Alox5 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Alox5 |
| Entrez Gene ID | 11689 |
| Full Name | arachidonate 5-lipoxygenase |
| Synonyms | 5-LO,5-LOX,5LO,5LX,AI850497,F730011J02 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_009662.2 | NP_033792.1 | arachidonate 5-lipoxygenase |
| Homo sapiens (human) | ALOX5 | NP_000689.1 |
| Oryza sativa (rice) | Os03g0738600 | NP_001051212.1 |
| Canis lupus familiaris (dog) | ALOX5 | NP_001192042.1 |
| Bos taurus (cattle) | ALOX5 | NP_001179721.1 |
| Arabidopsis thaliana (thale cress) | LOX5 | NP_188879.2 |
| Pan troglodytes (chimpanzee) | ALOX5 | XP_507763.3 |
| ALOX5 | XP_001102354.1 | |
| Mus musculus (house mouse) | Alox5 | NP_033792.1 |
| Rattus norvegicus (Norway rat) | Alox5 | NP_036954.1 |
| Gallus gallus (chicken) | ALOX5 | XP_003641560.1 |
| Xenopus tropicalis (tropical clawed frog) | alox5 | XP_004915982.1 |
| Oryza sativa (rice) | Os03g0700400 | NP_001050993.1 |
| Danio rerio (zebrafish) | alox5a | NP_001243676.1 |
| Arabidopsis thaliana (thale cress) | LOX1 | NP_175900.1 |
| Oryza sativa (rice) | Os03g0699700 | NP_001050990.1 |
| Oryza sativa (rice) | Os03g0700700 | NP_001050995.2 |
Related articles in PubMed
Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice.
Rauch F, Geng Y, Lamplugh L, Hekmatnejad B, Gaumond MH, Penney J, Yamanaka Y, Moffatt P
Bone107131-142(2018 Feb)
Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation.
Ibarra-Soria X, Jawaid W, Pijuan-Sala B, Ladopoulos V, Scialdone A, Jörg DJ, Tyser RCV, Calero-Nieto FJ, Mulas C, Nichols J, Vallier L, Srinivas S, Simons BD, Göttgens B, Marioni JC
Nature cell biology(2018 Jan)
Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation.
Yotsumoto S, Muroi Y, Chiba T, Ohmura R, Yoneyama M, Magarisawa M, Dodo K, Terayama N, Sodeoka M, Aoyagi R, Arita M, Arakawa S, Shimizu S, Tanaka M
Scientific reports7(1)16026(2017 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data indicate that 5-lipoxygenase (5-LO)/leukotriene B4 (LTB4) axis orchestrates graft-versus-host disease (GVHD) development and suggest it could be a target for the development of therapeutic strategies for GVHD treatment.
Title: Inhibition of 5-lipoxygenase alleviates graft-versus-host disease.
Findings demonstrate that the up-regulation of the ALOX5 gene pathway is responsible for the development of the biochemical and behavioral sequelae of high Hcy brain levels in the context of a neurodegenerative phenotype.
Title: Genetic absence of ALOX5 protects from homocysteine-induced memory impairment, tau phosphorylation and synaptic pathology.
Our data showed that besides the high parasite burden and lack of microbicidal molecules, an imbalance with high COX-2 and 5-LOX eicosanoid expression and a lack of regulatory PPAR-gamma cytoplasm-to-nucleus translocation in macrophages were observed in mice that develop cerebral malaria.
Title: Differences in the modulation of reactive species, lipid bodies, cyclooxygenase-2, 5-lipoxygenase and PPAR-γ in cerebral malaria-susceptible and resistant mice.
Homocysteine directly influences 5LO expression levels and establish a previously unknown cross talk between these two pathways.
Title: Homocysteine modulates 5-lipoxygenase expression level via DNA methylation.
This study demonstrates that LTB4 promotes macrophage phagocytosis of bacteria via BLT1, and that BLT2 can fulfill this role in the absence of BL
Title: Macrophage LTB
The following Alox5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Alox5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu22214 | |
| Clone ID Related Accession (Same CDS sequence) | NM_009662.2 | |
| Accession Version | NM_009662.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2025bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-11-15 | |
| Organism | Mus musculus(house mouse) | |
| Product | arachidonate 5-lipoxygenase | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY205433.1, AK171413.1 and BY555055.1. On Oct 26, 2006 this sequence version replaced NM_009662.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK136868.1, AK170879.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## | |
1 | ATGCCCTCCT ACACGGTCAC CGTGGCCACC GGCAGCCAGT GGTTCGCGGG CACCGACGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_033792.1 |
| CDS | 155..2179 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_009662.2 |
ORF Insert Sequence:
1 | ATGCCCTCCT ACACGGTCAC CGTGGCCACC GGCAGCCAGT GGTTCGCGGG CACCGACGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice. |
|
Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation. |
|
Hyperoxidation of ether-linked phospholipids accelerates neutrophil extracellular trap formation. |