×

FGF3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol FGF3
Entrez Gene ID 2248
Full Name fibroblast growth factor 3
Synonyms HBGF-3, INT2
General protein information
Preferred Names
fibroblast growth factor 3
Names
fibroblast growth factor 3
FGF-3
oncogene INT2
proto-oncogene Int-2
INT-2 proto-oncogene protein
heparin-binding growth factor 3
murine mammary tumor virus integration site 2, mouse
V-INT2 murine mammary tumor virus integration site oncogene homolog
fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q13

Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

164950

Disorder Html: Deafness, congenital with inner ear agenesis, microtia, and

mRNA and Protein(s)

mRNA Protein Name
NM_005247 NP_005238 fibroblast growth factor 3 precursor



Homo sapiens (human) FGF3 NP_005238.1
Pan troglodytes (chimpanzee) FGF3 XP_522092.2
Macaca mulatta (Rhesus monkey) FGF3 XP_001100658.1
Bos taurus (cattle) FGF3 XP_002699485.1
Mus musculus (house mouse) Fgf3 NP_032033.2
Rattus norvegicus (Norway rat) Fgf3 NP_570830.1
Gallus gallus (chicken) FGF3 NP_990658.1
Danio rerio (zebrafish) fgf3 NP_571366.1
Xenopus (Silurana) tropicalis (western clawed frog) fgf3 NP_001008154.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following FGF3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FGF3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Free ORF Clone
for Every Scientist
More Detail >>

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu18680 NM_005247 Homo sapiens fibroblast growth factor 3 (FGF3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $139.30
$199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18680
Clone ID Related Accession (Same CDS sequence) NM_005247
Accession Version NM_005247.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 720bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Product fibroblast growth factor 3 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X14445.1. This sequence is a reference standard in the RefSeqGene project. On Sep 6, 2001 this sequence version replaced gi:4885232. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC113739.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGGGCCTAA TCTGGCTGCT ACTGCTCAGC CTGCTGGAGC CCGGCTGGCC CGCAGCGGGC 
CCTGGGGCGC GGTTGCGGCG CGATGCGGGC GGCCGTGGCG GCGTCTACGA GCACCTTGGC
GGGGCGCCCC GGCGCCGCAA GCTCTACTGC GCCACGAAGT ACCACCTCCA GCTGCACCCG
AGCGGCCGCG TCAACGGCAG CCTGGAGAAC AGCGCCTACA GTATTTTGGA GATAACGGCA
GTGGAGGTGG GCATTGTGGC CATCAGGGGT CTCTTCTCCG GGCGGTACCT GGCCATGAAC
AAGAGGGGAC GACTCTATGC TTCGGAGCAC TACAGCGCCG AGTGCGAGTT TGTGGAGCGG
ATCCACGAGC TGGGCTATAA TACGTATGCC TCCCGGCTGT ACCGGACGGT GTCTAGTACG
CCTGGGGCCC GCCGGCAGCC CAGCGCCGAG AGACTGTGGT ACGTGTCTGT GAACGGCAAG
GGCCGGCCCC GCAGGGGCTT CAAGACCCGC CGCACACAGA AGTCCTCCCT GTTCCTGCCC
CGCGTGCTGG ACCACAGGGA CCACGAGATG GTGCGGCAGC TACAGAGTGG GCTGCCCAGA
CCCCCTGGTA AGGGGGTCCA GCCCCGACGG CGGCGGCAGA AGCAGAGCCC GGATAACCTG
GAGCCCTCTC ACGTTCAGGC TTCGAGACTG GGCTCCCAGC TGGAGGCCAG TGCGCACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005238.1
CDS492..1211
Misc Feature(1)627..1034(+)
Misc Feature(2)627..1034(+)
Misc Feature(3)963..1013(+)
Exon (1)1..711
Gene:FGF3
Gene Synonym:
Exon (2)712..815
Gene:FGF3
Gene Synonym:
Exon (3)816..1548
Gene:FGF3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_005247
Organism Homo sapiens (human)
Definition Homo sapiens fibroblast growth factor 3 (FGF3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005247

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGGCCTAA TCTGGCTGCT ACTGCTCAGC CTGCTGGAGC CCGGCTGGCC CGCAGCGGGC 
CCTGGGGCGC GGTTGCGGCG CGATGCGGGC GGCCGTGGCG GCGTCTACGA GCACCTTGGC
GGGGCGCCCC GGCGCCGCAA GCTCTACTGC GCCACGAAGT ACCACCTCCA GCTGCACCCG
AGCGGCCGCG TCAACGGCAG CCTGGAGAAC AGCGCCTACA GTATTTTGGA GATAACGGCA
GTGGAGGTGG GCATTGTGGC CATCAGGGGT CTCTTCTCCG GGCGGTACCT GGCCATGAAC
AAGAGGGGAC GACTCTATGC TTCGGAGCAC TACAGCGCCG AGTGCGAGTT TGTGGAGCGG
ATCCACGAGC TGGGCTATAA TACGTATGCC TCCCGGCTGT ACCGGACGGT GTCTAGTACG
CCTGGGGCCC GCCGGCAGCC CAGCGCCGAG AGACTGTGGT ACGTGTCTGT GAACGGCAAG
GGCCGGCCCC GCAGGGGCTT CAAGACCCGC CGCACACAGA AGTCCTCCCT GTTCCTGCCC
CGCGTGCTGG ACCACAGGGA CCACGAGATG GTGCGGCAGC TACAGAGTGG GCTGCCCAGA
CCCCCTGGTA AGGGGGTCCA GCCCCGACGG CGGCGGCAGA AGCAGAGCCC GGATAACCTG
GAGCCCTCTC ACGTTCAGGC TTCGAGACTG GGCTCCCAGC TGGAGGCCAG TGCGCACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Increased FGF3 and FGF4 gene dosage is a risk factor for craniosynostosis
Gene 534 (2), 435-439 (2014)
Grillo L, Greco D, Pettinato R, Avola E, Potenza N, Castiglia L, Spalletta A, Amata S, Di Benedetto D, Luciano D, Romano C and Fichera M.


book

Tooth agenesis association with self-reported family history of cancer
J. Dent. Res. 92 (2), 149-155 (2013)
Kuchler EC, Lips A, Tannure PN, Ho B, Costa MC, Granjeiro JM and Vieira AR.


book

Elevated FGF 23 and phosphorus are associated with coronary calcification in hemodialysis patients
Pediatr. Nephrol. 26 (6), 945-951 (2011)
Srivaths PR, Goldstein SL, Silverstein DM, Krishnamurthy R and Brewer ED.


book

LAMM syndrome with middle ear dysplasia associated with compound heterozygosity for FGF3 mutations
Am. J. Med. Genet. A 155A (5), 1096-1101 (2011)
Sensi A, Ceruti S, Trevisi P, Gualandi F, Busi M, Donati I, Neri M, Ferlini A and Martini A.


book

Variable expressivity of FGF3 mutations associated with deafness and LAMM syndrome
BMC Med. Genet. 12, 21 (2011)
Riazuddin S, Ahmed ZM, Hegde RS, Khan SN, Nasir I, Shaukat U, Riazuddin S, Butman JA, Griffith AJ, Friedman TB and Choi BY.


book

Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear
Development 117 (1), 13-28 (1993)
Mansour SL, Goddard JM and Capecchi MR.


book

Congenital Deafness with Labyrinthine Aplasia, Microtia, and Microdontia
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Ordonez,J. and Tekin,M.


book

The int-2 proto-oncogene is responsible for induction of the inner ear
Nature 353 (6344), 561-563 (1991)
Represa J, Leon Y, Miner C and Giraldez F.


book

Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells
Oncogene 4 (4), 429-436 (1989)
Brookes S, Smith R, Casey G, Dickson C and Peters G.


book

Characterization and chromosome assignment of the human homolog of int-2, a potential proto-oncogene
Mol. Cell. Biol. 6 (2), 502-510 (1986)
Casey,G., Smith,R., McGillivray,D., Peters,G. and Dickson,C.


 
*
*
*
*