGAGACCCC AGTCATCGTA GGCTCTGCTC TCTGTGCCCT TGAGGGTCGG GACCCTGAGT TAGGCCTGAA GTCTGTGCAG AAGCTACTGG ATGCTGTGGA CACTTACATC CCAGTGCCCG CCCGGGACCT GGAGAAGCCT TTCCTGCTGC CTGTGGAGGC GGTGTACTCC GTCCCTGGCC GTGGCACCGT GGTGACAGGT ACACTAGAGC GTGGCATTTT AAAGAAGGGA GACGAGTGTG AGCTCCTAGG ACATAGCAAG AACATCCGCA CTGTGGTGAC AGGCATTGAG ATGTTCCACA AGAGCCTGGA GAGGGCCGAG GCCGGAGATA ACCTCGGGGC CCTGGTCCGA GGCTTGAAGC GGGAGGACTT GCGGCGGGGC CTGGTCATGG TCAAGCCAGG TTCCATCAAG CCCCACCAGA AGGTGGAGGC CCAGGTTTAC ATCCTCAGCA AGGAGGAAGG TGGCCGCCAC AAGCCCTTTG TGTCCCACTT CATGCCTGTC ATGTTCTCCC TGACTTGGGA CATGGCCTGT CGGATTATCC TGCCCCCAGA GAAGGAGCTT GCCATGCCCG GGGAGGACCT GAAGTTCAAC CTAATCTTGC GGCAGCCAAT GATCTTAGAG AAAGGCCAGC GTTTCACCCT GCGAGATGGC AACCGGACTA TTGGCACCGG TCTAGTCACC AACACGCTGG CCATGACTGA GGAGGAGAAG AATATCAAAT GGGGTTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
CloneID
OHu61179
Clone ID Related Accession (Same CDS sequence)
XM_011545928.2
, NM_001365360.1
, NM_001365360.2
Accession Version
NM_001365360.1
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 1284bp)
Protein sequence
SNP
Vector
pcDNA3.1+ /C-(K)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2018-11-24
Organism
Homo sapiens(human)
Product
elongation factor Tu, mitochondrial isoform 2 precursor
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC133550.2. On Aug 20, 2018 this sequence version replaced XM_011545928.2.
Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR3476690.551915.1, SRR1163657.545971.1 [ECO:0000332]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: reported by MitoCarta
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 ATGACCACAA TGGCGGCCGC CACCCTGCTG CGCGCGACGC CCCACTTCAG CGGTCTCGCC GCCGGCCGGA CCTTCCTGCT GCAGGGTCTG TTGCGGCTGC TGAAAGCCCC GGCATTGCCT CTCTTGTGCC GCGGCCTGGC CGTGGAGGCC AAGAAGACTT ACGTGCGCGA CAAGCCACAT GTGAATGTGG GTACCATCGG CCATGTGGAC CACGGGAAGA CCACGCTGAC TGCAGCCATC ACGAAGATTC TAGCTGAGGG AGGTGGGGCT AAGTTCAAGA AGTACGAGGA GATTGACAAT GCCCCGGAGG AGCGAGCTCG GGGTATCACC ATCAATGCGG CTCATGTGGA GTATAGCACT GCCGCCCGCC ACTACGCCCA CACAGACTGC CCGGGTCATG CAGATTATGT TAAGAATATG ATCACAGGCA CTGCACCCCT CGACGGCTGC ATCCTGGTGG TAGCAGCCAA TGACGGCCCC ATGCCCCAGA CCCGAGAGCA CTTATTACTG GCCAGACAGA TTGGGGTGGA GCATGTGGTG GTGTATGTGA ACAAGGCTGA CGCTGTCCAG GACTCTGAGA TGGTGGAACT GGTGGAACTG GAGATCCGGG AGCTGCTCAC CGAGTTTGGC TATAAAGGGG AGGAGACCCC AGTCATCGTA GGCTCTGCTC TCTGTGCCCT TGAGGGTCGG GACCCTGAGT TAGGCCTGAA GTCTGTGCAG AAGCTACTGG ATGCTGTGGA CACTTACATC CCAGTGCCCG CCCGGGACCT GGAGAAGCCT TTCCTGCTGC CTGTGGAGGC GGTGTACTCC GTCCCTGGCC GTGGCACCGT GGTGACAGGC ATTGAGATGT TCCACAAGAG CCTGGAGAGG GCCGAGGCCG GAGATAACCT CGGGGCCCTG GTCCGAGGCT TGAAGCGGGA GGACTTGCGG CGGGGCCTGG TCATGGTCAA GCCAGGTTCC ATCAAGCCCC ACCAGAAGGT GGAGGCCCAG GTTTACATCC TCAGCAAGGA GGAAGGTGGC CGCCACAAGC CCTTTGTGTC CCACTTCATG CCTGTCATGT TCTCCCTGAC TTGGGACATG GCCTGTCGGA TTATCCTGCC CCCAGAGAAG GAGCTTGCCA TGCCCGGGGA GGACCTGAAG TTCAACCTAA TCTTGCGGCA GCCAATGATC TTAGAGAAAG GCCAGCGTTT CACCCTGCGA GATGGCAACC GGACTATTGG CACCGGTCTA GTCACCAACA CGCTGGCCAT GACTGAGGAG GAGAAGAATA TCAAATGGGG TTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
NP_001352289.1
CDS 80..1363
Translation
Target ORF information:
RefSeq Version NM_001365360.1
Organism Homo sapiens(human)
Definition Homo sapiens Tu translation elongation factor, mitochondrial (TUFM), transcript variant 2, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
NM_001365360.1
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 ATGACCACAA TGGCGGCCGC CACCCTGCTG CGCGCGACGC CCCACTTCAG CGGTCTCGCC GCCGGCCGGA CCTTCCTGCT GCAGGGTCTG TTGCGGCTGC TGAAAGCCCC GGCATTGCCT CTCTTGTGCC GCGGCCTGGC CGTGGAGGCC AAGAAGACTT ACGTGCGCGA CAAGCCACAT GTGAATGTGG GTACCATCGG CCATGTGGAC CACGGGAAGA CCACGCTGAC TGCAGCCATC ACGAAGATTC TAGCTGAGGG AGGTGGGGCT AAGTTCAAGA AGTACGAGGA GATTGACAAT GCCCCGGAGG AGCGAGCTCG GGGTATCACC ATCAATGCGG CTCATGTGGA GTATAGCACT GCCGCCCGCC ACTACGCCCA CACAGACTGC CCGGGTCATG CAGATTATGT TAAGAATATG ATCACAGGCA CTGCACCCCT CGACGGCTGC ATCCTGGTGG TAGCAGCCAA TGACGGCCCC ATGCCCCAGA CCCGAGAGCA CTTATTACTG GCCAGACAGA TTGGGGTGGA GCATGTGGTG GTGTATGTGA ACAAGGCTGA CGCTGTCCAG GACTCTGAGA TGGTGGAACT GGTGGAACTG GAGATCCGGG AGCTGCTCAC CGAGTTTGGC TATAAAGGGG AGGAGACCCC AGTCATCGTA GGCTCTGCTC TCTGTGCCCT TGAGGGTCGG GACCCTGAGT TAGGCCTGAA GTCTGTGCAG AAGCTACTGG ATGCTGTGGA CACTTACATC CCAGTGCCCG CCCGGGACCT GGAGAAGCCT TTCCTGCTGC CTGTGGAGGC GGTGTACTCC GTCCCTGGCC GTGGCACCGT GGTGACAGGC ATTGAGATGT TCCACAAGAG CCTGGAGAGG GCCGAGGCCG GAGATAACCT CGGGGCCCTG GTCCGAGGCT TGAAGCGGGA GGACTTGCGG CGGGGCCTGG TCATGGTCAA GCCAGGTTCC ATCAAGCCCC ACCAGAAGGT GGAGGCCCAG GTTTACATCC TCAGCAAGGA GGAAGGTGGC CGCCACAAGC CCTTTGTGTC CCACTTCATG CCTGTCATGT TCTCCCTGAC TTGGGACATG GCCTGTCGGA TTATCCTGCC CCCAGAGAAG GAGCTTGCCA TGCCCGGGGA GGACCTGAAG TTCAACCTAA TCTTGCGGCA GCCAATGATC TTAGAGAAAG GCCAGCGTTT CACCCTGCGA GATGGCAACC GGACTATTGG CACCGGTCTA GTCACCAACA CGCTGGCCAT GACTGAGGAG GAGAAGAATA TCAAATGGGG TTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
CloneID
OHu61179
Clone ID Related Accession (Same CDS sequence)
XM_011545928.2
, NM_001365360.1
, NM_001365360.2
Accession Version
NM_001365360.2 Latest version!
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 1284bp)
Protein sequence
SNP
Vector
pcDNA3.1+ /C-(K)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2020-01-03
Organism
Homo sapiens(human)
Product
elongation factor Tu, mitochondrial isoform 2 precursor
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC133550.2. On May 31, 2019 this sequence version replaced NM_001365360.1.
Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR3476690.551915.1, SRR5189667.403990.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145313 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
gene product(s) localized to mito. :: reported by MitoCarta
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 ATGACCACAA TGGCGGCCGC CACCCTGCTG CGCGCGACGC CCCACTTCAG CGGTCTCGCC GCCGGCCGGA CCTTCCTGCT GCAGGGTCTG TTGCGGCTGC TGAAAGCCCC GGCATTGCCT CTCTTGTGCC GCGGCCTGGC CGTGGAGGCC AAGAAGACTT ACGTGCGCGA CAAGCCACAT GTGAATGTGG GTACCATCGG CCATGTGGAC CACGGGAAGA CCACGCTGAC TGCAGCCATC ACGAAGATTC TAGCTGAGGG AGGTGGGGCT AAGTTCAAGA AGTACGAGGA GATTGACAAT GCCCCGGAGG AGCGAGCTCG GGGTATCACC ATCAATGCGG CTCATGTGGA GTATAGCACT GCCGCCCGCC ACTACGCCCA CACAGACTGC CCGGGTCATG CAGATTATGT TAAGAATATG ATCACAGGCA CTGCACCCCT CGACGGCTGC ATCCTGGTGG TAGCAGCCAA TGACGGCCCC ATGCCCCAGA CCCGAGAGCA CTTATTACTG GCCAGACAGA TTGGGGTGGA GCATGTGGTG GTGTATGTGA ACAAGGCTGA CGCTGTCCAG GACTCTGAGA TGGTGGAACT GGTGGAACTG GAGATCCGGG AGCTGCTCAC CGAGTTTGGC TATAAAGGGG AGGAGACCCC AGTCATCGTA GGCTCTGCTC TCTGTGCCCT TGAGGGTCGG GACCCTGAGT TAGGCCTGAA GTCTGTGCAG AAGCTACTGG ATGCTGTGGA CACTTACATC CCAGTGCCCG CCCGGGACCT GGAGAAGCCT TTCCTGCTGC CTGTGGAGGC GGTGTACTCC GTCCCTGGCC GTGGCACCGT GGTGACAGGC ATTGAGATGT TCCACAAGAG CCTGGAGAGG GCCGAGGCCG GAGATAACCT CGGGGCCCTG GTCCGAGGCT TGAAGCGGGA GGACTTGCGG CGGGGCCTGG TCATGGTCAA GCCAGGTTCC ATCAAGCCCC ACCAGAAGGT GGAGGCCCAG GTTTACATCC TCAGCAAGGA GGAAGGTGGC CGCCACAAGC CCTTTGTGTC CCACTTCATG CCTGTCATGT TCTCCCTGAC TTGGGACATG GCCTGTCGGA TTATCCTGCC CCCAGAGAAG GAGCTTGCCA TGCCCGGGGA GGACCTGAAG TTCAACCTAA TCTTGCGGCA GCCAATGATC TTAGAGAAAG GCCAGCGTTT CACCCTGCGA GATGGCAACC GGACTATTGG CACCGGTCTA GTCACCAACA CGCTGGCCAT GACTGAGGAG GAGAAGAATA TCAAATGGGG TTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
NP_001352289.1
CDS 80..1363
Translation
Target ORF information:
RefSeq Version NM_001365360.2
Organism Homo sapiens(human)
Definition Homo sapiens Tu translation elongation factor, mitochondrial (TUFM), transcript variant 2, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
NM_001365360.2
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 ATGACCACAA TGGCGGCCGC CACCCTGCTG CGCGCGACGC CCCACTTCAG CGGTCTCGCC GCCGGCCGGA CCTTCCTGCT GCAGGGTCTG TTGCGGCTGC TGAAAGCCCC GGCATTGCCT CTCTTGTGCC GCGGCCTGGC CGTGGAGGCC AAGAAGACTT ACGTGCGCGA CAAGCCACAT GTGAATGTGG GTACCATCGG CCATGTGGAC CACGGGAAGA CCACGCTGAC TGCAGCCATC ACGAAGATTC TAGCTGAGGG AGGTGGGGCT AAGTTCAAGA AGTACGAGGA GATTGACAAT GCCCCGGAGG AGCGAGCTCG GGGTATCACC ATCAATGCGG CTCATGTGGA GTATAGCACT GCCGCCCGCC ACTACGCCCA CACAGACTGC CCGGGTCATG CAGATTATGT TAAGAATATG ATCACAGGCA CTGCACCCCT CGACGGCTGC ATCCTGGTGG TAGCAGCCAA TGACGGCCCC ATGCCCCAGA CCCGAGAGCA CTTATTACTG GCCAGACAGA TTGGGGTGGA GCATGTGGTG GTGTATGTGA ACAAGGCTGA CGCTGTCCAG GACTCTGAGA TGGTGGAACT GGTGGAACTG GAGATCCGGG AGCTGCTCAC CGAGTTTGGC TATAAAGGGG AGGAGACCCC AGTCATCGTA GGCTCTGCTC TCTGTGCCCT TGAGGGTCGG GACCCTGAGT TAGGCCTGAA GTCTGTGCAG AAGCTACTGG ATGCTGTGGA CACTTACATC CCAGTGCCCG CCCGGGACCT GGAGAAGCCT TTCCTGCTGC CTGTGGAGGC GGTGTACTCC GTCCCTGGCC GTGGCACCGT GGTGACAGGC ATTGAGATGT TCCACAAGAG CCTGGAGAGG GCCGAGGCCG GAGATAACCT CGGGGCCCTG GTCCGAGGCT TGAAGCGGGA GGACTTGCGG CGGGGCCTGG TCATGGTCAA GCCAGGTTCC ATCAAGCCCC ACCAGAAGGT GGAGGCCCAG GTTTACATCC TCAGCAAGGA GGAAGGTGGC CGCCACAAGC CCTTTGTGTC CCACTTCATG CCTGTCATGT TCTCCCTGAC TTGGGACATG GCCTGTCGGA TTATCCTGCC CCCAGAGAAG GAGCTTGCCA TGCCCGGGGA GGACCTGAAG TTCAACCTAA TCTTGCGGCA GCCAATGATC TTAGAGAAAG GCCAGCGTTT CACCCTGCGA GATGGCAACC GGACTATTGG CACCGGTCTA GTCACCAACA CGCTGGCCAT GACTGAGGAG GAGAAGAATA TCAAATGGGG TTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
CloneID
OHu61179
Clone ID Related Accession (Same CDS sequence)
XM_011545928.2
, NM_001365360.1
, NM_001365360.2
Accession Version
XM_011545928.2 Latest version!
Documents for ORF clone product in default vector
Sequence Information
ORF Nucleotide Sequence (Length: 1284bp)
Protein sequence
SNP
Vector
pcDNA3.1+ /C-(K)DYK or customized vector
User Manual
Clone information
Clone Map
MSDS
Tag on pcDNA3.1+ /C-(K)DYK
C terminal DYKDDDDK tags
ORF Insert Method
CloneEZ™ Seamless cloning technology
Insert Structure
linear
Update Date
2016-06-05
Organism
Homo sapiens(human)
Product
elongation factor Tu, mitochondrial isoform X2
Comment
Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process
On Jun 6, 2016 this sequence version replaced XM_011545928.1.
##Genome-Annotation-Data-START##
Annotation Provider :: NCBI
Annotation Status :: Full annotation
Annotation Version :: Homo sapiens Annotation Release 108
Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline
Annotation Software Version :: 7.0
Annotation Method :: Best-placed RefSeq; Gnomon
Features Annotated :: Gene; mRNA; CDS; ncRNA
##Genome-Annotation-Data-END##
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 ATGACCACAA TGGCGGCCGC CACCCTGCTG CGCGCGACGC CCCACTTCAG CGGTCTCGCC GCCGGCCGGA CCTTCCTGCT GCAGGGTCTG TTGCGGCTGC TGAAAGCCCC GGCATTGCCT CTCTTGTGCC GCGGCCTGGC CGTGGAGGCC AAGAAGACTT ACGTGCGCGA CAAGCCACAT GTGAATGTGG GTACCATCGG CCATGTGGAC CACGGGAAGA CCACGCTGAC TGCAGCCATC ACGAAGATTC TAGCTGAGGG AGGTGGGGCT AAGTTCAAGA AGTACGAGGA GATTGACAAT GCCCCGGAGG AGCGAGCTCG GGGTATCACC ATCAATGCGG CTCATGTGGA GTATAGCACT GCCGCCCGCC ACTACGCCCA CACAGACTGC CCGGGTCATG CAGATTATGT TAAGAATATG ATCACAGGCA CTGCACCCCT CGACGGCTGC ATCCTGGTGG TAGCAGCCAA TGACGGCCCC ATGCCCCAGA CCCGAGAGCA CTTATTACTG GCCAGACAGA TTGGGGTGGA GCATGTGGTG GTGTATGTGA ACAAGGCTGA CGCTGTCCAG GACTCTGAGA TGGTGGAACT GGTGGAACTG GAGATCCGGG AGCTGCTCAC CGAGTTTGGC TATAAAGGGG AGGAGACCCC AGTCATCGTA GGCTCTGCTC TCTGTGCCCT TGAGGGTCGG GACCCTGAGT TAGGCCTGAA GTCTGTGCAG AAGCTACTGG ATGCTGTGGA CACTTACATC CCAGTGCCCG CCCGGGACCT GGAGAAGCCT TTCCTGCTGC CTGTGGAGGC GGTGTACTCC GTCCCTGGCC GTGGCACCGT GGTGACAGGC ATTGAGATGT TCCACAAGAG CCTGGAGAGG GCCGAGGCCG GAGATAACCT CGGGGCCCTG GTCCGAGGCT TGAAGCGGGA GGACTTGCGG CGGGGCCTGG TCATGGTCAA GCCAGGTTCC ATCAAGCCCC ACCAGAAGGT GGAGGCCCAG GTTTACATCC TCAGCAAGGA GGAAGGTGGC CGCCACAAGC CCTTTGTGTC CCACTTCATG CCTGTCATGT TCTCCCTGAC TTGGGACATG GCCTGTCGGA TTATCCTGCC CCCAGAGAAG GAGCTTGCCA TGCCCGGGGA GGACCTGAAG TTCAACCTAA TCTTGCGGCA GCCAATGATC TTAGAGAAAG GCCAGCGTTT CACCCTGCGA GATGGCAACC GGACTATTGG CACCGGTCTA GTCACCAACA CGCTGGCCAT GACTGAGGAG GAGAAGAATA TCAAATGGGG TTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
RefSeq
XP_011544230.1
CDS 234..1517
Translation
Target ORF information:
RefSeq Version XM_011545928.2
Organism Homo sapiens(human)
Definition Homo sapiens Tu translation elongation factor, mitochondrial (TUFM), transcript variant X2, mRNA.
Target ORF information:
Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+ /C-(K)DYK
XM_011545928.2
ORF Insert Sequence:
1 61 121 181 241 301 361 421 481 541 601 661 721 781 841 901 961 1021 1081 1141 1201 1261 ATGACCACAA TGGCGGCCGC CACCCTGCTG CGCGCGACGC CCCACTTCAG CGGTCTCGCC GCCGGCCGGA CCTTCCTGCT GCAGGGTCTG TTGCGGCTGC TGAAAGCCCC GGCATTGCCT CTCTTGTGCC GCGGCCTGGC CGTGGAGGCC AAGAAGACTT ACGTGCGCGA CAAGCCACAT GTGAATGTGG GTACCATCGG CCATGTGGAC CACGGGAAGA CCACGCTGAC TGCAGCCATC ACGAAGATTC TAGCTGAGGG AGGTGGGGCT AAGTTCAAGA AGTACGAGGA GATTGACAAT GCCCCGGAGG AGCGAGCTCG GGGTATCACC ATCAATGCGG CTCATGTGGA GTATAGCACT GCCGCCCGCC ACTACGCCCA CACAGACTGC CCGGGTCATG CAGATTATGT TAAGAATATG ATCACAGGCA CTGCACCCCT CGACGGCTGC ATCCTGGTGG TAGCAGCCAA TGACGGCCCC ATGCCCCAGA CCCGAGAGCA CTTATTACTG GCCAGACAGA TTGGGGTGGA GCATGTGGTG GTGTATGTGA ACAAGGCTGA CGCTGTCCAG GACTCTGAGA TGGTGGAACT GGTGGAACTG GAGATCCGGG AGCTGCTCAC CGAGTTTGGC TATAAAGGGG AGGAGACCCC AGTCATCGTA GGCTCTGCTC TCTGTGCCCT TGAGGGTCGG GACCCTGAGT TAGGCCTGAA GTCTGTGCAG AAGCTACTGG ATGCTGTGGA CACTTACATC CCAGTGCCCG CCCGGGACCT GGAGAAGCCT TTCCTGCTGC CTGTGGAGGC GGTGTACTCC GTCCCTGGCC GTGGCACCGT GGTGACAGGC ATTGAGATGT TCCACAAGAG CCTGGAGAGG GCCGAGGCCG GAGATAACCT CGGGGCCCTG GTCCGAGGCT TGAAGCGGGA GGACTTGCGG CGGGGCCTGG TCATGGTCAA GCCAGGTTCC ATCAAGCCCC ACCAGAAGGT GGAGGCCCAG GTTTACATCC TCAGCAAGGA GGAAGGTGGC CGCCACAAGC CCTTTGTGTC CCACTTCATG CCTGTCATGT TCTCCCTGAC TTGGGACATG GCCTGTCGGA TTATCCTGCC CCCAGAGAAG GAGCTTGCCA TGCCCGGGGA GGACCTGAAG TTCAACCTAA TCTTGCGGCA GCCAATGATC TTAGAGAAAG GCCAGCGTTT CACCCTGCGA GATGGCAACC GGACTATTGG CACCGGTCTA GTCACCAACA CGCTGGCCAT GACTGAGGAG GAGAAGAATA TCAAATGGGG TTGA
The stop codons will be deleted if pcDNA3.1+ /C-(K)DYK vector is selected.
Novel mutation in mitochondrial Elongation Factor EF-Tu associated to dysplastic leukoencephalopathy and defective mitochondrial DNA translation.
Biochimica et biophysica acta1863(4)961-967(2017 Apr)
Di Nottia M,Montanari A,Verrigni D,Oliva R,Torraco A,Fernandez-Vizarra E,Diodato D,Rizza T,Bianchi M,Catteruccia M,Zeviani M,Dionisi-Vici C,Francisci S,Bertini E,Carrozzo R