DPP4 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | DPP4 |
| Entrez Gene ID | 1803 |
| Full Name | dipeptidyl peptidase 4 |
| Synonyms | ADABP,ADCP2,CD26,DPPIV,TP103 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| XM_005246371.2 | XP_005246428.1 | dipeptidyl peptidase 4 isoform X1 |
| NM_001935.3 | NP_001926.2 | dipeptidyl peptidase 4 |
| Kluyveromyces lactis | KLLA0E11485g | XP_454468.1 |
| Magnaporthe oryzae (rice blast fungus) | MGG_07745 | XP_003712956.1 |
| Homo sapiens (human) | DPP4 | NP_001926.2 |
| Danio rerio (zebrafish) | dpp4 | NP_001154809.1 |
| Drosophila melanogaster (fruit fly) | CG11034 | NP_608961.2 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP008176 | XP_317288.4 |
| Eremothecium gossypii | AGOS_ACR073C | NP_983475.2 |
| Pan troglodytes (chimpanzee) | DPP4 | XP_515858.2 |
| DPP4 | NP_001034279.1 | |
| Mus musculus (house mouse) | Dpp4 | NP_034204.1 |
| Saccharomyces cerevisiae (baker's yeast) | DAP2 | NP_011893.1 |
| Schizosaccharomyces pombe (fission yeast) | SPACUNK4.08 | NP_593970.1 |
| Rattus norvegicus (Norway rat) | Dpp4 | NP_036921.1 |
| Canis lupus familiaris (dog) | DPP4 | XP_535933.3 |
| Gallus gallus (chicken) | DPP4 | NP_001026426.1 |
| Danio rerio (zebrafish) | fap | XP_001920834.4 |
| Caenorhabditis elegans (roundworm) | dpf-2 | NP_510461.1 |
| Neurospora crassa | NCU02515 | XP_965646.1 |
| Xenopus tropicalis (tropical clawed frog) | dpp4 | NP_001016233.1 |
Related articles in PubMed
Unique binding mode of Evogliptin with human dipeptidyl peptidase IV.
Lee HK, Kim MK, Kim HD, Kim HJ, Kim JW, Lee JO, Kim CW, Kim EE
Biochemical and biophysical research communications494(3-4)452-459(2017 12)
Identification of senescent cell surface targetable protein DPP4.
Kim KM, Noh JH, Bodogai M, Martindale JL, Yang X, Indig FE, Basu SK, Ohnuma K, Morimoto C, Johnson PF, Biragyn A, Abdelmohsen K, Gorospe M
Genes & development31(15)1529-1534(2017 Aug)
Elevated CD26 Expression by Skin Fibroblasts Distinguishes a Profibrotic Phenotype Involved in Scar Formation Compared to Gingival Fibroblasts.
Mah W, Jiang G, Olver D, Gallant-Behm C, Wiebe C, Hart DA, Koivisto L, Larjava H, H?kkinen L
The American journal of pathology187(8)1717-1735(2017 Aug)
Association of plasma dipeptidyl peptidase-4 activity with non-alcoholic fatty liver disease in nondiabetic Chinese population.
Zheng T, Chen B, Yang L, Hu X, Zhang X, Liu H, Qin L
Metabolism: clinical and experimental73125-134(2017 Aug)
DPP4 gene variation affects GLP-1 secretion, insulin secretion, and glucose tolerance in humans with high body adiposity.
B?hm A, Wagner R, Machicao F, Holst JJ, Gallwitz B, Stefan N, Fritsche A, H?ring HU, Staiger H
PloS one12(7)e0181880(2017)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Analysis of both the structures and inhibitory activities suggests that the binding of the trifluorophenyl moiety in the S1 pocket and the piperazine-2-one moiety have hydrophobic interactions with Phe357 in the S2 extensive subsite, and that the multiple hydrogen bonds made by the (R)-beta-amine group in the S2 pocket and the contacts made by the (R)-tert-butyl group with Arg125 contribute to the high potency observed...
Title: Unique binding mode of Evogliptin with human dipeptidyl peptidase IV.
the selective expression of DPP4 on the surface of senescent cells enables their preferential elimination.
Title: Identification of senescent cell surface targetable protein DPP4.
Plasma DPP4 activity is significantly associated with NAFLD. The underlying mechanisms may be partly attributed to the interactions between insulin resistance, oxidative stress, inflammation, and DPP4.
Title: Association of plasma dipeptidyl peptidase-4 activity with non-alcoholic fatty liver disease in nondiabetic Chinese population.
YS110 is a humanised IgG1 monoclonal antibody with high affinity to the CD26 antigen. YS110 demonstrated preclinical anti-tumour effects without significant side effects
Title: First-in-human phase 1 of YS110, a monoclonal antibody directed against CD26 in advanced CD26-expressing cancers.
A common variant, i.e., single nucleotide polymorphism rs6741949, in the DPP4 gene interacts with body adiposity and negatively affects glucose-stimulated GLP-1 levels, insulin secretion, and glucose tolerance.
Title: DPP4 gene variation affects GLP-1 secretion, insulin secretion, and glucose tolerance in humans with high body adiposity.
The following DPP4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DPP4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu23624 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_001935.3 | |
| Accession Version | NM_001935.3 Latest version! | Documents for ORF clone product in dufault vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2301bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | COA |
| ORF Insert Method | CloneEZ® Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-12-11 | |
| Organism | Homo sapiens(human) | |
| Product | dipeptidyl peptidase 4 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC065265.1. On May 7, 2004 this sequence version replaced NM_001935.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC065265.1, X60708.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length. | |
1 | ATGAAGACAC CGTGGAAGGT TCTTCTGGGA CTGCTGGGTG CTGCTGCGCT TGTCACCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001926.2 |
| CDS | 562..2862 |
| Misc Feature(1) | 532..534 |
| Misc Feature(2) | 580..645 |
| Misc Feature(3) | 883..1995 |
| Misc Feature(4) | <1753..2853 |
| Misc Feature(5) | 2236..2850 |
| Exon (1) | 1..567 |
| Exon (2) | 568..655 |
| Exon (3) | 656..754 |
| Exon (4) | 755..846 |
| Exon (5) | 847..927 |
| Exon (6) | 928..980 |
| Exon (7) | 981..1053 |
| Exon (8) | 1054..1174 |
| Exon (9) | 1175..1335 |
| Exon (10) | 1336..1448 |
| Exon (11) | 1449..1584 |
| Exon (12) | 1585..1629 |
| Exon (13) | 1630..1737 |
| Exon (14) | 1738..1805 |
| Exon (15) | 1806..1859 |
| Exon (16) | 1860..1981 |
| Exon (17) | 1982..2029 |
| Exon (18) | 2030..2128 |
| Exon (19) | 2129..2198 |
| Exon (20) | 2199..2393 |
| Exon (21) | 2394..2448 |
| Exon (22) | 2449..2548 |
| Exon (23) | 2549..2613 |
| Exon (24) | 2614..2686 |
| Exon (25) | 2687..2760 |
| Exon (26) | 2761..3900 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001935.3 |
ORF Insert Sequence:
1 | ATGAAGACAC CGTGGAAGGT TCTTCTGGGA CTGCTGGGTG CTGCTGCGCT TGTCACCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu35960 | |
| Clone ID Related Accession (Same CDS sequence) | XM_005246371.2 | |
| Accession Version | XM_005246371.2 Latest version! | Documents for ORF clone product in dufault vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2298bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ® Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-06-06 | |
| Organism | Homo sapiens(human) | |
| Product | dipeptidyl peptidase 4 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000002.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005246371.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGAAGACAC CGTGGAAGGT TCTTCTGGGA CTGCTGGGTG CTGCTGCGCT TGTCACCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_005246428.1 |
| CDS | 142..2439 |
| Misc Feature(1) | 460..1572 |
| Misc Feature(2) | <1330..2430 |
| Misc Feature(3) | 1813..2427 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_005246371.2 |
ORF Insert Sequence:
1 | ATGAAGACAC CGTGGAAGGT TCTTCTGGGA CTGCTGGGTG CTGCTGCGCT TGTCACCATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Unique binding mode of Evogliptin with human dipeptidyl peptidase IV. |
|
Identification of senescent cell surface targetable protein DPP4. |
|
Elevated CD26 Expression by Skin Fibroblasts Distinguishes a Profibrotic Phenotype Involved in Scar Formation Compared to Gingival Fibroblasts. |
|
Association of plasma dipeptidyl peptidase-4 activity with non-alcoholic fatty liver disease in nondiabetic Chinese population. |
|
DPP4 gene variation affects GLP-1 secretion, insulin secretion, and glucose tolerance in humans with high body adiposity. |